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Reduction of NO by CO using Pd–CeTb and Pd–CeZr catalysts supported on SiO_2 and La_2O_3–Al_2O_3

Journal of Environmental Sciences 2015年第1期27卷 87-96页

作者： victor ferrer Dora Finol Roger Solano Alexander Moronta Miguel Ramos Instituto de Superficies y Catálisis Facultad de Ingeniería Universidad del Zulia Instituto Zuliano de Investigaciones Tecnológicas km 15 carretera Vía a la Ca?ada Apartado 331 Venezuela

The catalytic activity of Pd catalysts supported on Ce0.73Tb0.27Ox/SiO2, Ce0.6Zr0.4Ox/Si O2,Ce0.73Tb0.27Ox/La2O3–Al2O3and Ce0.6Zr0.4Ox/La2O3–Al2O3was studied using the reduction of NO by CO. The catalysts were characterized by X-ray fluorescence, surface area, X-ray diffraction, temperature-programmed reduction, CO chemisorption and oxygen storage capacity. Temperature-programmed reduction results indicated that Tb or Zr incorporation improves the reducibility and oxygen storage capacity. CO chemisorption data suggested the presence of large Pd O particles due to the low CO/Pd ratio. No significant differences were obtained in light off temperatures（T Light off） for all Pd catalysts and the most active was1.5%Pd/Ce0.6Zr0.4Ox/SiO2.

关键词： Mixed oxides OSC Reduction of NO by CO Three way catalysts

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Colorectal cancer screening and surveillance in patients with inflammatory bowel disease in 2021

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World Journal of Gastroenterology 2022年第5期28卷 502-516页

作者： Jose Maria Huguet Luis ferrer-Barceló Patrícia Suárez Eva Sanchez Jose David Prieto victor Garcia Javier Sempere Department of Digestive Disease General University Hospital of ValenciaValencia 46014Spain

The detection of dysplasia in patients with inflammatory bowel disease(IBD)continues to be important given the increased risk of colorectal cancer in this ***,in 2017,we performed a review and update of the recommendations for the management and follow-up of patients with IBD based on the clinical practice guidelines of various scientific *** present manuscript focuses on new aspects of the detection,follow-up,and management of dysplasia according to the latest studies and *** chromoendoscopy with targeted biopsy continues to be the technique of choice for the screening and detection of dysplasia in IBD,the associated difficulties mean that it is now being compared with other techniques(virtual chromoendoscopy),which yield similar results with less technical ***,the emergence of new endoscopy techniques that are still being researched but seem promising(e.g.,confocal laser endomicroscopy and full-spectrum endoscopy),together with the development of devices that improve endoscopic visualization(e.g.,Endocuff Vision),lead us to believe that these approaches can revolutionize the screening and follow-up of dysplasia in patients with ***,further studies are warranted to define the optimal follow-up strategy in this patient population.

关键词： Colitis surveillance Colitis screening Chromoendoscopy Colorectal cancer Inflammatory bowel disease Ulcerative colitis

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Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis

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World Journal of Gastroenterology 2009年第21期15卷 2587-2594页

作者： Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana ferrer victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas Liver Surgery and Transplantation Unit IMDiMIDIBAPSHospital ClinicCIBERehdUniversity of Barcelona

AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these ***:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative ***,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively *** were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,*** with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse *** recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/*** patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two ***:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM.

关键词： Liver metastases Colorectal cancer Hepatic resection Survival Prognostic factors

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Ecto-GPR37:a potential biomarker for Parkinson’s disease

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Translational Neurodegeneration 2021年第1期10卷 77-90页

作者： Xavier Morato Paula Garcia-Esparcia Josep Argerich Franc Llorens Inga Zerr Wojciech Paslawski Eva Borras Eduard Sabido Ulla EPetaja-Repo victor Fernandez-Duenas Isidro ferrer Per Svenningsson Francisco Ciruela Pharm acology Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaUHospitalet de LlobregatSpain Neuroscience Program Bellvitge Biomedical Research InstituteIDIBELLL'Hospitalet de LlobregatSpain Section of Neurology Department of Clinical NeuroscienceDepartm ent of NeuroscienceKarolinska InstituteStockholmSweden Neuropathology Unit Departm ent of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaL'Hospitalet de LlobregatSpain CIBERNED Centro de Investigacion Biomedica en Red de Enfermedades NeurodegenerativasInstituto CarlosⅢMadridSpain Department of Neurology Clinical Dementia Center and National Reference Center for CID SurveillanceUniversity Medical SchoolGottingenGermany German Center for Neurodegenerative Diseases GottingenGermany Proteomics Unit Center for Genomic RegulationBarcelonaSpain Proteomics Unit Universitat Pompeu FabraBarcelonaSpain Research Unit of Biomedicine Medical Research Center OuluUniversity of OuluOuluFinland

Objective:a-Synuclein has been studied as a potential biomarker for Parkinson's disease(PD)with no concluding ***,there is an urgent need to find out reliable specific biomarkers for ***37 is an orphan G protein-coupled receptor that toxically accumulates in autosomal recessive juvenile ***,we investigated whether GPR37 is upregulated in sporadic PD,and thus a suitable potential biomarker for ***:GPR37 protein density and mRNA expression in postmortem substantia nigra(SN)from PD patients were analysed by immunoblot and RT-qPCR,*** presence of peptides from the N-terminus-cleaved domain of GPR37(***-GPR37)in human cerebrospinal fluid(CSF)was determined by liquid chromatography-mass spectrometric *** engineered in-house nanoluciferase-based immunoassay was used to quantify ecto-GPR37 in CSF samples from neurological control(NC)subjects,PD patients and Alzheimer's disease(AD)***:GPR37 protein density and mRNA expression were significantly augmented in sporadic *** amounts of ecto-GPR37 peptides in the CSF samples from PD patients were identified by mass spectrometry and quantified by the in-house ELISA ***,the CSF total a-synuclein level in PD patients did not differ from that in NC ***,the cortical GPR37 mRNA expression and CSF ecto-GPR37 levels in AD patients were also ***:GPR37 expression is increased in SN of sporadic PD *** ecto-GPR37 peptides are significantly increased in the CSF of PD patients,but not in AD *** results open perspectives and encourage further clinical studies to confirm the validity and utility of ecto-GPR37 as a potential PD biomarker.

关键词： GPR37 Pael-R Parkinson's disease Cerebrospinal fluid Biomarker Alzheimer's disease a-5ynuclein Orphan receptor

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