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负重条件下不同髋臼假体表面骨整合情况评价(英文)

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中国临床康复 2005年第14期9卷 182-185页

作者：赵鉴非卢猛 victor L.Fornasier 首都医科大学附属北京同仁医院骨科北京市100730 Pathology Department Bone and Joint Laborat orySt.Michael's HospitalU of TTorontoCanada

背景:为了提高非骨水泥假体骨整合率,将羟基磷灰石(hydroxyapatile,HA)喷涂在不同假体表面上,并在狗体内进行试验,许多研究是在狗股骨部分非负重情况下使用,那么在狗的髋臼假体负重情况下骨整合情况如何呢?目的:通过对一组活体狗所实施... 详细信息

背景:为了提高非骨水泥假体骨整合率,将羟基磷灰石(hydroxyapatile,HA)喷涂在不同假体表面上,并在狗体内进行试验,许多研究是在狗股骨部分非负重情况下使用,那么在狗的髋臼假体负重情况下骨整合情况如何呢?目的:通过对一组活体狗所实施的全髋关节置换手术模型,评价在负重情况下,不同髋臼假体表面骨整合情况。设计:以实验动物为研究对象,随机分组设计的观察对比研究。单位:北京同仁医院骨科,PathologyDepartment,BoneandJointLabora-tory,***'sHospital,uofT,Toronto,Canada。材料:实验于2001-10/12在加拿大***'s医院病理科骨关节实验室完成。健康成年狗40条,体质量在29～44kg,雌雄不限,由加拿大安大略省兽医院提供。40条狗被分为7组,分别接受7种不同结构髋臼假体的全髋关节置换,包括,组1:等离子喷涂HA钛丝表面(AD/HA);组2:溶淀HA钴铬珠表面(CoCrbeads/PA);组3:钛珠表面(CPTibeads);组4:钛孔30PPI泡沫假体;组5:溶淀HA钛孔30PPI泡沫假体;组6:钛孔40PPI泡沫假体;组7:溶淀HA钛孔40PPI泡沫假体。方法:关节置换术后即开始关节负重,两周后自由活动。分别在3个月和6个月时将狗杀死,并取出髋臼假体和部分骨组织,制成病理片,依靠组织形态计量学方法,将髋臼假体分为负重区和非负重区,并对假体表面骨?

关键词：假体和植入物羟基磷灰石类骨生成关节成形术,置换,髋

弹性厚板边缘的声脉冲散射:实验与数值计算的初步研究

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声学学报 1996年第5期21卷 815-823页

作者：曹卉 victor F Humphrey H O Berktay 哈尔滨工程大学水声研究所 School of physics University of BathU.K.

本文就弹性厚板边缘的声脉冲散射进行了初步实验研究和数值计算。在实验中除了测量到板边缘的声散射波以外，还测量到从板边缘进入板内的声波沿板传播并辐射的波。用弹性厚板理论对实验结果进行了定性分析。数值计算采用了有限差分法，... 详细信息

本文就弹性厚板边缘的声脉冲散射进行了初步实验研究和数值计算。在实验中除了测量到板边缘的声散射波以外，还测量到从板边缘进入板内的声波沿板传播并辐射的波。用弹性厚板理论对实验结果进行了定性分析。数值计算采用了有限差分法，可算出某时刻厚板边缘散射场的分布和某点声场随时间的变化。与实验进行了比较，现象完全符合。

关键词：声散射弹性厚板声脉冲数值计算

Resolving the inner jet of PKS 1749+096 with super-resolution VLBA images at 7 mm

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Research in Astronomy and Astrophysics 2021年第4期21卷 202-206页

作者： Lang Cui Ru-Sen Lu Wei Yu Jun Liu victor M.Patino-Alvarez Qi Yuan Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Max Planck Institute for Radio Astronomy Auf dem hiigel 69Bonn 53121Germany Instituto Nacional de Astroffsica Optica y ElectronicaLuis Enrique Erro#1TonantzintlaPuebla 72840Mexico university of Chinese Academy of Sciences Beijing 100049China

High resolution imaging of inner jets in Active Galactic Nuclei(AGNs)with Very Long Baseline Interferometry(VLBI)at millimeter wavelengths provides deep insight into the launching and collimation mechanisms of relativistic *** BL Lac object,PKS 1749+096,shows a core-dominated jet pointing toward the northeast on parsec-scales revealed by various VLBI *** order to investigate the jet kinematics,in particular,the orientation of the inner jet on the smallest accessible scales and the basic physical conditions of the core,in this work we adopted a super-resolution technique,the Bi-Spectrum Maximum Entropy Method(BSMEM),to reanalyze VLBI images based on the Very Long Baseline Array(VLBA)observations of PKS 1749+096 within the VLBA-Bu-BLAZAR 7 mm monitoring *** observations include a total of 105 epochs covering the period from 2009 to *** found that the stacked image of the inner jet is limb-brightened with an apparent opening angle of 50°.0±8°.0 and 42°.0±6°.0 at the distances of 0.2 and 0.3 mas(0.9 and 1.4 pc)from the core,corresponding to an intrinsic jet opening angle of 5°.2±1°.0 and 4°.3±0°.7,*** addition,our images show a clear jet position angle swing in PKS 1749+096 within the last ten *** discuss the possible implications of jet limb brightening and the connection of the position angle with jet peak flux density and gamma-ray brightness.

关键词： galaxies:quasars:individual:PKS 1749+096 galaxies:jets radio continuum:galaxies

A Mathematical Study to Gout Symptoms

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Journal of Applied Mathematics and Physics 2018年第12期6卷 2579-2588页

作者： Shuixian Yan victor Moreno Sanling Yuan Baojun Song Business School University of Shanghai for Science and Technology Shanghai China Key Laboratory of Jiangxi Province for Numerical Simulation and Emulation Techniques Gannan Normal University Ganzhou China Simon A. Levin Mathematical Computational and Modeling Sciences Center Arizona State University Tempe AZ USA College of Science University of Shanghai for Science and Technology Shanghai China Department of Mathematical Sciences Montclair State University Montclair NJ USA

Gout is a form of inflammatory arthritis characterized by sharp pain and severe swelling that often causes severe physical disability. Gout is caused by the chronic elevation of uric acid levels in the blood and is known as the disease of kings due to its strong association with a diet rich in fructose and beer. Recent studies suggest that a high uric acid concentration is the result of a dynamical process that highlights the interactions between leptin production, insulin resistance, low muscle mass and a diet rich in fructose. Once individuals develop hyperuricemia, reach a high uric acid concentration in excess of 7 mg/dL for men and 6 mg/dL for women, they become susceptible to developing gout. We propose a novel dynamic system to analyze and determine the connections between a diet involving different levels of fructose (in both adult men and women in the u.S.) and the concentration of uric acid in the blood. Our model simulations suggest that adult males under a diet containing levels of fructose stimulating a 0.5 uric acid growth rate, could develop hyperuricemia after around 10,000 days, while it only takes women about 5000 days with a diet stimulating a 0.4 growth rate.

关键词： Gout uric Acid Leptin Insulin Mathematical Models

Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity and Protect Against Lethal Systemic Infection

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Engineering 2021年第8期7卷 1149-1156页

作者： Jwa-Kyung Kim Satoshi uchiyama Hua Gong Alexandra Stream Liangfang Zhang victor Nizet Division of Nephrology Department of Internal Medicine&Kidney Research InstituteHallym University Sacred Heart HospitalAnyang 14068Republic of Korea Department of Clinical Immunology Hallym University Sacred Heart HospitalAnyang 14068Republic of Korea Division of Host-Microbe Systems and Therapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA Department of NanoEngineering University of California San DiegoLa JollaCA 92093USA Moores Cancer Center University of California San Diego HealthLa JollaCA 92037USA Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San DiegoLa JollaCA 92093USA

Staphylococcus aureus(***)is a leading human pathogen capable of producing severe invasive infections such as bacteremia,sepsis,and endocarditis with high morbidity and mortality,exacerbated by the increasingly widespread antibiotic resistance exemplified by methicillin-resistant strains(MRSA).*** pathogenesis is fueled by the secretion of toxins—such as the membrane-damaging pore-forming atoxin,which have diverse cellular targets including the epithelium,endothelium,leukocytes,and ***,we examine the use of human platelet membrane-coated nanoparticles(PNPs)as a biomimetic decoy strategy to neutralize *** toxins and preserve host cell defense *** PNPs blocked platelet damage induced by *** secreted toxins,thereby supporting platelet activation and bactericidal ***,the PNPs blocked macrophage damage induced by *** secreted toxins,thus supporting macrophage oxidative burst,nitric oxide production,and bactericidal activity,and diminishing MRSA-induced neutrophil extracellular trap *** a mouse model of MRSA systemic infection,PNP administration reduced bacterial counts in the blood and protected against *** together,the results from the present work provide a proof of principle of the therapeutic benefit of PNPs in toxin neutralization,cytoprotection,and increased host resistance to invasive *** infection.

关键词： Nanoparticle Nanosponge Platelet Staphylococcus aureus Bacterial toxins Sepsis

High-throughput predictions of metal-organic framework electronic properties:theoretical challenges,graph neural networks,and data exploration

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npj Computational Materials 2022年第1期8卷 1053-1062页

作者： Andrew S.Rosen victor Fung Patrick Huck Cody T.O’Donnell Matthew K.Horton Donald G.Truhlar Kristin A.Persson Justin M.Notestein Randall Q.Snurr Department of Materials Science and Engineering University of CaliforniaBerkeleyCA94720USA Miller Institute for Basic Research in Science University of CaliforniaBerkeleyBerkeleyCA94720USA Materials Science Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Department of Chemical and Biological Engineering Northwestern UniversityEvanstonIL60208USA Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN37831USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Department of Chemistry Chemical Theory Centerand Minnesota Supercomputing InstituteUniversity of MinnesotaMinneapolisMN55455USA Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA94720USA

With the goal of accelerating the design and discovery of metal–organic frameworks(MOFs)for electronic,optoelectronic,and energy storage applications,we present a dataset of predicted electronic structure properties for thousands of MOFs carried out using multiple density functional *** to more accurate hybrid functionals,we find that the widely used PBE generalized gradient approximation(GGA)functional severely underpredicts MOF band gaps in a largely systematic manner for semi-conductors and insulators without magnetic ***,an even larger and less predictable disparity in the band gap prediction is present for MOFs with open-shell 3d transition metal *** regards to partial atomic charges,we find that different density functional approximations predict similar charges overall,although hybrid functionals tend to shift electron density away from the metal centers and onto the ligand environments compared to the GGA point of *** more significant differences in partial atomic charges are observed when comparing different charge partitioning *** conclude by using the dataset of computed MOF properties to train machine-learning models that can rapidly predict MOF band gaps for all four density functional approximations considered in this work,paving the way for future high-throughput screening *** encourage exploration and reuse of the theoretical calculations presented in this work,the curated data is made publicly available via an interactive and user-friendly web application on the Materials Project.

关键词： charges electronic centers

Adjustment of Model Parameters to Estimate Distribution Transformers Remaining Lifespan

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Smart Grid and Renewable Energy 2018年第9期9卷 151-170页

作者： victor A. Jimenez Adrian Will Jorge Gotay Sebastián Rodríguez Grupo de Investigación en Tecnologías Informáticas Avanzadas—u.T.N.-F.R.T Tucumán Argentina Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires Argentina

Currently, the electrical system in Argentina is working at its maximum capacity, decreasing the margin between the installed power and demanded consumption, and drastically reducing the service life of transformer substations due to overload (since the margin for summer peaks is small). The advent of the Smart Grids allows electricity distribution companies to apply data analysis techniques to manage resources more efficiently at different levels (avoiding damages, better contingency management, maintenance planning, etc.). The Smart Grids in Argentina progresses slowly due to the high costs involved. In this context, the estimation of the lifespan reduction of distribution transformers is a key tool to efficiently manage human and material resources, maximizing the lifetime of this equipment. Despite the current state of the smart grids, the electricity distribution companies can implement it using the available data. Thermal models provide guidelines for lifespan estimation, but the adjustment to particular conditions, brands, or material quality is done by adjusting parameters. In this work we propose a method to adjust the parameters of a thermal model using Genetic Algorithms, comparing the estimation values of top-oil temperature with measurements from 315 kVA distribution transformers, located in the province of Tucumán, Argentina. The results show that, despite limited data availability, the adjusted model is suitable to implement a transformer monitoring system.

关键词： Distribution Transformer Thermal Model Transformer Lifespan Parameters Adjustment Genetic Algorithms

Whole lesion histogram analysis of apparent diffusion coefficient predicts therapy response in locally advanced rectal cancer

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World Journal of Gastroenterology 2022年第23期28卷 2609-2624页

作者： Mayra Evelia Jiménez de los Santos Juan Armando Reyes-Pérez victor Domínguez Osorio Yolanda Villaseñor-Navarro Liliana Moreno-Astudillo Itzel Vela-Sarmiento Isabel Sollozo-Dupont Department of Radiology National Cancer InstituteMexico 14080Mexico Department of Gastrointestinal Surgery National Cancer InstituteMexico 14080Mexico

BACKGROuND Whole-tumor apparent diffusion coefficient(ADC)histogram analysis is relevant to predicting the neoadjuvant chemoradiation therapy(nCRT)response in patients with locally advanced rectal cancer(LARC).AIM To evaluate the performance of ADC histogram-derived parameters for predicting the outcomes of patients with *** This is a single-center,retrospective study,which included 48 patients with *** patients underwent a pre-treatment magnetic resonance imaging(MRI)scan for primary tumor staging and a second restaging MRI for response *** sample was distributed as follows:18 responder patients(R)and 30 non-responders(non-R).Eight parameters derived from the whole-lesion histogram analysis(ADCmean,skewness,kurtosis,and ADC10^(th),25^(th),50^(th),75^(th),90^(th) percentiles),as well as the ADCmean from the hot spot region of interest(ROI),were calculated for each patient before and after *** all data were compared between R and non-R using the Mann-Whitney u *** measures of diagnostic accuracy were applied:the receiver operating characteristic curve and the diagnostic odds ratio(DOR).We also reported intra-and interobserver variability by calculating the intraclass correlation coefficient(ICC).RESuLTS Post-nCRT kurtosis,as well as post-nCRT skewness,were significantly lower in R than in non-R(both Pund that,after treatment,R had a larger loss of both kurtosis and skewness than non-R(Δ%kurtosis and Δ skewness,Pups were post-nCRT ADC10^(th),Δ%ADC10^(th),Δ%ADCmean,and ROIΔ%***,the best diagnostic performance was achieved byΔ%kurtosis at a threshold of 11.85%(Area under the receiver operating characteristic curve[AuC]=0.991,DOR=376),followed by post-nCRT kurtosis=0.78×10^(-3)mm^(2)/s(AuC=0.985,DOR=375.3),Δskewness=0.16(AuC=0.885,DOR=192.2)and post-nCRT skewness=1.59×10^(-3)mm^(2)/s(AuC=0.815,DOR=168.6).Finally,intraclass corr

关键词： Apparent diffusion coefficient Diffusion-weighted imaging Histogram analysis Magnetic resonance imaging Locally advanced rectal cancer

Azithromycin Exerts Bactericidal Activity and Enhances Innate Immune Mediated Killing of MDR Achromobacter xylosoxidans

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Infectious Microbes & Diseases 2020年第1期2卷 10-17页

作者： Erlinda R.ulloa Armin Kousha Hannah Tsunemoto Joe Pogliano Carmelo Licitra John J.LiPuma George Sakoulas victor Nizet Monika Kumaraswamy Collaborative to Halt Antibiotic-Resistant Microbes(CHARM) University of California San DiegoLa JollaCA 92093USA Department of Pediatrics University of California San DiegoLa JollaCA 92093USA Division of Infectious Disease Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA Department of Basic Sciences and Aquatic Medicine Norwegian University of Life SciencesOsloNorway Division of Biological Sciences University of California San DiegoLa JollaCA 92093USA Infectious Diseases Orlando Health Medical GroupOrlandoFL 32806USA Department of Pediatrics University of MichiganAnn ArborMI 48109USA Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San DiegoLa JollaCA 92093USA Infectious Diseas Section VA San Diego Healthcare SystemSan DiegoCA 92161USA Department of Medicine University of California San DiegoLa JollaCA 92093USA.

Azithromycin(AZM),the most commonly prescribed antibiotic in the united States,is thought to have no activity against multidrugresistant Gram-negative pathogens such as Achromobacter xylosoxidans(AX)per standard minimum inhibitory concentration testing in cation-adjusted Mueller Hinton *** we provide the first report of AZM bactericidal activity against carbapenemresistant isolates of AX,with a multifold decrease in minimum inhibitory concentration across 12 clinical isolates when examined under physiologic testing conditions that better recapitulate the in vivo human *** pharmaceutical activity,evident in eukaryotic tissue culture media,is associated with enhanced AZM intracellular penetration and synergistic killing with human whole blood,serum,and ***,AZM monotherapy inhibited preformed AX biofilm growth in a dose-dependent manner together with a reduction in viable *** an illustrative case,AZM in combination with piperacillin-tazobactam exerted clear therapeutic effects in a patient with carbapenem-resistant AX mediastinitis,sternal osteomyelitis,and aortic graft *** study reinforces how current antimicrobial testing practices fail to recapitulate the host environment or host-pathogen interactions and may misleadingly declare complete resistance to useful agents,adversely affecting patient *** conclude that AZM merits further exploration in the treatment of drug-resistant AX *** approaches to antimicrobial susceptibility testing that better recapitulate the host environment should be considered,especially as infections caused by multidrug-resistant Gram-negative bacterial pathogens are expanding globally with high morbidity and mortality.

关键词： Achromobacter xylosoxidans antimicrobial susceptibility testing azithromycin treatment host defense multidrug resistance