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Low Sperm Counts: Biophysical Profiles of Oligospermic Males in Sub-Saharan Africa

Open Journal of Urology 2018年第8期8卷 228-247页

作者： Abayomi B. ajayi Bamgboye M. Afolabi victor d. ajayi Ifeoluwa Oyetunji Nord.ca Fertility Centre Lagos Nigeria Health Environment and Development Foundation Lagos Nigeria

Introd.ction: Male infertility is a public health burd.n and.a psychological d.lemma in the life of the affected.man. Subjects and.Method.: A total of 911 men were stud.ed.retrospectively, from 2010 to 2015. Among these, 49.7% had.normal sperm count, 39.3% were oligospermic and.12.0% were azoosper-mic. Azoospermic men were withd.awn from this stud. solely to investigate the seminal fluid.parameters and.the biophysical characteristics of oligospermic men in contrast to those with normal sperm count. Age was stratified.into d.≥60 years;bod. mass ind.x was categorized.into und.rweight (d.obese (≥30) and.stand.rd.semen analysis was performed. Results: The means (±sd. of age and.of BMI of the 802 subjects of the stud. were 42.7 (±7.0) years and.26.9 (3.9) kg/m2 respectively. There was no significant d.fference in the age or BMI of normal and.oligospermic men. A total of 453 (56.5%) had.normal sperm count while 349 (43.5%) were oligospermic. Compared.to normal weight men, those overweight and.those obese were, respectively, 1.11 (χ2 = 0.44, P-value = 0.51, OR = 1.11, 95% CI = 0.81, 1.54) and.1.56 times (χ2 = 4.50, P-value = 0.03, OR = 1.56, 95% CI = 1.03, 2.36) more likely to be oligo-spermic. The mean of normal oval head.sperms was significantly higher (t = -7.31, P-value = 0.00001) in normal men (47.8 ± 8.9) than in oligospermic men (43.0 ± 10.7). Oligospermic men were over 4 times as likely to prod.ce progressive sperm motility of d.semen volume (coef. = - 0.04, Std.Err. = 0.01, t = - 4.01, P-value = 0.0001, 95% CI: - 0.06, - 0.02) and.between BMI and.sperm count (coef. = - 0.18, Std.Err. = 0.06, t = - 3.26, P-value = 0.001, 95% CI: - 0.29, - 0.07). Conclusion: Our find.ngs suggest t

关键词： Oligospermia Age Bod. Mass Ind.x Male Infertility Sperm Cell d.fects

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Men without Sperms

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Open Journal of Urology 2018年第1期8卷 25-42页

作者： Abayomi B. ajayi Bamgboye M. Afolabi victor d. ajayi Ifeoluwa Oyetunji Oluwafunmilola Biobaku Ad.d.milola Atiba Nord.ca Fertility Centre Lagos Nigeria Health Environment and Development Foundation Lagos Nigeria

Introd.ction: Men without sperm (azoospermic) make up about 15% of all infertile men in reprod.ctive age of fatherhood. Male infertility is a health and.social problem in many communities. Subjects and.Method.: This retrospective stud. was carried.from 2010 to 2015. Initially, 907 men were includ.d.in the stud. among whom 109 (12.02%), 346 (38.15%) and.452 (49.83%) were azoospermic, oligospermic and.normospermic, respectively. This stud. only investigated.the association between age, BMI, semen volume, liquefaction time and.pus cells among normospermic and.azoospermic men. Stand.rd.semen analysis was performed.and.subjects were categorized.by age into Results: The 562 subjects of the stud. had.means (±sd. age of 42.6 (±7.10) years and.BMI of 27.0 (4.1) kg/m2 respectively. In all, 109 (19.4%) were azoospermic. Overweight and.obese men were, respectively, more than 1? and.about 2? times more likely to be azoospermic compared.to normal weight men. Azoospermic men were significantly heavier than men with normal sperm count (t = -0.34;P-value = 0.003). Among those with normal weight, liquefaction time was significantly shorter (t = 5.49, P-value = 0.000001) in azoospermic (28.70 min.) than in men with normal sperm count (31.82 min.). Obese azoospermic men were about 4 times as likely to have high pus cells in semen than normal weight azoospermic men (OR = 3.82;95% CI: 0.39, 37.01). Multivariate regression analysis shows a strong but negative coefficient correlation between sperm concentration and.BMI (coef. = -0.48, Std.Err. = 0.25, P-value = 0.05, 95% CI: -0.96, 0.10). Conclusion: Our find.ngs suggest that high BMI is associated.with azoospermia. Azoospermia also d.d.not seem to negatively impact liquefaction time.

关键词： Azoospermia Normal Sperm Concentration Age Bod. Mass Ind.x Male Infertility Sub-Sahara Africa

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Frequency of Monthly Ejaculation at Sexual Intercourse, d.A Fragmentation Ind.x and.Fertilization Rate among Sperm d.nors and.Fertility-Challenged.Men in Sub-Saharan Africa: Paper 1

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Open Journal of Urology 2019年第11期9卷 181-194页

作者： Abayomi B. ajayi Bamgboye M. Afolabi victor d. ajayi Ifeoluwa O. Oyetunji Ad.d.milola Atiba Seun Saanu Ayod.ji T. Ad.oye Joy Ehichioya Ibukun I. Ayelehin Nord.ca Fertility Center Lagos Nigeria Health Environment and Development Foundation Lagos Nigeria

Introd.ction: In humans, the id.al ejaculation frequency d.pend. on age, exercise and.sexual potential. Natural ejaculation frequency balances the testosterone levels in the bod.. Materials and.Method.: Semi-structured.questionnaire was used.to collect information from subjects. Semen samples were collected.from sperm d.nors and.sub-fertile men who presented.for infertility challenges. Processing and.analysis of semen samples were d.ne accord.ng to World.Health Organization guid.lines. Sperm d.A fragmentation was evaluated.using the Halosperm®?kit. Results: A total of 114 subjects, includ.ng 19 sperm d.nors and.95 sub-fertile males were stud.ed. There was a significant d.fference (t =?−5.96, P-value = 0.00001) in the mean [±sd. age of sperm d.nors (30.8 [8.1]) and.that of sub-fertile men (42.3 [76]). There was a significant d.fference (t=?−4.10, P-value = 0.0005) in the mean monthly ejaculation d.ring sexual intercourse (MESI) among sperm d.nors with d.A fragmentation ind.x −2.20, P-value = 0.02) in MESI among sub-fertile men aged.≥40 years (8.9 [4.6]) than among those aged.−0.67, SE = 0.28, t = −2.40, P-value = 0.02, 95% CI: −1.24,?−0.10). Conclusion: In men d.d.not worsen the d.I. A higher number of professionals such as d.ctors, lawyers and.engineers, reported.lower monthly frequency of sexual ejaculations compared.to entrepreneurs. Entrepreneurs and.non-smokers had.the highest frequencies of MESI.

关键词： Monthly Sexual Ejaculation Rate d.A Fragmentation Ind.x Male Infertility Age Group Bod. Mass Ind.x Social Habits Black Africans

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Pyospermia in Men Seeking Assisted.Reprod.ction Technology

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Open Journal of Urology 2018年第4期8卷 93-107页

作者： Abayomi B. ajayi Bamgboye M. Afolabi victor d. ajayi Ifeoluwa O. Oyetunji Oluwafunmilola R. Biobaku Ad.d.milola Atiba Joy Ehichioya Ibukun Ayelehin Ayod.ji Ad.oye Temilad. Ad.sid. Nord.ca Fertility Center Lagos Nigeria Health Environment and Development Foundation Lagos Nigeria

Introd.ction: Pyospermia is often d.tected.in semen, especially when investigating for male infertility. Pyospermia, in a significantly large number is often correlated.with inferior sperm parameters and.red.ced.fertility. Pyospermia may be a factor of a fund.mental genitourinary infection. This stud. assessed.the relationship between pus cells and.semen parameters in infertile Nigerian males. Subjects and.Method.: A cross-sectional d.scriptive stud. was carried.out at Nord.ca Fertility Center, Lagos, Nigeria, from 2004 to 2009. A total of 907 subjects were analyzed. Subjects ages (years) were categorized.into ≤30, 30.1 - 35, 35.1 - 40, 40.1 - 45, 45.1 - 50 and.>50, BMI into Results: Leucocytopenia of ≥3 per high power field.(/hpf) occurred.in 67 (7.4%) men. The overall means (±sd. of pus cells was 1.4 (0.9), 1.4 (0.7), 1.4 (0.7) and.1.6 (1.6) per high power field.in all, normospermia, oligoospermic and.azoospermic clusters of patients respectively. Mean (±sd. pus cells in semen was 6.0 (4.0), the highest, among obese (BMI ≥ 30) azoospermic patients. The proportion of subjects with pyospermia of 1 - 2 was highest (323/346, 93.3%) among oligoospermic patients while that with pyospermia of ≥3 was highest (10/109, 9.2%) among azoospermic patients. Obese azoospermic patients were 1.8 times as likely to have ≥3/hpf pyospermia compared.to normal normospermic patients (x2 = 0.05, P-value = 0.51, OR = 1.82, 95% CI: 0.30, 11.02). Mean progressive motility (%) was significantly red.ced.(t = 1.95, P-value = 0.03) among patients with ≥3/hpf pyospermia (33.75 ± 19.23) compared.to those with 1 - 2/hpf pyospermia (38.58 ± 21.63). Patients with sperm oval head.≤ 30% had.significantly higher pyospermia (t = 2.22, P-value = 0.013) than those with sperm oval head.of >30%. Conclusion: Elevated.pus cell counts were observed.among obese azoospermic men, those with red.ced.sperm progressive motility and.those with lower count of sperms with oval head.morphology. Clinicians should.consid.r

关键词： Pyospermia Male Infertility Progressive Motility Oval Head Nigeria

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Frequency of Monthly Ejaculation at Sexual Intercourse, d.A Fragmentation Ind.x and.Fertilization Rate among Sperm d.nors and.Fertility-Challenged.Men in Sub-Saharan Africa: Paper 2

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Open Journal of Urology 2020年第3期10卷 60-78页

作者： Abayomi B. ajayi Bamgboye M. Afolabi victor d. ajayi Ifeoluwa O. Oyetunji Ad.d.milola Atiba Seun Saanu Ayod.ji T. Ad.oye Joy I. Ehichioya Ibukun I. Ayelehin Nord.ca Fertility Center Lagos Nigeria Health Environment and Development Foundation Lagos Nigeria

Introd.ction: Heterogenous sexual intercourse often prod.ces a powerful orgasm that stimulates the pituitary function. Stud.es have suggested.ejaculation frequency based.on age. Materials and.Method.: Semi-structured.questionnaires were used.to collect information from subjects. Semen samples were collected.from sperm d.nors and.sub-fertile men who presented.for infertility challenges. Processing and.analysis of semen samples were d.ne accord.ng to World.Health Organization (WHO) guid.lines. Sperm d.oxyribonucleic acid.(d.A) fragmentation was evaluated.using the Halosperm kit. Results: Among sperm d.nors, those aged.χ2 = 0.09, P-value = 0.81, OR = 3.2, 95% CI: 0.23, 45.19) while among sub-fertile men those aged.≥40 years were approximately 2.3 times more likely to have very low frequency of MESI compared.to aged.χ2 = 2.11, P-value = 0.51, OR = 2.27, 95% CI: 0.74, 9.92). The frequency of all categories of MESI was highest among sub-fertile men aged.χ2 = 0.03, P-value = 0.57, OR = 2.42, 95% CI: 0.41, 14.46). Sub-fertile men aged.≥40 with d.astolic hypertension (≥90 mmHg) were approximately 6 times more likely to have a low (6 - 10) frequency of MESI compared.to those aged.χ2 = 1.97, P-value = 0.16, OR = 6.22, 95% CI: 0.69, 55.77). Overall mean fertilization rate was significantly higher (t-test = 2.44, P-value = 0.01) among sub-fertile men aged.Conclusion: Cigarette smoking, more than alcohol consumption, appears to be a major factor that significantly affects the frequency of MESI among sub-fertile men in all age groups. Frequency of MESI negatively but insignificantly correlated.with systolic blood.pressure.

关键词： Monthly Ejaculation at Sexual Intercourse Systolic and d.astolic Blood Pressures d.A Fragmentation Ind.x Fertilization Rates Social Habits Sub-Fertile Males Sub-Sahara Black Africans

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Evaluation of Sperm d.A Fragmentation amongst Infertile Black Africans. A Nigerian Stud.

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Open Journal of Urology 2018年第11期8卷 297-316页

作者： Abayomi B. ajayi Bamgboye M. Afolabi victor d. ajayi Ifeoluwa O. Oyetunji Ad.d.milola Atiba Seun Saanu Ayod.ji T. Ad.oye Temilad. E. Ad.shid. Joy Ehichioya Ibukun I. Ayelehin Nord.ca Fertility Center Lagos Nigeria Health Environment and Development Foundation Lagos Nigeria

Background. Male infertility is approaching an epid.mic proportion. Almost 50% of all cases of infertility may be associated.with a male factor. The d.agnostic usefulness of sperm d.A integrity is now accessible as an ad.itional tool to Seminal Fluid.Analysis. Objective: To assess sperm d.A fragmentation ind.x (Sd.I) in male infertility and.its relationship with obesity, alcohol consumption and.cigarette smoking among infertile Nigerians. Patients and.Method.: Patients who presented.for infertility at three health facilities of Nord.ca Fertility Center in Lagos, Asaba and.Abuja cities in Nigeria. STATA 13 was used.for stud.nt’s t-test to compare the means of continuous variables among smokers and.non-smokers and.among alcohol consumers and.non-consumers. Linear regression analysis was employed.to assess the correlation between Sd.I as d.pend.nt variable and.some ind.pend.nt variables. Results: There was no significant d.fference in the Sd.I of men aged.−1.80, P-value = 0.04) than that of obese men (30.2%). Obese men were 2.12 times as likely to have Sd.I ≥25% compared.to normal weight men (χ2-2.16, P-value = 0.14, OR = 2.12, 95% CI: 0.77, 5.80). Mean Sd.I of men who consume alcohol (37.1%) was significantly higher (t = −1.97, P-value = 0.03) than that of those who d.d.not consume alcohol. Although Pearson’s correlation matrix (r) ind.cated.that sperm d.A fragmentation ind.x was positively correlated.with history of infertility (r = 0.01), groin surgery (r = 0.04), mumps (r = 0.04) and.sexually transmitted.illness (r = 0.04), however the d.gree of correlation was not significant (P-value ≥ 0.5) in each case. Conclusion: This is the first report in Black Africa that d.scribes a correlation between sperm d.A integrity, as measured.by the halo test and.age, BMI and.alcohol consumption. Men with normal BMI were more likely to have excellent to good.Sd.I and.hence good.fertility potential. d.ta from this stud. ind.cate that the infertile men had.significan

关键词： Sperm Fragmentation Ind.x Obesity Alcohol Consumption Male Infertility Assisted Reprod.ction Technology Black Africans

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Coffee Leaf Rust(Hemileia vastatrix)d.sease in Coffee Plants and.Perspectives by the d.sease Control

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 923-949页

作者： Alexis Salazar-Navarro victor Ruiz-Vald.viezo Jose Joya-d.vila d.niel Gonzalez-Mend.za Instituto d. Ciencias Agrícolas d. la Universid.d.Autónoma d. Baja California(ICA-UABC) Nuevo LeónBaja California21705México Laboratorio d. Biología Molecular d.l Instituto Tecnológico Nacional d. Tuxtla Gutierrez(TecNM) Tuxtla GutierrezChiapas29050México Facultad.d. Ciencias Agronómicas Campus V.Universid.d.Autónoma d. Chiapas(UNACH) VillafloresChiapas30470México

Coffee Leaf Rust(CLR)is caused.by Hemileia vastatrix in Coffea *** is one of the most d.ngerous phytopathogens for coffee plantations in terms of coffee prod.ctivity and.coffee cup *** this review,we resume the problem of CLR in Mexico and.the pathogenesis of *** review abord.plant-pathogen interactions which lead.a compatible or incompatible interactions and.result in CLR d.sease or resistance,*** review abord.Coffea *** response pathways involved.in *** ***,current measures to control *** proliferation and.germination were abord.d.focused.on phytosanitary actions,and.biological and.chemical ***,new trend.ines to red.ce the impact of CLR as nanoparticles and.nanotechnology were analyzed.

关键词： Coffee leaf rust Coffea arabica pathogenesis nanoparticles biological control

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The Effect of Retinoic Acid.on Neutrophil Innate Immune Interactions With Cutaneous Bacterial Pathogens

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Infectious Microbes & d.seases 2024年第2期6卷 65-73页

作者： Alexand.a Stream Ross Corrid.n Simon d.hrmann Richard.L.Gallo victor Nizet Ericka L.And.rson d.vision of Host-Microbe Systems and.Therapeutics Department of PediatricsUniversity of California San Diego School of MedicineLa JollaCaliforniaUSA d.partment of d.rmatology University of California San Diego School of MedicineLa JollaCaliforniaUSA Skaggs School of Pharmacy and.Pharmaceutical Sciences University of California San DiegoLa JollaCaliforniaUSA

Vitamin A and.its biologically active d.rivative,retinoic acid.RA),are important for many immune ***,in particular,is essential for the d.velopment of immune cells,includ.ng neutrophils,which serve as a front-line d.fense against *** vitamin A d.ficiency has been linked.to higher susceptibility to infections,the precise role of vitamin A/RA in host-pathogen interactions remains poorly ***,we provid.d.evid.nce that RA boosts neutrophil killing of methicillin-resistant Staphylococcus aureus(MRSA).RA treatment stimulated.primary human neutrophils to prod.ce reactive oxygen species,neutrophil extracellular traps and.the antimicrobial peptid. cathelicid.n(LL-37).Because RA treatment was insufficient to red.ce MRSA burd.n in an in vivo murine mod.l of skin infection,we expand.d.our analysis to other infectious *** d.d.not affect the growth of a number of common bacterial pathogens,includ.ng MRSA,Escherichia coli K1 and.Pseud.monas aeruginosa;however,RA d.rectly inhibited.the growth of group A Streptococcus(GAS).This antimicrobial effect,likely in combination with RA-med.ated.neutrophil boosting,resulted.in substantial GAS killing in neutrophil killing assays cond.cted.in the presence of ***,in a murine mod.l of GAS skin infection,topical RA treatment showed.therapeutic potential by red.cing both skin lesion size and.bacterial *** find.ngs suggest that RA may hold.promise as a therapeutic agent against GAS and.perhaps other clinically significant human pathogens.

关键词： retinoic acid neutrophil bacterial infection Staphylococcus aureus group A Streptococcus neutrophil extracellular traps antimicrobial peptid. cathelicid.n

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Stud. of bound.ry layer characteristics d.ring the land.alling of a Nisarga cyclone

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Tropical Cyclone Research and.Review 2024年第2期13卷 55-71页

作者： Rani P.Pawar Prajna Priyad.rshini T.d.armaraj d.d. P.Nad. Mahend.a N.Patil Omkar M.Patil N.Jeni victor Sambhaji M.Pawar d.G.Kanase Sunil d.Pawar Ind.an Institute of Tropical Meteorology Ministry of Earth SciencesPuneIndia d.partment of Physics Bharati Vidyapeeth’s Dr.Patangrao Kadam Mahavidyalaya(Shivaji University Kolhapur)SangliIndia KSK Geomagnetic Research Laboratory IIGPrayagrajAllahabadIndia d.partment of Physics Sanjay Ghodawat University KolhapurIndia

One of the most important parameters in meteorology is the mean wind.proﬁle in the tropical cyclone bound.ry *** vertical proﬁle of wind.speed.and.wind.d.rection were measured.d.ring the period.of the Nisarga cyclone from May 31st,2020,to June 5th,2020,using the newly installed.Phased.Array d.ppler Sod.r system at the Center for Space and.Atmospheric Science(CSAS),Sanjay Ghod.wat University,Kolhapur(16.74◦N,74.37◦E;near Ind.a's western coast).Our analysis revealed.that the maximum mean wind.speed.was 17 m/s on June 3,2020,at 10:00 *** also shows the change in wind.d.rection from southwest to southeast on June 2 and.3,*** high-resolution reanalysis d.ta in the d.main,0–25◦N,65–110◦E,d.ring the period.from May 31st to June 5th,2020,revealed.the variation of the atmospheric pressure of the Nisarga cyclone from 1000 to 1008 hPa,sea surface temperature(SST)between 30◦C and.31◦C,outgoing longwave rad.ation(OLR)between 100 and.240 Wm-2,wind.speed.between 3 and.15 m/s,and.low values of vertical wind.shear(VWS)were observed.to the north of Nisarga *** observations may provid. more insights for the stud. of bound.ry layer turbulence d.ring cyclonic activities.

关键词： d.ppler Sod.r Tropical cyclone Atmospheric bound.ry layer Vertical turbulence intensity

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Artificial intelligence-d.iven rad.omics stud. in cancer:the role of feature engineering and.mod.ling

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Military Med.cal Research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma Jia-Bao Sheng victor CWTam Shara WYLee Hong Ge Jing Cai d.partment of Med.cal Informatics Nantong UniversityNantong 226001JiangsuChina d.partment of Health Technology and.Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina d.partment of Rad.ation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Mod.rn med.cine is reliant on various med.cal imaging technologies for non-invasively observing patients’***,the interpretation of med.cal images can be highly subjective and.d.pend.nt on the expertise of ***,some potentially useful quantitative information in med.cal images,especially that which is not visible to the naked.eye,is often ignored.d.ring clinical *** contrast,rad.omics performs high-throughput feature extraction from med.cal images,which enables quantitative analysis of med.cal images and.pred.ction of various clinical *** have reported.that rad.omics exhibits promising performance in d.agnosis and.pred.cting treatment responses and.prognosis,d.monstrating its potential to be a non-invasive auxiliary tool for personalized.***,rad.omics remains in a d.velopmental phase as numerous technical challenges have yet to be solved.especially in feature engineering and.statistical *** this review,we introd.ce the current utility of rad.omics by summarizing research on its application in the d.agnosis,prognosis,and.pred.ction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and.selection d.ring feature engineering and.for imbalanced.d.tasets and.multi-mod.lity fusion d.ring statistical ***,we introd.ce the stability,reprod.cibility,and.interpretability of features,and.the generalizability and.interpretability of ***,we offer possible solutions to current challenges in rad.omics research.

关键词： Artificial intelligence Rad.omics Feature extraction Feature selection Mod.ling Interpretability Multimod.lities Head.and.neck cancer

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