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Toll-Like Receptor Gene Expression in Nasal Polyp

International Journal of Otolaryngology and Head & Neck Surgery 2016年第2期5卷 90-95页

作者： veysel yurttas Tayfun Apuhan Tugce Simsek Zeynep Ocak Uzeyir Gok Department of Otorhinolaryngology and Head and Neck Surgery Abant Izzet Baysal University Faculty of Medicine Bolu Turkey Department of Otorhinolaryngology and Head and Neck Surgery Intercontinental Hospital Istanbul Turkey Department of Genetic Abant Izzet Baysal University Bolu Turkey Department of Otorhinolaryngology and Head and Neck Surgery Medical Park Hospital Elazig Turkey

Objective: To investigate the expression of Toll-like receptors (TLRs) and the correlation between TLR expression and mucosal changes in chronic sinusitis-related nasal polyposis. Methods: Patients with nasal polyps were enrolled in this study as the study group. The control group consisted of individuals undergoing surgery due to nasal obstruction caused by concha hypertrophy who were not diagnosed with chronic sinusitis-related nasal polyposis (NP). There were 30 patients in the study group (individuals with NP) and 20 patients in the control group. Sterile tissue samples were taken from the patients and were kept at -80°C. A piece of tissue sample was put into the eppendorf tube. Expression of TLR2 and TLR4 gene was investigated in the tissue samples. The samples were taken after the surgery;they were carried into the liquid nitrogen and were kept at -80° C before study. Results: TLR2 and TLR4 expression was measured in both groups and then analyzed using Student’s t-test. In the experimental group, the level of TLR2 expression was significantly higher than in the control group (P < 0.001);however, TLR4 expression was not significantly different between the two groups (P = 0.656). Conclusion: TLRs are thought to play a role in the etiopathogenesis of NP. In addition, the authors consider that a possible treatment for NP could be a TLR-specific treatment. Thus, in the future it will be essential to determine the extent to which TLRs function in NP formation and to apply this knowledge to design a specific therapeutic regimen for the enhanced treatment of NP.

关键词： Nasal Polyposis Toll-Like Receptor Gene Expression Etiopathogenesis

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Kinetic study on leaching of nickel from Turkish lateritic ore in nitric acid solution

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Journal of Central South University 2016年第1期23卷 39-43页

作者： Tevfik AGACAYAK veysel ZEDEF Ali ARAS Department of Mining Engineering Faculty of EngineeringSelcuk University

Dissolution kinetics of nickel from lateritic ore in nitric acid solution was investigated. Experimental parameters used were stirring speed(100-600 r/min), temperature(40-96 °C), nitric acid concentration(0.1-2 mol/L) and particle size(<106 μm). The shrinking core model was applied to the results of experiments investigating the effects of leaching temperature in the range of 40-90 °C and nitric acid concentration in range of 0.1-2 mol/L on nickel dissolution rate. The kinetic analysis shows that the nickel dissolution from lateritic ore could be described by diffusion model. The activation energy(E_a) for the dissolution reaction is calculated as 79.52 kJ/mol.

关键词： leaching lateritic ore nickel kinetic analysis diffusion nitric acid

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Effects of reciprocating extrusion process on mechanical properties ofAA 6061/SIC composites

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Transactions of Nonferrous Metals Society of China 2016年第2期26卷 328-338页

作者： veysel ERTURUN M.Baki KARAMIS Faculty of Aeronautics and Astronautics/Airframes and Powerplants Erciyes University Kayseri 38039 Turkey Department of Mechanical Engineering Erciyes University Kayseri 38039 Turkey

A reciprocating extrusion （RE） process was used to improve the mechanical properties of Al-based composite manufactured using cast and powder metallurgy （PM）. AA 6063 cast and AA 6061 powders were used as the matrix materials, and the matrix was reinforced by 5% SiC （volume fraction） particles. The hardness and grain size of extruded samples decrease with increasing the number of extrusion pass, while the toughness and ductility increase. As the tensile strength of the samples decreases, the elongation of the extruded samples increases. Consequently, reciprocating extrusion is an effective method for improving the mechanical properties of metal matrix composites （MMC）.

关键词： reciprocating extrusion metal-matrix composites aluminum alloy mechanical properties

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Target Capturing in an Ellipsoidal Region for a Swarm of Double Integrator Agents

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IEEE/CAA Journal of Automatica Sinica 2022年第5期9卷 801-811页

作者： Antonio Bono Luigi D'Alfonso Giuseppe Fedele veysel Gazi IEEE Department of Informatics ModelingElectronics and Systems EngineeringUniversity of CalabriaRende 87036Italy Dept.Electrical and Electronics Eng. Faculty of EngineeringMarmara UniversityIstanbul 34722 Department of Control and Automation Engineering Faculty of Electrical and Electronics EngineeringYildiz Technical UniversityEsenler 34220Turkey

In this paper we focus on the target capturing problem for a swarm of agents modelled as double integrators in any finite space *** agent knows the relative position of the target and has only an estimation of its velocity and *** that the estimation errors are bounded by some known values,it is possible to design a control law that ensures that agents enter a user-defined ellipsoidal ring around the moving *** know the relative position of the other members whose distance is smaller than a common detection ***,in the case of no uncertainty about target data and homogeneous agents,we show how the swarm can reach a static configuration around the moving *** simulations are reported to show the effectiveness of the proposed strategy.

关键词： Agents-based systems cooperative control swarms target-capturing

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Sentinel-1 In SAR observations and time-series analysis of co-and postseismic deformation mechanisms of the 2021 Mw 5.8 Bandar Ganaveh Earthquake,Southern Iran

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Journal of Mountain Science 2023年第4期20卷 911-927页

作者： Reza SABER veysel ISIK Ayse CAGLAYAN Marjan TOURANI Department of Geological Engineering Tectonics Research GroupAnkara UniversityTR-06830AnkaraTürkiye Department of Geological Survey Ministry of Environment and UrbanisationGeneral Directorate of Spatial PlanningTR-06520AnkaraTürkiye

In the past two decades,because of the significant increase in the availability of differential interferometry from synthetic aperture radar and GPS data,spaceborne geodesy has been widely employed to determine the co-seismic displacement field of *** April 18,2021,a moderate earthquake(Mw 5.8)occurred east of Bandar Ganaveh,southern Iran,followed by intensive seismic activity and aftershocks of various *** use two-pass D-InSAR and Small Baseline Inversion techniques via the LiCSBAS suite to study the coseismic displacement and monitor the four-month post-seismic deformation of the Bandar Ganaveh earthquake,as well as constrain the fault geometry of the co-seismic faulting mechanism during the seismic *** show that the co-and postseismic deformation are distributed in relatively shallow depths along with an NW-SE striking and NE dipping complex reverse/thrust fault branches of the Zagros Mountain Front Fault,complying with the main trend of the Zagros *** average cumulative displacements were obtained from-137.5 to+113.3 mm/yr in the SW and NE blocks of the Mountain Front Fault,*** received maximum uplift amount is approximately consistent with the overall orogen-normal shortening component of the Arabian-Eurasian convergence in the Zagros *** surface ruptures were associated with the seismic source;therefore,we propose a shallow blind thrust/reverse fault(depth~10 km)connected to the deeper basal decollement fault within a complex tectonic zone,emphasizing the thin-skinned tectonics.

关键词： Sentinel‑1 InSAR time-series Neotectonic reactivation Seismogenic fault Bandar Ganaveh earthquakes Zagros Fold-Thrust Belt Arabian-Eurasian collision

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Scour and liquefaction issues for anchors and other subsea structures in floating offshore wind farms: A review

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Water Science and Engineering 2022年第1期15卷 3-14页

作者： B.Mutlu Sumer veysel Sadan Ozgur Kirca BM SUMER Consultancy&Research ITU ARI Teknokent 1Nol5Istanbul 34467Turkey Department of Civil Engineering Istanbul Technical UniversityMaslak 34467Turkey

This article reviews scouring and liquefaction issues for anchor foundations of floating offshore wind *** review is organized in two sections:(1)the scouring issues for drag-embedment anchors(DEAs)and other subsea structures associated with DEAs such as tensioners,clump weights,and chains in floating offshore wind farms;and(2)the liquefaction issues for the same types of structures,particularly for *** scouring processes are described in detail,and the formulae and design guidelines for engineering predictions are included for quantities like scour depth,time scale,and sinking due to general shear failure of the bed soil caused by scoui\The latter is furnished with numerical ***,in the second section,the liquefaction processes are described with special reference to residual liquefaction where pore-water pressure builds up in undrained soils(such as fine sand and silt)under waves,leading to liquefaction of the bed soil and precipitating failure of DEAs and their associated subsea *** integrated mathematical model to deal with liquefaction around and the resulted sinking failure of DEAs,introduced in a recent study,has been *** of the model is illustrated with a numerical *** is believed that the present review and the existing literatures from the"neighboring"fields form a complementary source of information on scour and liquefaction around foundations of floating offshore wind farms.

关键词： Floating structures Liquefaction Offshore structures Offshore wind energy Renewable energy Scouring

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Secondary causes of inflammatory bowel diseases

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World Journal of Gastroenterology 2020年第28期26卷 3998-4017页

作者： Yezaz A Ghouri veysel Tahan Bo Shen Department of Internal Medicine Division of Gastroenterology and HepatologyUniversity of Missouri-School of MedicineColumbiaMO 65201United States Department of Medicine and Surgery Interventional IBD CenterColumbia University Irving Medical Center/New York Presbyterian HospitalNew YorkNY 10032United States

Inflammatory bowel diseases(IBD),conventionally consist of Crohn’s disease(CD)and ulcerative *** occur in individuals with high risk genotype for the disease in the setting of appropriate environmental *** pathogenesis of IBD involves a dysregulated autoimmune response to gut dysbiosis,which in turn is triggered due to exposure to various inciting environmental *** there is no clearly defined etiology of IBD and this type of disease is termed as“idiopathic IBD”,“classic IBD”,or“primary IBD”.We reviewed the current medical literature and found that certain etiological factors may be responsible for the development of IBD or IBD-like conditions,and we consider this form of de novo IBD as“secondary IBD”.Currently known factors that are potentially responsible for giving rise to secondary IBD are medications;bowel altering surgeries and transplantation of organs,stem cells or fecal *** associated with the development of secondary IBD include;immunomodulators,anti-tumor necrosis factor alpha agents,anti-interleukin agents,interferons,immune stimulating agents and checkpoint *** can in some cases give rise to de novo CD,pouchitis of the ileal pouch,or postcolectomy enteritis *** solid organ transplantation or hematopoietic stem cell transplantation,the recipient may develop de novo IBD or IBD *** microbiota transplantation has been widely used to treat patients suffering from recurrent Clostridium difficile infection but can also causes IBD flares.

关键词： De novo inflammatory bowel disease Secondary inflammatory bowel disease Inflammatory bowel disease Crohn’s disease Ulcerative colitis

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Immune checkpoint inhibitors induced colitis, stay vigilant: A case report

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World Journal of Gastrointestinal Oncology 2020年第6期12卷 699-704页

作者： Suha Abu Khalaf Abdulmajeed Albarrak Mohamad Yousef veysel Tahan Department of Internal Medicine University of MissouriColumbiaMO 65212United States Department of Internal Medicine College of MedicineQassim UniversityBuraydah 81999Saudi Arabia Division of Gastroenterology and Hepatology University of MissouriColumbiaMO 65212United States

BACKGROUND Colitis is one of the immune-related side effects of ***,such type of side effect was reported to develop within a few weeks of treatment initiation,our case started within a few *** SUMMARY We present a case of a 37-year-old gentleman with bright red loose stools,abdominal pain,and tenesmus.A diagnosis of colitis was made based on endoscopic and histologic *** was thereafter continued with oral steroids and discontinuation of the immunotherapy *** resolved after starting the treatment and the patient continued to be symptomfree on subsequent *** unique about this case report is that the patient developed bloody diarrhea within five days of the 1st immunotherapy cycle,and the patient was on combined ipilimumab and *** Immunotherapy related complications might occur within days from being on immunotherapy;we need more research to open the way for future pathological and clinical research to further understand the pathophysiology behind it.

关键词： Immunotherapy Colitis Melanoma Case report Ipilimumab Hepatitis

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Influence of surface roughness of dune bedforms on flow and turbulence characteristics

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International Journal of Sediment Research 2020年第6期35卷 666-678页

作者： veysel Sadan Ozgur Kirca Seyed Mahdi Saghebian Kiyoumars Roushangar Oral Yagci Istanbul Technical University Department of Civil Engineering Department of Civil Engineering Ahar Branch Islamic Azad University Division of Hydraulics Department of Civil EngineeringUniversity of Tabriz

The current paper investigates the flow and turbulence characteristics over dune bedforms by means of laboratory experiments,where spatially dense and temporally high frequency velocity measurements were *** similar studies are available in the literature,the focus and novelty of the current study is to assess the influence of surface roughness of the dune bedforms on the nearbed *** direct comparison,two different surface roughness heights over idealized,fixed-shaped,high-angled dune bedforms were tested;one with a hydraulically-smooth surface,and the other with a fully-rough *** variation of time-averaged flow as well as turbulence statistics were examined,which was complemented by streamline plots and spectral *** results are interpreted from sediment entrainment and sediment transport points of *** results show that increased dune surface roughness reduces the nearbed flow velocity,but increases the flow velocities at upper *** upward directed flow near the dune crests becomes stronger in the case of smooth surface,while the reattachment point moves further downstream compared to the rough wall *** is concluded that the roughness of the dune surface affects the nearbed flow and turbulence characteristics qualitatively and quantitatively,which is shown to have direct consequences on sediment entrainment characteristics.

关键词： Bedforms Dunes Friction drag Turbulence Grain roughness Form drag

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N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat

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World Journal of Gastroenterology 2003年第1期9卷 125-128页

作者： Resat Ozaras veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk Department of Infectious Diseases and Clinical Microbiology University of IstanbulIstanbulTurkey Department of Internal Medicine University of IstanbulIstanbulTurkey Department of Biochemistry University of IstanbulIstanbulTurkey

AIM: There is increasing evidence that alcohol-induced liverdamage may be associated with increased oxidative *** aimed to investigate free-radical scavenger effect of n-acetylcysteine in rats intragastrically fed with ***: Twenty-four rats divided into three groups werefed with ethanol (6 g/kg/day, Group 1), ethanol and n-acetylcysteine (1 g/kg, Group 2), or isocaloric dextrose(control group, Group 3) for 4 weeks. Then animals weresacrificed under ether anesthesia, intracardiac blood andliver tissues were obtained. Measurements were performedboth in serum and in homogenized liver *** (MDA) level was measured by TBARSmethod. Glutathione peroxidase (GSH-Px) and superoxidedismutase (SOD) levels were studied by commercial ***-Wallis test was used for statistical ***: ALT and AST in Group 1 (154 U/Land 302 U/L,respectively) were higher than those in Group 2 (94 U/L and155 U/L) and Group 3 (99 U/L and 168 U/L) (P＝0.001 forboth). Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than Group 2(0.91 nmol/mL and 64 nmol/100 mg-protein) and Group 3(0.94 nmol/mL and 49 nmol/100 mg-protein) (P＜0.001 forboth). On the other hand, serum GSH-Px level in Group 1(8.21 U/g-Hb) was lower than Group 2 (16 U/g-Hb) andGroup 3 (16 U/g-Hb) (P＜0.001). Serum and liver tissue levelsof SOD in Group 1 (11 U/mL and 26 U/100 mg-protein)were lower than Group 2 (18 U/mL and 60 U/100 mg-protein)and Group 3 (20 U/mL and 60 U/100 mg-protein) (P＜0.001for both).CONCLUSION: This study demonstrated that ethanol-induced liver damage is associated with oxidative stress,and co-administration of n-acetylcysteine attenuates thisdamage effectively in rat model.

关键词： Oxidative Stress Acetylcysteine Animals Erythrocytes Ethanol dosage Free Radical Scavengers Glutathione Glutathione Peroxidase Lipid Peroxidation Liver Male Rats Rats, Wistar Research Support, Non-U.S. Gov't Superoxide Dismutase Thiobarbituric Acid Reactive Substances

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