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Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease

World Journal of Hepatology 2016年第27期8卷 1137-1148页

作者： Ilaria Croci Nuala M Byrne veronique s chachay Andrew P Hills Andrew D Clouston Trisha M O'Moore-sullivan Johannes B Prins Graeme A Macdonald Ingrid J Hickman school of Human Movement and Nutrition sciences University of Queensland Translational Research Institute the University of Queensland Diamantina Institute Bond Institute of Health and sport Bond University Institute of Health and Biomedical Innovation Queensland University of Technology school of Health sciences University of Tasmania Mater Research Institute University of Queensland school of Medi-cine the University of Queensland Department of Gastroenterology and Hepatology Princess Alexandra Hospital Translational Research Institute Department of Nutrition and Dietetics Princess Alexandra Hospital

AIM To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on wholebody and hepatic fat oxidation of patients with nonalcoholic fatty liver disease(NAFLD).METHODs Participants were randomised into either circuit exercise training(EX;n = 13;3 h/wk without changes in dietary habits),or dietary energy restriction(ER) without changes in structured physical activity(ER;n = 8).Respiratory quotient(RQ) and whole-body fat oxidation rates(Fatox) were determined by indirect calorimetry under basal,insulin-stimulated and exercise *** of disease and steatosis was determined by liver histology;hepatic Fatox was estimated from plasma β-hydroxybutyrate ***;cardiorespiratory fitness was expressed as VO2 ***-case analysis was performed(EX:n = 10;ER:n = 6).REsULTs Hepatic steatosis and NAFLD activity score decreased with ER but not with EX.β-hydroxybutyrate concentrations increased significantly in response to ER(0.08 ± 0.02 mmol/L vs 0.12 ± 0.04 mmol/L,P = 0.03) but remained unchanged in response to EX(0.10 ± 0.03 mmol/L vs 0.11 ± 0.07 mmol/L,P = 0.39).Basal RQ decreased(P = 0.05) in *** EX,while this change was not significant after ER(P = 0.38).VO_(2peak)(P se(P = 0.03) improved with EX but not with ER(P > 0.05).The increase in β-hydroxybutyrate concentrations was correlated with the reduction in hepatic steatosis(r =-0.56,P = 0.04).CONCLUsION ER and EX lead to specific benefits on fat metabolism of patients with *** hepatic Fat_(ox) in response to ER could be one mechanism through which the ER group achieved reduction in steatosis.

关键词： Non-alcoholic steatohepatitis steatosis Fat and carbohydrate oxidation Exercise Fitness Beta-hydroxybutyrate Ketone bodies Fatty acid oxidation

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