检索结果-南通市图书馆

Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates

引用

World Journal of Stem Cells 2021年第5期13卷 452-469页

作者： Vladimir P Baklaushev Oleg V Durov Vladimir A Kalsin Eugene V Gulaev Sergey V Kim Ilya L Gubskiy veronika A Revkova Ekaterina M Samoilova Pavel A Melnikov Dzhina D Karal-Ogly Sergey V Orlov Alexander V Troitskiy Vladimir P Chekhonin Alexander V Averyanov Jan-Eric Ahlfors Biomedical Research Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Neurosurgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBAMoscow 115682MoskvaRussia Department of Anesthesiology N.N.Blokhin Russian Cancer Research CentreMoscow 115478MoskvaRussia Radiology and Clinical Physiology Scientific Research Center Federal center of brain research and neurotechnologies of the Federal Medical Biological AgencyMoscow 117997Russia Department of Neurobiology Serbsky National Medical Research Center for Psychiatry and NarcologyMoscow 119992MoskvaRussia Department of Primatology Russian Acad Med SciResearch Institute of Medical PrimatologySochi 119992SochiRussia Department of Vascular Surgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Basic and Applied Neurobiology V.P.Serbsky Federal Medical Research Center for Psychiatry and NarcologyRussia Department of Medical Nanobiotechnology Pirogov Russian National Research Medical University(RNRMU)Moscow 115682MoskvaRussia New World Laboratories Laval H7V 4A7QuebecCanada

BACKGROUND The development of regenerative therapy for human spinal cord injury(SCI)is dramatically restricted by two main challenges:the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical *** reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first *** use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human *** To investigate the safety and efficacy of intraspinal transplantation of directly reprogrammed neural precursor cells(drNPCs).METHODS Seven non-human primates with verified complete thoracic SCI were divided into two groups:drNPC group(n=4)was subjected to intraspinal transplantation of 5 million drNPCs rostral and caudal to the lesion site 2 wk post injury,and lesion control(n=3)was injected identically with the equivalent volume of *** Follow-up for 12 wk revealed that animals in the drNPC group demonstrated a significant recovery of the paralyzed hindlimb as well as recovery of somatosensory evoked potential and motor evoked potential of injured *** resonance diffusion tensor imaging data confirmed the intraspinal transplantation of drNPCs did not adversely affect the morphology of the central nervous system or cerebrospinal fluid *** immunohistochemical analysis showed that drNPCs maintained SOX2 expression characteristic of multipotency in the transplanted spinal cord for at least 12 wk,migrating to areas of axon growth *** Our data demonstrated that drNPC transplantation was safe and contributed to improvement of spinal cord function after acute SCI,based on neurological status assessment and neurophysiological recovery within 12 wk after *** functional improvement described was not associated with neuronal differentiation of th

关键词： Direct cell reprogramming Neural precursor cells Directly reprogrammed neural precursor cells Spinal cord injury Nonhuman primates Regenerative therapy,Evoked potentials

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the Diurnal Dependence of fbEs-Variations Due to Earthquakes

引用

International Journal of Geosciences 2015年第7期6卷 656-665页

作者： Elena V. Liperovskaya Claudia-veronika Meister Dieter H. H. Hoffmann Alexandra S. Silina Natalia E. Vasil’eva Institute of Physics of the Earth of the Russian Academy of Sciences Moscow Russia Institut für Kernphysik Technische Universitat Darmstadt Darmstadt Germany Graduate School of Excellence Energy Science and Engineering Darmstadt Germany

In the present work, disturbances of the half-transparency frequency fbEs of the ionospheric sporadic E-layer are investigated in connection with earthquakes. The fbEs-frequency is proportional to the square root of the maximum ionisation density of the sporadic E-layer. In this work, it is shown that in 2/3 of the cases, two days before a seismic shock with magnitude M > 5.5 and on the day of the shock, an increase of the fbEs-frequency is obtained at sunset hours at distances from the epicenter R km. In contrast, before sunrise, the fbEs-value decreases. The data analysed are obtained by the three vertical ionospheric sounding stations“Kokubunji”, “Yamagawa”, and “Wakkanai” during some tens of years.

关键词： Earthquake Precursors Ionosphere Sporadic E-Layer Half-Transparency Frequency Earthquake Preparation Region Solar Influence on E-Layer Geomagnetic Influence on E-Layer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection

引用

World Journal of Gastroenterology 2015年第12期21卷 3736-3740页

作者： Thorsten Brechmann Justyna Swol veronika Knop-Hammad Jrg Willert Mirko Aach Oliver Cruciger Wolff Schmiegel Thomas A Schildhauer Uwe Hamsen Department of Gastroenterology and Hepatology Berufsge-nossenschaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum Department of General and Trauma Surgery Berufsgenossens--chaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum Institute of Laboratory Medicine Berufsgenossenschaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum Department of Neurotraumatology Berufsgenossenschaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum

A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile(C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up.

关键词： Clostridium difficile infection Spinal cord injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Morphological Characteristics of Thymus in the Newborns in Different Climatic and Geographical Conditions of Kyrgyzstan

引用

International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2020年第4期9卷 178-185页

作者： Tamara Abaeva Zhanibek Muratov Rustam Tukhvatshin Zhypargul Abdullaeva Aziza Seitova veronika Tursunova Mira Zhanganaeva Masalbek Satybaldiev Lazokatkhan Dzhumaeva Meerim Abdyraimova Feruza Mamasadykova Aiperi Alimbekova Department of Normal and Topographic Anatomy of I.K. Akhunbaev Kyrgyz State Medical Academy Bishkek Kyrgyzstan Department of Pathology Basic and Clinical Pharmacology International Medical Faculty Osh State University Osh Kyrgyzstan Department of Pathological Physiology I.K. Akhunbaev Kyrgyz State Medical Academy Bishkek Kyrgyzstan Department of Anatomy Histology and Normal Physiology International Medical Faculty Osh State University Osh Kyrgyzstan Science and Research Department Osh State University Osh Kyrgyzstan Department of Clinical Disciplines 2 International Medical Faculty Osh State University Osh Kyrgyzstan

This paper is describing a detailed study of morphological structures and characteristics newborns thymus in different climatic and geographical conditions of Kara-Balta, Cholpon-Ata, and Bishkek in Kyrgyzstan. Anatomical structure research done on 26 thymuses of newborn corpses. Research results showed that a significant amount of thymuses consisted of lobes with very thin connective tissues between them. It is observed that the Hassall cells were usually located in the medulla part of the thymus after using the coloring by Van-Gieson’s stain visible clear elastic and collagen fibers. In addition, cell population dynamics in a unit of conditional area of cortical substance thymus lobes in newborns determined.

关键词： Thymus Newborns Hassall Cells Climatic Conditions Histological Methods

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用卫星云图和模式输出参数研究与典型锢囚发展相反的云的形成过程

引用

气象科技 1984年第1期 28-30页

作者： veronika Zwatz-Meise G.Hailzl 楼光平

一、引言卫星云图,特别是卫星云图电影常可看到天气尺度云系的形成过程。这种云系在其发展后期阶段的形状,相似于经典极锋理论所描述的形状。但是,它的发展过程与经典过程有明显的差别。这些差别能在云图上看出来,也能在合理的数值参数... 详细信息

一、引言卫星云图,特别是卫星云图电影常可看到天气尺度云系的形成过程。这种云系在其发展后期阶段的形状,相似于经典极锋理论所描述的形状。但是,它的发展过程与经典过程有明显的差别。这些差别能在云图上看出来,也能在合理的数值参数场中看到。本文要叙述的是一个非典型的云系发展类型,它的最后阶段的形状与典型锢囚过程相似,但其发展史完全不同。文中将用定性的卫星云图和定量的模式输出参数表示出来。在下面的讨论中我们把这个过程叫作在冷锋后部的第二个云带的扩展。二、定性分析 2.1描述在卫星云图电影中很容易看到云系的整个发展过程,为了研究这个过程,我们给出了最早的扰动。

关键词：云带后部第一个输出参数冷锋卫星云图形成过程

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

六周(2022)

引用

电影画刊 2023年第3期 48-49页

作者： Noémi veronika Szakonyi Máté Artur Vincze Daniel Daoud

影片信息第25届上海国际电影节“一带一路”电影周入围影片，主演卡特琳·罗曼被评为媒体关注电影人。高中女生、乒乓球运动员索菲怀孕了。她与酗酒的母亲和年幼的妹妹同住，生活环境对新生婴儿不利。而且，她还打算继续练球，参加职业...

影片信息第25届上海国际电影节“一带一路”电影周入围影片，主演卡特琳·罗曼被评为媒体关注电影人。高中女生、乒乓球运动员索菲怀孕了。她与酗酒的母亲和年幼的妹妹同住，生活环境对新生婴儿不利。而且，她还打算继续练球，参加职业比赛。因此，她想通过社会程序将婴儿送养。按法律规定，她有六周考虑期，如改变决定可以要回孩子。在家照顾妹妹、妈妈的过程中，天然的母性在索菲心中一点一点苏醒，让她开始怀疑自己的决定。

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

“一带一路”倡议下中俄跨境电子商务研究

引用

中国市场 2020年第2期 82-83页

作者：尼卡江南大学商学院

随着全球经济一体化进程的不断加速提升,在国际纷繁复杂的背景下,面对美国在诸多领域的强权霸权主义,中国和俄罗斯的命运紧密联合在一起,在经济、政治、文化、军事等多领域展开深入交流合作。而同样在特殊的政治历史环境中,使得中俄电... 详细信息

随着全球经济一体化进程的不断加速提升,在国际纷繁复杂的背景下,面对美国在诸多领域的强权霸权主义,中国和俄罗斯的命运紧密联合在一起,在经济、政治、文化、军事等多领域展开深入交流合作。而同样在特殊的政治历史环境中,使得中俄电子商务贸易得到长足发展,尤其是在中国"一带一路"倡议背景下,两国电子商务也在稳步的合作深化中发展到了一个崭新的历史高度,因此,文章在介绍中俄跨境电子商务发展背景的基础上,对"一带一路"倡议环境下中俄跨境电子商务的发展现状进行总结分析,并结合当前国际政治经济发展环境,对中俄跨境电子商务的发展前景做出合理展望和相关建议,最后对本文的研究结论做出概况总结。

关键词： “一带一路”倡议中俄电子商务

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Renal cell carcinoma escapes NK cell-mediated immune surveillance through the downregulation of DNAM-1

引用

Cancer Communications 2023年第7期43卷 855-859页

作者： veronika Kremer Shi Yong Neo Yaxuan Liu Yi Chen Arnika Kathleen Wagner Ying Yang Ziqing Chen Christina Seitz Nicholas Patrick Tobin Maarten Alexander Ligtenberg Evren Alici Xinsong Chen Felix Haglund Barbara Seliger Ulrika Harmenberg Eugenia Colón Ann-Helén Scherman Plogell Lisa Lei Liu Andreas Lundqvist Department of Oncology-Pathology Karolinska InstitutetStockholmSweden Singapore Immunology Network Agency for ScienceTechnology and ResearchSingaporeSingapore Department of Medicine Columbia University Irving Medical CenterNew YorkUSA Department of Medicine Huddinge Karolinska InstitutetStockholmSweden Department of Molecular Biology Princeton UniversityNew JerseyUSA Institute of Environmental Medicine Karolinska InstitutetStockholmSweden Department of Molecular Oncology The Netherlands Cancer InstituteAmsterdamNetherlands Institute for Medical Immunology Martin-Luther University Halle-WittenbergHalleGermany Institute of Translational Immunology Medical School Theodor FontaneBrandenburg an der Havel14770and Fraunhofer Institute for Cell Therapy and ImmunologyLeipzigGermany Department ofWomen’s and Children’s Health Karolinska Institutet and S:t Göran’s Hospital-UnilabsStockholmSweden Department of Urology Stockholm South General HospitalStockholmSweden

Dear Editor,The activating receptor DNAX accessory molecule-1(DNAM-1)plays an important role in T and natural killer(NK)cell-mediated cytotoxicity via the interaction with its ligands poliovirus receptor(PVR,CD155)and Nectin-2(CD112).Compared with peripheral blood NK cells,tumor-infiltrating NK cells show reduced expression of DNAM-1 across several solid tumors,including ovarian and breast cancer resulting in impaired NK cell *** studies reported an inverse correlation between DNAM-1 expression and its ligands in leukemic blasts and ovarian cancer[1].

关键词： impaired cancer killer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

格利法扎第四公立幼儿园

引用

现代装饰 2018年第2期 42-49页

作者： Konstantinos Labrinopoulos veronika Vasileiou Petra Xynidou Myrto Lantza Mariana Bisti 彭佳希腊Klab Architecture Klab Architecture

在希腊,建筑师不负责施工,因此公共建筑的设计与施工存在着很大问题。而这个项目最大的挑战之一就是恢复建筑师在设计过程中的核心地位。建筑师旨在打造一个贴合使用者尺度的建筑,同时也希望在其中引入一种新型的都市村庄的理念。建筑... 详细信息

在希腊,建筑师不负责施工,因此公共建筑的设计与施工存在着很大问题。而这个项目最大的挑战之一就是恢复建筑师在设计过程中的核心地位。建筑师旨在打造一个贴合使用者尺度的建筑,同时也希望在其中引入一种新型的都市村庄的理念。建筑师在该项目采用了更加节约材料的预制技术,即首先明确建筑的最终形态,预制好建筑的各个部件,然后再通过卡车运送至建筑所在地进行组装。

关键词：建筑师室外活动

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

人的眼睛可以标准化么？

引用

照明设计 2017年第7期 38-43页

作者： Karolina M.Zielinska-Dabkowska veronika Labancova Amardeep M.Dugar 于瑶

在LED白光的作用下，个人的虹膜颜色会影响他们对色彩的喜好吗？为了解决这个问题，我们进行了一项研究，研究在使用LED照明时，不同颜色的虹膜对三种不同场景的色彩和亮度做出何种反应。

关键词：标准化 LED照明眼睛色彩颜色虹膜

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：