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Poly-hydroxylated bile acids and their prognostic roles in Alagille syndrome

World Journal of Pediatrics 2023年第7期19卷 652-662页

作者： Meng-Xuan Wang Jun Han Teng liu Ren-Xue Wang li-Ting li Zhong-Die li Jun-Cong Yang Lang-li liu Yi Lu Xin-Bao XieJing-Yu Gong Shi-Yu Lei Zhang victor ling J Jian-She Wang Department of Pediatrics Jinshan Hospital of Fudan UniversityShanghai 201508China The Center for Pediatric liver Diseases Children's Hospital of Fudan UniversityShanghai 201102China University of victoria-Genome BC Proteomics Centre and Division of Medical Sciences VictoriaBritish ColumbiaCanada BC Cancer Research Centre VancouverBritish ColumbiaCanadaDepartment of PediatricsJinshan Hospital of Fudan UniversityShanghai 201508China Institutes of Biomedical Sciences Fudan UniversityShanghai 201199China Shanghai Key Laboratory of Birth Defect Shanghai 201102China

Background The liver manifestations of Alagille syndrome(ALGS)are highly variable,and factors affecting its prognosis are poorly *** asked whether the composition of bile acids in ALGS patients with good clinical outcomes differs from that in patients with poor outcomes and whether bile acids could be used as prognostic *** Blood for bile acid profiling was collected from genetically confirmed JAG1-associated ALGS patients before one year of age.A good prognosis was defined as survival with native liver and total bilirubin(TB)liver transplantation,death from liver failure,or TB ≥ 85.5 μmol/L at the last *** We found that the concentrations of two poly-hydroxylated bile acids,tauro-2β,3α,7α,12α-tetrahydroxylated bile acid(THBA)and glyco-hyocholic acid(GHCA),were significantly increased in patients with good prognosis compared to those with poor prognosis[area under curve(AUC)=0.836 and 0.782,respectively]in the discovery *** same trend was also observed in the molar ratios of GHCA to glyco-chenodeoxycholic acid(GCDCA)and tetrahydroxylated bile acid(THCA)to tauro-chenodeoxycholic acid(TCDCA)(both AUC=0.836).A validation cohort confirmed these ***,tauro-2β,3α,7α,12α-THBA achieved the highest prediction accuracy of 88.00%(92.31%sensitivity and 83.33%specificity);GHCA at>607.69 nmol/L was associated with native liver survival[hazard ratio:13.03,95%confidence interval(CI):(2.662-63.753),P=0.002].Conclusions We identified two poly-hydroxylated bile acids as liver prognostic biomarkers of ALGS *** hydroxylation of bile acids may result in better clinical outcomes.

关键词： Alagille syndrome Bile acid profile Poly-hydroxylated bile acids Prognostic biomarkers

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A Generative Model Approach for Geo-Social Group Recommendation

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Journal of Computer Science & Technology 2018年第4期33卷 727-738页

作者： Peng-Peng Zhao Hai-Feng Zhu Yanchi liu Zi-Ting Zhou Zhi-Xu li Jia-Jie Xu Lei Zhao victor S. Sheng School of Computer Science and Technology Soochow University Suzhou 215006 China Department of Management Science and Information Systems Rutgers University Piscataway NJ 08854 U.S.A. Department of Computer Science University of Central Arkansas Conway 72035 U.S.A.

With the development and prevalence of online social networks, there is an obvious tendency that people are willing to attend and share group activities with friends or acquaintances. This motivates the study on group recommendation, which aims to meet the needs of a group of users, instead of only individual users. However, how to aggregate different preferences of different group members is still a challenging problem： 1） the choice of a member in a group is influenced by various factors, e.g., personal preference, group topic, and social relationship; 2） users have different influences when in diffe- rent groups. In this paper, we propose a generative geo-social group recommendation model （GSGR） to recommend points of interest （POIs） for groups. Specifically, GSGR well models the personal preference impacted by geographical information, group topics, and social influence for recommendation. Moreover, when making recommendations, GSGR aggregates the preferences of group members with different weights to estimate the preference score of a group to a POI. Experimental results on two datasets show that GSGR is effective in group recommendation and outperforms the state-of-the-art methods.

关键词： group recommendation topic model social network

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Observation of nonlinear fractal higher order topological insulator

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light(Science & Applications) 2024年第11期13卷 2699-2714页

作者： Hua Zhong victor O.Kompanets Yiqi Zhang Yaroslav V.Kartashov Meng Cao Yongdong li Sergei A.Zhuravitskii Nikolay N.Skryabin Ivan V.Dyakonov Alexander A.Kalinkin Sergei P.Kulik Sergey V.Chekalin victor N.Zadkov Key Laboratory for Physical Electronics and Devices Ministry of EducationSchool of Electronic Science and EngineeringXi’an Jiaotong University710049 Xi’anChina Institute of Spectroscopy Russian Academy of SciencesTroitskMoscow 108840Russia Quantum Technology Centre Faculty of PhysicsM.V.Lomonosov Moscow State UniversityMoscow 119991Russia Faculty of Physics Higher School of EconomicsMoscow 105066Russia

Higher-order topological insulators(HOTIs)are unique materials hosting topologically protected states,whose dimensionality is at least by 2 lower than that of the *** states in such insulators may be strongly confined in their corners which leads to considerable enhancement of nonlinear processes involving such ***,all nonlinear HOTIs demonstrated so far were built on periodic bulk lattice ***,we demonstrate the first nonlinear photonic HOTI with the fractal *** their fractional effective dimensionality,the HOTIs constructed here on two different types of the Sierpiński gasket waveguide arrays,may support topological corner states for unexpectedly wide range of coupling strengths,even in parameter regions where conventional HOTIs become *** demonstrate thresholdless spatial solitons bifurcating from corner states in nonlinear fractal HOTIs and show that their localization can be efficiently controlled by the input beam *** observe sharp differences in nonlinear light localization on outer and multiple inner corners and edges representative for these fractal *** findings not only represent a new paradigm for nonlinear topological insulators,but also open new avenues for potential applications of fractal materials to control the light flow.

关键词： materials. flow. topological

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On the Path to High-Temperature Josephson Multi-Junction Devices

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Electromagnetic Science 2024年第3期2卷 71-78页

作者： Xu Wang Fucong Chen Zefeng lin Shibing Tian Chunguang li victor Kornev Nikolay Kolotinskiy Institute of Physics Chinese Academy of SciencesBeijing 100190China Faculty of Physics Lomonosov Moscow State UniversityMoscow 119991Russia

We report our progress in the high-temperature superconductor(HTS)Josephson junction fabrication process founded on utilizing a focused helium ion beam damaging technique and discuss the expected device performance attainable with the HTS multi-junction device *** the achievable high value of characteristic voltage V_(C)=I_(C)R_(N)of Josephson junctions and the ability to design a large number of arbitrary located Josephson junctions allow narrowing the existing gap in design abilities for lowtemperature superconductor(LTS)and HTS circuits even with using a single YBa_(2)Cu_(3)O_(7-x) film layer.A one-layer topology of active electrically small antenna is suggested and its voltage response characteristics are considered.

关键词： Josephson junctions High-temperature superconductors YBa_(2)Cu_(3)O_(7-x)(YBCO) Focused helium ion beam fabrication technique Josephson multi-junction devices Superconducting quantum interference device Active electrically small antenna

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Drugging IGF-1R in cancer: New insights and emerging opportunities

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Genes & Diseases 2023年第1期10卷 199-211页

作者： Panpan Wang victor CY.Mak Lydia WT.Cheung School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

The insulin-like growth factor(IGF)axis plays important roles in cancer development and *** type 1 IGF receptor(IGF-1R)is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer *** we review the occurrence of IGF-1R aberrations and activation mechanisms in cancers,which justify the development of anti-IGF-1R *** describe the therapeutic agents available for IGF-1R inhibition,with focuses on the recent or ongoing pre-clinical and clinical *** include antisense oligonucleotide,tyrosine kinase inhibitors and monoclonal antibodies which may be conjugated with cytotoxic ***,simultaneous targeting of IGF-1R and several other oncogenic vulnerabilities has shown early promise,highlighting the potential benefits of combination ***,we discuss the challenges in targeting IGF-1R so far and new concepts to improve therapeutic efficacy such as blockage of the nuclear translocationofIGF-1R.

关键词： Cancer IGF-1R Targeted therapy Metastasis Combination therapy

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Trapping the Short-Chain Odd Carbon Number Olefins Using Nickel(Ⅱ)-Catalyzed Tandem Ethylene Oligomerization and Friedel-Crafts Alkylation of Toluene

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Chinese Journal of Chemistry 2023年第21期41卷 2855-2865页

作者： Sergey V.Zubkevich Vladislav A.Tuskaev Svetlana Ch.Gagieva Alexander A.Pavlov victor N.Khrustalev Fei Wang li Pan Yuesheng li Daniele Saracheno Anton A.Vikhrov Dmitry N.Zarubin Boris M.Bulychev Department of Chemistry Lomonosov Moscow State UniversityLeninskie Gory 1Moscow119991 Russian Federation Materials Research and Technology Department Luxembourg Institute of Science and Technology5Avenue des Hauts-FourneauxL-4362 Esch-sur-AlzetteLuxembourg A N Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesVavilova st.28Moscow119991 Russian Federation BMSTU Center of National Technological Initiative“Digital Material Science:New Material and Substances” Bauman MoscowState Technical University2nd Baumanskaya st.5MoscowRussian Federation Peoples’Friendship University of Russia(RUDN University) Miklukho-Maklay St.6Moscow117198 Russian Federation Zelinsky Institute of Organic Chemistry Russian Academy of SciencesLeninsky Prospekt 47Moscow119991 Russian Federation Institute of Advanced Polymer Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350 China

Nickel(Ⅱ)complexes with pyrazole-based ligands are widely employed in catalysis of ethylene oligomerization and subsequent Friedel-Crafts alkylation of *** have prepared ten new nickel(Ⅱ)dibromide complexes with various substituted bis(azolyl)*** have been characterized using^(1)H NMR,IR,high resolution mass spectrometry and elemental *** structures of three complexes have been unambiguously established using X-ray *** was found that these complexes in the presence of Et2AlCl or Et_(3)Al_(2)Cl_(3)are active both in ethylene oligomerization and Friedel-Crafts alkylation processes(activity up to 3720 kgoligomer·mol[Ni]^(−1)·h^(−1)).The use of Et_(3)Al_(2)Cl_(3)results in a higher share of alkylated products(up to 60%).Moreover,catalytic systems activated with Et_(3)Al_(2)Cl_(3)produced small amounts of odd carbon number olefins(up to 0.8%).The Friedel-Crafts alkylation was used as a trap for previously undetected short-chain odd carbon number olefins(C_(3)and C_(5)).

关键词： Ethylene oligomerization Friedel-Crafts alkylation Nickel(Ⅱ)complexes N-ligands Odd carbon number olefins

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Reaction Time of Children with and without Autistic Spectrum Disorders

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Open Journal of Medical Psychology 2017年第2期6卷 166-178页

作者： Brett Baisch Sean Cai Zongming li victor Pinheiro Constellation Schools Cleveland OH USA School of Sport Science & Wellness Education University of Akron Akron OH USA Departments of Biomedical Engineering Physical Medicine and Rehabilitation and Orthopaedic Surgery Cleveland Clinic Foundation Cleveland OH USA

This study was conducted to evaluate and compare simple and choice reaction times for the comparison of perceptual-motor development levels found in children with and without autism. The participants of the study consisted of 24 children with autism and 10 typically developing (TD) children. Within the group of children with autism, only 10 were able to offer a full set data and four offered partial data. Data were collected through a computer-based procedure of reaction time test software, where the participant reacted by pressing a key on a laptop upon the appearance of one of the boxes turning yellow. Simple and choice reaction times appeared on the screen and were then recorded. The means and standard deviations were calculated for comparison and the data were evaluated from the results of a t-test. Significant differences were found among all reaction time tasks, whereas the group consisting of children with autism demonstrated slower reaction times and greater standard deviations compared with the typically developing/control group.

关键词： Autism Reaction Time Perceptual-Motor Development Motor Impairments Physical Education

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Review Integration of smartphone technology and artificial intelligence for advanced ophthalmic care:A systematic review

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Advances in Ophthalmology Practice and Research 2024年第3期4卷 120-127页

作者： Kai Jin Yingyu li Hongkang Wu Yih Chung Tham victor Koh Yitian Zhao Ryo Kawasaki Andrzej Grzybowski Juan Ye Eye Center The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang Provincial Key Laboratory of OphthalmologyZhejiang Provincial Clinical Research Center for Eye DiseasesZhejiang Provincial Engineering Institute on Eye DiseasesHangzhouChina Centre for Innovation and Precision Eye Health National University of SingaporeSingapore Department of Ophthalmology National University of SingaporeSingapore Singapore Eye Research Institute Singapore National Eye CentreSingapore Ophthalmology and Visual Science Academic Clinical Program Duke-NUS Medical SchoolSingapore Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Ningbo Eye Hospital NingboChina Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Division of Public Health Department of Social MedicineGraduate School of MedicineOsaka UniversityOsakaJapan Artificial Intelligence Center for Medical Research and Application Osaka University HospitalOsakaJapan Institute for Research in Ophthalmology Foundation for Ophthalmology DevelopmentPoznanPoland

Background:The convergence of smartphone technology and artificial intelligence(AI)has revolutionized the landscape of ophthalmic care,offering unprecedented opportunities for diagnosis,monitoring,and management of ocular ***,there is a lack of systematic studies on discussing the integration of smart-phone and AI in this *** text:This review includes 52 studies,and explores the integration of smartphones and AI in ophthalmology,delineating its collective impact on screening methodologies,disease detection,telemedicine initiatives,and patient *** collective findings from the curated studies indicate promising performance of the smartphone-based AI screening for various ocular diseases which encompass major retinal diseases,glaucoma,cataract,visual impairment in children and ocular surface ***,the utilization of smartphone-based imaging modalities,coupled with AI algorithms,is able to provide timely,efficient and cost-effective screening for ocular *** modality can also facilitate patient self-monitoring,remote patient monitoring and enhancing accessibility to eye care services,particularly in underserved *** involving data pri-vacy,algorithm validation,regulatory frameworks and issues of trust are still need to be ***,evaluation on real-world implementation is imperative as well,and real-world prospective studies are currently ***:Smartphone ocular imaging merged with AI enables earlier,precise diagnoses,personalized treat-ments,and enhanced service accessibility in eye *** is crucial to navigate ethical and data security challenges while responsibly leveraging these innovations,promising a potential revolution in care access and global eye health equity.

关键词： Artificial intelligence Smartphone imaging Ophthalmology Telemedicine Ocular disease management

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Prolongation Structure Analysis of a Coupled Dispersionless System

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Chinese Physics Letters 2011年第2期28卷 12-15页

作者： Souleymanou Abbagari Bouetou Bouetou Thomas Kuetche Kamgang victor Mouna Ferdinand Timoleon Crepin Kofane National Advanced School of Engineering University of Yaounde IP.O.Box.8390Cameroon Department of Physics Faculty of ScienceUniversity of Yaounde IP.O.Box.812Cameroon Department of Mathematics Higher Teacher’s Training CollegeUniversity of MarouaP.O.Box.46Cameroon Department of Mathematics Faculty of ScienceUniversity of Yaounde IP.O.Box 812Cameroon

We address the problem of integrability of a coupled dispersionless system recently introduced by Zhaqilao,Zhao and li[***.B 18(2009)1780]which physically describes the propagation of electromagnetic fields within an optical nonlinear medium,but also arrives in the physical description of a charged object dynamics in an external magnetic *** the prolongation structure analysis developed by Wahlquist and Estabrook,we derive a more general form of Lax pairs of the previous coupled dispersionless system and its concrete nonAbelian lie algebra resorting to a hidden ***,we construct the Bäcklund transformation of the system using the Riccati form of the linear eigenvalue problem.

关键词： field system Dispersion

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Tridecanuclear Gd(III)-silsesquioxane:Synthesis,structure,and magnetic property

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ChemPhysMater 2022年第4期1卷 247-251页

作者： Kai Sheng Ran Wang Alexey Bilyachenko victor Khrustalev Marko Jagodič Zvonko Jagličić Zhaoyang li likai Wang Chenho Tung Di Sun School of Aeronautics Shandong Jiaotong UniversityJinan 250037China School of Chemistry and Chemical Engineering State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology and School of Chemistry and Chemical EngineeringLiaocheng UniversityLiaocheng 252000China A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesMoscow 119991Russia and Peoples’Friendship University of RussiaMoscow 117198Russia Peoples’Friendship University of Russia Moscow 117198Russia and Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscow 119991Russia Institute of Mathematics Physicsand MechanicsLjubljana 1000Slovenia School of Materials Science and Engineering Nankai UniversityTianjin 300350China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255049China

Polynuclear metal clusters,particularly those with aesthetically appealing structures,are of increasing *** this study,by employing C 4 symmetrical macrocyclic silsesquioxane ligand,a novel tridecanuclear Gd(III)cluster(Gd13)with a{Gd 13 O 8}core featuring unprecedent body-centered Archimedean cuboctahedron conformation is realized using an efficient solvothermal method instead of conventional Schlenk *** the best of our knowledge,Gd13 cluster is thus far the highest nuclearity of ***,a magnetic study reveals a weak antiferromagnetic interaction between adjacent Gd ions in the *** addition,Gd13 exhibits cryogenic magnetocaloric effects with a maximum−ΔS M value of 20 J kg^(−1) K^(−1) at 2 K andΔH=7.0 T.

关键词： Gd-silsesquioxane Crystal structure Archimedean solid Magnetic property Magnetocaloric effects

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