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Nociceptive and Neuropathic Pain Qualities in Men and Women with Acute Coronary Syndromes: A Complex Pain Presentation

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Open journal of Nursing 2017年第3期7卷 331-344页

作者： Sheila O’Keefe-McCarthy Michael McGillion Charles j. victor Sheila Rizza judith McFetridge-Durdle Brock University St. Catharines Ontario Canada Heart and Stroke Foundation/Michael G. De Groote Endowed Chair in Cardiovascular Nursing Research School of Nursing Faculty of Health Sciences Hamilton Ontario Canada University of Toronto Toronto Ontario Canada Nurse Practitioner Heart Failure Clinic Trillium Health Partners-Credit Valley Site Mississauga Ontario Canada Florida State University College of Nursing Tallahassee Florida US

Background: Cardiac pain arising from acute coronary syndrome (ACS) is a multi-factorial phenomenon. Historically, episodes of cardiac pain have been captured using a one-dimensional numeric pain rating scale. Lacking in clinical practice are acute pain assessments that employ a comprehensive evaluation of an emergent ACS episode. Aim: To examine the sensory-discriminative, motivational-affective and cognitive-evaluative dimensions of ACS-related pain. Methods: A descriptive-correlational, repeated-measure design was used to collect data on 121 ACS patients of their cardiac pain intensity. The (numeric rating scale-NRS 0-10 scale) measured chest pain “Now” and “Worst pain in the previous 2 hours over 8 hours” and the McGill Pain Questionnaire Short-Form (MPQ-SF) measured pain at 4 hours. Results: Mean age was 67.6 ± 13, 50% were male, 60% had unstable angina and 40% had Non-ST-elevation myocardial infarction. Cardiac pain intensity scores remained in the mild range from 1.1 ± 2.2 to 2.4 ± 2.7. MPQ-SF: 66% described pain as distressing and 26% reported pain was horrible or excruciating. Participants described ACS pain quality as acute injury (nociceptive pain: heavy, cramping, stabbing), as nerve damage (neuropathic: gnawing, hot-burning, shooting) and as a mixture of acute and chronic pain qualities (aching, tender and throbbing). Conclusions: Patients reported both nociceptive and neuropathic cardiac pain. It is unclear if pain perceptions are due to: i) pathophysiology of clot formation, ii) occurrence of a first or repeated ACS episode, or iii) complex co-morbidities. Pain arising from ACS requires an understanding of the interplay of ischemic, metabolic and neuropathophysiological mechanisms that contribute to complex cardiac pain experiences.

关键词： Acute Coronary Syndromes Nociceptive Pain Neuropathic Pain Pain Descriptors Emergency Department

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基于熵的项目组合配置协同度研究

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科技管理研究 2017年第7期37卷 164-171页

作者：白礼彪白思俊 victor Shi 北京航空航天大学经济管理学院北京100191 长安大学经济与管理学院陕西西安710061 西北工业大学管理学院陕西西安710072 School of Business and Economics Wilfrid Laurier University

以熵为理论出发点,在定义正协同、负协同、模糊协同和协同度等概念的基础上,提出定量描述项目级、工序级配置组件协同关系矩阵,设计以阶段协同熵加权反映配置组件模糊协同关系、以组件内外协同关系之和度量项目组合配置组件协同度的分... 详细信息

以熵为理论出发点,在定义正协同、负协同、模糊协同和协同度等概念的基础上,提出定量描述项目级、工序级配置组件协同关系矩阵,设计以阶段协同熵加权反映配置组件模糊协同关系、以组件内外协同关系之和度量项目组合配置组件协同度的分析方法,构建基于熵的项目组合配置协同度决策模型,并通过企业实践对模型的可操作性进行验证。

关键词：项目组合配置熵模糊协同协同度

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Anal Cancer in a HIV Sero-Positive Bisexual Bachelor—A Case Report and Literature Review

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Case Reports in Clinical Medicine 2018年第12期7卷 601-607页

作者： victor Nwagbara M. E. Asuquo j. A. Ashindoitiang S. O. Akpan Department of Surgery University of Calabar Calabar Nigeria

Anal cancer, especially squamous cell carcinoma (SCC) variety, is evolving with rising incidence globally. This is due to the increasing adoption of risky life styles and social habits even in populations with rare occurrences previously. This case report aims to expose risk factors exhibited by a patient recently managed for anal cancer in our facility before his demise. Early exposure to bisexual orientation, receptive anal intercourse and multiple sexual partners, are notable high risk factors for the development of anal SCC. The permissive role of smoking, illicit drug and alcohol use enhances the disease occurrence. Acquisition of human immune-deficiency virus (HIV) sero-positive status further reduces the body’s immune competence and enhances early age of onset as well as accelerates development of anal SCC. Proper history exploring the risk factors, physical/anorectal examination and histological analysis, are vital for proper diagnosis and staging which guides appropriate treatment with chemo-radiation as mainstay.

关键词： Anal Cancer Bisexual Human Immune-Deficiency Virus Sero-Positive Status Squamous Cell Carcinoma

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Energetic-protein supplementation in the last 60 days of gestation improves performance of beef cows grazing tropical pastures

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journal of Animal Science and Biotechnology 2018年第1期9卷 208-216页

作者： Aline Gomes da Silva Mário Fonseca Paulino Edenio Detmann Henrique jorge Fernandes Lincoln da Silva Amorim Román Enrique Maza Ortega victor Valério de Carvalho josilaine Aparecida da Costa Lima Felipe Henrique de Moura Mariana Benevides Monteiro jéssika Almeida Bitencourt Universidade Federal de Vicosa VicosaMinas Gerais 36570-000Brazil Universidade Federal de Mato Grosso do Sul Campo GrandeMato Grosso do Sul 79074-460Brazil Universidade Estadual de Mato Grosso do Sul AquidauanaMato Grosso do Sul 79200-000Brazil Biotran Biotecnologia e Treinamento em Reproducao Animal AlfenasMinas Gerais 37130-000Brazil Universidade Federal do Acre Rio BrancoAcre 69920-900Brazil

Background： Nutrition is one of the most important factors that affect animal performance, and it therefore also impacts on financial results in beef systems. In this way, finding the best strategy for feeding supplements is of paramount importance. Aiming to evaluate the effect of supplement feeding strategies for beef cows in the last third of gestation, two experiments were conducted. In Experiment 1, 35 pregnant Nellore cows were assigned to a completely randomized design with four treatments： control, which received no supplement; supplementation for the last 30 d of gestation（30-d; 3.0 kg/d）; supplementation for the last 60 d of gestation（60-d; 1.5 kg/d）; or supplementation for the last 90 d of gestation（90-d; 1.0 kg/d）. All supplemented treatments received the same total amount of supplement throughout the experiment： 90 kg（20% of crude protein）. A second experiment（Experiment 2） was delineated to evaluate the effects of the amounts offered in Experiment 1 on intake and metabolism. Four multiparous pregnant Nellore cows were assigned to a 4 × 4 Latin square design, with periods of15 d ***： There was a linear effect of the number of days of supplementation on calving body weight（BW; P 〈 0.05）and a quadratic effect on BW change from parturition to d 31 post-calving（P 〈 0.05）, with cows on the 60-d strategy losing less BW post-calving. No difference was found in offspring birth BW（P 〉 0.10）. A significant linear effect on interval from parturition to conception（P 〈 0.05） was observed, with the highest calving to conception interval being observed in the 90-d strategy. The level of supplementation did not affect forage intake or neutral detergent fiber digestibility（P 〉 0.10）. Nitrogen excreted through urine tended to increase linearly with the level of supplementation（P 〈 0.10）.Conclusion： Providing 1.5 kg of supplement during the last 60 d of gestation improves cow performance after calving, reducing the magnitude of BW lost, and reduces the number of

关键词： Flushing Nutrition Parturition Reproduction

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Site-Specific Conjugation of Cell Wall Polyrhamnose to Protein SpyAD Envisioning a Safe Universal Group A Streptococcal Vaccine

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Infectious Microbes & Diseases 2021年第2期3卷 87-100页

作者： Nina j.Gao Satoshi Uchiyama Lucy Pill Samira Dahesh joshua Olson Leslie Bautista Shilpa Maroju Aym Berges janet ZLiu Raymond HZurich Nina Mvan Sorge jeff Fairman Neeraj Kapoor victor Nizet Division of Host-Microbe Systems and Therapeutics Department of PediatricsUC San DiegoLa JollaCaliforniaUSA Vaxcyte Inc.Foster CityCaliforniaUSA Department of Medical Microbiology and Infection Prevention Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Netherlands Reference Laboratory for Bacterial Meningitis Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Skaggs School of Pharmacy and Pharmaceutical Sciences UC San DiegoLa JollaCaliforniaUSA

Development of an effective vaccine against the leading human bacterial pathogen group A Streptococcus(GAS)is a public health *** species defining group A cell wall carbohydrate(GAC,Lancefield antigen)can be engineered to remove its immunodominant N-acetylglucosamine(GlcNAc)side chain,implicated in provoking autoimmune cross-reactivity in rheumatic heart disease,leaving its polyrhamnose core(GACPR).Here we generate a novel protein conjugate of the GACPR and test the utility of this conjugate antigen in active *** of conjugation to a standard carrier protein,we selected SpyAD,a highly conserved GAS surface protein containing both B-cell and T-cell epitopes relevant to the bacterium that itself shows promise as a vaccine *** was synthesized using the XpressTM cell-free protein expression system,incorporating a non-natural amino acid to which GACpr was conjugated by site-specific click chemistry to yield high molecular mass SpyAD-GACPR conjugates and avoid disruption of important T-cell and B-cell immunological *** conjugated SpyAD-GACPR elicited antibodies that bound the surface of multiple GAS strains of diverse M types and promoted opsonophagocytic killing by human *** immunization of mice with a multivalent vaccine consisting of SpyAD-GACPR,together with candidate vaccine antigens streptolysin O and C5a peptidase,protected against GAS challenge in a systemic infection model and localized skin infection model,without evidence of cross reactivity to human heart or brain tissue *** general approach may allow GAC to be safely and effectively included in future GAS subunit vaccine formulations with the goal of broad protection without autoreactivity.

关键词： group A Streptococcus Streptococcus pyogenes group A carbohydrate Lancefield antigen conjugate vaccine XpressCFTM non-natural amino acids SpyAD Introduction

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旋切钛基复合材料(Ti-MMC)的超细微粒粉尘排放（英文）

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journal of Central South University 2019年第6期26卷 1563-1572页

作者： Seyed Ali NIKNAM Masoud SABERI jules KOUAM Ramin HASHEMI victor SONGMENE Marek BALAZINSKI School of Mechanical Engineering Iran University of Science and TechnologyHengam St.Resalat SquareFehran 13114-16846Iran Department of Mechanical Engineering Ecole de Technologie Superieure (ETS)MontrealQCH3C 1K3Canada Department of Mechanical Engineering Polytechnique MontrealMontrealQCH3T 1J4Canada

钛基复合材料(Ti-MMC)具有优异的特性和相容性,有望取代已广泛应用的商用钛和高温合金。尽管Ti-MMC具有优越的性能,但因生产成本高、工件基体的刚性和存在的磨料陶瓷颗粒等因素,被归类为加工性能差的极难切削材料。采用润滑方法加工Ti-M... 详细信息

钛基复合材料(Ti-MMC)具有优异的特性和相容性,有望取代已广泛应用的商用钛和高温合金。尽管Ti-MMC具有优越的性能,但因生产成本高、工件基体的刚性和存在的磨料陶瓷颗粒等因素,被归类为加工性能差的极难切削材料。采用润滑方法加工Ti-MMCs的工艺参数很少被研究。考虑到可切削性能,选择了超细粒(UFPs)和细颗粒(FPs),研究了影响粉尘排放的因素。根据实验观察,无论使用哪种类型涂层,较高的流量水平会导致较少的超细粉,但没有观察到对细颗粒的显著影响。在类似的切削条件下,使用无涂层刀片时会排放较高水平的细颗粒。此外,切削速度对超细粉没有显著影响,但对细的颗粒有显著的影响,且与插入类型无关。

关键词：金属基复合材料(MMCS) 颗粒排放粉尘排放旋切润滑模式

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Factorization of Operators in Krein Spaces and Linear-Fractional Relations of Operator Balls

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Advances in Pure Mathematics 2013年第1期3卷 29-33页

作者： victor Anatoly Khatskevich Valery Anatoly Senderov Department of Mathematics ORT Braude Academic College Karmiel Israel Pyatnitskoe Highway 23-2-156 Moscow Russia

We consider plus-operators in Krein spaces and generated operator linear fractional relations of the following form: . We study some special type of factorization for plus-operators T, among them the following one: T = BU, where B is a lower triangular plus-operator, U is a j-unitary operator. We apply the above factorization to the study of basical properties of relations (1), in particular, convexity and compactness of their images with respect to the weak operator topology. Obtained results we apply to the known Koenigs embedding problem, the Krein-Phillips problem of existing of invariant semidefinite subspaces for some families of plus-operators and to some other fields.

关键词： Krein Space Linear Fractional Relation Plus-Operator Factorization

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Detection of dengue virus serotype 3 in Cajamarca,Peru:Molecular diagnosis and clinical characteristics

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Asian Pacific journal of Tropical Medicine 2021年第10期14卷 456-462页

作者： Miguel Angel Aguilar-Luis Hugo Carrillo-Ng Sungmin Kym Wilmer Silva-Caso Eduardo Verne Luis j.del Valle jorge Bazán-Mayra victor Zavaleta-Gavidia Daniel Cornejo-Pacherres Yordi Tarazona-Castro Ronald Aquino-Ortega Angela Cornejo-Tapia juana del Valle-Mendoza School of Medicine Research and Innovation Center of the Faculty of Health SciencesUniversidad Peruana de Ciencias AplicadasLimaPeru Laboratorio de Biologia Molecular Instituto de Investigación NutricionalLimaPeru Facultad de Medicina Alberto Hurtado Universidad Peruana Cayetano HerediaLimaPeru Division of Infectious Diseases Department of Internal MedicineChungnam National University School of MedicineDaejeonRepublic of Korea Barcelona Research Center for Multiscale Science and Engineering Departament d'Enginyeria QuímicaEEBEUniversitat Politècnica de Catalunya(UPC)BarcelonaSpain Laboratorio Regional de Cajamarca Dirección Regional de Salud de Cajamarca(DIRESA)CajamarcaPeru

Objective:To describe and molecularly characterize an outbreak of dengue virus(DENV)infection in Cajamarca,an Andean region in ***:A total of 359 serum samples from patients with acute febrile illness were assessed for the presence of DENV via RT-PCR,ELISA NS1,Ig M and Ig G in Cajamarca,Peru from january 2017 to june *** evaluation of the different diagnostic tests and their applicability was ***:Dengue virus was detected in 24.7%of samples by ***,serological analysis detected 30.3%positive cases via ELISA NS1 antigen,16.7%via ELISA Ig G and 9.7%via ELISA Ig *** of the cases corresponded to DENV-3(77.5%).The use of RT-PCR performed better in primary infections(Pjamarca,*** findings encourage the use of NS1 antigen and Ig M *** findings demonstrate an increasing expansion of DENV-3 in Peru and highlight the importance of molecular diagnosis and serotype characterization among the clinically defined dengue cases to strengthen the Peruvian epidemiological surveillance.

关键词： Dengue DENV Arbovirus Diagnosis Peru

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应用微卫星分型方法进行大熊猫父亲鉴定

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遗传 2003年第5期25卷 504-510页

作者：张志和沈富军孙姗 victor A.David 张安居 Stephen j.O'Brien 成都大熊猫繁育研究基地成都610081 美国国立癌症研究所基因组多样性实验室马里兰217021201

选用18对大熊猫特异的微卫星引物对成都动物园、成都大熊猫繁育研究基地的大熊猫幼子及其母亲和可疑父亲DNA作了PCR扩增。扩增产物在ABI373测序仪上做基因扫描。应用Genotyper672软件处理分型数据,经Cervus2.0软件对亲子关系进行分析。... 详细信息

选用18对大熊猫特异的微卫星引物对成都动物园、成都大熊猫繁育研究基地的大熊猫幼子及其母亲和可疑父亲DNA作了PCR扩增。扩增产物在ABI373测序仪上做基因扫描。应用Genotyper672软件处理分型数据,经Cervus2.0软件对亲子关系进行分析。结果表明,在母子关系确实的情况下,18个基因座联合的父亲鉴定排除概率E为0.999921,置信度为95%。而在母子关系不清的条件下,E=0.994109,但置信度低于80%。由于圈养大熊猫的母子关系都是确实的。因此,基因型分析的结果能有效确认出这些大熊猫之间的父子关系。但要准确鉴定出野生大熊猫的亲缘关系,我们还需更多的微卫星标记。

关键词：微卫星基因分型大熊猫亲子鉴定

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Author Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

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Cellular & Molecular Immunology 2022年第8期19卷 965-966页

作者： Daniel Perez-Zsolt jordana Muñoz-Basagoiti jordi Rodon Marc Elosua-Bayes Dàlia Raïch-Regué Cristina Risco Martin Sachse Maria Pino Sanjeev Gumber Mirko Paiardini jakub Chojnacki Itziar Erkizia Xabier Muñiz-Trabudua Ester Ballana Eva Riveira-Muñoz Marc Noguera-julian Roger Paredes Benjamin Trinité Ferran Tarrés-Freixas Ignacio Blanco victor Guallar jorge Carrillo juliàBlanco Amalio Telenti Holger Heyn joaquim Segalés Bonaventura Clotet javier Martinez-Picado júlia Vergara-Alert Nuria Izquierdo-Useros IrsiCaixa AIDS Research Institute 08916 Badalona Spain Germans Trias i Pujol Research Institute (IGTP) Can Ruti Campus 08916 Badalona Spain University of Vic—Central University of Catalonia (UVic-UCC) Vic 08500 Spain Catalan Institution for Research and Advanced Studies (ICREA) 08010 Barcelona Spain IRTA Centre de Recerca en Sanitat Animal (CReSA IRTA-UAB) Campus de la UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain CNAG-CRG Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology (BIST) 08028 Barcelona Spain Universitat Pompeu Fabra (UPF) Barcelona Spain Centro Nacional de Biotecnología CSIC 28049 Madrid Spain Division of Microbiology and Immunology Yerkes National Primate Research Center Emory University Atlanta GA USA Department of Pathology and Laboratory Medicine School of Medicine Emory University Atlanta GA USA Division of Pathology Yerkes National Primate Research Center Emory University Atlanta GA USA Barcelona Supercomputing Center (BSC) 08034 Barcelona Spain Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA 92037 USA UAB CReSA (IRTA-UAB) Campus de la UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain Departament de Sanitat i Anatomia Animals Facultat de Veterinària UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain

Correction to:Cellular&Molecular Immunology https://***/10.1038/s41423-021-00794-6,published online 15 November 2021 In the version of this correspondence initially published,one of the SARS-CoV-2 variants used in Fig.1B,which was originally described in the article as the SARS-CoV-2 variant‘B.1.***.248.2 Gamma’,is actually the‘P.2 Zeta’SARS-CoV-2 variant of *** GISAID accession ID EPI_ISL_1831696 provided is correct。

关键词： interaction media initially

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