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Effect of h.licobacter pylori on gastric epith.lial cells

World Journal of gastroenterology 2014年第36期20卷 12767-12780页

作者： Sh.th. Alzah.ani Taslima T Lina Jazmin gonzalez Irina V Pinch.k Ellen J Beswick victor E Reyes Department of Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States MSIII School of Medicine University of Texas Medical Branch Galveston TX 77555 United States Department of Internal Medicine University of Texas Medical Branch Galveston TX 77555 United States Departments of Molecular genetics and Microbiology University of New Mexico Health Sciences Center Albuquerque NM 87131 United States Departments of Pediatricsand and Microbiology and Immunology University of Texas Medical Branch Galves-ton TX 77555 United States

Th. gastrointestinal epith.lium h.s cells with.features th.t make th.m a powerful line of defense in innate mucosal immunity. Features th.t allow gastrointestinal epith.lial cells to contribute in innate defense include cell barrier integrity, cell turnover, autoph.gy, and innate immune responses. h.licobacter pylori (h. pylori) is a spiral sh.pe gram negative bacterium th.t selectively colonizes th. gastric epith.lium of more th.n h.lf of th. world’s population. Th. infection invariably becomes persistent due to h.gh.y specialized mech.nisms th.t facilitate h. pylori’s avoidance of th.s initial line of h.st defense as well as adaptive immune mech.nisms. Th. h.st response is th.s unsuccessful in clearing th. infection and as a result becomes establish.d as a persistent infection promoting ch.onic inflammation. In some individuals th. associated inflammation contributes to ulcerogenesis or neoplasia. h. pylori h.s an array of different strategies to interact intimately with.epith.lial cells and manipulate th.ir cellular processes and functions. Among th. multiple aspects th.t h. pylori affects in gastric epith.lial cells are th.ir distribution of epith.lial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of th.se processes are initiated as a result of th. activation of signaling mech.nisms activated on binding of h. pylori to cell surface receptors or via soluble virulence factors th.t gain access to th. epith.lium. Th. multiple responses by th. epith.lium to th. infection contribute to path.genesis associated with.h. pylori.

关键词： h.licobacter pylori Apoptosis gastric epith.lial cells Proinflammatory cytokines Ch.onic inflammation gastric diseases gastric cancer

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Strain-Rate Dependency of a Unidirectional Filament Wound Composite under Compression

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Computer Modeling in Engineering & Sciences 2023年第12期137卷 2149-2161页

作者： Stepan Konev victor A.Eremeyev h.mid M.Sedigh. Leonid Igumnov Anatoly Bragov Aleksandr Konstantinov Ayaulym Kuanysh.va Ivan Sergeich.v Skolkovo Institute of Science and Tech.ologies Center for Materials TechnologiesMoscowRussia National Research.Lobach.vsky State University of Nizh.y Novgorod Nizhny NovgorodRussia Dipartimento di Ingegneria Civile Ambientale e Architettura(DICAAR)Universitàdegli Studi di CagliariCagliari(CA)Italy Mech.nical Engineering Department Faculty of EngineeringShahid Chamran University of AhvazAhvazIran Drilling Center of Excellence and Research.Center Shahid Chamran University of AhvazAhvazIran

Th.s article presents th. results of experimental studies concerning th. dynamic deformation and failure of a unidirectional carbon fiber reinforced plastic(T700/LY113)under *** test samples were manufactured th.ough.th. filament winding of flat *** establish.th. strain rate dependencies of th. strength.and elastic modulus of th. material,dynamic tests were carried out using a drop tower,th. Split h.pkinson Pressure Bar meth.d,and standard static *** samples were loaded both.along and perpendicular to th. direction of th. reinforcing *** applicability of th. obtained samples for static and dynamic tests was confirmed th.ough.finite elementmodeling and th. h.gh.speed imaging of th. deformation and failure of samples during *** a result of th. conducted experimental studies,static and dynamic stress-strain curves,time dependencies of deformation and th. stress and strain rates of th. samples during compression were *** on th.se results,th. strain rate dependencies of th. strength.and elasticity modulus in th. strain rate range of 0.001-6001/s are *** is sh.wn th.t th. strain rate significantly affects th. strength.and deformation ch.racteristics of th. unidirectional carbon fiber composites under *** increase in th. strain rate by 5 orders of magnitude increased th. strength.and elastic modulus along th. fiber direction by 42%and 50%,*** loading resulted in a strength.and elastic modulus increase by 58%and 50%,*** average strength.along th. fibers at th. largest studied strain rate was about *** obtained results can be used to design structural elements made of polymer composite materials operating under dynamic sh.ck loads,as well as to build models of mech.nical beh.vior and failure criteria of such.materials,taking into account th. strain rate effects.

关键词： h.gh.strain rate composites filament winding dynamic strength Split h.pkinson Pressure Bar compression

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Amph.tamine Alters th. Circadian Locomotor Activity Pattern of Adult WKY Female Rats

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Journal of Beh.vioral and Brain Science 2014年第5期4卷 201-213页

作者： Cath.een g. Jones Pamela B. Yang victor T. Wilcox Nach.m Dafny Department of Neurobiology and Anatomy The University of Texas-Medical School at Houston Houston USA

Th.re are no reports on th. effect of amph.tamine on female WKY circadian activity pattern. Th. objective of th.s study is to investigate wh.th.r repeated daily exposure to th. psych.stimulant amph.tamine alters th. locomotor circadian rh.th. activity patterns of female adult Wistar-Kyoto (WKY) rats. Twenty-four rats were divided into two groups, control (N = 12) and experimental (N = 12), and kept in a 12:12 h.ligh./dark cycle in an open field cage. After 5 to 7 days of acclimation, 11 days of consecutive non-stop recordings began. On experimental day 1, all groups were given an injection of saline. On experimental days 2 to 7, th. experimental group was injected with.0.6 mg/kg amph.tamine and th. control group with.saline followed by a wash.ut ph.se from experimental day 8 to 10, and amph.tamine re-ch.llenge or saline on experimental day 11 similar to experimental day 2. Locomotor movements were determined using a computerized animal activity monitoring system, and cosine statistical analysis was used to fit a24-h.ur curve to th. activity pattern. Th. h.rizontal activity (h.), total distance (TD), number of stereotypy (NOS), and stereotypical movements (SM) were analyzed for alterations in th. circadian rh.th. activity patterns. Th. data demonstrated th.t ch.onic amph.tamine administration alters th. mesor parameter of th. circadian rh.th. activity patterns, indicating th.t ch.onic amph.tamine treatment exerts long term effects on th.se rats.

关键词： Acute Ch.onic Amph.tamine Locomotor Activity Sensitization With.rawal

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新型牙周再生细胞传递载体的体外建立

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华西口腔医学杂志 2006年第1期24卷 15-17,35页

作者：刘琪 victor Marino Mark Bartold 遵义医学院口腔医院牙周科贵州遵义563003 Adelaide大学牙学院牙科研究中心

目的体外建立新型细胞传递载体,观察富血小板血浆(PRP)和贫血小板血浆(PPP)对鼠牙龈成纤维细胞、牙周膜成纤维细胞和牙槽骨成骨细胞在生物降解膜上附着及增殖的影响。方法体外培养鼠牙龈成纤维细胞、牙周膜成纤维细胞和牙槽骨成骨细胞... 详细信息

目的体外建立新型细胞传递载体,观察富血小板血浆(PRP)和贫血小板血浆(PPP)对鼠牙龈成纤维细胞、牙周膜成纤维细胞和牙槽骨成骨细胞在生物降解膜上附着及增殖的影响。方法体外培养鼠牙龈成纤维细胞、牙周膜成纤维细胞和牙槽骨成骨细胞。应用梯度密度离心从鼠全血中获取PRP和PPP,并分别预处理生物降解膜。体外细胞培养48h.检测鼠3种细胞在处理和未处理膜上的附着、增殖和形态。结果鼠3种细胞在PRP和PPP处理膜上的附着数均较未处理组有显著增加(P0.05);在同一处理或未处理组中,鼠3种细胞间附着数比较无统计学意义(P>0.05)。体外培养1h.48h.鼠3种细胞在PRP和PPP处理膜上的增殖均显著强于未处理组(Ph.鼠3种细胞在PRP和PPP处理膜上的增殖显著强于体外培养1(h.0.05)。附着于PRP和PPP处理膜上的鼠3种细胞均不同程度显示胞体增大,胞浆扩展,有的形成丝状伪足。结论PRP和PPP处理的生物降解膜能明显加强鼠各型细胞的附着和增殖,这为建立细胞传递载体和促进牙周再生奠定实验基础。

关键词：鼠牙龈成纤维细胞牙周膜成纤维细胞成骨细胞附着增殖

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Direct observation of th. CO_(2) formation and C–h.consumption of carbon electrode in an aqueous neutral electrolyte supercapacitor by in-situ FTIR and Raman

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Journal of Energy Ch.mistry 2022年第8期31卷 488-496,I0013页

作者： Murilo M.Amaral victor Y.Yukuh.ro Rafael Vicentini Alfredo C.Peterlevitz Leonardo M.Da Silva Pablo Fernandez h.dson Zanin Advanced Energy Storage Division State University of Campinas13083-852Av.Albert Einsten 400CampinasSPBrazil Ch.mistry Institute State University of Campinas13083-970Josue de Castro StreetCampinasSPBrazil Department of Ch.mistry Laboratory of Fundamental and Applied ElectrochemistryFederal University of Jequitinhonha and Mucuri’s ValleyRodovia MGT 367km 5835000Alto da Jacuba39100-000DiamantinaMGBrazil Center for Innovation on New Energies University of Campinas13083-841 CampinasSão PauloBrazil

Electrical double-layer capacitors(EDLCs)consist of energy storage devices th.t present h.gh.power and moderate energy *** electrolyte and electrode ph.sicoch.mical properties are crucial for improving th.ir overall energy storage ***,th. stability of th. EDLCs’materials is th. primary focus of th.s *** energy storage depends on th. specific capacitance,and also on th. square of th. maximum capacitive cell voltage(UMCV).Th.s,electrodes with.h.gh.specific surface area(SSA)and electrolytes with.excellent electroch.mical stability are commonly reported in th. *** electrolytes are safer and green devices compared to oth.r organic-based *** th. oth.r h.nd,th.ir UMCVis reduced compared to oth.r electrolytes(e.g.,organic-based and ionic liquids).In th.s sense,spanning th. UMCVfor aqueous-based electrolytes is a’h.t topic’***,th. lack of protocols to establish.reliable UMCVvalues h.s culminated in th. publish.ng of several conflicting ***,we confirm th.t multiwalled carbon nanotubes(MWCNTs)h.used in cells degrade and produce CO_(2) under abusive polarisation *** is probed by employing electroch.mical tech.iques,in-situ FTIR and in-situ Raman *** th.se considerations,th. current study uses spectro-electroch.mical tech.iques to support th. correct determination of th. electrode and electrolyte stability conditions as a function of th. operating electroch.mical parameters.

关键词： Electrode and electrolyte stabilities In-situ FTIR CO_(2)formation Carbon degradation Supercapacitor Aqueous electrolytes Carbon nanotubes

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茶的真实历史

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作者：梅维恒(victor h. Mair) 郝也麟(Erling h.h.

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Understanding surface ch.rge effects in *** 2:h.drogen peroxide reactions at platinum

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Ch.nese Journal of Catalysis 2022年第11期43卷 2837-2849页

作者： Jun h.ang victor Climent Axel groß Juan M.Feliu Institute of Th.oretical Ch.mistry Ulm University89069 UlmGermany Instituto de Electroquímica Universidad de AlicanteApdo.99AlicanteSpain h.lmh.ltz Institute Ulm(h.U)Electroch.mical Energy Storage 89069 UlmGermany

Electrocatalytic activity is influenced by th. surface ch.rge on th. solid ***,our attention h.s been focused on h.w th. surface ch.rge sh.pes th. electric potential and concentration of ionic reactant(s)in th. local reaction *** h.(2)O_(2)redox reactions at Pt(111)as a model system,we reveal a peculiar surface ch.rge effect using ab initio molecular dynamics simulations of electrified Pt(111)-water *** th.s scenario,th. negative surface ch.rge on Pt(111)repels th. O-O bond of th. reactant(h.(2)O_(2))farth.r away from th. electrode *** leads to a h.gh.r activation barrier for breaking th. O-O *** th.s microscopic mech.nism into a microkinetic-double-layer model,we are able to semi-quantitatively interpret th. ph.dependent activity of h.(2)O_(2)redox reactions at Pt(111),especially th. anomalously suppressed activity of h.(2)O_(2)reduction with.decreasing electrode *** relevance of th. present surface ch.rge effect is also examined in wider scenarios with.different electrolyte cations,solution ph.,crystal facets of th. catalyst,and model *** contrast with.previous mech.nisms focusing on h.w surface ch.rge influences th. local reaction condition at a fixed reaction plane,th. present work gives an example in wh.ch.th. location of th. reaction plane is adjusted by th. surface ch.rge.

关键词： Electrocatalysis Surface ch.rge effect h.drogen peroxide reaction Pt(111)-aqueous solution interface Microkinetic-double-layer model

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Molecular Modeling and Synth.sis of Eth.l Benzyl Carbamates as Possible Ixodicide Activity

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Computational Ch.mistry 2019年第1期7卷 1-26页

作者： Vazquez-Valadez victor h.go h.rnandez-S.Manuel Alejandro Velazquez-S.Ana Maria Rosales-h.Maria Leyva-R.Marco Antonio Prado-O.Maria guadalupe Munoz-g.Marco Antonio Alba-h.Fernando Abrego victor Cruz-A.Diego Angeles Enrique Laboratorio de Quimica Medicinal Departamento de Ciencias QuimicasFES-Cuautitlan UNAMEdo.Mex.Mexico Laboratorio de Investigacion Nave 3000 Departamento de Ciencias QuimicasFES-Cuautitlan UNAMEdo.Mex.Mexico Departamento de Quimica CINVESTAVCd.Mx.Mexico Laboratorio 1 de la UIM Departamento de Ciencias BiologicasFES-Cuautitlan UNAMEdo.Mex.Mexico QSAR Analytics S.A.de C.V. Edo.Mex.Mexico

Carbamates are molecules th.t h.ve different types of biological activities and provide a particular ch.mical control against ticks. Th. new structures of th. proposed compounds were optimized and synth.tized respectively, th.ough.a molecular model using th. meth.ds:PM3, h. and DFT applying th. B3LYP functional, with.th. basis 6-31+g(d) and 6-311+g(d,p), BVP86 and PBEPBE with.6-31+g(d) and th. vibrational frequencies computed. Th.se calculated frequencies were compared with.th. experimental ones to determine th. most accurate level of th.ory for th. prediction of vibrational frequencies of th. compounds. Th. best results were obtained th.ough.h./631+g(d). Additionally, we report a modification to obtain th.s type of compounds, and based on th. amino-deh.logenation of eth.l ch.oroformate, different benzyl eth.l carbamates were synth.sized modifying th. base molecule. Th. performances obtained were compared to oth.rs already reported. Th. meth.dology used allowed us to synth.size new carbamates using benzylamine derivatives th.ough.a modification on th. basic catalysis of th. addition-elimination reaction.

关键词： N-Carbamates Ixodicide Molecular Modeling

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芳香传奇催情植物的爱欲物语

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环球人文地理 2018年第9期 72-79页

作者： victor·h.Adam

"我要把颤抖的手指长久地,插进你浓密的鬃毛。在散发着你香味的衬裙里,埋下我痛苦的头颅。"——(法)波德莱尔《恶之花》"埃及艳后"克娄巴特拉七世,才貌出众、聪慧机智,是古埃及托勒密王朝最后一任女法老。公元前40年,28岁的克娄巴特拉扮... 详细信息

"我要把颤抖的手指长久地,插进你浓密的鬃毛。在散发着你香味的衬裙里,埋下我痛苦的头颅。"——(法)波德莱尔《恶之花》"埃及艳后"克娄巴特拉七世,才貌出众、聪慧机智,是古埃及托勒密王朝最后一任女法老。公元前40年,28岁的克娄巴特拉扮成"爱神"维纳斯,乘坐一条豪华楼船,前去引诱罗马名将安东尼。那迎接安东尼的划艇、船桨都在茉莉油中浸泡过,而美艳的女王身上洒满茉莉花水,正静候在铺满玫瑰花瓣的寝宫内。芬芳馥郁的空气,斜卧软榻的倾城美人,此情

关键词：晚香玉属茉莉花依兰属

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Mass Spectrometric Analyses Reveal a Central Role for Ubiquitylation in Remodeling th. Arabidopsis Proteome during Ph.tomorph.genesis

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Molecular Plant 2017年第6期10卷 846-865页

作者： victor Aguilar-h.rnandez Do-Young Kim Robert J. Stankey Mark Scalf Lloyd M. Smith.Rich.rd D. Vierstra Department of Biology Washington University in St. Louis Campus Box 1137 One Brookings Drive St. Louis MO 63130 USA Department of genetics 425-G Henry Mall Department of Ch.mistry 1101 University Avenue University of Wisconsin-Madison Madison WI 53706 USA Advanced Bio Convergence Center Pohang Technopark Gyeong-Buk South Korea 37668

Th. switch.from skotomorph.genesis to ph.tomorph.genesis is a key developmental transition in th. life of seed plants. Wh.le much.of th. underpinning proteome remodeling is driven by ligh.-induced ch.nges in gene expression, th. proteolytic removal of specific proteins by th. ubiquitin-26S proteasome system is also likely paramount. Th.ough.mass spectrometric analysis of ubiquitylated proteins affinity-purified from etiolated Arabidopsis seedlings before and after red-ligh. irradiation, we identified a number of influential proteins wh.se ubiquitylation status is modified during th.s switch. We observed a substantial enrich.ent for proteins involved in auxin, abscisic acid, eth.lene, and brassinosteroid signaling, peroxisome function, disease resistance, protein ph.sph.rylation and ligh. perception, including th. ph.toch.ome （Ph.） A and ph.totropin ph.toreceptors. Soon after red-ligh. treatment, Ph.A becomes th. dominant ubiquitylated species, with.ubiquitin attach.ent sites mapped to six lysines. A Ph.A mutant protected from ubiquitin addition at th.se sites is substantially more stable in planta upon ph.toconversion to Pfr and is h.peractive in driving ph.tomorph.genesis. h.wever, ligh. still stimulates ubiquitylation and degradation of th.s mutant, implying th.t oth.r attach.ent sites and/or proteolytic path.ays exist. Collectively, we expand th. catalog of ubiquitylation targets in Arabidopsis and sh.w th.t th.s post- translational modification is central to th. rewiring of plants for ph.toautotroph.c growth.

关键词： Arabidopsis ubiquitin mass spectrometry ph.tomorph.genesis ph.toch.ome degradation

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