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一种减少废水中总溶解固体和铬含量的新型铬鞣工艺

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中国皮革 2015年第1期44卷 37-41页

作者： victor john sundar Chellappa Muralidharan Asit Baran Mandal 陈小珂中央皮革研究所科学和工业研究理事会印度金奈600020 不详

制革废水中的氯化物和铬引起了一系列环境问题。如何消除或减少废水中的氯化物和铬是全球皮革研究的活跃领域。研究开发了一种无盐鞣制工艺,以解决目前制革工业的难题。新工艺除了彻底取消氯化钠的使用,还减少了铬鞣剂的用量。铬单位消... 详细信息

制革废水中的氯化物和铬引起了一系列环境问题。如何消除或减少废水中的氯化物和铬是全球皮革研究的活跃领域。研究开发了一种无盐鞣制工艺,以解决目前制革工业的难题。新工艺除了彻底取消氯化钠的使用,还减少了铬鞣剂的用量。铬单位消耗量(每吨生皮所消耗的铬量)的减少,为该工艺提供了巨大的经济效益,且采用新工艺还能有效减少废液中总溶解固体(TDS)含量。该工艺主要基于改变反应物活性,以保证鞣制材料的高吸收率。同时,鞣后革内铬分布均匀。化学、物理和显微分析结果表明,新工艺鞣后成革的性能可与常规鞣制工艺相媲美。该项创新工艺为商业化实施提供了一个经济、简单的技术方案,解决了一个世纪难题。

关键词：氯化钠铬皮革加工盐度生皮鞣制

Wrapping up the role of pericytes in Parkinson's disease

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Neural Regeneration Research 2023年第11期18卷 2395-2396页

作者： Taylor john Stevenson Birger victor Dieriks Department of Pharmacology University of AucklandAucklandNew Zealand Centre for Brain Research University of AucklandAucklandNew Zealand Department of Anatomy and Medical Imaging University of AucklandAucklandNew Zealand

Pericytes are classically defined as contra ctile cells within the central nervous system that regulate blood flow and permeability of the blood-brain barrier(BBB).This one-sided view is gradually changing,and pericytes are now considered versatile cells that can switch their function in response to different stimuli(Uemura et al.,2020).In addition to their role as gatekeepers of the BBB and maintaining homeostasis of the brain’s microenvironment through adj usting the vascular intraluminal dia meter,pericytes are both sensors and initiators of inflammation.

关键词： homeostasis pericyte

Self-referenced photonic chip soliton Kerr frequency comb

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Light(Science & Applications) 2016年第1期5卷 282-287页

作者： victor Brasch Erwan Lucas john D Jost Michael Geiselmann Tobias J Kippenberg École Polytechnique Fédérale de Lausanne(EPFL)–IPHYS Lausanne CH-1015Switzerland

Self-referencing turns pulsed laser systems into self-referenced frequency *** frequency combs allow counting of optical frequencies and have a wide range of *** required optical bandwidth to implement self-referencing is typically obtained via nonlinear broadening in optical *** advances in the field of Kerr frequency combs have provided a path toward the development of compact frequency comb sources that provide broadband frequency combs,exhibit microwave repetition rates and are compatible with on-chip photonic *** devices have the potential to significantly expand the use of frequency *** to date,self-referencing of such Kerr frequency combs has only been attained by applying conventional,fiber-based broadening *** we demonstrate external broadening-free self-referencing of a Kerr frequency *** optical spectrum spanning two-thirds of an octave is directly synthesized from a continuous wave laser-driven silicon nitride microresonator using temporal dissipative Kerr soliton formation and soliton Cherenkov *** this coherent bandwidth and two continuous wave transfer lasers in a 2f–3f self-referencing scheme,we are able to detect the offset frequency of the soliton Kerr frequency *** stabilizing the repetition rate to a radio frequency reference,the self-referenced frequency comb is used to count and track the continuous wave pump laser’s *** work demonstrates the principal ability of soliton Kerr frequency combs to provide microwave-to-optical clockworks on a chip.

关键词： frequency combs integrated optics Kerr frequency combs metrology microresonator frequency combs nonlinear optics

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美国和欧洲生物类似药的发展（英文）

药物分析杂志 2015年第5期35卷 777-787页

作者： Richard Markus victor Fung sundar Ramanan Biosimilars Development Amgen Inc. Thousand Oaks CA 91320 USA Global Biosimilars Regulatory Policy Amgen Inc. Thousand Oaks CA 91320 USA

生物类似药(biosimilars)是与已批准上市的生物制品高度相似的药物,与小分子仿制药物(generics)不同,生物类似药并不是他们参比制品的精确复制品。尽管高度相似,生物类似药在某些方面仍然可能与参比制品不同,生物类似药间也会互不相同... 详细信息

生物类似药(biosimilars)是与已批准上市的生物制品高度相似的药物,与小分子仿制药物(generics)不同,生物类似药并不是他们参比制品的精确复制品。尽管高度相似,生物类似药在某些方面仍然可能与参比制品不同,生物类似药间也会互不相同。生物制品不仅由于其复杂的性质和生产过程,还由于存在独特的免疫原性和活性的安全隐患,给研发和监管带来了相当大的挑战。欧洲药品管理局和美国食品药品管理局的指导原则建议采用"证据链完备性"(totality-of-evidence)的方法全面覆盖生物类似药物开发的各个步骤,包括分析表征化、结构相似性和功能等效性等的证据。这种"证据链完备性"是生物类似药整个研发过程中其余工作的基石,包括必须的动物试验研究、人体药代动力学/药效学研究,以及至少1个临床研究,以证实生物类似药功效等效,并且免疫原性或安全性风险没有增加。临床研究应选择敏感人群来进行试验,以便发现任何有临床意义的差异。工艺稳定质量恒定的生物类似药的研发需要丰富的经验和专业技能,只有这样才能够确保患者得到良好治疗。

关键词：生物类似药的研发监管指导原则欧洲药品管理局指导原则美国食品药品管理局指导原则证据链完备性生物相似性

Problems,assumptions and solutions in locomotive design,traction and operational studies

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Railway Engineering Science 2022年第3期30卷 265-288页

作者： Maksym Spiryagin Qing Wu Oldrich Polach john Thorburn Wenhsi Chua Valentyn Spiryagin Sebastian Stichel sundar Shrestha Esteban Bernal Sanjar Ahmad Colin Cole Tim McSweeney Centre for Railway Engineering Central Queensland UniversityRockhampton 4702Australia Independent Consultant Neuhausen am RheinfallSwitzerland Progress Rail NewcastleAustralia BHP Port HedlandAustralia Engineering Centre for Railway Transport SkolkovoRussian Federation KTH Royal Institute of Technology StockholmSweden

Locomotive design is a highly complex task that requires the use of systems engineering that depends upon knowledge from a range of disciplines and is strongly oriented on how to design and manage complex systems that operate under a wide range of different train operational conditions on various types of *** that field investigation programs for locomotive operational scenarios involve high costs and cause disruption of train operations on real railway networks and given recent developments in the rollingstock compliance standards in Australia and overseas that allow the assessment of some aspects of rail vehicle behaviour through computer simulations,a great number of multidisciplinary research studies have been performed and these can contribute to further improvement of a locomotive design technique by increasing the amount of computer-based *** paper was focused on the presentation of the all-important key components required for locomotive studies,starting from developing a realistic locomotive design model,its validation and further applications for train *** integration of all engineering disciplines is achieved by means of advanced simulation approaches that can incorporate existing AC and DC locomotive designs,hybrid locomotive designs,full locomotive traction system models,rail friction processes,the application of simplified and exact wheel-rail contact theories,wheel-rail wear and rolling contact fatigue,train dynamic behaviour and intrain forces,comprehensive track infrastructure details,and the use of co-simulation and parallel *** cosimulation and parallel computing approaches that have been implemented on Central Queensland University’s High-Performance Computing cluster for locomotive studies will be *** confidence in these approaches is based on specific validation procedures that include a locomotive model acceptance procedure and field test *** problems and limitations presented in locomot

关键词： Locomotive Design Simulation Virtual prototyping Digital twin Traction Braking Wheel-rail wear Damage

Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： victor Abiola Adepoju OKECHUKWU Innocent Onyezue SAFAYET Jamil OLALEKAN john Okesanya DON Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

Real-time ore sorting using color and texture analysis

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International Journal of Mining Science and Technology 2023年第6期33卷 659-674页

作者： David G.Shatwell victor Murray Augusto Barton Hochschild Mining PLC La Colonia 180Lima 15023Peru Department of Electrical Engineering Universidad de Ingenieria y Tecnologia-UTECLima 15063Peru john A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridge 02134USA Department of Electrical and Computer Engineering University of New MexicoAlbuquerque 87131USA

Sensor-based ore sorting is a technology used to classify high-grade mineralized rocks from low-grade waste rocks to reduce operation *** ore-sorting algorithms using color images have been proposed in the past,but only some validate their results using mineral grades or optimize the algorithms to classify rocks in *** paper presents an ore-sorting algorithm based on image processing and machine learning that is able to classify rocks from a gold and silver mine based on their *** algorithm is composed of four main stages:(1)image segmentation and partition,(2)color and texture feature extraction,(3)sub-image classification using neural networks,and(4)a voting system to determine the overall class of the *** algorithm was trained using images of rocks that a geologist manually classified according to their mineral content and then was validated using a different set of rocks analyzed in a laboratory to determine their gold and silver *** proposed method achieved a Matthews correlation coefficient of 0.961 points,higher than other classification algorithms based on support vector machines and convolutional neural networks,and a processing time under 44 ms,promising for real-time ore sorting applications.

关键词： Ore sorting Image color analysis Image texture analysis Machine learning

CD74 in antigen presentation,inflammation,and cancers of the gastrointestinal tract

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World Journal of Gastroenterology 2009年第23期15卷 2855-2861页

作者： Ellen J Beswick victor E Reyes Department of Pediatrics University of Texas Medical Branch Galveston TX 77555 United States Department of Pediatrics and Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States

CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori （H pylon）. The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erkl/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

关键词： CD74 Invariant chain Cancer Inflammation Helicobacterpylori Gastrointestinal tract

Revisiting “Non-Thermal” Batch Microwave Oven Inactivation of Microorganisms

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American Journal of Analytical Chemistry 2023年第1期14卷 28-54页

作者： victor john Law Denis Pius Dowling School of Mechanical and Materials Engineering University College Dublin Dublin Ireland

Over the last few decades there has been active discussion concerning the mechanisms involved in “non-thermal” microwave-assisted inactivation of microorganisms. This work presents a novel non-invasive acoustic measurement of a domestic microwave oven cavity-magnetron operating at fo = 2.45 ± 0.05 GHz (λo ~ 12.2 cm) that is modulated in the time-domain (0 to 2 minutes). The measurements reveal the cavity-magnetron cathode filament cold-start warm-up period and the pulse width modulation periods (time-on time-off and base-time period, where time-on minus base-time = duty cycle). The waveform information is used to reconstruct historical microwave “non-thermal” homogeneous microorganism inactivation experiments: where tap-water is used to mimic the microorganism suspension;and ice, crushed ice, and ice slurry mixture are used as the cooling media. The experiments are described using text, diagrams, and photographs. Four key experimental parameters are indentified that influence the suspension time-dependent temperature profile. First, where the selected process time > the time-base, the cavity-magnetron continuous wave rated power should be used for each second of microwave illumination. Second, external crushed ice and ice slurry baths induce different cooling profiles due to difference in their heat absorption rates. In addition external baths may shield the suspension resulting in a retarding of the time-dependent heating profile. Third, internal cooling systems dictate that the suspension is directly exposed to microwave illumination due to the absence of surrounding ice volume. Fourth, four separated water dummy-loads isolate and control thermal heat transfer (conduction) to and from the suspension, thereby diverting a portion of the microwave power away from the suspension. Energy phase-space projections were used to compare the “non-thermal” energy densities of 0.03 to 0.1 kJ·m-1 at 800 W with reported thermal microwave-assisted

关键词： Thermal Non-Thermal Microwave-Assisted Microwave Oven Acoustic Food Microorganisms