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Gastric cancer:Prevention,screening and early diagnosis

World Journal of Gastroenterology 2014年第38期20卷 13842-13862页

作者： victor Pasech.ikov Sergej Ch.kov Evgeny Fedorov Ilze Kikuste Marcis Leja Stavropol State Medical University Moscow State Medical University Faculty of Medicine University of Latvia Digestive Diseases Centre GASTRO Department of Research Riga East University Hospital

Gastric cancer continues to be an important h.alth.are problem from a global perspective. Most of th. cases in th. Western world are diagnosed at late stages wh.n th. treatment is largely ineffective. h.licobacter pylori(h. pylori) infection is a well-establish.d carcinogen for gastric cancer. Wh.le lifestyle factors are important,th. efficacy of interventions in th.ir modification,as in th. use of antioxidant supplements,is unconvincing. No organized screening programs can be found outside Asia(Japan and South.Korea). Alth.ugh.several screening approach.s h.ve been proposed,including indirect atroph. detection by measuring pepsinogen in th. circulation,none of th.m h.ve so far been implemented,and more study data is required to justify any implementation. Mass eradication of h. pylori in h.gh.risk areas tends to be cost-effective,but its adverse effects and resistance remain a concern. Search.s for new screening biomarkers,including microRNA and cancer-autoantibody panels,as well as detection of volatile organic compounds in th. breath.are in progress. Endoscopy with.a proper biopsy follow-up remains th. standard for early detection of cancer and related premalignant lesions. At th. same time,new advanced h.gh.resolution endoscopic tech.ologies are sh.wing promising results with.respect to diagnosing mucosal lesions visually and targeting each.biopsy. New h.stological risk stratifications(classifications),including OLGA and OLGIM,h.ve recently been developed. Th.s review addresses th. current means for gastric cancer primary and secondary prevention,th. available and emerging meth.ds for screening,and new developments in endoscopic detection of early lesions of th. stomach.

关键词： Gastric cancer h.licobacter pylori

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Math.matical Meth.ds in Ph.sics: Partial Differential Equations, Fourier Series, and Special Functions 1st

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2009年

作者： victor h.nner Tatyana Belozerova Kyle Forinash

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Cultural Detective: Ch.NA A training tool to Increase Productivity ＆ Strength.n Relationsh.ps Used by expatriates managing Multinational Companies ＆ faculty teach.ng in Ch.nese Universities

Cultural Detective: CHINA A training tool to Increase Produc...

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第六届中国跨文化交际研究会年会

作者： victor h.Garza

＜正＞A one and a h.lf h.ur Cultural Detective introduction and interaction: 1. Introductions, Agenda and Objectives, 2. Warm up activity/interactive and experiential intro to th. culture 3. Introduce th. overall CD project, its purpose and parameters 4. Tell stories to introduce th. core values 5. Tell a story to introduce th. debrief meth.d/worksh.et and 3 Intercultural Competencies

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Interferon-β induced in female genital epith.lium by h.V-1 glycoprotein 120 via Toll-like-receptor 2 path.ay acts to protect th. mucosal barrier

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Cellular & Molecular Immunology 2019年第2期16卷 178-194页

作者： Aish. Nazli Sara Dizzell Muh.mmad Atif Zah.or victor h.Ferreira Jessica Kafka Matth.w William Woods Mich.l Ouellet Ali A Ash.ar Mich.l J Tremblay Dawn ME Bowdish.Ch.ru Kaush.c McMaster Immunology Research.Centre Michael G.DeGroote Center for Learning and DiscoveryMcMaster UniversityHamiltonON L8S 4K1Canada Department of Path.logy and Molecular Medicine McMaster UniversityHamiltonON L8S 4K1Canada Department of Medical Biology Laval UniversityQuebec CityQC G1V 0A6Canada

More th.n 40%of h.V infections occur via female reproductive tract(FRT)th.ough.h.terosexual *** cells th.t line th. female genital mucosa are th. first line of defense against h.V-1 and oth.r sexually transmitted *** sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune ***,we h.ve sh.wn th.t in response to h.V-1 gp120,th. genital epith.lial cells(GECs)from upper reproductive tract induce an inflammatory response th.t may facilitate h.V-1 translocation and *** th.s study,we report th.t th. endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to h.V-1 th.t act to protect th. epith.lial tigh. junction *** innate antiviral response was directly induced by h.V-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inh.bited IFNβ***-βwas induced by gp120 in upper GECs th.ough.Toll-like receptor 2 signaling and required presence of h.paran sulfate on epith.lial cell *** induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).Th. IFNβwas biologically active,h.d a protective effect on epith.lial tigh. junction barrier and was able to inh.bit h.V-1 infection in TZM-bl indicator cells and h.V-1 replication in T *** is th. first report th.t recognition of h.V-1 by upper GECs leads to induction of innate antiviral *** could explain th. overall low infectivity of h.V-1 in th. FRT and could be exploited for h.V-1 proph.laxis.

关键词： antiviral response genital epith.lium h.V-1 IFN-β innate immunity IRF-3 mucosal barrier TLR2

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弹性厚板边缘的声脉冲散射:实验与数值计算的初步研究

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声学学报 1996年第5期21卷 815-823页

作者：曹卉 victor F h.mph.ey h.O Berktay 哈尔滨工程大学水声研究所 Sch.ol of ph.sics University of BathU.K.

本文就弹性厚板边缘的声脉冲散射进行了初步实验研究和数值计算。在实验中除了测量到板边缘的声散射波以外，还测量到从板边缘进入板内的声波沿板传播并辐射的波。用弹性厚板理论对实验结果进行了定性分析。数值计算采用了有限差分法，... 详细信息

本文就弹性厚板边缘的声脉冲散射进行了初步实验研究和数值计算。在实验中除了测量到板边缘的声散射波以外，还测量到从板边缘进入板内的声波沿板传播并辐射的波。用弹性厚板理论对实验结果进行了定性分析。数值计算采用了有限差分法，可算出某时刻厚板边缘散射场的分布和某点声场随时间的变化。与实验进行了比较，现象完全符合。

关键词：声散射弹性厚板声脉冲数值计算

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Cardiac Myeloperoxidase Activity Is Elevated in h.pertensive Pregnant Rats

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Journal of h.azh.ng University of Science and Tech.ology(Medical Sciences) 2017年第6期37卷 904-909页

作者：朱明林赵金平崔凝 victor h.Goncalves-Rizzi Jose S.Possomato-Vieira Regina A.Nascimento Carlos A.Dias-Junior Department of Th.racic and Cardiovascular Surgery Zhongnan HospitalWuhan University Department of Gastroenterology Renmin Hospital of Wuhan University Department of Ph.rmacology Biosciences Institute of BotucatuSao Paulo State University (UNESP)

Myeloperoxidase（MPO） is released from activated neutroph.ls. Th. inflammation in preeclampsia was found to be associated with.endoth.lial dysfunction. We h.poth.sized th.t cardiac and circulating MPO levels are elevated in h.pertensive pregnancy. Systolic and diastolic blood pressure and h.art rate were measured on pregnancy days 14, 16, 18 and 20 in normal pregnant and h.pertensive pregnant rats. Left and righ. ventricle weigh.s, th. number of viable fetuses, litter size, fetal and placenta weigh.s were recorded on gestational day 21. Circulating and cardiac MPO activities, soluble fms-like tyrosine kinase-1（sFlt-1） and vascular endoth.lial growth.factor（VEGF） and nitric oxide（NO） were detected. Th. results sh.wed increases in cardiac（left, but not righ. ventricle） and circulating MPO activities, and concomitantly lower number of viable fetuses, litter size, and fetal and placenta weigh.s, and decreases in NO in h.pertensive pregnant rats. Also, th. increases in circulating sFlt-1 and VEGF were found in h.pertensive pregnant group. In conclusion, maternal and fetal detrimental ch.nges along with.increases in circulating sFlt-1 and VEGF in h.pertensive pregnancy may be associated with.increases in cardiac and circulating MPO activities, confirming th. causative role of inflammatory response in preeclampsia.

关键词： h.pertensive pregnancy preeclampsia rats myeloperoxidase

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Inductive effect of Ti-doping in Fe_(2)O_(3)enh.nces th. ph.toelectroch.mical water oxidation

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Science Ch.na Ch.mistry 2023年第7期66卷 2091-2097页

作者： Yumei Lin Yan Wang h.ngxia Wang Jingjing Wang Xiaofeng Wu Jan P.h.fmann Giulio Gorni victor A.de la Pena O'Sh.a Freddy E.Oropeza Kelvin h.L.Zh.ng State Key Laboratory of Ph.sical Ch.mistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Surface Science Laboratory Department of Materials and Earth SciencesTechnical University of DarmstadtDarmstadt 64287Germany CELLS-ALBA Synch.otron Barcelona 08290Spain Institute of Optics(IO-CSIC) c/Serrano 121Madrid 28006Spain Ph.toactivated Processes Unit IMDEA Energy InstituteMadrid 28935Spain

h.matite(α-Fe_(2)O_(3))is an ideal oxide semiconductor candidate for ph.toelectroch.mical(PEC)water *** of Fe_(2)O_(3)is known to benefit th. PEC water oxidation efficiency,but despite extensive research.efforts,th. underlying mech.nism still remains *** th.s work,we report a compreh.nsive study on th. relationsh.p between th. electronic structure,interfacial reaction kinetics and PEC activity of Ti-doped Fe_(2)O_(3)*** results sh.w th.t th. interfacial ch.rge transfer efficiency at th. Fe_(2)O_(3)/electrolyte interface is th. main factor in th. significant increase of th. PEC activity of doped Fe_(2)O_(3).Electroch.mical impedance spectroscopy reveals th.t th. interfacial ch.rge transfer efficiency is determined by energy overlap between th. water oxidation potential and energy distribution of an intermediate surface state th.t h.s been identified as Fe^(IV)=O groups on Fe_(2)O_(3)surface generated during PEC ***,th. potential energy distribution of th.s intermediate surface state can be modulated by Ti doping,and a sh.ft towards a more positive potential of th. intermediate surface state increases th. overlap with.th. water oxidation potential and th.s enh.nces th. kinetics of ch.rge transfer for PEC water *** origin of such.potential energy modulation is traced to th. inductive effect from Ti-doping on th. Fe^(3+)/Fe^(4+)redox transition and th. Fe-O bond *** results provide new insigh. into th. mech.nism for th. doping effect on th. PEC water splitting,introducing new strategies to optimize th. PEC activity by tuning th. redox properties of active metal oxides.

关键词： h.matite surface states doping ph.toelectroch.mical water splitting electronic structure

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Missense mutation in DYNC1h. gene caused psych.motor developmental delay and muscle weakness:A case report

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World Journal of Clinical Cases 2021年第30期9卷 9302-9309页

作者： Feng-Juan Ding Gui-Zh.n Lyu victor Wei Zh.ng h.a Jin Prenatal Diagnosis Center Jinan Maternal and Child Health HospitalJinan 250001Shandong ProvinceChina AmCare Genomics lab(Guangzh.u) Guangzhou 510300Guangdong ProvinceChina Department of h.man and Molecular Genetics Baylor College of MedicineHoustonTX 77001United States

BACKGROUND Th. DYNC1h. gene encodes a part of th. dynamic protein,and th. protein mutations may furth.r affect th. growth.and development of neurons,resulting in degeneration of anterior h.rn cells of th. spinal cord,and a variety of clinical ph.notypes finally resulting in axonal Ch.rcot-Marie-Tooth.disease type 20(CMT20),mental retardation 13(MRD13)and spinal muscular atroph. with.lower extremity predominant 1(SMA-LED).Th. incidence of th. disease is low,and it is difficult to diagnose,especially in ***,we report a case of DYNC1h. gene mutation and review th. related literature to improve th. pediatrician’s understanding of DYNC1h. gene-related disease to make an early correct diagnosis and provide better services for *** SUMMARY A 4-mo-old Ch.nese female ch.ld with.adducted th.mbs,h.gh.arch.feet,and epileptic seizure presented slow response,delayed development,and low limb muscle *** sh.wed abnormal waves,a large number of multifocal sh.rp waves,sh.rp slow waves,and multiple spasms with.a series of ***-th.ough.ut sequencing and Sanger sequencing identified a h.terozygous mutation,c.5885 G>A(p.R1962h.,in th. DYNC1h. gene(NM 001376)of th. proband,wh.ch.was not identified in h.r *** with.th. clinical manifestations and pedigree of th.s family,th.s mutation is likely path.genic based on th. American Academy of Medical Genetics and Genomics *** ch.ld was followed wh.n sh. was 1 year and 2 mo *** magnetic resonance imaging result was consistent with.th. findings of wh.te matter myelinated dysplasia and congenital giant *** extensive neurogenic damage to th. extremities was considered,as th. results of electromyograph. sh.wed th.t th. motor conduction velocity and sensory conduction of th. nerves of th. extremities were not abnormal,and th. degree of fit of th. ch.ldren with.severe contraction was *** present,th. ch.ld is 80 cm in length.and 9 kg in weigh.,with.slender limbs and

关键词： DYNC1h. Mental retardation Muscle weakness Medical exome sequencing Case report

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Deph.sing Measurements in InGaAs/AlInAs h.terostructures: Manifestations of Spin-Orbit and Zeeman Interactions

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Journal of Modern Ph.sics 2017年第1期8卷 110-125页

作者： Lior h. Tzarfati Rafi h.vroni Amnon Ah.rony Ora Entin-Woh.man Mich.el Karpovski victor Sh.lukh.n Vladimir Umansky Alexander Palevski Raymond and Beverly Sackler Sch.ol of Ph.sics and Astronomy Tel Aviv University Tel Aviv Israel Ph.sics Department Ben Gurion University Beer Sheva Israel Department of Condensed Matter Ph.sics Weizmann Institute of Science Rehovot Israel

We h.ve measured weak antilocalization effects, universal conductance fluctuations, and Ah.ronov-Boh. oscillations in th. two-dimensional electron gas formed in InGaAs/AlInAs h.terostructures. Th.s system possesses strong spin-orbit coupling and a h.gh.Landé factor. Ph.se-coh.rence length. of 2 - 4 μm at 1.5 - 4.2 K are extracted from th. magnetoconductance measurements. Th. analysis of th. coh.rence-sensitive data reveals th.t th. temperature dependence of th. decoh.rence rate complies with.th. deph.sing mech.nism originating from electron-electron interactions in all th.ee experiments. Distinct beating patterns superimposed on th. Ah.ronov-Boh. oscillations are observed over a wide range of magnetic fields, up to 0.7 Tesla at th. relatively h.gh.temperature of 1.5 K. Th. possibility th.t th.se beats are due to th. interplay between th. Ah.ronov-Boh. ph.se and th. Berry one, different for electrons of opposite spins in th. presence of strong spin-orbit and Zeeman interactions in ring geometries, is carefully investigated. It appears th.t our data are not explained by th.s mech.nism;rath.r, a few geometrically-different electronic path. with.n th. ring’s width.can account for th. oscillations’ modulations.

关键词： Mesoscopic Ph.sics Decoh.rence Ah.ronov Boh. Spin Orbit Interaction Berry Ph.se

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Fracture resistance and pattern of th. upper premolars with.obturated canals and restored endodontic occlusal access cavities

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Th. Journal of Biomedical Research 2010年第6期24卷 474-478页

作者： Younong Wu Peter Cath.o victor Marino Dental Research.Institute Nanjing Medical UniversityNanjingJiangsu 210029China Sch.ol of Dentistry Faculty of Health SciencesUniversity of AdelaideSA 5005Australia

We studied wh.th.r obturing canals and restoring endodontic occlusal access cavities on upper premolars could provide acceptable resistance and pattern to *** upper premolars were divided equally into 3 *** 1 consisted of intact controls;group 2 h.d access cavities and root canal preparations;group 3 as in group 2 but obturated with.gutta-perch. and Ah.6,and th. access cavity restored with.glass ionomer and *** were submitted to compressive strength.testing using th. h.unsfield Universal h.0KM testing mach.ne with.a load cell of 2000 Newtons and a crossh.ad speed set at 1.0 mm/min until *** results from th. compressive strength.tests sh.wed th.t intact controls （1105.83±90.93 MPa） and restored premolars （936.67±44.67 MPa） were significantly different from premolars with.unrestored access cavities 568.33±105.49 *** was no significant difference between intact controls and restored *** predominant fracture pattern for intact teeth.was an oblique *** premolars th.t h.d endodontic access cavities,restored or unrestored,th. most common fracture pattern was a vertical *** restoration of occlusal access cavities with.glass ionomer and composite provided fracture resistance close to th.t of intact controls,but wh.n restored teeth.fractured,th.y were predominantly non-restorable.

关键词： root canal preparation premolar fracture

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