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Impact of Connexins on Atherogenesis: A Brief Review

Journal of Integrative Medicine（双语） 2018年第2期7卷 12-19页

作者： veronika A. Myasoedova Dongwei Zhang Reinhard Wetzker Andrey V. Grechko Alexander N. Orekhov Laboratory of Angiopathology Institute of General Pathology and PathophysiologyMoscow 125315Russia Dabetes Research Center Traditional Chinese Medicine SchoolBeijing University of Chinese MedicineBeijing 100029China Klinik für Anasthesiologie und Intensivmedizin Universitatsklinikum Jena Austria Federal Scientific Clinical Center for Resuscitation and Rehabilitation MoscowRussia Institute for Atherosclerosis Research Skolkovo Innovative CenterMoscow 121609Russia Centre of Collective Use Institute of Gene BiologyMoscow 121552Russia

Connexins family in humans consists of 21 highly conserved proteins that are responsible for contact formation between cells. On the cell surface, connexins form hemichannels, or connexons. Two hemichannels brought together form a gap junction, a form of intercellular contact that allows for direct transfer of material and signals between the adjacent cells. Gap junctions serve for transporting ions and other soluble, low molecular weight molecules therefore synchronizing the microenvironment of the contacting cells and maintaining cell and tissue homeostasis. Impairment of gap junctions is associated with different pathological conditions. Importantly, it has been described in atherosclerosis, which causes local cellular dysfunction in the arterial wall tissues followed by the development of atherosclerotic plaque. There are 3 main connexins expressed in human cardiovascular system: Cx37, Cx40, and Cx43. Alterations in the arterial wall cells observed in atherosclerosis include changes in the expression pattern of the main connexins and impairment of intercellular contacts and communication. According to the currently available data, Cx37 and Cx40 have anti-atherogenic and vasculoprotective properties, while Cx43 appears to be more pro-atherogenic. However, the effects of connexins are cell type-dependent and in many cases, remain to be studied in detail. In this review, we summarize the available knowledge on connexins of the arterial wall cells involved in atherosclerosis development.

关键词： Connexin Connexon Gap junction Atherosclerosis Vascular wal

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From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1629-1647页

作者： Tran Thi Van Anh Alilou Mostafa Zhigang Rao Simona Pace Stefan Schwaiger Christian Kretzer veronika Temml Carsten Giesel Paul M.Jordan Rossella Bilancia Christina Weinigel Silke Rummler Birgit Waltenberger Tran Hung Antonietta Rossi Hermann Stuppner Oliver Werz Andreas Koeberle Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Faculty of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City 700000Viet Nam Michael Popp Institute and Center for Molecular Biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Department of Pharmaceutical/Medicinal Chemistry Institute of PharmacyFriedrich Schiller University JenaJena 07743Germany Institute of Pharmacy Department of Pharmaceutical and Medicinal ChemistryParacelsus Medical University SalzburgSalzburgSalzburg 5020Austria Department of Pharmacy School of MedicineUniversity of Naples FedericoⅡNaples'80131Italy Institute of Transfusion Medicine University Hospital JenaJena 07747Germany

Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory *** mediators orchestrate both the initiation and resolution of *** from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation,though drug candidates exhibiting such features are *** from a library of Vietnamese medical plant extracts,we identified isomers of the biflavanoid 8-methylsocotrin-4’-ol from Dracaena cambodiana,which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators(SPM).Elucidation of the absolute configurations of 8-methylsocotrin-4’-ol revealed the 2 S,γSisomer being most active,and molecular docking studies suggest that the compound binds to an allosteric site between the 5-lipoxygenase *** identified additional subordinate targets within lipid mediator biosynthesis,including microsomal prostaglandin E2 *** production is efficiently suppressed in activated human neutrophils,macrophages,and blood,while the induction of SPM biosynthesis is restricted to M2 *** shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo and accompanied by a substantial decrease in immune cell *** summary,we disclose a promising drug candidate that combines potent 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles.

关键词： Lipoxygenase Inflammation Resolution Natural product Lipidomics Lipid mediator

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Linking of Environmental and Health Indicators by Neural Networks:Case of Breast Cancer Mortality,Slovak Republic

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Open Journal of Geology 2013年第2期3卷 101-112页

作者： Stanislav Rapant Mária Letkovicová veronika Cvecková Andrej Durza Katarína Fajcíková Hana Zach State Geological Institute of D.Stúr BratislavaSlovak Republic Environment a.s.NitraSlovak Republic Faculty of Natural Sciences Comenius UniversityBratislavaSlovak Republic

This study deals with the analysis of relationship between 67 environmental indicators in geological environment and breast cancer mortality in Slovakia. Primary data comprises a database of 67 environmental indicators for groundwater and soils as a mean value for every Slovak municipality and the data on relative mortality from breast cancer for Slovak municipalities (about 2900) collected for the period of 22 years. The training neural network was used as a mathematical model for data analysis. The top 200 networks have identified 12 environmental indicators (8 for soils: pHKCl, carbonates, Ca, Mg, Na, Co, Sr and 4 for groundwater: Ba, SiO2, Zn, Fe) with high rate of influence. As the most influential environmental indicator was identified pHKCl in soil that should be within the range of acids, definitely under the neutral point. Most of environmental indicators were unambiguously identified as negative (Mg, Ca, Sr, carbonates, Ba, SiO2, Zn and Fe). These indicators should be at the lowest level of their concentration in related geological component. Three environmental indicators, Ce, Na and Co had parabolic function where certain essential concentration levels of these elements are presumed with protective effect on human health. For all influential indicators limit values with respect to the lowest mortality were proposed. The verification of achieved results was performed through regressive model of breast cancer mortality for 12 calculated influential environmental indicators for all municipalities in the Slovak Republic. The revealed difference between real mortality levels and the model values was found for 6 environmental indicators (pHKCl, Mg, Ca, Sr, Ba, Zn). Each executed limit has decreased breast cancer mortality for about 0.79 cases per 100,000 inhabitants.

关键词： Neural Network Breast Cancer Mortality Environmental Indicators Soil Groundwater Slovak Republic

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Background and Research Prospect of Geo-ecological Survey and Monitor in the Critical Zone of Black Soil

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Acta Geologica Sinica(English Edition) 2019年第S1期93卷 126-129页

作者： LI Zhizhong WANG Daming DAI Huimin WANG Xisheng LIANG Shuai XU Jiang YANG Jiajia WANG Lei CHEN Shengbo A lecos DEMETRIADES veronika KOPACKOVA Igor SAVIN Douglas A.HOWARD Timothy FILLEY GENG Xiaoyuan Shenyang Geological Survey of China Geological Survey Shenyang 110030LiaoningChina China Geological Survey Beijing 100000China Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100000China British Geological Survey Ctr Environm SciNottingham NG125GGEngland Jilin University Institute of Geology and Mineral Exploration Olympic VillageChangchun 130026JilinChina Czech Geological Survey Remote Sensing DepartmentPrague11821Czech Republic Russian Academy of Sciences Kirensky Institute of Physics Krasnoyarsk660036Russia Department of Geology Arizona State University TempeArizona85287-1404USA Purdue Univ Dept Earth Atmospher&Planetary Sci550 Stadium Mall DrW LafayetteIN 47907USA Kentville Research and Development Centre Agriculture and Agri-Food CanadaKentvilleNS B4N 1J5Cancda

The American Science journal,on the occasion of its 125 publication anniversary,in 2016,released 125 of the most challenging scientific issues(Kennedy et al.,2005)to the *** to the basics,breadth and the influence,25 of the issues which considered to be the most important were screened,including"How many people can the Earth carry?"(Stokstad,2005;Dailyg et al.,1992;Cohen,1995)and"How high will the greenhouse effect make the earth temperature?

关键词： black soils resource black soil critical zone earth critical zone

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骨细胞膜

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国外医学.创伤与外科基本问题分册 1983年第2期 92-96页

作者： messer HH 柴本甫

骨细胞的功能,可以用骨细胞膜现象来解释。在透射电镜及扫描电镜下初步揭开了它的解剖学奥秘。骨细胞膜受激素的影响而对细胞外液及骨液间的钙浓度起调节作用;它具有电性能,在机械应力下产生压电效应,可刺激骨生长;它有二种电流来源,所... 详细信息

骨细胞的功能,可以用骨细胞膜现象来解释。在透射电镜及扫描电镜下初步揭开了它的解剖学奥秘。骨细胞膜受激素的影响而对细胞外液及骨液间的钙浓度起调节作用;它具有电性能,在机械应力下产生压电效应,可刺激骨生长;它有二种电流来源,所产生的电位差可影响钙的渗透性。在它的表面有激素受体,对多种激素如PTH、CT等产生细胞应答。胞体钙浓度及cAMP的改变,很大程度上传递着激素应答和电反应。目前国外对骨细胞膜的研究,尚在萌芽阶段。其重要性表现在,此研究已达骨细胞超微结构的水平,已超越单一器官的范畴。因此,有的国家如西德己将此列为国家科研项目,这是国外医学新的动向之一,值得注意。

关键词：基质小泡钙浓度骨吸收超微结构 ATP 细胞外液破骨细胞折缘 PTH 胞体细胞钙 cAMP 细胞突细胞外基质基质(细胞) 肾上腺素肾上腺能α-受体兴奋药焦磷酸盐调节激素

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Oxytocin but Not Testosterone Modulates Behavioral Patterns in Autism Spectrum Disorders

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Open Journal of Medical Psychology 2014年第1期3卷 48-53页

作者： Silvia Lakatosova Sheinberg Nurit Pivovarciova Anna Husarova veronika Rozenfeld Irina Ostatnikova Daniela Castejon Ana Maria College of Osteopathic Medicine Nova Southeastern University Fort Lauderdale USA College of Pharmacy Nova Southeastern University Fort Lauderdale USA Institute of Physiology Comenius University in Bratislava Bratislava Slovakia Mailman Segal Center Nova Southeastern University Fort Lauderdale USA

Autism spectrum disorder (ASD) is a neurodevelopmental disorder of unknown etiology. Social deficits represent one of the core symptoms of the diagnosis. The aim was to reveal possible correlations among peripheral levels of oxytocin and testosterone with behavioral and symptom characteristics in patients with ASD. 8 children with ASD were recruited and underwent psychological profiling. Blood oxytocin and testosterone levels were analyzed using ELISA method. Oxytocin levels positively correlated with Adaptation to change category of CARS-2 (P = 0.008, R = 0.848) and Vineland-II maladaptive behavior scores (P = 0.004, R = 0.884). No significant correlations were found among testosterone levels and behavioral parameters. Higher oxytocin levels were connected with more severe adaptive behavior in ASD patients. Increased oxytocin levels in children with more severe phenotype could be a result of compensatory mechanism of impaired oxytocin signaling. Oxytocin seems to employ distinct mechanisms in regulating social behavior in autism and healthy population.

关键词： Autism Oxytocin Testosterone Maladaptive Behavior

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Large-scale error-tolerant programmable interferometer fabricated by femtosecond laser writing

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Photonics Research 2024年第3期12卷 I0028-I0040页

作者： ILYA KONDRATYEV veronika IVANOVA SUREN FLDZHYAN ARTEM ARGENCHIEV NIKITA KOSTYUCHENKO SERGEY ZHURAVITSKII NIKOLAY SKRYABIN IVAN DYAKONOV MIKHAIL SAYGIN STANISLAV STRAUPE ALEXANDER KORNEEV SERGEI KULIK Quantum Technology Centre and Faculty of Physics M.V.Lomonosov Moscow State UniversityMoscow 119991Russia Russian Quantum Center Moscow 121205Russia Laboratory of Quantum Engineering of Light South Ural State UniversityChelyabinsk 454080Russia

We introduce a programmable eight-port interferometer with the recently proposed error-tolerant architecture capable of performing a broad class of *** interferometer has been fabricated with femtosecond laser writing,and it is the largest programmable interferometer of this kind to *** have demonstrated its advantageous error tolerance by showing an operation in a broad wavelength range from 920 to 980 nm,which is particularly relevant for quantum photonics due to efficient photon sources existing in this wavelength *** work highlights the importance of developing novel architectures of programmable photonics for information processing.

关键词： interferometer laser femtosecond

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19世纪蒙古地区反清斗争的形式(英文)

19世纪蒙古地区反清斗争的形式(英文)

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作者： veronika Veit 德国波恩大学中亚语言文化研究所

研究19世纪蒙古地区反清斗争的形式不仅要注意内、外蒙古间地区差异,而且还要认识到时代特征。外蒙古反清斗争的矛头直指旅蒙商的不法行为,清政府的征兵政策以及当地旗扎萨克的压迫,有暴力和非暴力两种形式。暴力反清活动只是零星的和...

研究19世纪蒙古地区反清斗争的形式不仅要注意内、外蒙古间地区差异,而且还要认识到时代特征。外蒙古反清斗争的矛头直指旅蒙商的不法行为,清政府的征兵政策以及当地旗扎萨克的压迫,有暴力和非暴力两种形式。暴力反清活动只是零星的和自发性的暴动,并未形成有计划有组织的起义。外蒙古反清非暴力活动从18世纪末开始,主要形式是蒙古社会各阶层派代表情愿参加。内蒙古反清斗争形式与外蒙古基本相似,但由于更加恶劣的社会和政治条件,他们的斗争形式更进了一步。随着清政府对蒙地的放垦,反垦斗争成为内蒙古人民反清斗争的主要形式。其中持续时间较长,影响范围较大的要属鄂尔多斯独归龙运动。19世纪蒙古人民反清斗争给蒙古社会带来的影响是巨大的,具有悠久历史的蒙古族诗歌、寓言、传说也深深地烙上了反清的印记,对其进行探讨,有助于我们对19世纪反清斗争的研究工作。

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和平发展与人权保障:东西方人权观的差异及中国经验的启示

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人权 2023年第4期 58-62页

作者： [印尼]韦珍玉印尼国际战略研究中心(CSIS)中国研究中心

一、理解真正的人权人类自群居的灵长类动物发展而来,经过漫长的进化,最终脱离灵长类的生活环境,步入文明社会。人类越是进化,与灵长类之间的距离就越远。人类在长期的社会生活中逐渐产生了善的意识,也就是把其他具有生物属性的人视作... 详细信息

一、理解真正的人权人类自群居的灵长类动物发展而来,经过漫长的进化,最终脱离灵长类的生活环境,步入文明社会。人类越是进化,与灵长类之间的距离就越远。人类在长期的社会生活中逐渐产生了善的意识,也就是把其他具有生物属性的人视作自己的同类;并最终形成了以“仁”为基础的善,对同类怀有慈悲之心。这种人心是人权的基础。

关键词：灵长类动物生物属性人权保障进化

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不同脂肪酶酶解奶油制备奶味香基的研究

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中国油脂 2015年第4期40卷 74-78页

作者：张宁赵金利 CYRIL Suseno 滕英来汪勇李爱军 LIANA veronika Yapriadi 暨南大学食品科学与工程系广州510632 暨南大学一萨斯喀切温大学油料生物炼制与营养联合实验室广州510632 暨南大学国际学院广州510632

选用Hansen calf lipase、Amano lipase A6、Lipozyme RM IM 3种脂肪酶对无水奶油进行适度酶解制备奶味香基。采用气相色谱分析了酶解奶油中游离脂肪酸组成,结合顶空固相微萃取-气相色谱质谱联用技术对酶解奶油中的挥发性风味成分进行研... 详细信息

选用Hansen calf lipase、Amano lipase A6、Lipozyme RM IM 3种脂肪酶对无水奶油进行适度酶解制备奶味香基。采用气相色谱分析了酶解奶油中游离脂肪酸组成,结合顶空固相微萃取-气相色谱质谱联用技术对酶解奶油中的挥发性风味成分进行研究,并通过感官评价对酶解奶油进行风味剖面分析并对烘焙产品偏好性评定。结果表明:3种脂肪酶选择性酶解产生中短链脂肪酸的能力均较强,其中动物来源的Hansen calf lipase对中短链脂肪酸的选择性酶解能力最高,酶解奶油中短链脂肪酸相对含量为42.9%,且该酶解奶油和烘焙产品具有令人愉悦的奶味和干酪味;3种酶解奶油中的挥发性风味成分主要为脂肪酸、醛类、酮类、内酯类物质。

关键词：脂肪酶奶油游离脂肪酸感官评价风味成分

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