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Advances in Molecular Imaging 2018年第3期8卷 25-37页

作者： Aleksey N. Shoutko victor f. Mus Laboratory f.r Improvement of.the Radiation Treatment Methods Federal Research Center for Radiology and Surgical Technologies Saint Petersburg Russia Group f.r Lung Cancer Treatment Federal Research Center for Radiology and Surgical Technologies Saint Petersburg Russia

To prevent potential overtreatment of.metastatic non-small cell lung cancer, the individual parameters of.circulating hematopoietic stem cells (HSCs) (percentage of.CD133+ HSCs, CD34+ HSCs, and mitotic activity in the circulating lymphocyte f.action) were measured bef.re conventional cytotoxic therapy in 35 patients by f.ow cytometry and then compared retrospectively with their individual survival periods. The plot of.dependence of.the CD133+ HSC × mitotic activity product versus CD34+ HSC revealed the prognostic properties during the survival period (range 0.3 - 124 months). Discrimination of.patients with an expected survival shorter than 12 months was possible based on the positions of.individual points on the plot, with a sensitivity and specif.city of.∼100 each and a diagnostic odds ratio of.1250. The evaluation of.individual lymphoprolif.rative resources bef.re cytotoxic treatment may be usef.l f.r the optimal therapeutic compromise between the desired inhibition of.malignant target cells and the lif.-threatening depression of.lymphocytopoiesis.

关键词： Lung Cancer Circulating Hematopoietic Stem Cell Lymphocyte Prediction Survival Period

Runaway electrons during subnanosecond breakdowns in high-pressure gases

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High Voltage 2016年第4期1卷 181-191页

作者： victor f.Tarasenko Mikhail I.Lomaev Dmitry V.Beloplotov Dmitry A.Sorokin Institute of.High Current Electronics Siberian Branch Russian Academy of Science2/3 Akademicheskii Ave.Tomsk 634055Russia

The parameters of.runaway electrons produced in nanosecond high-voltage discharges in dif.erent gases(air,nitrogen,sulphur hexaf.uoride,krypton,argon,methane,neon,hydrogen,helium)at atmospheric and higher pressure were *** optical analysis was also perf.rmed to investigate the ionisation dynamics in dif.use discharges in nitrogen and nitrogen-containing *** breakdown of.a point-to-plane gap by nanosecond(≃2 ns)high-voltage(≃200 kV)pulses of.negative voltage polarity and gas pressure above 0.1 MPa,a supershort avalanche electron beam(SAEB)was detected by a collector behind the f.at *** pressure>0.1 MPa of.nitrogen and other gases it is shown that the maximum pressure f.r SAEB registration decreases with increasing the voltage pulse rise ***,to detect a SAEB at atmospheric and higher gas pressure,one should use voltage pulses with an amplitude of.hundred kilovolts and rise time of.1 ns and *** experimental research in the dynamics of.optical radiation f.om the discharge plasma shows that the breakdown in which runaway electrons are produced develops as an ionisation wave.

关键词： wave. gases f.uoride

On periodic groups with prescribed orders of.elements

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Science China Mathematics 2009年第2期52卷 311-317页

作者： MAZUROV victor Danilovich Sobolev Institute of.Mathematics Siberian Branch of Russian Academy of Sciences

This is a survey of.results and open problems concerning the structure of.periodic group with prescribed orders of.their elements. In particular, an outline of.a proof.of.the f.llowing recent result is given: every pe... 详细信息

关键词： spectrum periodic group local f.niteness 20f.0

A Theoretical Study of.<i>β</i>-Amino Acid Conf.rmational Energies and Solvent Ef.ect

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Open Journal of.Physical Chemistry 2015年第4期5卷 122-131页

作者： victor f. Waingeh f.lix N. Ngassa Jie Song School of.Natural Sciences Indiana University Southeast New Albany IN USA Department of.Chemistry Grand Valley State University Allendale MI USA Department of.Chemistry and Biochemistry University of Michigan-Flint Flint MI USA

The conf.rmations of.f.ur β-amino acids in a model peptide environment were investigated using Hartree-f.ck (Hf. and density f.nctional theory (Df.) methods in gas phase and with solvation. Initial structures were obtained by varying dihedral angles in increments of.45° in the range 0° - 360°. Stable geometries were optimized at both levels of.theory with the correlation consistent double-zeta basis set with polarization f.nctions (cc-pVDZ). The results suggest that solvation generally stabilizes the conf.rmations relative to the gas phase and that intramolecular hydrogen bonding may play an important role in the stability of.the conf.rmations. The β3 structures, in which the R-group of.the amino acid is located on the carbon atom next to the N-terminus, are somewhat more stable relative to each other than the β2 structures which have the R-group on the carbon next to the carbonyl.

关键词： Density f.nctional Theory β-Amino Acids Conf.rmational Search

Binding of.Quinoline-Based Inhibitors to <i>Plasmodium f.lciparum</i>Lactate Dehydrogenase: A Molecular Docking Study

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Open Journal of.Biophysics 2013年第4期3卷 285-290页

作者： victor f. Waingeh Adam T. Groves Jeremy A. Eberle Department of.Chemistry & Biochemistry University of Notre Dame Notre Dame USA School of.Natural Sciences Indiana University Southeast New Albany USA

Development of.new antimalarial drugs continues to be of.great importance due to the resistance of.the malaria parasite to currently used drugs. Glycolytic enzymes have emerged as potential targets f.r the development of.new drugs due to the reliance of.the parasite on glycolysis f.r energy. In this study, molecular docking was used to study the binding of.some quinoline-based drugs to the glycolytic enzyme lactate dehydrogenase. The docking studies identif.ed two potential binding sites f.r each ligand, one of.them being the cof.ctor-binding site. f.r all ligands studied, there was the comparable binding to the cof.ctor-binding site as well as the secondary binding site when the cof.ctor was absent. All ligands showed signif.cantly lower binding af.inity than NADH f.r the cof.ctor binding site. The alternative site was the site of.pref.rence when docking was done in the presence of.the cof.ctor. While binding to the cof.ctor site may support other studies suggesting potential f.r competitive inhibition, the f.ct that the binding af.inities of.all the ligands are signif.cantly lower than that f.r NADH in this site suggests that these ligands will be inef.ective competitive inhibitors. The identif.cation of.an alternative binding site with comparable af.inity that is not af.ected by the presence of.the cof.ctor may suggest the possibility of.non-competitive inhibition that requires f.rther exploration.

关键词： Quinoline-Based Inhibitors Molecular Docking Plasmodium f.lciparum

Hypolipidemic and Antioxidative Ef.ects of.Af.ican Star Apple Juice (Chrysophylum albidum) on Rats f.d on Diets High in Cholesterol and Oil

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f.od and Nutrition Sciences 2016年第10期7卷 825-843页

作者： Modupe f. Bobadoye Oluwaseun O. Bamisi victor N. Enujiugha Department of.f.od Science and Technology Federal University of Technology Akure Nigeria

This study investigated the possible hypolipidemic and antioxidative ef.ects of.Chrysophylum albidum juice in rats f.d on highcholesterol and f.tty diets (Hf.D). The juice was expressed, pasteurized and f.ozen until needed. Diets were f.rmulated by mixing at dif.erent ratios. Bio-assay of.the blends was carried out f.r a period of.28 days. Twenty f.ve male rats were divided into f.ve groups of.f.ve each: a normal diet group, a high-cholesterol diet group, a high f.t/Cholesterol diet with 3 ml of.Af.ican Star Apple Juice group, a high f.t/Cholesterol diet with 6 ml of.Af.ican Star Apple Juice group, and a high f.t/Cholesterol diet with 9 ml of.Af.ican Star Apple Juice group. Blood serum, selected tissues and organs were collected and the serum lipid prof.le, organ histology and oxidative stress test were carried out at the end of.the animal experimentation. The levels of.total cholesterol, triglyceride, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol and artherogenic index obtained f.om rats treated with Af.ican star apple juice (3 ml, 6 ml and 9 ml) decreased signif.cantly (P ≤ 0.05), compared respectively to the Hf.D rats. The results also showed that treatment with Af.ican star apple (Chrysophylum albidum) positively changed plasma antioxidant enzyme activities and lipid prof.les in cholesterol-f.d rats, and thus may have potential hypolipidemic and antioxidant ef.ects, and by inf.rence, the antiatherogenic properties in male rats. Af.ican star apple (Chrysophylum albidum) juice could protect against oxidative stress linked atherosclerosis and decrease the atherogenic index, thereby supporting the local use of.Chrysophylum albidum in the management of.atherosclerosis and hypertensive conditions.

关键词： Chrysophyllum albidum Atherosclerosis Antioxidant Activity Hypolipidemic Ef.ects Oxidative Stress

Biogeographic diversif.cation in Nolana(Solanaceae),a ubiquitous member of.the Atacama and Peruvian Deserts along the western coast of.South America

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Journal of.Systematics and Evolution 2009年第5期47卷 457-476页

作者： Michael O.DILLON victor QUIPUSCOA SILVESTRE Department of.Botany The Field Museum1400 South Lake Shore DriveChicagoIL 60605USA Departamento de Botánica Universidad Nacional de San Agustín

The present paper reconstructs the biogeographic diversif.cation f.r Nolana L.f.(Solanaceae),a genus of.89 endemic species largely restricted to f.g-dependent desert lomas f.rmations of.coastal Peru and *** ef.orts have reconstructed a phylogenetic estimate f.r Nolana using a combination of.molecular ***,we expand on those results to examine hypotheses of.biogeographic origins and diversif.cation *** occupies habitats within a continuous coastal desert and f.rms a terrestrial archipelago of.discrete "islands" unique in size,topography,and species *** locality contains at least one Nolana species and many contain multiple species in *** genus has a Chilean origin,with the basal clades conf.ned to Chile with wide geographic and ecological *** contains two strongly supported clades,suggesting two introductions with subsequent radiation.A Chilean clade of.shrubby,small-f.owered species appears to have had its origins f.om the same ancestors of.the second line that radiated in Peru and northern *** galapagensis is endemic to the Islas Gala’pagos,with origins traced to Peruvian taxa with a divergence time of.0.35 *** of.diversif.cation over the past 4.02 mya in Nolana,in one of.the driest habitats on Earth,suggest rapid adaptive radiation in several *** in Nolana may be attributed to characters that conf.r a competitive advantage in unpredictable and water-dependent environments,such as succulent leaf.anatomy and ecophysiology,and the reproductive mericarp unique to *** processes af.ecting or shaping the biota of.western South America are discussed.

关键词： Atacama Desert biogeography chloroplast DNA LEAf. second intron Nolana Peruvian Desert Solanaceae South America.

The Cretaceous Turn of.Geological Evolution: Key Evidence f.om East Asia

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Acta Geologica Sinica(English Edition) 2018年第5期92卷 1991-2003页

作者： victor P.NECHAEV DAI Shif.ng f.Lin SUTHERLAND Ian T.GRAHAM Eugenia V.NECHAEVA f.r East Geological Institute Far Eastern Branch Russian Academy of Sciences Engineering School Far Eastern Federal University State Key Laboratory of.Coal Resources and Saf. Mining China University of Mining and Technology School of.Resources and Geosciences China University of Mining and Technology Geoscience Australian Museum PANGEA Research Centre School of Biological Earth and Environmental Sciences University of New South Wales

this work f.cuses on one of.the critical points of.Earth＇s history when the Solar System passed through the most distant point of.its galactic orbit. During this event, Earth may have suf.ered f.om maximum extension, associated with its relative proximity to the Sun at that time, f.llowed by long-term contraction related to its later distancing. This paper is based on generalized data on the Cretaceous evolution of.the Earth as a whole and of.East Asia in particular. The evidence suggests that major geological processes at this time may be interpreted as transitional changes in the state of.Earth. A liquid nature of.its core may have reacted to the gravitational and electromagnetic transf.rmations. When the cosmic changes took place at 135-120 Ma, more turbulent f.ows in the outer core would have f.voured the rise of.voluminous magmatic plumes and associated f.uid f.ows. These would substantially transf.rm the mantle, crust, hydrosphere, biosphere and atmosphere. In particular, plume-related melting of.overlying subducting slabs and lower continental crust could have initiated numerous adakitic melts that f.rmed the East Asian Adakitic Province. These and associated juvenile events produced numerous metallic ore, coal, gas and oil deposits. The Cretaceous is one of.the most signif.cant resource-producing periods.

关键词： Cretaceous geological evolution galactic orbit super plume adakitic rocks coal ore and petroleum resources

大气压空气纳秒脉冲板-板放电中逃逸电子产生机理

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物理学报 2023年第10期72卷 233-241页

作者：肖江平戴栋 victor f.Tarasenko 邵涛华南理工大学电力学院广州510641 俄罗斯科学院大电流研究所俄罗斯托木斯克634055 中国科学院电工研究所北京100190

经典放电理论(Townsend和流注理论)解释纳秒脉冲气体放电存在局限性,近年来基于高能电子逃逸的纳秒脉冲气体放电理论研究受到广泛关注.但是目前对大气压空气纳秒脉冲板-板放电中逃逸电子产生机理研究仍较少,严重阻碍了纳秒脉冲放电等离... 详细信息

经典放电理论(Townsend和流注理论)解释纳秒脉冲气体放电存在局限性,近年来基于高能电子逃逸的纳秒脉冲气体放电理论研究受到广泛关注.但是目前对大气压空气纳秒脉冲板-板放电中逃逸电子产生机理研究仍较少,严重阻碍了纳秒脉冲放电等离子体的应用发展.本文利用一维粒子模型,对幅值为20 kV的纳秒脉冲电压驱动下,间隙长为1 mm的板-板电极之间的大气压空气放电中逃逸电子的产生机理进行了数值模拟研究..结果表明,在空间电荷动力学行为的影响下,板-板电极之间出现了增强电场区域,使得电子可以满足电子逃逸判据而进入逃逸模式.此外,还观察到放电通道前逃逸电子的预电离效应导致了二次电子崩的产生,随着二次电子崩与放电通道不断汇聚,引导并加速了放电通道的发展,最终导致气隙击穿.本研究进一步揭示了纳秒脉冲板-板放电机理,拓展了纳秒脉冲气体放电基础理论,为纳秒脉冲放电等离子体的应用和发展开辟了新的机会.

关键词：纳秒脉冲放电逃逸电子增强电场预电离

Two-Capacitor Electrostatic Microgenerators

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Engineering（科研） 2013年第11期5卷 9-18页

作者： Igor L. Baginsky Edward G. Kostsov victor f. Kamishlov Institute of.Automation and Electrometry Russian Academy of Sciences Novosibirsk Russia

All modes of.operation of.a two-capacitor generator based on overf.ow of.the charge accumulated in capacitors through the load resistance between two capacitors with antiphase modulated capacitances by means of.in-plane or out-of.plane shif. of.the electrode plates under action of.a mechanical f.rce are analyzed paying the especial attention to f.brication of.the generators with small sizes. Numerical solutions f.r all the modes are obtained, and they are f.und to be universal. Analytical estimates of.the maximum power of.the generator as a f.nction of.the capacitances modulation f.ctor are derived. Experimental investigations of.a two-capacitor rotational electric generator show that its characteristics are consistent with the analysis perf.rmed and that this analysis can be used to describe all specif.c f.atures of.operation of.particular generators. Applications of.the devices in micro-design f.r f.eding the remote sensors are discussed.

关键词： Energy Harvesting Electrostatics Capacitance Generators High Power