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Self-compatibility in peach[Prunus persica(L.)Batsch]:patterns of diversity surrounding the S-locus and analysis of SFB alleles

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Horticulture Research 2020年第1期7卷 675-689页

作者： Donia Abdallah Ghada Baraket veronica perez Amel Salhi Hannachi Jose I.Hormaza Author details 1Facultédes Sciences de Tunis Département BiologieUniversitéde Tunis El Manar2092 TunisTunisie Laboratorio de Agrobiología Juan JoséBravo Rodríguez(Cabildo Insular de La Palma) Unidad Técnica del Instituto de Productos Naturales y Agrobiología(IPNA-CSIC)38700 S/C La PalmaCanary IslandsSpain Instituto de Hortofruticultura Subtropical y Mediterránea La Mayora(IHSM La Mayora-UMA-CSIC) 29750 Algarrobo-CostaMalagaSpain

Self-incompatibility(SI)to self-compatibility(SC)transition is one of the most frequent and prevalent evolutionary shifts in flowering *** L.(Rosaceae)is a genus of over 200 species most of which exhibit a Gametophytic SI ***[Prunus persica(L.)Batsch;2n=16]is one of the few exceptions in the genus known to be a fully selfcompatible ***,the evolutionary process of the complete and irreversible loss of SI in peach is not well understood and,in order to fill that gap,in this study 24 peach accessions were *** tube growth was controlled in self-pollinated flowers to verify their self-compatible *** linkage disequilibrium association between alleles at the S-locus and linked markers at the end of the sixth linkage group was not significant(P>0.05),except with the closest markers suggesting the absence of a signature of negative frequency dependent selection at the *** of SFB1 and SFB2 protein sequences allowed identifying the absence of some variable and hypervariable domains and the presence of additionalα-helices at the *** and evolutionary analysis of SFB nucleotide sequences showed a signature of purifying selection in SFB2,while the SFB1 seemed to evolve ***,our results show that the SFB2 allele diversified after *** and ***(almond)divergence,a period which is characterized by an important bottleneck,while SFB1 diversified at a transition time between the bottleneck and population expansion.

关键词： compatibility linkage alleles

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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Axonal tuning by GABA_(A) receptor unveils novel tricks from an old dog

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Neural Regeneration Research 2023年第3期18卷 533-534页

作者： veronica Bonalume Valerio Magnaghi Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilanItaly

In the last years,axonal conductance of action potential trains became a novel subject of study,changing the view of axons,from a static cable-like compartment to a more complex and dynamic system(Debanne et al.,2011).Axonal computation,indeed,is canonically constituted by the action of voltage-gated ion channels,such as the classic Na+and K+channels,but recent studies demonstrated that it can be modulated by the action of other ion channel pumps,and metabolic factors(Byczkowicz et al.,2019;Zang and Marder.

关键词： tuning action classic

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Sensitivity of a solid Eu(Ⅲ) complex towards acetonitrile vapor:Structural and spectroscopic characterization

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Journal of Rare Earths 2020年第5期38卷 571-576页

作者： Fabio Piccinelli veronica Paterlini Magda Monari Marco Bettinelli Luminescent Materials Laboratory DBUniversita di Veronaand INSTMUdR VeronaStrada Le Grazie 1537134VeronaItaly Dipartimento di Chimica"G.Ciamician" Universita di BolognaVia Selmi 240126BolognaItaly

The Eu(Ⅲ)nitrate complex of the meso-N,N’-bis(2-pyridylmethylene)-1,2-(R,S)-cyclohexanediamine ligand was synthesized and characterized by single crystal and powder X-ray *** crystal lattice of the complex is capable of absorbing and desorbing selectively acetonitrile molecules,at 293 K upon an acetonitrile vapor pressure of^0.1×10^5 *** process,which is partially reversible,can be easily followed by both powder X-ray diffraction(P-XRD)and Eu(III)luminescence *** acetonitrile molecule,located in the outer coordination sphere of the metal ion,does not affect the radiative transition probability of 5 D0 level of Eu(Ⅲ)and also it does not activate further non-radiative channels from this *** the other hand,this molecule is capable of affecting the energy position and intensities of the crystal field components of the 5 D0→7 F2 *** complex in solid form can be considered a promising material for the optical sensing of acetonitrile vapors.

关键词： Eu(Ⅲ) X-ray diffraction Crystal structure Luminescence spectroscopy Rare earths

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L^1→L^q Poincare Inequalities for 0

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Acta Mathematica Sinica,English Series 2002年第1期18卷 1-20页

作者： perez Carlos Departamento dr Matematicas. Universidad Autónoma de Madrid. 28049 Madrid. Spain

Civen two doubling measures μ and v in a metric apace (S.p)of homogeneous type. let B_0 S be a given ball. It has been a well-known result bv now (see)[1 4])theat the validity of an L^1→L^1 Poincaré inequality of the following form: f_B|f-f_B|dv≤cr(B)f_Bgdμ. for all metric balls B B_0 S, implies a variant of representation formula of fractonal integral type: |f(x)-f_(B(11))|≤C integral from n=B_(11) g(y)p(x, y)/μ(B(x, p(x, y)))dμ(y)+C(r(B_0))/(μ(B_0))integral from n=B_0 g(y)dμ(y). One of the main results of this paper shows that an L^1 to L^q Poincaré inequality for some 01, i.e.. (f_B|f-f_B|~q dv)^(1/q)≤cr(B) f_B gdμ, for all metric balls B B_0. will suffice to imply the above representation formula. As an immediate corollary, we can show that the weak-type condition. sup_(λ>0)(λv({x ∈ B:|f(x)-f_B|>λ}))/v(B)≤Gr (B)f_B gdμ. also implies the same formula. Analogous theorems related to high-order Poincaréinequalities and Sobolev spaces in metric spaces are also proved.

关键词： Sobolev spaces Representation formulas High-order derivatives Vector fields Metric spaces Polynomials Doubling measures Poincare inequalities

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Surrogate potency assays:Comparison of binding profiles complements dose response curves for unambiguous assessment of relative potencies

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Journal of Pharmaceutical Analysis 2018年第2期8卷 138-146页

作者： Robert Karlsson veronica Fridh Asa Frostell Purification and Analysis GE Healthcare Life SciencesUppsalaSweden

Surface plasmon resonance(SPR) systems are widely used for detailed characterization of antibody activities including antigen and Fc-receptor binding. During the later stages of development, where the focus is to ensure that established critical quality attributes(CQAs) are maintained during cell culture,purification and formulation processes, analysis is simplified, and relative potencies are often determined. Here, simulation of binding data revealed that relative potency values, determined via parallel line analysis(PLA) and half maximal effective concentration(EC50) analysis accurately reflect changes in active concentration only if binding kinetics remain unchanged. Changes in the association rate constant shifted dose response curves, and therefore relative potencies, in the same way as changes in analyte concentration do. However, for interactions characterized by stable binding, changes in the dissociation rate constant did not result in any shift, suggesting that this type of change may go unnoticed in the dose response curve. Thus, EC50 and PLA analyses of dose response curves obtained with an anti-TNF-α antibody were complemented with the Biacore functionality for sensorgram comparison analysis, whereby changes in antigen and Fc-receptor binding profiles could be detected. Next, analysis of temperature stressed TNF-α antibody revealed that calibration free concentration analysis(CFCA) data correlated perfectly with relative potency values. Together, these results demonstrate that combinations of SPR based dose response curves, sensorgram comparison and CFCA can be used to strengthen the confidence in relative potency assessments, and suggest that SPR can potentially be used as a surrogate potency assay in the quality control of biotherapeutic medicines.

关键词： Surface plasmon resonance EC50 Sensorgram comparison Calibration free concentration analysis Surrogate potency assay TNF-a

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Interactions between Axillary Branches of Arabidopsis

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Molecular Plant 2008年第2期1卷 388-400页

作者： veronica Ongaro Katherine Bainbridge Lisa Williamson Ottoline Leyser Department of Biology University of York PO Box 373--Area 11York YO10 5YW UK Present address: Institute of Plant Sciences University of Bern CH-3013 Bern Switzerland

Studies of apical dominance have benefited greatly from two-branch assays in pea and bean, in which the shoot system is trimmed back to leave only two active cotyledonary axillary branches. In these two-branch shoots, a large body of evidence shows that one actively growing branch is able to inhibit the growth of the other, prompting studies on the nature of the inhibitory signals, which are still poorly understood. Here, we describe the establishment of two-branch assays in Arabidopsis, using consecutive branches on the bolting stem. As with the classical studies in pea and bean, these consecutive branches are able to inhibit one another＇s growth. Not only can the upper branch inhibit the lower branch, but also the lower branch can inhibit the upper branch, illustrating the bi-directional action of the inhibitory signals. Using mutants, we show that the inhibition is partially dependent on the MAX pathway and that while the inhibition is clearly transmitted across the stem from the active to the inhibited branch, the vascular connectivity of the two branches is weak, and the MAX pathway is capable of acting unilaterally in the stem.

关键词： shoot branching auxin MAX vascularization.

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Micromechanical adaptation as a treatment for spinal cord injury

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Neural Regeneration Research 2019年第11期14卷 1909-1911页

作者： veronica estrada Hans werner Müller Molecular Neurobiology Laboratory Department of Neurology Heinrich-Heine-University Medical Center Düsseldorf

Spinal cord injury: Thus far injury of the spinal cord is incurable and, in the majority of cases, a devastating and life-changing event. The worldwide incidence rate of spinal cord injury (SCI) ranges from 250,000 to 900,000 (***, 2013;Kumar et al., 2018) new cases per year. SCI outcome includes the damage of axons, demyelination of axons, loss of signal transduction, and consequential long-lasting motor and sensory deficits. Additionally, the non-use of muscles can lead to atrophy and joint contractures, thereby further reducing the possibility of recovery. Depending on the spinal level and the severity of the injury, the extent of the damage can vary and spontaneous recovery is possible to varying degrees.

关键词： Micromechanical adaptation spinal cord injury spinal cord injury(SCI)

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Magnesium-based alloys with adapted interfaces for bone implants and tissue engineering

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Regenerative Biomaterials 2023年第1期10卷 1632-1692页

作者： Iulian Antoniac veronica Manescu(Paltanea) Aurora Antoniac Gheorghe Paltanea Faculty of Material Science and Engineering National University of Science and Technology POLITEHNICA Bucharest060042 BucharestRomania Academy of Romanian Scientists 050094 BucharestRomania Faculty of Electrical Engineering National University of Science and Technology POLITEHNICA Bucharest060042 BucharestRomania

Magnesium and its alloys are one of the most used materials for bone implants and tissue *** are characterized by numerous advantages such as biodegradability,high biocompatibility and mechanical properties with values close to the human ***,the implant surface must be adequately tuned,or Mg-based alloys must be alloyed with other chemical elements due to their increased corrosion effect in physiological *** article reviews the clinical challenges related to bone repair and regeneration,classifying bone defects and presenting some of the most used and modern therapies for bone injuries,such as Ilizarov or Masquelet techniques or stem cell *** implant interface challenges are related to new bone formation and fracture healing,implant degradation and hydrogen release.A detailed analysis of mechanical properties during implant degradation is extensively described based on different literature studies that included in vitro and in vivo tests correlated with material properties’***-based trauma implants such as plates and screws,intramedullary nails,Herbert screws,spine cages,rings for joint treatment and regenerative scaffolds are presented,taking into consideration their manufacturing technology,the implant geometrical dimensions and shape,the type of in vivo or in vitro studies and fracture *** technologies that modify or adapt the Mg-based implant interfaces are described by presenting the main surface microstructural modifications,physical deposition and chemical conversion *** last part of the article provides some recommendations from a translational perspective,identifies the challenges associated with Mg-based implants and presents some future *** review outlines the available literature on trauma and regenerative bone implants and describes the main techniques used to control the alloy corrosion rate and the cellular environment of the implant.

关键词： adapted interfaces bone tissue engineering fracture healing Mg-based alloys surface modifications

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Challenges and perspectives on high and intermediate-temperature sodium batteries

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Nano Research 2017年第12期10卷 4082-4114页

作者： Karina B. Hueso veronica Palomares Michel Armand Teofilo Rojo Inorganic Chemistry Department University of the Basque Country UPV/EHU P.O. Box. 644 48080 Bilbao Spain CIC ENERGIGUNE Parque Tecnologico de Alava Albert Einstein 48 ED. CIC 01510 Minano Spain

Energy storage systems are selected depending on factors such as storage capacity, available power, discharge time, self-discharge, efficiency, or durability. Additional parameters to be considered are safety, cost, feasibility, and environmental aspects. Sodium-based batteries （Na-S, NaNiC12） typically require operation temperatures of 300-350 ~C. The high operating temperatures substantially increase the operating costs and raise safety issues. This updated review describes the state-of-the-art materials for high-temperature sodium batteries and the trends towards the development and optimization of intermediate and low-temperature devices. Recent advances in inorganic solid electrolytes, glass-ceramic electrolytes, and polymer solid electrolytes are of immense importance in all-solid-state sodium batteries. Systems such as Na~ super ionic conductor （NASICON, Nal^xZr2PB-~SixOl2 （0 -〈 x _〈 3））, glass-ceramic 94Na3PS4＂6Na4SiS4, and polyethylene oxide （PEO）-sodium triflate （NaCF3SO3） are also discussed. Room temperature ionic liquids （RTILs） are also included as novel electrolyte solvents. This update discusses the progress of on-going strategies to enhance the conductivity, optimize the electrolyte/electrode interface, and improve the cell design of emerging technologies. This work aims to cover the recent advances in electrode and electrolyte materials for sodium- sulfur and sodium-metal-halide （zeolite battery research Africa project （ZEBRA）） batteries for use at high and intermediate temperatures.

关键词： sodium batteries high-temperature intermediate-temperature electrolytes

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