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Schwann cell development,maturation and regeneration：a focus on classic and emerging intracellular signaling pathways

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Neural Regeneration Research 2017年第7期12卷 1013-1023页

作者： Luca Franco Castelnovo veronica bonalume Simona Melfi Marinella Ballabio Deborah Colleoni Valerio Magnaghi Dipartimento di Scienze Farmacologiche e Biomolecolari Universita degli Studi di Milano Milan Italy

The development,maturation and regeneration of Schwann cells（SCs）,the main glial cells of the peripheral nervous system,require the coordinate and complementary interaction among several factors,signals and intracellular pathways.These regulatory molecules consist of integrins,neuregulins,growth factors,hormones,neurotransmitters,as well as entire intracellular pathways including protein-kinase A,C,Akt,Erk/MAPK,Hippo,mTOR,etc.For instance,Hippo pathway is overall involved in proliferation,apoptosis,regeneration and organ size control,being crucial in cancer proliferation process.In SCs,Hippo is linked to merlin and YAP/TAZ signaling and it seems to respond to mechanic/physical challenges.Recently,among factors regulating SCs,also the signaling intermediates Src tyrosine kinase and focal adhesion kinase（FAK）proved relevant for SC fate,participating in the regulation of adhesion,motility,migration and in vitro myelination.In SCs,the factors Src and FAK are regulated by the neuroactive steroid allopregnanolone,thus corroborating the importance of this steroid in the control of SC maturation.In this review,we illustrate some old and novel signaling pathways modulating SC biology and functions during the different developmental,mature and regenerative states

关键词： myelin neuroactive steroids electromagnetic field peripheral nervous system

Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： YANG Le Mei ZHENG Qi LIU Xiao Jia LI Xian Xian veronica Lim CHEN Qi ZHAO Zhong Hua WANG Shu Yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,respectively.Dual-luciferase reporter gene assay was used to determine the target gene of miR-224-5p.The protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western blot.Flow cytometry was used to detect cell cycle and apoptosis.Cell proliferation was measured by CCK8 and EdU assay.Results The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC stage.CRC cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or paracrine.Moreover,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC tissues.Interestingly,ULK2 inhibited CRC cell proliferation in a p53-dependent manner.Furthermore,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC cells.Conclusion Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

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自动化技术助力绿氢安全高效生产

流程工业 2024年第5期 32-34页

作者： veronica Constantin 艾默生

自动化技术在推动向清洁燃料经济转型的过程中扮演着至关重要的角色,本文讲述了自动化技术是如何促进更安全且高效的绿氢生产。绿氢生产目前正处于其发展的初级阶段,伴随着行业的逐步探索与成长,短期内确实可能面临更为复杂的安全挑战... 详细信息

自动化技术在推动向清洁燃料经济转型的过程中扮演着至关重要的角色,本文讲述了自动化技术是如何促进更安全且高效的绿氢生产。绿氢生产目前正处于其发展的初级阶段,伴随着行业的逐步探索与成长,短期内确实可能面临更为复杂的安全挑战。氢作为一种能源载体,如同所有可燃物质一样,具有相应的潜在危险。其高度易燃的特性意味着即使氢气与空气的混合比例很低——低至空气中氢气含量达到4%时,就足以构成爆炸风险。

关键词：自动化技术经济转型能源载体潜在危险氢气含量混合比例清洁燃料安全挑战

Bloom-forming cyanobacteria and dinoflagellates in five Argentinian reservoirs:Multi-year sampling

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Water Biology and Security

Water Biology and Security 2024年第1期3卷 28-36页

作者： Florencia Soledad Alvarez Dalinger Borja Claudia Nidia veronica Laura Lozano Liliana Beatriz Morana María Monica Salusso Facultad de Ciencias Naturales Universidad Nacional de SaltaAvenida Bolivia 5150Salta4400Argentina Consejo Nacional de Investigaciones Científicas y T'ecnicas(CONICET) Godoy Cruz 2290Ciudad Autonoma de Buenos AiresArgentina

Harmful algal blooms are important threats to reservoir condition.Over a 15-year period,we sampled five Argentinian reservoirs to identify the responsible species for harmful algal blooms and determine the water quality factors driving their occurrence.These reservoirs exhibit diverse morphological and hydrological characteristics and are distributed across varying climatic zones.Cyanobacterial blooms included an array of species,including toxin producers such as Raphidiopsis raciborskii,Aphanizomenon gracile,and Microcystis aeruginosa.In contrast,dinoflagellate blooms were predominantly characterized by Ceratium.The cyanobacterial blooms primarily occurred in the shallower reservoirs located in warmer regions,whereas dinoflagellate blooms occurred where temperatures were lower.The most intense blooms occurred during the summer,and although cyanobacterial and chlorophyte blooms co-occurred,they never coexisted with dinoflagellate blooms.We identified cyanotoxins in the reservoirs over the past three years,a phenomenon previously unreported in the region.Given that these reservoirs are drinking water sources for human populations,ongoing and systematic monitoring is needed to protect public health.Controlling the proliferation of algae and cyanobacteria in reservoirs requires resource management at the watershed level,and in the case of the Itiyuro and El Limon,requires binational management with Bolivia.

关键词： HABs Freshwater South America Toxins

Don’t stop me now, I’m having such a good time! Czechoslovakian wolfdogs renovate the motivation to play with a bow

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Current Zoology 2023年第1期69卷 50-58页

作者： veronica Maglieri Anna Zanoli Fosca Mastrandrea Elisabetta Palagi Unit of Ethology Department of BiologyUniversity of PisaPisa 56126Italy Department of Life Sciences and Systems Biology University of TurinTorino 10123Italy

Dogs engage in play behavior at every age and the play bow is their most iconic playful posture.However,the function of this posture is still under debate.Here,we selected the Czechoslovakian Wolfdog(CWD)as a model breed to clarify the function of the play bow.We analyzed frame-by-frame 118 sessions of 24 subjects and recorded 76 play bow events.We found that all the play bows were performed in the visual field of the playmate suggesting that the sender takes into account the attentional state of the receiver when releasing the signal.By drawing survival curves and using log-rank test we found that play bow was mainly performed during a short pause in an ongoing session and that its performance triggered the playmate’s reaction again.These findings show that play bow functions in restoring the partner motivation to play.Finally,by using a sequential analysis and a generalized mixed model,we found no evidence supporting the metacommunicative function of the play bow.The signal did not necessarily precede a contact offensive behavior(e.g.,play biting and play pushing)and it was not affected by the level of asymmetry of the play session.In conclusion,in CWDs play bow can be considered a visual signal useful to maintain the motivation to play in the receiver.Therefore,we suggest that the mismatched number of play bows emitted by the 2 players in a given session can be predictive of their different motivations to play.

关键词： Canis lupus familiaris first-order intentionality metacommunication motivation play fighting wolf-like traits

Functional in vivo assessment of stem cell-secreted pro-oligodendroglial factors

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Neural Regeneration Research 2022年第10期17卷 2194-2196页

作者： Jessica Schira-Heinen Iria Samper Agrelo veronica Estrada Patrick Küry Department of Neurology Neuroregeneration LaboratoryMedical FacultyHeinrich-Heine-UniversityDüsseldorfGermany

The role of adult neural stem cells(NSCs)in demyelinating diseases of the central nervous system(CNS):Multipotent NSCs hold great potential for cell replacement in diseases and upon injury of the CNS.Originating from radial glial cells during nervous system development,adult NSCs are localized in the subgranular zone of the hippocampus and the subventricular zone(SVZ)of the lateral brain ventricles,the main neurogenic zones of the adult brain.Hippocampal precursor cells(type 1 cells)exhibiting properties of radial glial cells give rise to granule neurons through distinct intermediate precursor cells,and integrate into the hippocampal circuitry[reviewed by Kempermann et al.(2015)].Likewise,under physiological conditions,neuron generation by mouse SVZ-derived NSCs(also known as type B cells)is the predominant cell fate,which thereby results in large numbers of transient amplifying precursor cells(also known as type C cells)which in turn differentiate into neuroblasts(type A cells).These cells migrate along the rostral migratory stream into the olfactory bulb where they undergo maturation into local interneurons.The structure of the rodent SVZ differs from that of the human SVZ since the proliferative capacity is reduced,and migration of neuroblasts is a rare event in adult humans[reviewed by Lim and Alvarez-Buylla(2016)].

关键词： thereby migrate predominant

Stem cells as an option for the treatment of COVID-19

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World Journal of Clinical Cases 2022年第18期10卷 6338-6340页

作者： Maria veronica Cuevas-González Juan Carlos Cuevas-González Institute of Biomedical Sciences Universidad Autonoma de Ciudad JuarezJuarez 32310ChihuahuaMexico Institute of Biomedical Sciences Autonomous University of Ciudad JuárezCiudad Juarez 32310ChihuahuaMexico

The application of stem cells is among the many strategies currently available for the treatment of multiple diseases.Stem cells are characterized as undifferentiated cells that have the ability to differentiate towards multiple lineages and selfrenewal,among other attributes.Since the first umbilical cord stem cell transplant for the treatment of Fanconi anemia,the use of stem cells for the treatment of multiple diseases,including coronavirus disease 2019,has increased,showing promising results that require evaluation through research studies that include a longer follow-up time.Therefore,the main objective of this Letter is to provide an update on the use of stem cells in the treatment of severe acute respiratory syndrome coronavirus 2,as well as identify the main challenges and limitations presented by this type of therapy.

关键词： COVID-19 Stem cells Multiple diseases Undifferentiated cells Appropriate treatment Cytokines granulocyte-macrophage colony-stimulating factor

Failure of levees induced by toe uplift:Investigation of post-failure behavior using material point method

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第4期15卷 970-983页

作者： veronica Girardi Francesca Ceccato Alex Rohe Paolo Simonini Fabio Gabrieli University of Padua Department of CivilEnvironmental and Architectural EngineeringVia Ognissanti 39PaduaItaly GeoHal Graswinckelstraat 50DelftNetherlands

Levees are essential structures in flood defense systems,and their failures can lead to devastating consequences on the surrounding territories.One of the failure mechanisms mostly controlled by the foundation soil stratigraphy is the instability of the land side slope,triggered by the development of high uplift pressures in the foundation.This complex phenomenon has been investigated experimentally with centrifuge tests or large-scale tests and numerically with the limit equilibrium method(LEM)and the finite element method(FEM).In this work,we applied a multiphase formulation of the material point method(MPM)to analyze the development of toe uplift instability mechanism,from the onset of failure to large displacements.The numerical model is inspired by an experiment carried out in a geotechnical centrifuge test by Allersma and Rohe(2003).The comparison with the experiment allows for understanding critical pore pressure triggering large displacements in the foundation soils.Moreover,we numerically evaluated the impact of different values of foundation soils’hydraulic conductivity on the failure mechanism.The results show that hydraulic conductivity mainly influences the time of failure onset and the extension of shear localization at depth.Finally,the advantages of using large displacement approaches in the safety assessment of earth structures are discussed.Unlike FEM,there are no issues with element distortions generating difficulties with numerical convergence,allowing for full postfailure reproduction.This capability permits precise quantification of earth structure damages and post-failure displacements.The ensuing reinforcement systems’design is no longer over-conservative,with a significant reduction in associated costs.

关键词： Slopes safety assessment Levees Uplift pressure Large deformation analysis

Diversity of Arbuscular Mycorrhizal Fungi Associated with Six Rice Cultivars in Italian Agricultural Ecosystem Managed with Alternate Wetting and Drying

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Rice science 2023年第4期30卷 348-358,I0028-I0030页

作者： veronica VOLPE Franco MAGURNO Paola BONFANTE Stefano GHIGNONE Erica LUMINI Department of Life Sciences and Systems Biology University of TurinV.le P.A.Mattioli 25I-10125 TurinItaly Institute of Biology Biotechnology and Environmental ProtectionFaculty of Natural SciencesUniversity of Silesia in KatowiceJagiellońska 28Katowice 40-032Poland Institute for Sustainable Plant Protection-Turin Unit National Research Council of ItalyV.le P.A.Mattioli 25I-10125 TurinItaly

Alternate wetting and drying(AWD)system,in which water has been reduced by approximately 35%with an increased occurrence of beneficial arbuscular mycorrhizal(AM)symbiosis and no negative impact on rice yield,was proposed to utilize water and nutrients more sustainable.In this study,we selected six rice cultivars(Centauro,Loto,Selenio,Vialone nano,JSendra and Puntal)grown under AWD conditions,and investigated their responsiveness to AM colonization and how they select diverse AM taxa.In order to investigate root-associated AM fungus communities,molecular cloning-Sanger sequencing on small subunit rDNA data were obtained from five out of the six rice cultivars and compared with Next Generation Sequencing(NGS)data,which were previously obtained in Vialone nano.The results showed that all the cultivars were responsive to AM colonization with the development of AM symbiotic structures,even if with differences in the colonization and arbuscule abundance in the root systems.We identified 16 virtual taxa(VT)in the soil compartment and 7 VT in the root apparatus.We emphasized that the NGS analysis gives additional value to the results thanks to a more in-depth reading of the less represented AM fungus taxa.

关键词： alternate wetting and drying system arbuscular mycorrhizal fungi rice molecular diversity virtual taxa