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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz veronica ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Axonal tuning by GABA_(A) receptor unveils novel tricks from an old dog

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Neural Regeneration Research 2023年第3期18卷 533-534页

作者： veronica Bonalume Valerio Magnaghi Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilanItaly

In the last years,axonal conductance of action potential trains became a novel subject of study,changing the view of axons,from a static cable-like compartment to a more complex and dynamic system(Debanne et al.,2011).Axonal computation,indeed,is canonically constituted by the action of voltage-gated ion channels,such as the classic Na+and K+channels,but recent studies demonstrated that it can be modulated by the action of other ion channel pumps,and metabolic factors(Byczkowicz et al.,2019;Zang and Marder.

关键词： tuning action classic

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Some facets of the Mg/Na_(3)VCr_(0.5)Fe_(0.5)(PO_(4))_(3) battery

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Chinese Chemical Letters 2024年第10期35卷 469-473页

作者： Gregorio F.ortiz Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021China

Magnesium rechargeable batteries(MRBs)present opportunities for grid-scale energy storage applications as a complement to Li-ion batteries(LIBS).The major challenges are the low reversible capacity,inferior cycling stability and unsatisfactory energy ***_(3)VCr_(0.5)Fe_(0.5)(PO_(4))_(3) with a well-defined NASIONtype structure is used as cathode in Mg ***-electrons reaction(~116 m Ah/g),1.5 V average voltage and 65%of capacity retention over 100 cycles are *** is inserted by a biphasic reaction with the participation of V3+/V4+/V5+redox couples in the electrochemical reaction while the non-active redox couples such as Cr^(3+)/Cr^(4+)and Fe^(2+)/Fe^(3+)served as stabilizer to buffer the volume variation.A thermal stability up to~412℃ is also ***,incorporating a mixture of three transition metal(V/Cr/Fe)in this type of structures will broaden new perspectives for realizing high performance cathodes for MRBs.

关键词： Multi-electron reaction Mg batteries NASICON Na_(3)VCr_(0.5)Fe_(0.5)(PO_(4))_(3) Ironand chromium doping

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Sensitivity of a solid Eu(Ⅲ) complex towards acetonitrile vapor:Structural and spectroscopic characterization

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Journal of Rare Earths 2020年第5期38卷 571-576页

作者： Fabio Piccinelli veronica Paterlini Magda Monari Marco Bettinelli Luminescent Materials Laboratory DBUniversita di Veronaand INSTMUdR VeronaStrada Le Grazie 1537134VeronaItaly Dipartimento di Chimica"G.Ciamician" Universita di BolognaVia Selmi 240126BolognaItaly

The Eu(Ⅲ)nitrate complex of the meso-N,N’-bis(2-pyridylmethylene)-1,2-(R,S)-cyclohexanediamine ligand was synthesized and characterized by single crystal and powder X-ray *** crystal lattice of the complex is capable of absorbing and desorbing selectively acetonitrile molecules,at 293 K upon an acetonitrile vapor pressure of^0.1×10^5 *** process,which is partially reversible,can be easily followed by both powder X-ray diffraction(P-XRD)and Eu(III)luminescence *** acetonitrile molecule,located in the outer coordination sphere of the metal ion,does not affect the radiative transition probability of 5 D0 level of Eu(Ⅲ)and also it does not activate further non-radiative channels from this *** the other hand,this molecule is capable of affecting the energy position and intensities of the crystal field components of the 5 D0→7 F2 *** complex in solid form can be considered a promising material for the optical sensing of acetonitrile vapors.

关键词： Eu(Ⅲ) X-ray diffraction Crystal structure Luminescence spectroscopy Rare earths

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Recovery of carbon monoxide from flue gases by reactive absorption in ionic liquid imidazolium chlorocuprate(I): Mass transfer coefficients

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Chinese Journal of Chemical Engineering 2015年第5期23卷 769-774页

作者： Gabriel Zarca Inmaculada ortiz Ane Urtiaga Department of Chemical and Biomolecular Engineering Universidad de Cantabria Av. Los Castros s/n.

Recovery of carbon monoxide from flue gases by selective absorption of carbon monoxide in an imidazolium chlorocuprate（l） ionic liquid is considered in this work as an alternative to the use of molecular volatile solvents such as aromatic hydrocarbons. The present work evaluates the CO mass transfer rates from the gas phase to the ionic liquid solutions in the absence of chemical reaction. To that end, carbon dioxide was employed as an inert model gas and absorption experiments were performed to assess the influence of different process variables in a batch reactor with fiat gas-liquid interface. The experimental mass transfer coefficients showed significant var- iation with temperature, （3.4-10.9） × 10^-7 m·s^-1 between 293 and 313 K; stirring speed, （10.2- 33.1）× 10^-7 m.s 1 between 100 and 300 r·min^-1; and concentration of copper（1）, （6.6-10.2） × 10^-7 m·s^-1 between 0.25 and 2 mol· L^- 1. In addition, the mass transfer coefficients were eventually found to follow a poten- tial proportionality of the type kL ∝μ^-0.5 and the dimensionless correlation that makes the estimation of the mass transfer coefficients possible in the studied range of process variables was obtained： Sh=10^-2.64 Re^1.07 , Sc^0.75,These results constitute the first step in the kinetic analysis of the reaction between CO and imidazolium chlorocuprate（I） ionic liquid that determines the design of the separation units.

关键词： Carbon monoxide Ionic liquid Copper(I)Reactive absorption Mass transfer kinetics Mass transfer coefficient Carbon dioxide

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Surrogate potency assays:Comparison of binding profiles complements dose response curves for unambiguous assessment of relative potencies

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Journal of Pharmaceutical Analysis 2018年第2期8卷 138-146页

作者： Robert Karlsson veronica Fridh Asa Frostell Purification and Analysis GE Healthcare Life SciencesUppsalaSweden

Surface plasmon resonance(SPR) systems are widely used for detailed characterization of antibody activities including antigen and Fc-receptor binding. During the later stages of development, where the focus is to ensure that established critical quality attributes(CQAs) are maintained during cell culture,purification and formulation processes, analysis is simplified, and relative potencies are often determined. Here, simulation of binding data revealed that relative potency values, determined via parallel line analysis(PLA) and half maximal effective concentration(EC50) analysis accurately reflect changes in active concentration only if binding kinetics remain unchanged. Changes in the association rate constant shifted dose response curves, and therefore relative potencies, in the same way as changes in analyte concentration do. However, for interactions characterized by stable binding, changes in the dissociation rate constant did not result in any shift, suggesting that this type of change may go unnoticed in the dose response curve. Thus, EC50 and PLA analyses of dose response curves obtained with an anti-TNF-α antibody were complemented with the Biacore functionality for sensorgram comparison analysis, whereby changes in antigen and Fc-receptor binding profiles could be detected. Next, analysis of temperature stressed TNF-α antibody revealed that calibration free concentration analysis(CFCA) data correlated perfectly with relative potency values. Together, these results demonstrate that combinations of SPR based dose response curves, sensorgram comparison and CFCA can be used to strengthen the confidence in relative potency assessments, and suggest that SPR can potentially be used as a surrogate potency assay in the quality control of biotherapeutic medicines.

关键词： Surface plasmon resonance EC50 Sensorgram comparison Calibration free concentration analysis Surrogate potency assay TNF-a

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Interactions between Axillary Branches of Arabidopsis

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Molecular Plant 2008年第2期1卷 388-400页

作者： veronica Ongaro Katherine Bainbridge Lisa Williamson Ottoline Leyser Department of Biology University of York PO Box 373--Area 11York YO10 5YW UK Present address: Institute of Plant Sciences University of Bern CH-3013 Bern Switzerland

Studies of apical dominance have benefited greatly from two-branch assays in pea and bean, in which the shoot system is trimmed back to leave only two active cotyledonary axillary branches. In these two-branch shoots, a large body of evidence shows that one actively growing branch is able to inhibit the growth of the other, prompting studies on the nature of the inhibitory signals, which are still poorly understood. Here, we describe the establishment of two-branch assays in Arabidopsis, using consecutive branches on the bolting stem. As with the classical studies in pea and bean, these consecutive branches are able to inhibit one another＇s growth. Not only can the upper branch inhibit the lower branch, but also the lower branch can inhibit the upper branch, illustrating the bi-directional action of the inhibitory signals. Using mutants, we show that the inhibition is partially dependent on the MAX pathway and that while the inhibition is clearly transmitted across the stem from the active to the inhibited branch, the vascular connectivity of the two branches is weak, and the MAX pathway is capable of acting unilaterally in the stem.

关键词： shoot branching auxin MAX vascularization.

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An Efficient Representation of Quadtrees and Bintrees for Multiresolution Terrain Models

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Geo-Spatial Information Science 2011年第3期14卷 198-206页

作者： Yusnier Valle José ortiz Center of Geoinformatics and Digital Signals University of Informatics Sciences Dean of the Faculty 1 University of Informatics Sciences

A space-filling curve in 2,3,or higher dimensions can be thought as a path of a continuously moving *** its main goal is to preserve spatial proximity,this type of curves has been widely used in the design and implementation of spatial data structures and nearest neighbor-finding *** paper is essentially focused on the efficient representation of Digital Ele-vation Models(DEM) that entirely fit into the main *** propose a new hierarchical quadtree-like data structure to be built over domains of unrestricted size,and a representation of a quadtree and a binary triangles tree by means of the Hilbert and the Sierpinski space-filling curves,respectively,taking into account the hierarchical nature and the clustering properties of this kind of *** triangulation schemes are described for the space-filling-curves-based approaches to efficiently visualize multiresolu-tion surfaces.

关键词： bintrees quadtrees space-filling curves spatial data structures digital terrain models

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Micromechanical adaptation as a treatment for spinal cord injury

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Neural Regeneration Research 2019年第11期14卷 1909-1911页

作者： veronica estrada Hans werner Müller Molecular Neurobiology Laboratory Department of Neurology Heinrich-Heine-University Medical Center Düsseldorf

Spinal cord injury: Thus far injury of the spinal cord is incurable and, in the majority of cases, a devastating and life-changing event. The worldwide incidence rate of spinal cord injury (SCI) ranges from 250,000 to 900,000 (***, 2013;Kumar et al., 2018) new cases per year. SCI outcome includes the damage of axons, demyelination of axons, loss of signal transduction, and consequential long-lasting motor and sensory deficits. Additionally, the non-use of muscles can lead to atrophy and joint contractures, thereby further reducing the possibility of recovery. Depending on the spinal level and the severity of the injury, the extent of the damage can vary and spontaneous recovery is possible to varying degrees.

关键词： Micromechanical adaptation spinal cord injury spinal cord injury(SCI)

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