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Journal of Environmental Sciences 2022年第11期34卷 1-12页

作者： Xiang-Yang Lou Roberto Boada veronica verdugo Laura Simonelli Gustavo Pérez Manuel Valiente GTS-UAB Research Group Department of ChemistryFacultat de CiènciesUniversitat Autonoma de Barcelona08193 BellaterraSpain ALBA Synchrotron Carrer de la llum 2-26Cerdanyola del Valles08290 BarcelonaSpain Centro de Excelencia en Nanotecnologia Leitat ChileSantiago 7500724Chile

In this study, a commercial cube-shaped open-celled cellulose sponge adsorbent was modified by in-situ co-precipitation of superparamagnetic iron oxide nanoparticles(SPION) and used to remove As(V) from aqueous solutions. Fe K-edge X-ray absorption spectroscopy(XAS) and TEM identified maghemite as the main iron phase of the SPION nanoparticles with an average size 13 nm. Batch adsorption experiments at 800 mg/L showed a 63% increase of adsorption capacity when loading 2.6 wt.% mass fraction of SPION in the *** determination of the adsorption thermodynamic parameters indicated that the As(V) adsorption on the composite material is a spontaneous and exothermic *** K-edge XAS results confirmed that the adsorption enhancement on the composite can be attributed to the nanoparticles loaded. In addition, adsorbed As(V) did not get reduced to more toxic As(Ⅲ) and formed a binuclear corner-sharing complex with SPION. The advantageous cube-shape of the sponge-loaded SPION composite together with its high affinity and good adsorption capacity for As(V), good regeneration capability and the enhanceddiffusion attributed to its open-celled structure make this adsorbent a good candidate for industrial applications.

关键词： Adsorption Cube composite adsorbent Arsenate removal Regeneration X-ray absorption spectroscopy

Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： YANG Le Mei ZHENG Qi LIU Xiao Jia LI Xian Xian veronica Lim CHEN Qi ZHAO Zhong Hua WANG Shu Yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,***-luciferase reporter gene assay was used to determine the target gene of *** protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western *** cytometry was used to detect cell cycle and *** proliferation was measured by CCK8 and EdU *** The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC *** cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or ***,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC ***,ULK2 inhibited CRC cell proliferation in a p53-dependent ***,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC *** Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

Literature Review of the Prevalence of Hypertension at Gulu University, Gulu City, Acholi Subregion, Northern Uganda

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World Journal of Cardiovascular Diseases 2024年第9期14卷 588-602页

作者： Lamwaka Alice veronica Mboowa John Bosco Department of Pharmacy Faculty of Medicine Gulu University Gulu City Uganda

Hypertension is a big problem worldwide. The purpose of this study is to examine the prevalence, knowledge, attitude, and practice about hypertension at Gulu University, Gulu city, Gulu district, Acholi subregion, Northern Uganda. A literature search on hypertension was done. It showed that, in Uganda, a representative number of 17,777 adult patients’ data were analyzed from January 2014 to February 2024. The epidemiological data on awareness of hypertension was found to be at 8%. Of this, 18.3% of the people with hypertension had it under control. The results of the findings were promising. Hypertension is an important public health challenge in Uganda particularly in Northern Uganda where Gulu University falls. In comparison with the two regions of Central Uganda and Northern Uganda, there was a significant number of populations that were not aware of their condition. Those diagnosed were on treatment but the treatment was not adhered to due to stock outs of medicines. Therefore, Measures are required to prevent hypertension, improve awareness, treatment and control within the community, especially at Gulu University where research has never been done.

关键词： Prevalence Hypertension Blood Pressure Knowledge Attitude Practices Cross Sectional Studies

Bloom-forming cyanobacteria and dinoflagellates in five Argentinian reservoirs:Multi-year sampling

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Water Biology and Security 2024年第1期3卷 28-36页

作者： Florencia Soledad Alvarez Dalinger Borja Claudia Nidia veronica Laura Lozano Liliana Beatriz Morana María Monica Salusso Facultad de Ciencias Naturales Universidad Nacional de SaltaAvenida Bolivia 5150Salta4400Argentina Consejo Nacional de Investigaciones Científicas y T'ecnicas(CONICET) Godoy Cruz 2290Ciudad Autonoma de Buenos AiresArgentina

Harmful algal blooms are important threats to reservoir *** a 15-year period,we sampled five Argentinian reservoirs to identify the responsible species for harmful algal blooms and determine the water quality factors driving their *** reservoirs exhibit diverse morphological and hydrological characteristics and are distributed across varying climatic *** blooms included an array of species,including toxin producers such as Raphidiopsis raciborskii,Aphanizomenon gracile,and Microcystis *** contrast,dinoflagellate blooms were predominantly characterized by *** cyanobacterial blooms primarily occurred in the shallower reservoirs located in warmer regions,whereas dinoflagellate blooms occurred where temperatures were *** most intense blooms occurred during the summer,and although cyanobacterial and chlorophyte blooms co-occurred,they never coexisted with dinoflagellate *** identified cyanotoxins in the reservoirs over the past three years,a phenomenon previously unreported in the *** that these reservoirs are drinking water sources for human populations,ongoing and systematic monitoring is needed to protect public *** the proliferation of algae and cyanobacteria in reservoirs requires resource management at the watershed level,and in the case of the Itiyuro and El Limon,requires binational management with Bolivia.

关键词： HABs Freshwater South America Toxins

Robotic management of urinary fistula

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Asian Journal of Urology 2024年第3期11卷 357-365页

作者： Luis G.Medina Randall A.Lee Valeria Celis veronica Rodriguez Jaime Poncel Aref S.Sayegh Rene Sotelo The Catherine and Joseph Aresty Department of Urology USC Institute of UrologyKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Division of Urology Department of SurgeryFox Chase Cancer CenterTemple University Health SystemPhiladelphiaPAUSA

Objectives:To highlight critical preoperative and intraoperative considerations in approaching fistula repair ***:A search of the literature was conducted to identify relevant articles pertaining to robotic management of urinary ***:Fistulae of the genitourinary tract can be a challenging dilemma for urologists,as definitive management may require surgical *** of both enteric and non-enteric fistulae are multifactorial,and successful repair hinges on the meticulous perioperative evaluation,planning,and *** open techniques can subject patients to increased morbidity and prolonged *** its introduction,the robotic surgical platform has continued to expand its *** three-dimensional visualization and tremor free wristed instrument movements have made the robotic platform an attractive option for genitourinary fistula ***:Robotic management of complex urinary fistulae is feasible in expert hands;more studies are needed to define its role in the treatment algorithm of this devastating conditions.

关键词： Fistula Robotic surgery Rectourethral Rectovesical Vesicovaginal

Distribution and Relation of Primes with Tesla Numbers 3, 6, and 9

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1021-1027页

作者： Javier Mendoza-Navarrete Huetzin Perez Ismael Ojeda Victor verdugo Gabriel Luna Sandoval Ricardo Jimenez Garcia Jaime Alvarez Departametno de Matemá ticas CBTis 256 DGETI Cabo San Lucas M&#233xico DCI Departamento de Fisica Mé dica Universidad de Guanajuato Leon M&#233xico Divisió n de Ingenieria en Sistemas Computacionales Tecnol&#243gico Nacional de M&#233xico ITES Los Cabos Cabo San Lucas M&#233xico Departamento de Ingenieria Industrial en Manufactura Universidad Estatal de Sonora Navojoa M&#233xico Departamento de Elé ctrica-Electr&#243nica Tecnol&#243gico Nacional de M&#233xico Campus Mexicali Mexicali M&#233xico Guanajuato M&#233xico

This work presents a different approach to twin primes, an approach from the perspective of the Tesla numbers and gives a refresh and new observation of twin primes that could lead us to an answer to the Twin Prime Conjecture problem. We expose a peculiar relation between twin primes and the generation of prime numbers with Tesla numbers. Tesla numbers seem to be present in so many domains like time, vibration and frequency [1], and the space between twin primes is not the exception. Let us say that twin primes are more than just prime numbers plus 2 or minus 2, and Tesla numbers are more involved with twin primes than we think, and hopefully, this approach give us a better understanding of the distribution of the twin pairs.

关键词： Tesla Numbers Prime Number Twin Prime Numbers Twin Pair

The Nikola Tesla Constant and Its Relation to the Circumference Inscribed in a Square

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Journal of Applied Mathematics and Physics 2024年第1期12卷 277-283页

作者： Javier Mendoza Navarrete José Ismael Ojeda Campaña Huetzin Perez Gabriel Luna-Sandoval Victor verdugo Ricardo Jiménez Garcia Departamento de Matemáticas CBTis 256 DGETI Cabo San Lucas México División de Ingeniería en Sistemas Computacionales Tecnológico Nacional de México/ITES de Los Cabos Cabo San Lucas México DCI Departamento de Física Médica Universidad de Guanajuato León México Departamento de Ingeniería Industrial en Manufactura Universidad Estatal de Sonora Navojoa México Departamento de Eléctrica-Electrónica Tecnológico Nacional de México Campus Mexicali Mexicali México

This research work relates the surface of a square and the area circumscribed by a circle, resulting in a value called Nikola Tesla constant. This constant starts with the calculation of the areas of the square and the inscribed circle, giving a ratio of 9/40 and from which a residual area of the area proportions of the geometric figures described is obtained. Plotting smooth curves, particularly those in round shapes, can be represented efficiently with the use of Nikola Tesla constant, reducing complex mathematical calculus.

关键词： Tesla Numbers Prime Number Circle Binary Area

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自动化技术助力绿氢安全高效生产

流程工业 2024年第5期 32-34页

作者： veronica Constantin 艾默生

自动化技术在推动向清洁燃料经济转型的过程中扮演着至关重要的角色,本文讲述了自动化技术是如何促进更安全且高效的绿氢生产。绿氢生产目前正处于其发展的初级阶段,伴随着行业的逐步探索与成长,短期内确实可能面临更为复杂的安全挑战... 详细信息

自动化技术在推动向清洁燃料经济转型的过程中扮演着至关重要的角色,本文讲述了自动化技术是如何促进更安全且高效的绿氢生产。绿氢生产目前正处于其发展的初级阶段,伴随着行业的逐步探索与成长,短期内确实可能面临更为复杂的安全挑战。氢作为一种能源载体,如同所有可燃物质一样,具有相应的潜在危险。其高度易燃的特性意味着即使氢气与空气的混合比例很低——低至空气中氢气含量达到4%时,就足以构成爆炸风险。

关键词：自动化技术经济转型能源载体潜在危险氢气含量混合比例清洁燃料安全挑战

Farmers’ Knowledge and Awareness towards the Use of Agrochemicals in Vegetable Cultivation, Fako Cameroon

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Journal of Geoscience and Environment Protection 2024年第9期12卷 215-229页

作者： Amungwa Ivan Tabikam veronica Ebot Manga Godswill Azinwie Asongwe Elmer Kanjo Ekinzog Mantah Marian Ngwatezeh Victorine Neh Akenji Department of Environmental Science University of Buea Buea Cameroon Institute of Agricultural Research and Development (IRAD) Batoke-Limbe Cameroon GAP AG Munich Germany GIS and DTM Assistant IOM-UN Yaound Cameroon South West Regional Center for Scientific Research and Innovation Buea Cameroon

Agrochemicals are contemporary, omnipresent tool used in vegetable cultivation. Farmers’ knowledge and awareness of the proper usage of agrochemicals are critical for mitigating the negative effects on human health. This cross-sectional study was aimed at assessing the usage knowledge, risk awareness of toxicological and chemical classes, proper handling and use practices for agrochemicals homologated for use in vegetable farming, and the occurrence of health-related symptoms as a result of exposure among these farmers. The study included 93 vegetable growers from agricultural hotspot towns in Fako, southwest Cameroon. The field study, ran from November 2021 to December 2023, using a questionnaire to collect information on farmers demographic, and their knowledge of pesticide classes, and the related risk of associated with the handling of agrochemicals. Results show that all vegetable farmers, particularly those engaged in agribusiness, employ pesticide inputs to maximize production. Six pesticides, two fertilizer types, and one unknown substance were identified. While 23 active compounds were found, the most utilized were abamectin, emamectin (10.46%), dimethoate (9.30%,) and ethoprophos (8.13%). Two active chemicals, dimethoate and methalaxyl, are illegal yet remain in circulation. Toxicological classes I and II, with the greatest harmful effect on human health, were the most commonly utilized (64.27%). Thirty-nine percent of farmers never use personal protection equipment when working with agrochemicals, demonstrating a significant gap in knowledge and awareness of agrochemicals and their various applications and handling procedures in the field. The government should implement an intensive specialized educational program for on-field farmers with incentives in order to promote sustainable agriculture methods that ensure environmental and human safety.

关键词： Farmers Knowledge Agrochemical Risk Awareness Vegetable Cultivation Agrochemical Use Practices Health Risk

SPINOPHILIN: A multiplayer tumor suppressor

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Genes & Diseases 2023年第1期10卷 187-198页

作者： Eva M.verdugo-Sivianes Amancio Carnero Instituto de Biomedicina de Sevilla IBISHospital Universitario Virgen del RocioConsejo Superior de Investigaciones CientificasUniversidad de SevillaSeville 41013Spain CIBERONC Instituto de Salud Carlos IlMadrid 28029Spain

SPINOPHILIN(SPN,PPP1R9B or NEURABIN-2)is a multifunctional protein that regulates protein-protein interactions in different cell signaling *** is also one of the regulatory subunits of protein phosphatase 1(PP1),implicated in the dephosphorylation of retinoblastoma protein(pRB)during cell *** SPN gene has been described as a tumor suppressor in different human tumor contexts,in which low levels of SPN are correlated with a higher grade and worse *** addition,mutations of the SPN protein have been reported in human ***,an oncogenic mutation of sPN,A566V,was described,which affects both the SPN-PP1 interaction and the phosphatase activity of the holoenzyme,and promotes p53-dependent tumorigenesis by increasing the cancer stem cell(CsC)pool in breast ***,the loss or mutation of SPN could be late events that promotes tumor progression by increasing the CSC pool and,eventually,the malignant behavior of the tumor.

关键词： Cancer therapy Phosphatase PP1 SPINOPHILIN Tumor suppressor Tumorigenesis