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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： victor V.Chizhikov Igor Y.Iskusnykh department of Anatomy and neurobiology University of Tennessee Health Science CenterMemphisTNUSA

development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

new insights into petrogenesis of Miocene magmatism associated with porphyry copper deposits of the Andean Pampean flat slab,Argentina

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geoscience Frontiers 2018年第5期9卷 1565-1576页

作者： Silvia I.Carrasquero nora A.Rubinstein Anabel L.R.gómez Massimo Chiaradia Dénis Fontignie victor A.Valencia Facultad de Ciencias naturales y Museo Universidad Nacional de La Plata Instituto de geociencias básicas aplicadas y ambientales de Buenos Aires (IgeBA) Departamento de Ciencias Geológicas Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos-CONICET department of Earth Sciences University of Geneva School of Earth and Environmental Sciences Faculty Washington State University

The Paramillos de Uspallata mining district located in the backarc region of the Pampean flat-slab segment(28°-33°S) features porphyry-type deposits genetically associated with Middle Miocene volcanics. This mineralizing magmatism comprising hydrothermally altered(sodic-calcic, potassic and phyllic alteration) subvolcanic and pyroclastic rocks of andesite-basaltic andesite and dacite-rhyolite composition with a typical arc signature, represents the eastward broadening of the Farellones arc by ~17 Ma. Its geochemistry also reveals a residual mineralogy of amphibole ± garnet with limited plagioclase fractionation resulting in an adakitic signal; however, according to the isotopic data collected in our study, the contributions of MASH(melting-assimilation-storage-homogenization) processes in the acquisition of this signal cannot be *** the broadening of the Farellones arc and its residual mineralogy e typical of relatively deep magmatic chambers e are consistent with a slab shallowing and outcoming crustal thickening *** tectonic scenario could be interpreted as a result of an early effect of the Juan Fernandez Ridge collision that was further to the north by ~17 Ma. Our findings suggest that magmas were fertile for porphyry type deposits during the early stages of the slab shallowing.

关键词： Porphyry copper deposits

(In)visibilities About the Vulnerabilities of People with Visual Impairments to Disasters and Climate Change:A Case Study in Cuiabaá,Brazil

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International Journal of Disaster Risk Science 2022年第1期13卷 38-51页

作者： giselly gomes victor Marchezini Michele Sato Federal University of Mato grosso(PPgE/UFMT) CuiabaMT 78060-900Brazil ICEMAT-Institute of the Blind of the State of Mato grosso CuiabaMT 78058-340Brazil Cemaden-national Early Warning and Monitoring Center of natural Disasters Avenida Altino BondesanDistrito de Eugenio de MeloSao Jose dos CamposSP 12247-016Brazil Doctorate Program on Earth System Science National Institute for Space ResearchSao Jose dos CamposBrazil Programa de Pos-graduaao em desastres naturais ICT/Unesp-CemadenSao Jose dos CamposBrazil

People with visual impairments(PwVI)represent a heterogeneous social group who often experience significant disabling barriers in exercising their rights throughout their life *** dimensions of vulnerability of PwVI to disasters and climate change is an important issue to reduce the culture of neglected *** date,few studies have analyzed visual impairment and disaster risk reduction(DRR)in the countries of Latin America and the *** exploratory qualitative research project analyzed how to include PwVI in the DRR policies of *** research question is:how can we include PwVI in the discussion of DRR and climate change?The response to this question is part of a joint effort that involved a university,a hazard monitoring agency,and three institutions that work with *** three main results of the project are:(1)a mapping method to identify the exposure of PwVI to landslides and floods,and to create tactile risk maps tailored to them;(2)incorporating the voices of PwVI regarding their vulnerabilities and capacities with respect to disasters and climate change,achieved through shared interaction during 15 face to face interviews and one workshop attended by 100 people;and(3)an initiative of inclusive education to reduce some of the disabling barriers that intensify vulnerability.

关键词： Brazil Climate injustice Disaster risk Environmental education Inclusive education Sight impairment

Real-time ore sorting using color and texture analysis

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International Journal of Mining Science and Technology 2023年第6期33卷 659-674页

作者： David g.Shatwell victor Murray Augusto Barton Hochschild Mining PLC La Colonia 180Lima 15023Peru department of Electrical Engineering Universidad de Ingenieria y Tecnologia-UTECLima 15063Peru John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridge 02134USA department of Electrical and Computer Engineering University of New MexicoAlbuquerque 87131USA

Sensor-based ore sorting is a technology used to classify high-grade mineralized rocks from low-grade waste rocks to reduce operation *** ore-sorting algorithms using color images have been proposed in the past,but only some validate their results using mineral grades or optimize the algorithms to classify rocks in *** paper presents an ore-sorting algorithm based on image processing and machine learning that is able to classify rocks from a gold and silver mine based on their *** algorithm is composed of four main stages:(1)image segmentation and partition,(2)color and texture feature extraction,(3)sub-image classification using neural networks,and(4)a voting system to determine the overall class of the *** algorithm was trained using images of rocks that a geologist manually classified according to their mineral content and then was validated using a different set of rocks analyzed in a laboratory to determine their gold and silver *** proposed method achieved a Matthews correlation coefficient of 0.961 points,higher than other classification algorithms based on support vector machines and convolutional neural networks,and a processing time under 44 ms,promising for real-time ore sorting applications.

关键词： Ore sorting Image color analysis Image texture analysis Machine learning

Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés gómez-de león Yesica A López-Mora Valeria garcía-Zárate Ana Varela-Constantino Sergio U Villegas-de leon Xitlaly J gonzález-leal Raúl del Toro-Mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz victor Mingura-ledezma Perla R Colunga-Pedraza Olga g Cantú-Rodríguez César H gutiérrez-Aguirre Luz Tarín-Arzaga Elías E gonzález-López David gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKgROUnD The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of nuevo leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(nRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and Cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).no differences in OS,event-free-survival,nRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

TiO_(2)/WO_(3)heterogeneous structures prepared by electrospinning and sintering steps:Characterization and analysis of the impedance variation to humidity

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Journal of Advanced Ceramics 2019年第2期8卷 238-246页

作者： Evando S.ARAuJO victor n.S.leAO Research group on Electrospinning and nanotechnology Applications(gPEA-nano) Department of Materials ScienceUniversidade Federal do Vale do Sao Francisco

Relative humidity(RH) is a critical environmental variable for transportation and storage of products and for the quality guarantee of several other production processes and services. Heterogeneous structures prepared from the selective semiconductor oxides may improve the sensitivity to humidity due to the better electronic and surface properties, when compared to pristine oxides. This work shows an alternative fabrication route for producing titanium dioxide/tungsten trioxide(TiO2/WO3) heterogeneous structures(by electrospinning and sintering) for potential application on the RH detection. The microstructural properties of the materials were analyzed by scanning electron microscopy(SEM), energy dispersive X-ray analysis(EDS), X-ray diffraction, and Raman spectroscopy. The electrical characterization of the structures was performed by electrical impedance spectroscopy in RH range of 10%–100%. Results indicated a p-to n-type conduction transition at around 30%–40% RH for all tested settings. The analysis of the impedance signature to humidity showed that the amount of fiber layers on the electrode and working temperature are important parameters to improve the humidity sensing of the TiO2/WO3 systems.

关键词： electrospinning heterogeneous structures preparation relative humidity semiconductors

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Conservative management of perforated duodenal diverticulum: A case report and review of the literature

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World Journal of gastroenterology 2008年第12期14卷 1949-1951页

作者： David Martínez-Cecilia Alvaro Arjona Sánchez Manuel gómez álvarez Eva Torres Tordera Antonio Luque Molina victor Valentí Azcárate Javier Briceo delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea Hospital Universitario Reina Sofia Av. Menendez Pidal sn. 14005. Córdoba Spain. Clínica Universitaria de navarra Avenida de Pio XII 36 Pamplona 31008 Spain.

Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs.

关键词： Duodenal diverticula Perforation Conservativemanagement

Molecular isolation and identification of Mycobacterium avium *** in Didelphis virginiana from Hidalgo,Mexico

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Asian Pacific Journal of Tropical Medicine 2020年第3期13卷 131-136页

作者： nallely Rivero-Perez Juan Ocampo-López Benjamín Valladares-Carranza Fabián R.gómez de Anda Francisco J.Pena Jiménez victor M.Martínez Juárez Armando Peláez Acero Jose I.Olave leyva deyanira Ojeda-Ramírez Adrian Zaragoza-Bastida Area Académica de Medicina Veterinaria y Zootecnia Instituto de Ciencias AgropecuariaUniversidad Autónoma del Estado de HidalgoAv.Universidad Km 1Ex-Hda.de AquetzalpaC.P.43600 TulancingoHidalgoMéxico Centro de Investigación y Estudios Avanzados en Salud Animal Facultad de Medicina Veterinaria y ZootecniaUniversidad Autónoma del Estado de MéxicoKm 15.5 Carretera Panamericana Toluca-AtlacomulcoC.P.50200 TolucaEstado de MéxicoMéxico Centro Universitario del Sur/División de Ciencias de la Salud/departamento de Ciencias Clínicas/Hospital Veterinario CUSUR Universidad de guadalajara Av.Enrique Arreola Silva No.883colonia centro C.P.49000Ciudad GuzmánJaliscoMéxico

Objective:To isolate and identify the exact species of the genus Mycobacterium from Didelphis(D.)virginiana,and the direct implications of this bacterium to public health and veterinary ***:Thirty-one *** were captured and necropsied in Hidalgo,*** samples were collected to culture mycobacteria present and examine individual specimens’*** identification was obtained through the application of amplification and sequencing of 16S rDnA ***:Three strains were isolated and identified as Mycobacterium(M.)avium *** by utilizing *** complexspecific *** lesions were observed in the subpleural zone(granuloma gradeⅡ)and bronchial(granuloma gradeⅠ)of the lungs of *** with positive ***:Three strains of *** ***,from lung tissue samples of *** were *** subspecies of *** has important implications in public health and veterinary medicine.

关键词： Didelphis virginiana Mycobacterium avium complex Mycobacterium avium subsp.hominissuis Public health