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IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis

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World Journal of Gastroenterology 2017年第3期23卷 447-454页

作者： Sarah Fischer Erzsébet Kovesdi Lili Magyari veronika Csongei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós Division of Gastroenterology 1st Department of Internal MedicineUniversity of Pécs7624 PécsHungary Department of Medical Genetics University of Pécs7624 PécsHungary Szentágothai Research Centre 7624 PécsHungary Institute for Translational Medicine University of Pécs7624 PécsHungary

AIM To investigate the association of seven single nucleotide polymorphisms(SNPs) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss(P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of *** We demonstrated susceptible or protective character of the investigated IL23 R SNPs on the phenotype of UC, confirming the genetic association.

关键词： IL23R gene Ulcerative colitis Phenotype Polymorphism Hungarian

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符拉迪沃斯托克中俄边境旅游消费行为研究

符拉迪沃斯托克中俄边境旅游消费行为研究

作者： Grek veronika 东北林业大学

学位级别：硕士

旅游业是一个有利可图的行业,对边境地区特别方便。中华人民共和国（中国）和俄罗斯联邦（俄罗斯）共享其边界的很大一部分,需要超过4159公里。滨海边疆区是俄罗斯边境地区之一,位于与中国旅游特别便利的位置。消费者行为作为一个独立... 详细信息

旅游业是一个有利可图的行业,对边境地区特别方便。中华人民共和国（中国）和俄罗斯联邦（俄罗斯）共享其边界的很大一部分,需要超过4159公里。滨海边疆区是俄罗斯边境地区之一,位于与中国旅游特别便利的位置。消费者行为作为一个独立的知识领域,起源于经济学,市场营销和心理学的交叉点,不仅包括这些理论立场和方法,还包括许多其他与行为科学相关的知识领域,主要是心理学和社会学。消费者行为的内容基础是消费者购买决策过程及决定购买决策的因素。这项工作的目的是研究俄罗斯和中国之间的边界符拉迪沃斯托克市的消费行为。根据目标定义了以下任务:研究消费者行为的概念和模型;识别影响消费者行为的因素;考虑消费者行为研究的方法;分析该地区市场的状态和发展趋势;制定一个方法论的方法来研究该地区的消费者行为;分析消费者在该地区市场的行为;制定建议的市场运营商。这项研究的目的是消费者在符拉迪沃斯托克市场上的俄罗斯和中国之间的边界的行为。这项研究的主题是该地区消费者行为的特殊性。

关键词：旅游消费行为边疆俄罗斯中国

Recombinant IgM expression in mammalian cells: A target protein challenging biotechnological production

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Advances in Bioscience and Biotechnology 2013年第4期4卷 38-43页

作者： Alexander Mader veronika Chromikova Renate Kunert Department of Biotechnology VIBT-BOKU University of Natural Resources and Life Sciences (Vienna) Vienna Austria

For many years, the potential of immunoglobulin M (IgM) antibodies was not fully understood because of characteristics different to the well-known immunoglobulin G type like low target affinity, cross reactivity and complex protein structure. In the meanwhile IgMs have been positively evaluated for their use as therapeutic agent in the mucosal environment but also in serum to eradicate upcoming tumor cells and invading antigens. Therefore IgM class of antibodies will play a significant role in clinical applications but also diagnosis in the future. To evaluate the full potential of this kind of antibody molecules large amounts of high quality product will be needed. In this review the focus is set on the biotechnological aspect of producing IgM class antibodies recombinantly in mammalian cells. Current achievements in expression and purification of this molecule are highlighted and compared.

关键词： IgM Mammalian Expression Recombinant Antibody Expression Antibody Purification

An inverted triplesalen ligand by a convergent synthesis and its influence on trinuclear Fe_3~Ⅲ complexes

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Science China Chemistry 2012年第6期55卷 951-966页

作者： FELDSCHER Bastian KRICKEMEYER Erich MOSELAGE Marc THEIL Hubert HOEKE veronika KAISER Yvonne STAMMLER Anja BGGE Hartmut GLASER Thorsten Lehrstuhl für Anorganische Chemie I Fakultt für Chemie Universitt Bielefeld Universittsstr. 25 D-33615 Bielefeld Germany

The inverted triplesalen ligand H6feldMe has been synthesized from 2,4,6-triformyl-phloroglucinol and a ketimine salen half-unit in a convergent synthesis. NMR, IR, and UV-vis spectroscopy reveal that this ligand is not in the O-protonated tau- tomer but in the N-protonated tautomer with substantial heteroradialene contribution. This ligand and the conventional triple- salen ligand H6talent-au2 have been used to synthesize the trinuclear Fem complexes [（feldMe）（FeCl）3] and [（talent-Bu2）（FeC1）3], respectively. The molecular structures of these complexes were obtained by single-crystal X-ray diffraction. Two trinuclear Fem complexes of [（feldMe）（FeCl）3] dimerize via two Fe-phenolate bonds, whereas due to steric hindrance no dimerization is observed for [（talent-Bu2）（FeC1）3]. The structural data also reveal some heteroradialene contribution in the trinuclear complexes. Whereas UV-vis and MOlSbauer spectroscopy are not suitable to distinguish between the two complexes, FT-IR spectra show characteristic features due to the different substitution patterns of the conventional and the inverted triplesalen ligands. Another handle is provided by electrochemistry. Whereas both complexes exhibit an irreversible oxidation wave （0.94 V vs. Fc＋/Fc for [（feldMe）（FeC1）3] and 0.84 V vs. Fc~/Fc for [（talent-Bu2）（FeC1）3]）, which is assigned to the oxidation of the central backbone, higher potential oxidations are reversible for [（talent-Bu2）（FeC1）3]） but irreversible for [（feldMe）（FeC1）3]. This is attributed to the reversible oxidation of the terminal phenolates in the di-tert-butyl substituted [（talentBu2）（FeCl）3] in contrast to the mono-methyl-substituted phenolates in [（feld^ae）（FeC1）3]. The magnetic properties of [（talen^-Bu2）（FeC1）3] reveal a very small ferromagnetic coupling with significant zero-field splitting of the Feul S = 5/2 ions. In contrast, the dimerization of two trinu- clear complexes in [（feldMe）（FeCl）3] results in antiferromagnetic interactions between the two pheno

关键词： magnetic properties iron complexes spin-polarization triplesalen

Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection

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World Journal of Gastroenterology 2015年第12期21卷 3736-3740页

作者： Thorsten Brechmann Justyna Swol veronika Knop-Hammad Jrg Willert Mirko Aach Oliver Cruciger Wolff Schmiegel Thomas A Schildhauer Uwe Hamsen Department of Gastroenterology and Hepatology Berufsge-nossenschaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum Department of General and Trauma Surgery Berufsgenossens--chaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum Institute of Laboratory Medicine Berufsgenossenschaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum Department of Neurotraumatology Berufsgenossenschaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum

A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile(C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up.

关键词： Clostridium difficile infection Spinal cord injury

Cerebrovascularβ-dystroglycan immunoreactivity in vertebrates:not detected in anurans and in the teleosts Ostariophysi and Euteleostei

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Integrative Zoology 2020年第1期15卷 16-31页

作者： Mihály KÁLMÁN David L.LŐRINCZ Olivér M.SEBŐK Csilla ARI Erzsébet OSZWALD Hiroaki SOMIYA veronika JANCSIK Department of Anatomy Histology and EmbryologySemmelweis UniversityBudapestHungary University of Leicester Dept.of NeurosciencePsychology and BehaviourLeicesterUnited Kingdom Hyperbaric Neuroscience Research Lab. Dept of PsychologyUniversity of South FloridaTampaFloridaUSA Department of Environmental Biology Chubu UniversityChubuJapan Department of Anatomy Veterinary UniversityBudapestHungary

The aim of the present paper was to check for the presence of cerebrovascular dystroglycan in vertebrates,because dystroglycan,which is localized in the vascular astroglial end-feet,has a pivotal function in glio-vascular *** mammalian brains,the immunoreactivity ofβ-dystroglycan subunit delineates the *** results of the present study demonstrate similar patterns in other vertebrates,except for anurans and the teleost groups Ostariophysi and *** this study,we investigated 1 or 2 representative species of the main groups of Chondrichthyes,teleost and non-teleost ray-finned fishes,urodeles,anurans,and *** also investigated 5 mammalian and 3 bird *** were obtained from breeders or *** presence ofβ-dystroglycan was investigated immunohistochemically in free-floating ***-embedding electron microscopical immunohistochemistry on Heterodontus japonicus shark brains demonstrated that in Elasmobranchii,β-dystroglycan is also localized in the perivascular glial end-feet despite the different construction of their blood-brain *** results indicated that the cerebrovascularβ-dystroglycan immunoreactivity disappeared separately in anurans,and in teleosts,in the latter group before its division to Ostariophysi and ***munohistochemistry in muscles and western blots from brain homogenates,however,detected the presence ofβ-dystroglycan,even in anurans and all teleosts.A possible explanation is that in the glial end-feet,β-dystroglycan is masked in these animals,or disappeared during adaptation to the freshwater habitat.

关键词： anurans cerebrovascular dystroglycan elasmobranchs teleosts

An Application of Positive Psychology in an Inclusive Primary School in Slovakia

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Psychology Research 2020年第5期10卷 171-180页

作者： Eva Gajdosova veronika Bisaki Silvia Majercakova Albertova Paneuropean University BratislavaSlovak Republic

In recent years,there has been an increasing interest to identify and assess indicators of school quality in ***-emotional health of pupils and teachers has been identified as one of the most important criterion of school *** chapter reports on social-emotional health of pupils and teachers in a Slovak inclusive primary *** main organizational principles of an inclusive primary school in Bratislava,Slovakia are *** social-emotional health of teachers and students was assessed via an adapted Social-Emotional Health Survey-Secondary(SEHS-S).Findings of this pilot project indicate that teachers and pupils reported high level of social-emotional health associated with school’s core organizational principles guided by positive education frameworks.

关键词： positive psychology mental health social-emotional health inclusive school

Aetiology of Vesico Vaginal Fistula (VVF)—Observation in Patients Managed at CCBRT (Comprehensive Community Based Rehabilitation in Tanzania) Hospital, Dar es Salaam, Tanzania. January to March 2016

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Open Journal of Obstetrics and Gynecology 2017年第6期7卷 649-677页

作者： Peter Majinge veronika Siebenkotten-Branca Babanding Daffeh Comprehensive Community Based Rehabilitation in Tanzania (CCBRT) Dar es Salaam Tanzania Mèdecins Sans Frontières (MSF) (Aerzte Ohne Grenzen—Doctors without Borders) Berlin Germany Serekunda General Hospital Kanifing The Gambia

In this manuscript the authors have studied the various causes of vesico-vaginal fistula (VVF) and described etiology, clinical characteristics, and surgical outcome of VVF patients managed at CCBRT. They show that out of 155 patients 104 had surgery for VVF, 25 for stress incontinence (SI), 7 for perineal tears, 6 for recto-vaginal fistula (RVF) and 5 for other reasons, such as urethral strictures and bladder stones. They found a rate of 37 (35.58% out of 104 patients) with definitely iatrogenic fistula and therefore support the observation also made by others that there is a shift in etiology of VVF.

关键词： Obstetric Fistula iatrogenic fistula Vesico-Vaginal Fistula Etiology Cesarean Section

纳米比亚Ompundja区数学教师解决八年级学生代数学习困难的策略探究

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纳米比亚Ompundja区数学教师解决八年级学生代数学习困难的策略探...

作者： veronika Ngemweshimwene David 华东师范大学

学位级别：硕士