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Neural Regeneration Research 2017年第7期12卷 1013-1023页

作者： Luca Franco Castelnovo veronica Bonalume Simona Melfi Marinella Ballabio Deborah Colleoni Valerio Magnaghi Dipartimento di Scienze Farmacologiche e Biomolecolari Universita degli Studi di Milano Milan Italy

The development,maturation and regeneration of Schwann cells（SCs）,the main glial cells of the peripheral nervous system,require the coordinate and complementary interaction among several factors,signals and intracellular *** regulatory molecules consist of integrins,neuregulins,growth factors,hormones,neurotransmitters,as well as entire intracellular pathways including protein-kinase A,C,Akt,Erk/MAPK,Hippo,mTOR,*** instance,Hippo pathway is overall involved in proliferation,apoptosis,regeneration and organ size control,being crucial in cancer proliferation *** SCs,Hippo is linked to merlin and YAP/TAZ signaling and it seems to respond to mechanic/physical ***,among factors regulating SCs,also the signaling intermediates Src tyrosine kinase and focal adhesion kinase（FAK）proved relevant for SC fate,participating in the regulation of adhesion,motility,migration and in vitro *** SCs,the factors Src and FAK are regulated by the neuroactive steroid allopregnanolone,thus corroborating the importance of this steroid in the control of SC *** this review,we illustrate some old and novel signaling pathways modulating SC biology and functions during the different developmental,mature and regenerative states

关键词： myelin neuroactive steroids electromagnetic field peripheral nervous system

Risk factors for suicidal behaviour in late-life depression:A systematic review

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World Journal of Psychiatry 2022年第1期12卷 187-203页

作者： veronica Fernandez-Rodrigues Yolanda Sanchez-Carro Luisa Natalia Lagunas Laura Alejandra Rico-Uribe Andres Pemau Patricia Diaz-Carracedo Marina Diaz-Marsa Gonzalo Hervas Alejandro de la Torre-Luque Department of Psychology Universidad Complutense de MadridMadrid 28223Spain Department of Psychiatry Universidad Autonoma de MadridMadrid 28046Spain Centre for Biomedical Research in Mental Health(CIBERSAM) Madrid 28029Spain Department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28046Spain of Psychology La Rioja International UniversityLogrono 26006Spain Institute of Psychiatry and Mental Health San Carlos Clinical HospitalMadrid 28040Spain

BACKGROUND Suicide is a leading cause of preventable death worldwide,with its peak of maximum incidence in later *** often puts an individual at higher risk for suicidal *** turn,depression deserves particular interest in old age due to its high prevalence and dramatic impact on health and *** To gather integrated evidence on the potential risk factors for suicide behaviour development in depressive older adults,and to examine the effects of depression treatment to tackle suicide behaviour in this *** A systematic review of empirical studies,published from 2000 onwards,was *** behaviour was addressed considering its varying forms(i.e.,wish to die,ideation,attempt,and completed suicide).RESULTS Thirty-five papers were selected for review,comprising both clinical and epidemiological *** of studies focused on suicidal ideation(60%).The studies consistently pointed out that the risk was related to depressive episode severity,psychiatric comorbidity(anxiety or substance use disorders),poorer health status,and loss of *** social support and loneliness were also associated with suicide behaviour in depressive older ***,the intervention studies showed that suicidal behaviour was a robust predictor of depression treatment *** in suicidal ideation were moderated by reductions in risk factors for suicide *** To sum up,common and age-specific risk factors seem to be involved in suicide development in depressive older adults.A major effort should be made to tackle this serious public health concern so as to promote older people to age healthily and well.

关键词： Late-life depression Suicide behaviour Disability Chronic disease Loneliness

Role of myelin auto-antigens in pain:a female connection

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Neural Regeneration Research 2016年第6期11卷 890-891页

作者： veronica I.Shubayev Alex Y.Strongin Tony L.Yaksh Department of Anesthesiology University of CaliforniaSan DiegoLa JollaCAUSA VA San Diego Healthcare System La JollaCAUSA Sanford-Burnham-Prebys Medical Discovery Institute La jollaCAUSA

Following injury to the peripheral nerve,pain secondary to low threshold innocuous mechanical stimulation（mechanical allodynia）is commonly *** origins are poorly understood and the pain is often refractory to common analgesic *** past two decades has brought major advances in our understanding of the complexity of systems that underlie processing of neuropathic pain（pain arising from damage or disease of the somatosensory system）.

关键词： myelin understood stimulation poorly refractory analgesic microglia immunity signaling likely

Cost-effective hybrid long-short read assembly delineates alternative GC-rich Streptomyces hosts for natural product discovery

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Synthetic and Systems Biotechnology 2023年第2期8卷 253-261页

作者： Elena Heng Lee Ling Tan Dillon W.P.Tay Yee Hwee Lim Lay-Kien Yang Deborah C.S.Seow Chung Yan Leong veronica Ng Siew Bee Ng Yoganathan Kanagasundaram Fong Tian Wong Lokanand Koduru Molecular Engineering Laboratory Institute of Molecular and Cell Biology(IMCB)Agency for ScienceTechnology and Research(A*STAR)61 Biopolis Drive#07-06ProteosSingapore138673Singapore Green Chemistry and Biocatalysis Institute of Sustainability for ChemicalsEnergy and Environment(ISCE2)Agency for ScienceTechnology and Research(A*STAR)8 Biomedical GroveNeuros#07-01Singapore138665Singapore Singapore Institute of Food and Biotechnology Innovation(SIFBI) Agency for ScienceTechnology and Research(A*STAR)31 Biopolis WayLevel 2NanosSingapore138669Singapore

With the advent of rapid automated in silico identification of biosynthetic gene clusters(BGCs),genomics pre-sents vast opportunities to accelerate natural product(NP)***,prolific NP producers,Strepto-myces,are exceptionally GC-rich(>80%)and highly repetitive within *** pose challenges in sequencing and high-quality genome assembly which are currently circumvented via intensive ***,we outline a more cost-effective workflow using multiplex Illumina and Oxford Nanopore sequencing with hybrid long-short read assembly algorithms to generate high quality *** protocol involves subjecting long read-derived assemblies to up to 4 rounds of polishing with short reads to yield accurate BGC *** successfully sequenced and assembled 8 GC-rich Streptomyces genomes whose lengths range from 7.1 to 12.1 Mb with a median N50 of 8.2 *** analysis revealed previous misrepresentation among these strains and allowed us to propose a potentially new species,Streptomyces *** comprehensive characterization of their biosynthetic,pan-genomic and antibiotic resistance features especially for molecules derived from type I polyketide synthase(PKS)BGCs reflected their potential as alternative NP ***,the genome assemblies and insights presented here are envisioned to serve as gateway for the scientific community to expand their avenues in NP discovery.

关键词： Streptomyces GC-Rich Hybrid assembly Biosynthetic gene cluster(BGC) Natural product(NP)chassis Type I polyketide Synthase(PKS)

The role of genomic structural variation in the genetic improvement of polyploid crops

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The Crop Journal 2019年第2期7卷 127-140页

作者： Sarah-veronica Schiessl Elvis Katche Elizabeth Ihien Harmeet Singh Chawla Annaliese S.Mason Department of Plant Breeding Justus Liebig University

Many of our major crop species are polyploids, containing more than one genome or set of chromosomes. Polyploid crops present unique challenges, including difficulties in genome assembly, in discriminating between multiple gene and sequence copies, and in genetic mapping, hindering use of genomic data for genetics and breeding. Polyploid genomes may also be more prone to containing structural variation, such as loss of gene copies or sequences(presence–absence variation) and the presence of genes or sequences in multiple copies(copynumber variation). Although the two main types of genomic structural variation commonly identified are presence–absence variation and copy-number variation, we propose that homeologous exchanges constitute a third major form of genomic structural variation in polyploids. Homeologous exchanges involve the replacement of one genomic segment by a similar copy from another genome or ancestrally duplicated region, and are known to be extremely common in polyploids. Detecting all kinds of genomic structural variation is challenging, but recent advances such as optical mapping and long-read sequencing offer potential strategies to help identify structural variants even in complex polyploid genomes. All three major types of genomic structural variation(presence–absence, copy-number, and homeologous exchange) are now known to influence phenotypes in crop plants, with examples of flowering time, frost tolerance, and adaptive and agronomic traits. In this review,we summarize the challenges of genome analysis in polyploid crops, describe the various types of genomic structural variation and the genomics technologies and data that can be used to detect them, and collate information produced to date related to the impact of genomic structural variation on crop phenotypes. We highlight the importance of genomic structural variation for the future genetic improvement of polyploid crops.

关键词： Presence–absence variation Copy-number variation Homeologous exchanges Genome structure Pan-genome

Genetic Structure and Diversity Study of Cassava (Manihot esculenta) Germplasm for African Cassava Mosaic Disease and Fresh Storage Root Yield

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Open Journal of Genetics 2023年第1期13卷 23-47页

作者： Janatu veronica Sesay Aiah Lebbie Richard Wadsworth Ephraim Nuwamanya Souleymane Bado Prince Emmanuel Norman Sierra Leone Agricultural Research Institute PMB 1313 Tower Hill Freetown Sierra Leone Department of Biological Sciences School of Environmental Sciences Njala University Njala Sierra Leone Makerere University Kampala Kampala Uganda Department of Plant Science Phytoprise GmbH DI Rudolf Schober-StraBe 4 7400 Oberwart Oberwart Austria

A better understanding of population structure and genetic diversity among cassava germplasm for African cassava mosaic disease and fresh root yield traits is useful for cassava improvement programme. Phenotype-based selection for these traits is cumbersome due to phenotypic plasticity and difficulty in screening of phenotypic-induced variations. This study assessed quantitative trait loci (QTL) regions associated with African cassava mosaic disease (ACMD) and fresh storage root yield (FSRY) in 131 cassava (Manihot esculenta) genotypes using a genome-wide association study (GWAS). The single nucleotide polymorphism (SNP) loci and associated candidate genes, when validated, would be a valuable resource for marker-assisted selection in the breeding process for development of new cassava genotypes with improved resistance to ACMD and desirable high root yield. Population structure analysis using 12,500 SNPs differentiated the 131 genotypes into five distinct sub-groups (K = 5). Marker-trait association (MTA) analysis using the generalized linear model identified two QTL regions significant for ACMD and three for FSRY. This study demonstrated that DArTseq markers are useful genomic resources for genome-wide association studies of ACMD and FSRY traits in cassava for the acceleration of varietal development and release.

关键词： Population Structure Genetic Variability GWAS SNP Markers Cassava

Pathways towards the integration of periurban agrarian ecosystems into the spatial planning system

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Ecological Processes 2014年第1期3卷 67-82页

作者： Marian Simon Rojo Ana Zazo Moratalla Nerea Moran Alonso veronica Hernandez Jimenez GIAUS(Architecture Urbanism and Sustainability Research Group)School of ArchitectureTechnical University of MadridAvda.Juan de Herrera s/n.28040 MadridSpain ECOPAI(Ecology and Landscape Research Group) School of ForestryPolytechnical University of MadridAvda.Ramiro de Maeztu s/n.28040 MadridSpain

Introduction:The potential of periurban agrarian ecosystems is recognized as one of the cornerstones for improving urban sustainability;however,this potential has been disregarded in spatial planning and decision *** main goal of the PAEc-SP project was to assess the feasibility of integrating periurban agricultural areas into spatial planning by developing a viable ecosystem services-based ***:The research unfolded along three axes:i)mapping ecosystem services in periurban areas,distinguishing between the current state and the future potential by applying a set of indicators;ii)analyzing the regulatory framework,identifying gaps in the consideration of agrarian ecosystem services;and iii)analyzing the perceptions of these areas held by local *** services(food)are widely recognized by actors and plans,but this leads to weak ***:Cultural services(identity,recreation)are also recognized by all actors and addressed by local urban planning,though this is not connected to farming *** services(CO_(2) storage,water quality)are barely addressed by spatial planning and actors do not value them *** services(biodiversity)are mostly associated with natural *** technicians are reluctant to changes,while new farmers and civil society demand a new holistic ***:The reluctant attitude to change of some actors and the inadequate understanding of ecosystem services,render it imperative to adopt a comprehensive approach through a participatory process of urban *** ecosystem services,calculations,and graphs are a valuable communication tool both in discussing the consequences of the loss of agrarian ecosystems with different actors and in planning future scenarios.

关键词： Ecosystem service indicators Institutional inertia Land use planning Participatory mapping Periurban farming Rural-urban fringe

Development and validation of a novel PCR-RFLP based method for the detection of 3 primary mitochondrial mutations in Leber's hereditary optic neuropathy patients

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Eye and Vision 2015年第1期2卷 170-176页

作者： Siobhan Eustace Ryan Fergus Ryan David Barton veronica O’Dwyer Derek Neylan National Optometry Centre Dublin Institute of TechnologyKevin StreetDublin 8Ireland School of Biological Sciences Dublin Institute of TechnologyKevin StreetDublin 8Ireland Centre for Medical Genetics Our Lady’s Hospital for Sick ChildrenCrumlinDublin 12Ireland

Background:Leber’s Hereditary Optic Neuropathy(LHON;MIM 535000)is one of the most commonly inherited optic neuropathies and it results in significant visual morbidity among young adults with a peak age of onset between the ages of 15–*** worldwide incidence of LHON is approximately 1 in 31,000.95%of LHON patients will have one of 3 primary mitochondrial mutations,G3460A(A52T of ND1),G11778A(R340H of ND4)and T14484C(M64V of ND6).There is incomplete penetrance and a marked gender bias in the development of visual morbidity with approximately 50%of male carriers and 10%of female carriers developing optic *** recovery can occur but is dependent on the mutation present with the highest level of visual recovery seen in patients who have the T14484C *** 3 primary mutations are typically identified by individual end-point PCR-restriction fragment length polymorphism(RFLP)or individual targeted bi-directional Sanger sequencing *** purpose of this study was to design a simple multiplex PCR-RFLP that could detect these 3 primary LHON mutations in one ***:PCR primers were designed to incorporate a MaeIII restriction site in the presence of 3460A and 14484C mutations with the 11778A mutation naturally incorporating a MaeIII site.A multiplex PCR-RFLP assay was developed to detect the 3 common mutations in a single *** LHON controls based on the mitochondrial genome harbouring the 3 common mutations were synthesized and cloned into plasmids to act as reliable assay *** from previously tested patients and the synthetic LHON controls were subjected to the multiplex PCR-RFLP *** RFLP products were detected by agarose gel ***:The novel PCR-RFLP assay accurately detects the 3 primary mutations both in patient DNA and in synthesized DNA control samples with a simple visual mutation detection *** synthesized DNA was demonstrated to be a robust control for the detection of LHON Mutations

关键词： LHON Mitochondrial mutations Mutation detection Visual morbidity Multiplex PCR

Essential oils as solvents and core materials for the preparation of photo-responsive polymer nanocapsules

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Nano Research 2018年第5期11卷 2783-2795页

作者： Valentina Marturano Valentina Bizzarro Adriana De Luise Anna Calarco veronica Ambrogi Marta Giamberini Bartosz Tylkowski Pierfrancesco Cerruti Department of Chemical Sciences University of Naples "Federico Ⅱ" Via Cynthia 4 Napoli 80125 Italy Institute for Polymers Composites and Biomaterials (IPCB-CNR) Via Campi Flegrei 34 Pozzuoli (NA) 80078 Italy Institute of Agro-Environmental and Forest Biology (IBAF-CNR) Via Pietro Castellino 111 Napoli 80131 Italy Department of Chemical Materials and Production Engineering (DICMAPI) University of Naples "Federico Ⅱ" P. le Tecchio 80 Napoli 80125 Italy Department of Chemical Engineering (DEQ) Universitat Rovira i Virgili Av. Pa'fsos Catalans 26 Tarragona 43007 Spain Chemistry Technology Centre of Catalonia (CTQC) C/Marcel-Ⅱ Domingo Tarragona 43007 Spain

Light-triggered release of active ingredients from polymeric nanosized capsules can be employed in a wide range of applications, such as biomedicine, active packaging, and cosmetics. However, the preparation of core-shell polymeric nanocarriers typically involves the use of toxic organic solvents. To improve the sustainability and safety of nanocapsule applications, we demonstrate that natural essential oils can be used both as solvent and active material in light-responsive nanocapsules synthesized via miniemulsion polycondensation. The documented antimicrobial, anti-inflammatory, and antioxidant activity of essential oils enables the design of multipurpose light-responsive delivery platforms. The photo-responsive behavior of the capsules, achieved by means of photochromic azobenzene segments embedded in the capsule shell, is triggered by UV light irradiation （λmax= 360 nm）. Light-induced release kinetics of the essential oils and a fluorescent probe molecule, coumarin-6, is evaluated via UV-vis spectroscopy and spectrofluorimetry, respectively, demonstrating the efficiency and reliability of the release mechanism. Biological tests prove that the capsules are non-cytotoxic and readily internalized by cells, indicating the suitability of these smart nanocarriers for biological applications.

关键词： light-responsive polymer nanocapsules essential oils azobenzene controlled release cytotoxicity

Chinese employees＇ leadership preferences and the relationship with power distance orientation and core self-evaluation

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Frontiers of Business Research in China 2018年第1期12卷 15-36页

作者： Cai-Hui veronica Lin Jian-Min James Sun School of Labor and HumanResources Renmin University ofChina Beijing China Full list ofauthor information isavailable at the end of the article

Informed by implicit leadership theories, this study investigates contemporary Chinese employees＇ preferences for paternalistic leadership （including three components： moral leadership, benevolent leadership and authoritarian leadership） and transformational leadership. It further examines the relationship between power distance orientation, core self-evaluation （CSE） and leadership preferences. The study finds that contemporary Chinese employees most prefer moral leadership, but are also highly receptive to transformational leadership. They prefer authoritarian leadership least. Moreover, preferences for authoritarian leadership are predicated on followers＇ power distance orientation. However, the opposite is true for moral leadership. CSE is positively related to followers＇ preference for authoritarian leadership, benevolent leadership and transformational leadership, but not except for moral leadership. A positive interaction effect is found between power distance orientation and CSE with regard to authoritarian leadership preference. The theoretical and practical implications of the findings are discussed.

关键词： Contemporary Chinese employees Leadership preference Power distanceorientation Core self-evaluation (CES)