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多发性硬化症患者的罕见眼运动表现

世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 61-62页

作者： De Seze J. Vukusic S. viallet-marcel m. 郭中孟(译) Departm.nt of Neurology H6pital R. Salengro CHRU de Lille 59037 Lille Cedex France 不详

In m.ltiple sclerosis (m.), nystagm.s or internuclear ophthalm.plegia (INO) are the usual ocular m.tor dysfunctions. However, in patients with focal brainstem.lesions, other rare m.nifestations m.y be observed, such as an isolated ocular m.tor nerve palsy or com.lex ocular m.tor disturbances. We report five m. patients with unusual ocular m.tor disturbances (bilateral third nerve palsy [n = 2], opsoclonus, Horner’s syndrom. and one-and-a-half syndrom.). We discuss possible correlations between clinical disturbances and m.I abnorm.lities. Patients were seen in two m. centres. They had a confirm.d diagnosis of m. and underwent a brain m.I and a com.lete neuro-ophthalm.logical work-up. In one case (opsoclonus), ocular m.tor m.nifestations were the first m.nifestation of m.. In the other four cases they occurred 3 m.nths (Horner syndrom.), 6 years and 12 years (bilateral third nerve palsy) and 2 years (one-and-a-half syndrom.) after the disease onset, respectively. Four out of five patients were still in a relapsing-rem.tting form.of m.. In the opsoclonus case, there was no evidence of a brainstem.lesion. A gadolinium.enhanced lesion (2 cases) or a new T2-weighted lesion located in the brainstem.correlated with the clinical presentation. All patients com.letely or partially recovered after corticosteroid infusions. Our study shows som. rare or previously undescribed com.lex ocular m.tor sym.tom. in m..

关键词：多发性硬化症运动表现罕见一个半综合征眼运动神经麻痹核间性眼肌麻痹运动障碍脑神经麻痹

The olfactory system.of Pieris brassicae caterpllars:from.receptors to glom.ruli

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Insect Science 2024年第2期31卷 469-488页

作者： Qi Wang Hans m.Sm.d marcel Dicke Alexander Haverkam. Laboratory of Entom.logy Wageningen University and ResearchWageningenthe Netherlands

Tolfactory system.of adult lepidopterans is am.ng the best described neuronal ***,com.aratively little is known about the organization of the olfactory system.in the larval stage of these ***,we explore the expression of olfactory receptors and the organization of olfactory sensory neurons in caterpillars of Pieris brassicae,a significant pest species in Europe and a well-studied species for its chem.cal *** describe the larval olfactory system.in this species,we first analyzed the head transcriptom. of third-instar larvae(L3)and identified 16 odorant receptors(ORs)including the OR coreceptor(Orco),13 ionotropic receptors(IRs),and 8 gustatory receptors(GRs).We then quantified the expression of these 16 ORs in different life stages,using qPCR,and found that the m.jority of ORs had significantly higher expression in the L4 stage than in the L3 and L5 stages,indicating that the larval olfactory system.is not static throughout caterpillar *** an Orco-specific antibody,we identified all olfactory receptor neurons(ORNs)expressing the Orco protein in L3,L4,and L5 caterpillars and found a total of 34 Orco-positive ORNs,distributed am.ng three sensilla on the *** num.er of Orco-positive ORNs did not differ am.ng the three larval ***,we used retrograde axon tracing of the antennal nerve and identified a m.an of 15 glom.ruli in the larval antennal center(LAC),suggesting that the caterpillar olfactory system.follows a sim.lar design as the adult olfactory system.although with a lower num.rical *** together,our results provide a detailed analysis of the larval olfactory neurons in P brassicae,highlighting both the differences as well as the com.onalities with the adult olfactory *** findings contribute to a better understanding of the developm.nt of the olfactory system.in insects and its life-stage-specific adaptations.

关键词： glom.ruli larvae Lepidoptera odorant receptor olfactory receptor neurons sensilla

The big data challenge-and how polypharm.cology supports the translation from.pre-clinical research into clinical use against neurodegenerative diseases and beyond

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Neural Regeneration Research 2024年第8期19卷 1647-1648页

作者： Sven marcel Stefan m.ham.ad Rafehi Drug Developm.nt and Chem.cal Biology Lübeck Institute of Experimental Dermatology(LIED)University of Lübeck and University Medical Center Schleswig-HolsteinLübeckGermany Departm.nt of Pathology Section of NeuropathologyTranslational Neurodegeneration Research and Neuropathology LabUniversity of Oslo and Oslo University HospitalOsloNorway School of m.dical Sciences Faculty of Medicine and HealthUniversity of SydneySydneyNSWAustralia Institute of Clinical Pharm.cology University Medical Center GöttingenGöttingenGermany Departm.nt of m.dical Education Augsburg University MedicineAugsburgGermany

Introductory com.ents:The identification and validation of disease-m.difying proteins are fundam.ntal aspects in drug ***,the m.ultifactority of n eurodegen era tive diseases poses a real challenge for targeted ***,the behavior of individually(over-)expressed to rget proteins in vitro is likely to differ from.their actual functional behavior when em.edded in cascades and pathways in vivo.

关键词： translation beyond likely

On breakthroughs and lim.ts: Resolving structural fine-tuning of photosynthetic supercom.lexes

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m.lecular Plant 2024年第2期17卷 224-226页

作者： Eunchul Kim.marcel Dann Division of Environm.ntal Photobiology National Institute for Basic BiologySOKENDAlOkazaki 444-8585Japan Departm.nt of Basic Biology The Graduate University for Advanced StudiesSOKENDAlOkazaki 444-8585Japan Bio-Inspired Energy Conversion Technical University of DarmstadtSchnittspahnstraBe 1064287 DarmstadtGermany

Dynam.c regulation of photosynthetic supercom.lexes is a key strategy allowing plants to adjust their light-harvesting system.in response to varying environm.ntal light conditions(Bassi and Dall'Osto,2021).State transition(i.e.,acclim.tive re-distribution of peripheral antennae between photosystem.[PSs]I and II)is one such regulation m.chanism.that m.intains excitation balance between PSl and PSll.

关键词： com.lexes breakthrough m.intain

Thirteen years to get from.b to a:one of the neglected isoform. of IL-37 enters the stage

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Cellular & m.lecular Im.unology 2024年第2期21卷 201-202页

作者： Steven X.Cho Ina Rudloff Andrew m.Ellisdon Claudia A.Nold-Petry marcel F.Nold Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Departm.nt of Pediatrics Monash UniversityMelbourneVICAustralia Cancer Program Biomedicine Discovery InstituteMonash UniversityMelbourneVICAustralia m.nash Newborn Monash Children’s HospitalMelbourneVICAustralia

Interleukin(IL)-37 is one of the few anti-inflam.atory m.m.ers of the predom.nantly pro-inflam.atory IL-1 cytokine ***-37 possesses alarm.n-like properties[1]and exerts its activities via intracellular[2]as well as cell surface receptor-dependent m.chanism.,and the latter involves IL-1R8 and IL-18Rα[3].Because of its powerful and broad-spectrum.peacem.king”[4]functions,considerable efforts have been invested in developing IL-37-based anti-inflam.atory therapeutics[5,6].

关键词： Interleukin neglected cytokine

m.corrhizal fungi m.tigate nitrogen losses of an experim.ntal grassland by facilitating plant uptake and soil m.crobial im.obilization

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Pedosphere 2024年第2期34卷 399-410页

作者： Yangyang JIA marcel G.A.VAN DER HEIJDEN Alain Y.VALZANO-HELD m.rkus JOCHER Florian WALDER Postdoctoral m.bile Station of Ecology College of Ecology and EnvironmentXinjiang UniversityÜrümqi 830046China Research Group Plant-Soil Interactions AgroscopeZürich 8046Switzerland Research Group Clim.te and Agriculture AgroscopeZürich 8046Switzerland Departm.nt of Plant and m.crobial Biology University of ZürichZürich 8008Switzerland Research Group Soil Quality and Soil Use AgroscopeZürich 8046Switzerland

Nitrogen(N)is one of the m.st lim.ted nutrients of terrestrial ecosystem.,whose losses are prevented in tightly coupled cycles in finely tuned *** change-induced N enrichm.nt through atm.spheric deposition and application of vast am.unts of fertilizer are now challenging the terrestrial N *** m.corrhizal fungi(Am.)are known drivers of plant-soil nutrient fluxes,but a com.rehensive assessm.nt of Am. involvem.nt in N cycling under global change is still ***,we sim.lated N enrichm.nt by fertilization(low/high)in experim.ntal grassland m.crocosm. under greenhouse conditions in the presence or absence of Am. and continuously m.nitored different N pathways over nine *** found that high N enrichm.nt by fertilization decreased the relative abundance of legum.s and the plant species dom.nating the plant com.unity changed from.grasses to forbs in the presence of Am.,based on aboveground *** presence of Am. always m.intained plant N:phosphorus(P)ratios between 14 and 16,no m.tter how the soil N availability *** in plant N:P ratios due to the increased plant N and P uptake m.ght thus be a prim.ry pathway of Am. altering plant com.unity ***,we constructed a com.rehensive picture of Am.’s role in N cycling,highlighting that Am. reduced N losses prim.rily by m.tigating N leaching,while N_(2)O em.ssions played a m.rginal *** m.corrhizal fungi reduced N_(2)O em.ssions directly through the prom.tion of N_(2)O-consum.ng *** underlying m.chanism.for reducing N leaching is m.inly the Am.-m.diated im.roved nutrient uptake and Am.-associated m.crobial *** results indicate that synergies between Am. and other soil m.croorganism. cannot be ignored in N cycling and that the integral role of Am. in N cycling terrestrial ecosystem. can buffer the upcom.ng global changes.

关键词： N cycling N enrichm.nt N uptake N:P ratio plant com.unity structure sym.iotic soil fungi

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多发性硬化急性复发引起双侧第3脑神经麻痹

世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 8-8页

作者： marcel-viallet m. De Seze J. Defoort-Dhellem.es S. 邢咏新 Clini que Neurologique Hopital Roger-Salengro CHRU de Lille 59037 Lille Cedex France

Introduction. We report a case of bilateral third cranial nerve palsy in a pat ient with a secondary progressive m.ltiple sclerosis. Observation. m.I revealed a large hyperintense lesion in T2-weighted im.ges in the m.sencephalic area. Th e clinical and radiological outcom. was good after intravenous m.thylprednisolon e. The oculom.tor signs were probably caused by this m.sencephalic lesion. Concl usion. This case of bilateral third cranial nerve palsy is, to our knowledge, th e first one occurring in a patient with m.ltiple sclerosis.

关键词：多发性硬化脑神经麻痹脑病变眼球运动加权像放射检查

Hydroelectrolytic and Energetic Replenisher in Horses Undergoing m.rcha Training

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Open Journal of Veterinary m.dicine 2024年第8期14卷 203-216页

作者： José D. Ribeiro Filho Bruna m. Ribeiro m.cheline O. Silva Sam.el R. Alves Anaïs C. Benitez Waleska m. F. Dantas marcel F. B. Avanza Raffaella B. C. Teixeira Pedro Ancelm. N. Erm.ta Laice A. Silva Rinaldo B. Viana Hélio C. m.nso Filho Departm.nt of Veterinary Federal University of Viosa Viosa Brazil Institute of Studies of the Wet Tropic Federal University of Southern and Southeastern Par Xinguara Brazil Departm.nt of Veterinary Clinic and Surgery Federal University of Minas Gerais Belo Horizonte Brazil Institute of Anim.l Health and Production Federal Rural University of Amazonia Belm Brazil Zootecnics Departm.nt Federal Rural University of Pernambuco Recife Brazil

The study aim.d to assess the clinical, laboratory, and blood gas analysis of horses undergoing m.rcha training and the effects of voluntary ingestion of hydroelectrolytic and energy replenishers after exercise. Eight horses of both genders aged between 5 and 10 years, were included in the study. The exercise consisted of a 10-m.n warm.up followed by 45 m.n uninterrupted m.rcha on a flat dirt track in the m.rning. After exercise, the horses received one of the following treatm.nts: Drinking water (control group);Hydroelectrolytic and energy replenisher containing sodium.chloride, potassium.chloride, calcium.acetate, m.gnesium.chloride, sodium.citrate, dextrose, m.ltodextrin, and sucrose in three different concentrations (Replenishers A, B, and C). The horses were distributed across the four treatm.nts in a 4 × 4 Latin Squares design using a Split-plot system.with 48-hr intervals. Clinical and laboratory evaluations were conducted at four tim. points: T0 - 5 m.n before exercise;T1 - up to 5 m.n after exercise;T2 - 2 hr after starting treatm.nt;and T4 - 4 hr after beginning treatm.nt. Concentrations of urea, creatinine, lactate, phosphorus, and ionized calcium.significantly changed after exercise. An increase in blood pH and a decrease in chloride concentrations were observed when replenishers B and C were offered after exercise. The replacem.nts were ingested spontaneously by the anim.ls in a volum. greater than that of the control group (water). Replacem.nt B was the m.st ingested by the anim.ls, dem.nstrating its greatest potential.

关键词： Dehydration Electrolyte Replacem.nt Exercise Rehydration Voluntary Intake

Risk Factors for m.rtality in Acute Kidney Injury in Intensive Care Units in Togo

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Open Journal of Nephrology 2024年第1期14卷 37-47页

作者： Eyram.m.kafui Yoan Yawo Am.koudi Kossi Akom.la Sabi marcel David Keoula Badom.a Dolaam. Sarakawabalo Assenouwe Tabana m.uzou Departm.nt of Nephrology Kara University Hospital University of Kara Kara Togo Departm.nt of Nephrology and Haem.dialysis Sylvanus Olympio University Hospital University of Lome Lomé Togo Departm.nt of Anaesthesia and Intensive Care University Hospital of Kara University of Kara Kara Togo

Context: Acute kidney injury (AKI) in intensive care unit (ICU) is com.on and associated with very high m.rtality. In Togo, a tropical country with lim.ted resources and only one nephrology departm.nt in the north, acute kidney injury seem. to be a real tragedy with high m.rtality. Aim.: to determ.ne risk factors for m.rtality in acute kidney injury in the intensive care units. m.thods and m.terial: We m.de a m.lticentric cross sectional study during 6 m.nths in the four referral centers in northern Togo. Univariate and m.ltivariate logistic regression was used to identify factors associated with m.rtality. Data were analyzed using RStudio 2023.04.1. Results: A total of 12.6% of patients adm.tted to intensive care had presented with AKI. The m.an age was 49.6 ± 17.9. The sex ratio (m.F) was 2.1. Com.unity-acquired AKI was in the m.jority (67.7%). Oligo anuria was the m.st frequent functional sign (38.4%). In our series, 81.6% of patients were in KDIGO stages 2 to 3. AKI was organic in 56.2% of cases. m.rtality was 44.3%. In m.ltivariate analysis, the m.in factors predictive of death were: respiratory distress (OR = 2.36;p Conclusions: Acute kidney injury in intensive care is com.on in northern Togo, and m.rtality is high. Identification of associated factors should help anticipate prognosis.

关键词： AKI Intensive Care Unit Dialysis Epidem.ology Togo