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Redefining pandemic preparedness:Multidisciplinary insights from the CERP modelling workshop in infectious diseases,workshop report

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Infectious Disease Modelling 2024年第2期9卷 501-518页

作者： Marta C.Nunes Edward Thommes Holger Fröhlich Antoine Flahault Julien Arino Marc Baguelin Matthew Biggerstaff Gaston Bizel-Bizellot Rebecca Borchering Giacomo Cacciapaglia Simon Cauchemez Alex Barbier--Chebbah Carsten Claussen Christine Choirat Monica Cojocaru Catherine Commaille-Chapus Chitin Hon Jude Kong Nicolas lambert Katharina B.Lauer Thorsten Lehr Cédric Mahe Vincent Marechal Adel Mebarki Seyed Moghadas Rene Niehus Lulla Opatowski Francesco Parino Gery Pruvost Andreas Schuppert Rodolphe Thiébaut Andrea Thomas-Bachli Cecile Viboud Jianhong Wu Pascal Crépey PascalCrepey Center of Excellence in Respiratory Pathogens(CERP) Hospices Civils de Lyon(HCL)and Centre International de Recherche en Infectiologie(CIRI)Équipe SantéPubliqueÉpidémiologie etÉcologieÉvolutive des Maladies Infectieuses(PHE3ID)Inserm U1111CNRS UMR5308ENS de LyonUniversitéClaude Bernard Lyon 1LyonFrance South African Medical Research Council Vaccines&Infectious Diseases Analytics Research UnitFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa New Products and Innovation(NPI) Sanofi Vaccines(Global)TorontoOntarioCanada Department of Mathematics and Statistics University of GuelphGuelphOntarioCanada Fraunhofer Institute for Algorithms and Scientific Computing(SCAI) Department of BioinformaticsSchloss BirlinghovenSankt AugustinGermany University of Bonn Bonn-Aachen International Center for IT(b-it)BonnGermany Institute of Global Health Faculty of MedicineUniversity of GenevaGenevaSwitzerland and Swiss School of Public HealthZürichSwitzerland Department of Mathematics University of ManitobaWinnipegManitobaCanada MRC Centre for Global Infectious Disease Analysis School of Public HealthImperial College LondonLondonUK Centre for Mathematical Modelling of Infectious Diseases Department of Infectious Disease EpidemiologyLondon School of Hygiene&Tropical MedicineLondonUK National Center for Immunization and Respiratory Diseases(NCIRD) US Centers for Disease Control and Prevention(CDC)AtlantaGAUSA Departement of Computational Biology Departement of Global HealthInstitut PasteurParisFrance Institut de Physique des Deux Infinis de Lyon(IP2I) UMR5822IN2P3/CNRSUniversitéClaude Bernard Lyon 1VilleurbanneFrance Mathematical Modelling of Infectious Diseases Unit Institut PasteurUniversitéParis CitéUMR2000 CNRSParisFrance Decision and Bayesian Computation Institut PasteurUniversitéParis CitéCNRS UMR 3571France Fraunhofer-Institute for Translational Medicine and Pharmacology HamburgGermany Institute of Global Health Faculty of MedicineUniversity of

In July 2023,the Center of Excellence in Respiratory Pathogens organized a two-day workshop on infectious diseases modelling and the lessons learnt from the Covid-19 *** report summarizes the rich discussions that occurred during the *** workshop participants discussed multisource data integration and highlighted the benefits of combining traditional surveillance with more novel data sources like mobility data,social media,and wastewater *** advancements were noted in the development of predictive models,with examples from various countries showcasing the use of machine learning and artificial intelligence in detecting and monitoring disease *** role of open collaboration between various stakeholders in modelling was stressed,advocating for the continuation of such partnerships beyond the pandemic.A major gap identified was the absence of a common international framework for data sharing,which is crucial for global pandemic ***,the workshop underscored the need for robust,adaptable modelling frameworks and the integration of different data sources and collaboration across sectors,as key elements in enhancing future pandemic response and preparedness.

关键词： Modelling Covid-19 Infectious diseases Pandemic preparedness Workshop

Production performance and plasma metabolite concentrations of broiler chickens fed low crude protein diets differing in Thr and Gly

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Animal Nutrition 2021年第2期7卷 472-480页

作者： Laura Star Sophie Tesseraud Marije van Tol Ilaria Minussi Etienne Corrent William lambert Schothorst Feed Research Meerkoetenweg 268218 NA Lelystadthe Netherlands INRAE BOAUniversitéde Tours37380 NouzillyFrance Orffa Additives B.V. Vierlinghstraat 514251 LC Werkendamthe Netherlands Ajinomoto Animal Nutrition Europe 32 rue Guersant75017 ParisFrance

The aim of the study was to test the interaction between Thr and Gly in low crude protein(CP)diets in 7 to 28 d broilers on production performance and plasma metabolites.A total of 2,040 broilers were allocated to 17 treatments.A positive control(PC)diet(20.5%CP)was formulated to be adequate in dietary Thr and Gly.A negative control(NC)diet(18.5%CP,deficient in Thr and Gly)was supplemented with crystalline L-Thr and Gly to obtain a 4 Thr×4 Gly *** Thr was tested at an apparent faecal digestibility(AFD)Thr-to-Lys ratio,which was 55%,58%,61%or 64%,and dietary Gly was tested at an AFD(Gly+Ser)-to-Lys ratio,which was 135%,142%,149%or 156%.Plasma samples were collected at 28 *** low CP diet,formulated at 64%Thr and 156%Gly,resulted in a higher body weight gain(BWG)(P<0.01)and similar feed conversion ratio(FCR)as the high CP treatment(PC).FCR was improved(P<0.001)by L-Thr *** response to dietary Thr was significant for feed intake(FI),BWG and FCR(P<0.01).A near-significant interaction for Thr×Gly was observed for FI and BWG(Plinear=0.091 and P=0.074,respectively).Gly did not affect production *** interaction between Thr×Gly on plasma free AA level was observed(P<0.05).Free AA concentration in plasma linearly decreased with increase in AFD Thr-to-Lys ratio,and increased with increase in AFD(Gly+Ser)-to-Lys *** uric acid concentration was higher in PC than in all of the other diets,and plasma triglyceride concentration was decreased by L-Thr supplementation,but not by *** conclusion,Gly was not limiting for growth at low dietary CP level unless Thr was deficient,showing that adequate amounts of Thr in broiler diets can overcome marginal supply of Gly and Ser and allow reduction of dietary CP from 20.5%to 18.5%for broilers from 7 to 28 d of age.

关键词： Broiler Threonine Glycine Low protein Performance Plasma metabolite

The Relationship between Model Biases in East Asian Summer Monsoon Rainfall and Land Evaporation

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Advances in Atmospheric Sciences 2023年第11期40卷 2029-2042,I0004-I0013页

作者： Ruth GEEN Marianne PIETSCHNIG Shubhi AGRAWAL Dipanjan DEY FHugo lambert Geoffrey KVALLIS School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUK Department of Mathematics and Statistics University of ExeterExeter EX44QJUK Department of Earth and Environmental Sciences Indian Institute of Science Education and ResearchBhopal 462066India School of Ocean and Earth Science University of SouthamptonSouthampton SO171BJUK

The East Asian Summer Monsoon(EASM)provides the majority of annual rainfall to countries in East *** state-of-the-art models broadly project increased EASM rainfall,the spread of projections is large and simulations of present-day rainfall show significant climatological *** evapotranspiration biases occur locally over East Asia,and globally over land,in simulations both with and without a coupled *** study explores the relationship between evapotranspiration and EASM precipitation ***,idealized model simulations are presented in which the parameterization of land evaporation is modified,while sea surface temperature is *** results suggest a feedback whereby excessive evapotranspiration over East Asia results in cooling of land,a weakened monsoon low,and a shift of rainfall from the Philippine Sea to China,further fueling ***-model regressions against evapotranspiration over China indicate a similar pattern of behavior in Atmospheric Model Intercomparison Project(AMIP)*** causes of this pattern are *** feedback is not explained by an overly intense global hydrological cycle or by differences in radiative *** of land-only simulations indicates that evapotranspiration biases are present even when models are forced with prescribed *** are strengthened when coupled to the atmosphere,suggesting a role for land-model errors in driving atmospheric *** atmosphere-ocean models are shown to have similar evapotranspiration biases to those in AMIP over China,but different precipitation biases,including a northward shift in the ITCZ over the Pacific and Atlantic Oceans.

关键词： monsoon East Asia China evapotranspiration model bias

Synthesis, Surface Characterization and Photocatalytic Activity of TiO_2 Supported on Almond Shell Activated Carbon

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Journal of Materials Science & Technology 2014年第9期30卷 894-902页

作者： A.Omri S.D.lambert J.Geens F.Bennour M.Benzina Laboratory of Water-Energy-Environment (LR35 Code: AD-10-02 National School of Engineers of SfaxUniversity of SfaxBP W 3038 Sfax Tunisia Laboratory of Chemical Engineering B6a University of LiègeB-4000 Liège Belgium Tunisian Chemical Group Sfax -Tunisia B.P 393/3018 Tunisia

Three types of photocatalysts were synthesized by metal organic chemical vapor deposition and impregnation methods using the almond shell activated carbon as support. These photocatalysts denoted by （TiO2/ASAC （V）, TiO2/ASAC （11） and TiO2/ASAC （12）） were characterized by scanning electron microscopy （SEM）, X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR）, diffuse reflectance spectroscopy （DRS） and nitrogen adsorption-desorption isotherms. SEM observation shows that TiO2 was deposited on activated carbon surface. XRD results confirm that TiO2 existed in a mixture of anatase and rutile phases. The DRS spectra show the characteristic absorption edge of TiO2 at approximate 380 nm corresponding to the optical band gap of 3.26 eV. Besides, FTIR spectrum indicated the presence of （Ti-O） groups. The specific surface area of photocatalysts decreased drastically in comparison with the original activated carbon. The catalysts were very efficient for the photodegradation of total organic carbon （TOC） from industrial phosphoric acid solution under UV irradiation. The kinetics of photocatalytic TOC degradation was found to follow a pseudo- first-order model. The prepared TiO2/ASAC showed high photoactivity for the photodegradation of TOC in the following order： TiO2/ASAC （V）〉 TiO2/ASAC （11）〉 TiO2/ASAC （12）〉 ASAC 〉 TiO2 （P25）.

关键词： Almond shell activated carbon Photocatalyst Vapor deposition Impregnation Total organic carbon

Role of matrix metalloproteinases in chronic wound healing： diagnostic and therapeutic implications

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Chinese Medical Journal 2014年第8期127卷 1572-1581页

作者： Ren Yanhan Gu Guosheng Yao Min vickie R. Driver Class of 2014 University of Rochester NY USA Department of Surgery Jinling Hospital Nanjing Jiangsu 210002 China Department of Surgery Limb Preservation and Wound Care Research VA New England Health Care Division Providence RI USA

Matrix metalloproteinases （MMPs） are members of the family of zinc-dependent endopeptidases.

关键词： matrix metalloproteinase wound healing chronic wounds matrix metalloproteinase zinc-dependentnzymes diabetic foot ulcers

Supramolecular gating of guest release from cucurbit[7]uril using de novo design

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npj Computational Materials 2022年第1期8卷 172-179页

作者： Hugues lambert Alvaro Castillo Bonillo Qiang Zhu Yong-Wei Zhang Tung-Chun Lee Institute of High Performance Computing A*STAR1 Fusionopolis WayConnexis Tower138632SingaporeSingapore Department of Chemistry Christopher Ingold BuildingUniversity College London(UCL)20 Gordon StreetLondonWC1H 0AJUK Institute for Materials Discovery University College London(UCL)LondonUK Institute of Materials Research and Engineering A*STAR2 Fusionopolis WayInnovis Tower138634SingaporeSingapore

Herein we computationally explore the modulation of the release kinetics of an encapsulated guest molecule from the cucurbit[7]uril(CB7)cavity by ligands binding to the host *** uncovered a correlation between the ligand-binding affinity with CB7 and the guest residence time,allowing us to rapidly predict the release kinetics through straightforward energy minimization *** high-throughput predictions in turn enable a Monte-Carlo Tree Search(MCTS)to de novo design a series of cap-shaped ligand molecules with large binding affinities and boosting guest residence times by up to 7 orders of ***,halogenated aromatic compounds emerge as top-ranking *** modeling suggests the presence of halogen-bonding between the ligands and the CB7 ***,the binding of top-ranked ligands is supported by^(1)H NMR and 2D *** findings open up possibilities in gating of molecular transport through a nanoscale cavity with potential applications in nanopore technology and controlled drug release.

关键词： release kinetics straight

Vegetation change as related to terrain factors at two glacier forefronts, Glacier National Park, Montana, U.S.A.

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Journal of Mountain Science 2020年第1期17卷 1-15页

作者： Callie B.lambert Lynn M・RESLER Yang SHAO David R.BUTLER Department of Geography Virginia Tech220 Stanger StreetBlacksburgVA24061USA Texas State University Department of GeographySan MarcosTX 78666USA

Glacier recession is a globally occurring trend. Although a rich body of work has documented glacial response to climate warming, few studies have assessed vegetation cover change in recently deglaciated areas, especially using geospatial technologies. Here, vegetation change at two glacier forefronts in Glacier National Park, Montana, *** quantified through remote sensing analysis,fieldwork validation, and statistical ***, we assessed the spatial and temporal patterns of landcover change at the two glacier forefronts in Glacier National Park and determined the role of selected biophysical terrain factors(elevation, slope, aspect, solar radiation, flow accumulation, topographic wetness index, and surficial geology) on vegetation change(from nonvegetated to vegetated cover) at the deglaciated *** imagery of the study locations in 1991, 2003,and 2015 were classified and validated using visual interpretation. Model results revealed geographic differences in biophysical correlates of vegetation change between the study areas, suggesting that terrain variation is a key factor affecting spatialtemporal patterns of vegetation change. At Jackson Glacier forefront, increases in vegetation over some portion or all of the study period were negatively associated with elevation, slope angle, and consolidated bedrock. At Grinnell Glacier forefront,increases in vegetation associated negatively with elevation and positively with solar *** geospatial and field approaches to the study of vegetation change in recently deglaciated terrain are recommended to understand and monitor processes and patterns of ongoing habitat change in rapidly changing mountain environments.

关键词： Land cover change Physical geography Glacial forefronts Vegetation change Glacier National Park Terrain factors

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商务英语热门话题42个

Treatment of Coats' disease: an analysis of pooled results

2007年

作者：盛小利 (美)vickie Wen校注

本书采用英汉对照的会话形式，把商务活动中一些常用的重点词汇和句型放在实际工作和生活环境中，以便读者在学习英语和掌握地道商务知识的同时，掌握在具体工作、生活情景下正常运用语言的技能。

ISBN: (纸本)9787801445001

关键词：英语口语

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 668-674页

作者： Janelle Fassbender Adeniran Sarah M Duff Michael Mimouni Nathan lambert Aparna Ramasubramanian Department of Ophthalmology & Visual Sciences University of Louisville School of Medicine Rambam Hospital University of Utah

AIM: To elucidate the association of treatment modality to vitreoretinal fibrosis and traction retinal detachment(TRD) in Coats' ***: A PubMed search for Coats' disease with included studies describing eyes with clinical features and treatment course of Coats' disease. Binary logistic regression with fibrosis at presentation and treatment type as independent variables was performed to determine predictors of TRD historically(since 1921) and in the antivascular endothelial growth factor(VEGF) era(since2007). Odds ratios(OR) with 95% confidence intervals(CI)***: Of 175 articles described 1183 eyes. Vitreoretinal fibrosis increased from presentation(5.4%) to follow-up(15.5%) and TRD increased from 0.44% to 3.9% at follow up. Laser was protective against vitreoretinal fibrosis(OR0.6, 95%CI 0.4-0.9) but TRD was borderline(OR 0.6, 95%CI0.3-1.1). Cryotherapy showed a higher association with TRD(OR 1.9, 95%CI 1.0-3.7) than with vitreoretinal fibrosis(OR 0.8, 95%CI 0.5-1.2). Similarly, intravitreal anti-VEGF alone was not associated with fibrosis(OR 1.1, 95%CI 0.6-1.8) nor TRD(OR 1.1, 95%CI 0.5-2.6) but the combination of laser and anti-VEGF therapy was protective [Fibrosis: 0.1(0.03, 0.35); TRD: 0.05(0.01, 0.23)] compared to anti-VEGF plus cryotherapy(P<0.001). Disease stage ≤2 B or ≥3 A was not associated with ***: Vitreoretinal fibrosis and TRD increase after treatment in Coats' disease. The combination of antiVEGF agents and cryotherapy may lead to higher risk for TRD. Presence of pre-treatment fibrosis is the highest risk factor for post-treatment worsening of vitreoretinal fibrosis and TRD.

关键词： Coats’ disease cryotherapy anti-vascular endothelial growth factor traction retinal detachment vitreoretinal fibrosis