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First isolation and identification of H1N1 swine influenza viruses in Colombian pig farms

Health 2012年第10期4卷 983-990页

作者： Gloria Consuelo Ramirez-Nieto Cesar Augusto Diaz Rojas victor julio vera alfonso Jairo Jaime Correa Jose Dario Mogollon Galvis Línea de Microbiología y Epidemiología Posgrado en Salud Animal Facultad de Medicina Veterinaria y de Zootecnia Universidad Nacional de Colombia Bogotá Colombia

The pig industry in Colombia has grown 30% in the last decade achieving high levels of technology and efficiency;in spite of that, respiratory diseases remain a constraint. Since 1970, serological evidence and histological findings suggested the role of swine influenza virus (SIV) as part of the porcine respiratory disease complex;nevertheless, elusive and molecular typing isolates are missing. This study was aimed at isolating SIV from intensive pig farms and to achieve molecular characterization to determine strains circulating in the field. In order to accomplish this goal, 242 samples were taken from nasal swabs, 25 from bronchial washes and 8 from lung tissue. Samples were collected during a period of three years, between 2008 and 2010 and were originated from 78 farms of the three main pig production regions of the country. The samples were transported in BHI broth with 2% antibiotic and antimycotic solution and stored at –70?C until processed. The swabs were inoculated in 9 - 11 days old embryo chicken eggs and in MDCK (Madin Darby Canine Kidney) cell cultures with the addition of trypsin. The isolates were identified by the HA (hemoagglutination) test and by RT-PCR targeting the HA (hemagglutinin), NA (Neuraminidase) and M (Matrix) genes. Full length sequence of the HA and NA glycoproteins from four selected virus isolates was conducted (Macrogen?. USA). As a result, fifteen SIV isolates from nine farms distributed in the three regions were obtained. Twelve of the isolates are related to the swine origin H1N1 virus that caused the 2009 influenza pandemic. The remaining three viruses were related to classical swine influenza viruses.

关键词： Swine Influenza H1N1 Colombia First Isolation Classical Pandemic

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Dynamic assessment of variations in pupil diameter using swept‑source anterior segment optical coherence tomography after phakic collamer lens implantation

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Eye and Vision 2021年第6期8卷 396-403页

作者： Felix Gonzalez‑Lopez Carmen Bouza‑Miguens victor Tejerina Vasyl Druchkiv Blas Mompean julio Ortega‑Usobiaga Rafael Bilbao‑Calabuig Department of Refractive Surgery Clinica BavieraMelchor Fernández Almagro928029 MadridSpain Department of Research and Development Clinica BavieraValenciaSpain

Purpose:To dynamically assess variations in pupil diameter induced by changes in brightness in myopic eyes implanted with an implantable collamer lens(ICL,STAAR Surgical)with a central ***:This prospective,observational single-center case series study comprised 65 eyes from 65 consecutive patients undergoing ICL implant.A modified commercially available swept-source Fourier-domain anterior segment optical coherence tomography(AS-OCT)device was used for imaging and performing dynamic pupillometry under changing light conditions before and after a mean follow-up interval of four months after ***:Preoperative mean pupil size under photopic conditions was 3.38±0.64 mm;after surgery,this increased to 3.48±0.61 *** pupil size under scotopic light conditions was 5.72±0.79 mm before surgery and 5.84±0.77 mm *** differences between preoperative and postoperative pupil diameter in miosis and mydriasis were 0.10±0.44 mm(P=0.078)and 0.12±0.58 mm(P=0.098),*** scotopic pupil exceeded the optic zone of the implanted lens in 39 eyes(60%).The mean central vault value was 412±177μm under maximum miosis and 506±190μm under maximum *** found a positive correlation between vault and differences in pupil diameter under all light conditions(P<0.05).Conclusion:Dynamic AS-OCT enables a very precise determination of the pupillary diameter in the iris *** changes in the pupil diameter under different light conditions after the implantation of an ICL are related to the postoperative vault.

关键词： Phakic collamer lens ICL Pupil OCT Central hole Central port Posterior chamber phakic lens

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Effect of Kaolin Film Particle Applications (Surround WP<sup>®</sup>) and Water Deficit on Physiological Characteristics in Rose Cut Plants (<i>Rose spp</i>L.)

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American Journal of Plant Sciences 2011年第3期2卷 354-358页

作者： Yuly Marcela Sotelo-Cuitiva Hermann Restrepo-Díaz Alexandra García-Castro Augusto Ramírez-Godoy victor julio Flórez-Roncancio 不详

The effect of foliar applications of a kaolin clay particle film (Surround WP) on leaf temperature (Tlf), chlorophyll fluorescence (Fv/Fm), shoot length, production and water relations in well-irrigated and water-stressed rose cut plants (Rose spp) were studied during ten weeks. Plants were sprayed twice at first and fifth week after the experiment started with aqueous suspensions of Kaolin (Surround) at a dose of 5% (w/v). The interaction between Kaolin applications and water status did not showed significances. Water stress decreased the stomatal conductance (gs), leaf water content (LWC), shoot length and the number of marketable floral stems. Kaolin sprays did not affect on SPAD readings, chlorophyll fluorescence, gs, LWC and shoot length. Kaolin reduced leaf temperature by 2.5°C approximately at midday compared to plants non-sprayed with kaolin. These results show that kaolin foliar applications could be considered an useful tool at early growth stage in improving rose plant acclimation to high temperatures levels under greenhouse conditions in tropical regions.

关键词： Surround WP Leaf Water Content Stomatal Conductance Leaf Temperature Shoot Length

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Can antiretroviral therapy be tailored to each human immunodeficiency virus-infected individual? Role of pharmacogenomics

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World Journal of Virology 2015年第3期4卷 169-177页

作者： victor Asensi julio Collazos Eulalia Valle-Garay Infectious Diseases-HIV Unit Hospital Universitario Central de AsturiasOviedo University School of Medicine Infectious Diseases Unit Hospital de Galdácano Biochemistry and Molecular Biology Department Oviedo University School of Medicine

Pharmacogenetics refers to the effect of single nucleotide polymorphisms(SNPs) within human genes on drug therapy outcome. Its study might help clinicians to increase the efficacy of antiretroviral drugs by improving their pharmacokinetics and pharmacodynamics and by decreasing their side effects. HLAB*5701 genotyping to avoid the abacavir-associated hypersensitivity reaction(HSR) is a cost-effective diagnostic tool, with a 100% of negative predictive value, and, therefore, it has been included in the guidelines for treatment of human immunodeficiency virus(HIV) infection. HALDRB*0101 associates with nevirapine-induced HSR. CYP2B6 SNPs modify efavirenz plasma levels and their genotyping help decreasing its central nervous system, hepatic and HSR toxicities. Cytokines SNPs might influence the development of drug-associated lipodystrophy. APOA5, APOB, APOC3 and APOE SNPs modify lipids plasma levels and might influence the coronary artery disease risk of HIV-infected individuals receiving antiretroviral therapy. UGT1A1*28 and ABCB1(MDR1) 3435 C > T SNPs modify atazanavir plasma levels and enhance hyperbilirubinemia. Much more effort needs to be still devoted to complete large prospective studies with multiple SNPs genotyping in order to reveal more clues about the role played by host genetics in antiretroviral drug efficacy and toxicity.

关键词： Pharmacogenomics Pharmacokinetics Antiretroviral drugs Adverse effects Human immunodeficiency virus infection Single nucleotide polymorphisms

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Thyroid Nodule: Alpha Score 2.0 Classification for FNAB Selection, Multicentric Study in Latin America

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Open Journal of Radiology 2021年第4期11卷 160-174页

作者： Glenn Mena Maria Cristina Chammas Carlos Mario Gonzalez Vasquez Lylian Rocío Villagómez Marco Alfredo Muñoz Pico Patricio Alejandro Montalvo Santiago Mena-Bucheli julio Olmedo Elizabeth Quintero Pedro Henrique de Marqui Moraes Osmar Cassio Saito Hubertino Diaz Denise Romero Gabriela Velalcazar Angel Ramón Sosa Fleitas Yamil Oliver Quevedo Ontaneda victor Ricardo Chara Alpha Imagen Radiología e Intervencionismo Quito Ecuador Hospital das Clínicas Faculdade de Medicina da Universidade de Sã o Paulo S&#227 o Paulo Brasil Hospital Pablo Tobón Uribe Medellin Colombia Hospital del Instituto Ecuatoriano de Seguridad Social Quito Sur Quito Ecuador Hospital San Francisco de Quito Quito Ecuador Hospital Edgardo Rebagliati Martins Lima Perú Hospital Carlos Andrade Marín Quito Ecuador Hospital de Clínicas San José de San Martín Buenos Aires Argentina Hospital Universitario de Los Andes Mérida Venezuela Hospital de la Policía Quito Ecuador Hospital Sisol Tacna Perú

Introduction: To perform a Latin-American multicentric study for the prediction of benign and malignant thyroid nodules using Alpha Score, and to compare it with ACR TIRADS® and Bethesda®. Materials and Methods: A prospective multicentric study in 10 radiological hospitals and institutions of Latin America was performed and 818 thyroid nodules were analyzed by ultrasound and classified by using both ACR TIRADS® and Alpha Score;fine-needle aspiration biopsy was performed when needed and classified with Bethesda. The relationships between predictors were analyzed by using binary logistic regression, statistical significance was defined by a p-value of 0.05, with an error margin of 4% and 95% confidence intervals. Results: Alpha Score 2.0 establishes five types of malignant predictors: microcalcifications, irregular borders, taller-than-wide shape, predominant solid texture and hypoechogenicity;a diameter equal to or greater than 1.5 cm adds an extra point to the final score. Resulting classification divides TNs into 4 categories: benign (1.9%), low suspicion (8.7%), mild suspicion (13.6%) and high suspicion (75.7%) of malignancy probability;sensitivity of 82%, specificity of 74%, the positive predictive value of 94%, the negative predictive value of 51%, the statistical accuracy of 81%, odds ratio of 108.89 and correlation with ACR TIRADS of 0.77 and Bethesda of 0.91. Conclusions: Alpha Score 2.0 has superior diagnostic accuracy and performance compared to the previously published Alpha Score and is able to classify a benign TN in a precise, safe and accurate way, avoiding unnecessary FNABs or determining the necessity of FNAB in cases of moderate to high suspicion of malignancy.

关键词： Thyroid Cancer-Clinical Radiology-Imaging Thyroid Nodule Alpha Score TIRADS® Thyroid Ultrasonography

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Evolution of Pre-Columbian Metallurgy from the North of Peru Studied with a Portable Non-invasive Equipment Using Energy-Dispersive X-Ray Fluorescence

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材料科学与工程（中英文B版） 2011年第1期1卷 48-81页

作者： Roberto Cesareo Angel Bustamante D julio Fabian S Sandra Zambrano A Walter Alva Luis Chero del Carmen Espinoza C Rosendo Rodriguez R Marco Seclen F Fidel Gutierrez V E.B. Ldvano Gonzales A. Marcia A. Rizzutto Enrico Poli Cristiane Calza Marcelino dos Anjos Ricardo T. Lopes Giovanni E. Gigante Gabriel M. Ingo Cristina Riccucci Carlos Elera Izumi Shimada victor Curay Castillo G and Fabio Lopes Dipartimento di Matematica e Fisica Universith di Sassari Sassari Italy Universidad Nacional Mayor de San Marcos Lima Peri4 Museo ＂Tumbas Reales de Sip6n ＂ Lambayeque Perlt Instituto de Fisica Universidade de S6o Paulo SP Brasil Asociaci6n cultural e Museo Enrico Poli Lima Peru COPPE Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil Dipartimento di Energetica Universith di Roma ＂La Sapienza ＂ Rome Italy lstituto Studio dei Materiali Nanostrutturati-CNR Area Ricerca RM1-Montelibretti Rome Italy Museo de Sic6n Ferrahqfe Perit Istituto Nacional de Cultura Piura Peru Universidade Estadual de Londrina Londrina PR Brasil

On the north coast of present-day Peru, between the Andes and the Pacific Ocean, prospered approximately between 1000 BC and 1375 AD, several relevant cultures: Chavín (1000-200 BC), Vicús and Frías (200 BC - 300 AD), Moche (400 BC-700 AD), Sicán (700-1375 AD). These cultures are interconnected and characterized by a high metallurgical ability, demonstrated by the presence of beautiful artifacts on gold, silver and copper alloys. More than hundred metal artefacts from these cultures were analyzed with a portable equipment which uses the non-destructive and non-invasive technique of energy-dispersive X-ray fluorescence (EDXRF). Following objects were analyzed: (1) gold, silver and copper objects from the Chavín culture (Museo Municipal of Piura and and Museo Enrico Poli in Lima); (2) gold and silver objects from the Vicús and Frías cultures (Museo Municipal of Piura); (3) gold, silver and copper objects from the Moche culture ("Museo Tumbas Reales de Sipán", "Museo de Sitio de Huaca Rajada" in Lambayeque and Museo Enrico Poli in Lima); (4) gold, silver and copper objects from the Sicán culture (Museum of Sicán, Ferra?afe). Portable equipments were employed, mainly composed of a small size X-ray tube and a thermoelectrically cooled, small size, Si-PIN or Si-drift X-ray detectors. The main characteristics of the EDXRF-technique is of being non destructive and multi-elemental. Standard samples of gold and silver alloys were employed for calibration and quantitative analysis. The aims of this campaign of analysis were: (1) to analyze a large number of objects; (2) to differentiate gold, gilded copper and tumbaga (this last being a poor gold alloy enriched at the surface by depletion gilding); (3) to correlate, when possible, composition of analyzed alloys to the specific culture; (4) to determine a possible evolution of metallurgy; (5) to better determine characteristics and beginning time of tumbaga production. It was determined that the analyzed artefacts are composed

关键词： X射线荧光技术能量色散侵入性冶金鲁北设备使用便携式哥伦布

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Thyroid Nodule: Alpha Score 2.0 Classification for FNAB Selection, Multicentric Study inLatin America

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Open Journal of Radiology（放射学期刊） 2021年第4期

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