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Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract

World Journal of Gastroenterology 2017年第25期23卷 4500-4507页

作者： Andrea Ferrigno Clarissa Berardo Laura G Di Pasqua veronica Siciliano Plinio Richelmi Mariapia Vairetti Department of Internal Medicine and Therapeutics (Cellular and Molecular Pharmacology and Toxicology) University of Pavia

Metabotropic glutamate receptor subtype 5(mGluR5) is a Group I mGlu subfamily of receptors coupled to the inositol trisphosphate/diacylglycerol pathway. Like other m Glu R subtypes, mGluR5 s contain a phylogenetically conserved, extracellular orthosteric binding site and a more variable allosteric binding site, located on the heptahelical transmembrane domain. The mGluR5 receptor has proved to be a key pharmacological target in conditions affecting the central nervous system(CNS) but its presence outside the CNS underscores its potential role in pathologies affecting peripheral organs such as the gastrointestinal(GI) tract and accessory digestive organs such as the tongue, liver and pancreas. Following identification of mGluR5s in the mouth, various studies have subsequently demonstrated its involvement in mechanical allodynia, inflammation, pain and oral cancer. mGluR5 expression has also been identified in gastroesophageal vagal pathways. Indeed, experimental and human studies have demonstrated that mGluR5 blockade reduces transient lower sphincter relaxation and reflux episodes. In the intestine, mGluR5s have been shown to be involved in the control of intestinal inflammation, visceral pain and the epithelial barrier function. In the liver, mGluR5s have a permissive role in the onset of ischemic injury in rat and mice hepatocytes. Conversely, livers from mice treated with selective negative allosteric modulators and mGluR5 knockout mice are protected against ischemic injury. Similar results have been observed in experimental models of free-radical injury and in vivo mouse models of acetaminophen intoxication. Finally, mGluR5s in the pancreas are associated with insulin secretion control. The picture is, however, far from complete as the review attempts to establish in particular as regards identifying specific targets and innovative therapeutic approaches for the treatment of GI disorders.

关键词： Metabotropic glutamate 受体子类型 5 食管肠肝胰

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Esophageal cell proliferation in gastroesophageal reflux disease: Clinical-morphological data before and after pantoprazole

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World Journal of Gastroenterology 2009年第8期15卷 936-941页

作者： Carlo Calabrese Davide Treré Giuseppina Liguori veronica Gabusi Manuela Vici Giovanna Cenacchi Massimo Derenzini Giulio Di Febo Department of Clinical Medicine University of Bologna Bologna 40138 Italy Department of Experimental Pathology Clinical Pathology University of Bologna Bologna 40138 Italy Clinical Department of Radiologic and Histopathologic Sciences University of Bologna Bologna 40138 Italy

AIM: To evaluate esophageal mucosal defense mechanisms at an epithelial level to establish if pantoprazole treatment can induce ultrastructural healing and improvement in the proliferation activity of the esophageal epithelium in gastroesophageal reflux disease (GERD). METHODS: This was a single-blinded study for pHmonitoring, and histological, ultrastructural and MIB1 immunostaining evaluation. Fifty eight patients with GERD were enrolled and underwent 24 h pH-monitoring and endoscopy. Patients were treated for 12 and 24 mo with pantoprazole. Esophageal specimens were taken for histological and ultrastructural evaluation, before and after the treatment. RESULTS: With transmission electron microscopy, all patients with GERD showed ultrastructural signs of damage with dilation of intercellular spaces (DIS). After 3 mo of therapy the mean DIS values showed asignificant reduction and the mean MIB1-LI values of GERD showed an increase in cell proliferation. A further 3 mo of therapy significantly increased cell proliferation only in the erosive esophagitis (ERD) group. CONCLUSION: Three months of pantoprazole therapy induced ultrastructural healing of mucosal damage in 89% and 93% of ERD and non-erosion patients, respectively. Moreover, long-term pantoprazole treatment may be helpful in increasing the capability for esophageal cell proliferation in GERD, particularly in ERD patients.

关键词：胃食管反流病癌细胞增殖形态数据胃食管反流性疾病糜烂性食管炎治疗前后透射电子显微镜超微结构

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A Scientific Legacy: Theory of Dynamic Interactions

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World Journal of Mechanics 2017年第3期7卷 85-100页

作者： veronica Barceló Advanced Dynamics C.B. Madrid Spain

This paper describes the theses that constitute the Theory of Dynamic In-teractions. It is the scientific legacy of its promoter, Dr. Barceló who, after more than forty years developing this research project, has published his first book in the English language: New Paradigm in Physics. This book, as well as the bibliography and videos on this dynamic theory, is described in this article, which analyzes the behavior of rigid bodies subjected to accelerations by rotational movements, contributing new hypotheses of dynamic behavior.

关键词： Paradigm Non-Inertial Dynamics Systems Intrinsic Rotation Orbit Dynamic Model

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E-Consumer Interests Calls for Protection in Cross-border Purchasing

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China's Foreign Trade 2014年第Z1期 52-53页

作者： veronica Zhang

Recently,Neven Mimica,Commissioner for Consumer Policy in the DirectorateGeneral for Health and Consumers of the European Commission,paid a visit to *** his visit,a joint statement between the Commission and the State... 详细信息

关键词： border statement signed visit cooperation Republic

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Self-compatibility in peach[Prunus persica(L.)Batsch]:patterns of diversity surrounding the S-locus and analysis of SFB alleles

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Horticulture Research 2020年第1期7卷 675-689页

作者： Donia Abdallah Ghada Baraket veronica Perez Amel Salhi Hannachi Jose I.Hormaza Author details 1Facultédes Sciences de Tunis Département BiologieUniversitéde Tunis El Manar2092 TunisTunisie Laboratorio de Agrobiología Juan JoséBravo Rodríguez(Cabildo Insular de La Palma) Unidad Técnica del Instituto de Productos Naturales y Agrobiología(IPNA-CSIC)38700 S/C La PalmaCanary IslandsSpain Instituto de Hortofruticultura Subtropical y Mediterránea La Mayora(IHSM La Mayora-UMA-CSIC) 29750 Algarrobo-CostaMalagaSpain

Self-incompatibility(SI)to self-compatibility(SC)transition is one of the most frequent and prevalent evolutionary shifts in flowering *** L.(Rosaceae)is a genus of over 200 species most of which exhibit a Gametophytic SI ***[Prunus persica(L.)Batsch;2n=16]is one of the few exceptions in the genus known to be a fully selfcompatible ***,the evolutionary process of the complete and irreversible loss of SI in peach is not well understood and,in order to fill that gap,in this study 24 peach accessions were *** tube growth was controlled in self-pollinated flowers to verify their self-compatible *** linkage disequilibrium association between alleles at the S-locus and linked markers at the end of the sixth linkage group was not significant(P>0.05),except with the closest markers suggesting the absence of a signature of negative frequency dependent selection at the *** of SFB1 and SFB2 protein sequences allowed identifying the absence of some variable and hypervariable domains and the presence of additionalα-helices at the *** and evolutionary analysis of SFB nucleotide sequences showed a signature of purifying selection in SFB2,while the SFB1 seemed to evolve ***,our results show that the SFB2 allele diversified after *** and ***(almond)divergence,a period which is characterized by an important bottleneck,while SFB1 diversified at a transition time between the bottleneck and population expansion.

关键词： compatibility linkage alleles

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Anxiety and Utopia in the Anthropocene

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2018年第4期12卷 565-582页

作者： veronica Hollinger Department of Cultural Studies Trent UniversityPeterboroughOntario K9J788Canada

The current ecological crisis is the single most pressing problem for utopian projects today. The ever-expanding intersections of technology and capital in the Age of the Anthropocene are, if nothing else, invitations to consider the possibilities for utopian thought particularly as it is embodied in the formal structures of science fiction (sf). Science fiction is a genre whose origins in post-Enlightenment industrial modernity align it with globalization’s valorization of the scientific progress and limitless economic expansion that have contributed so much to the shape of the current crisis. This introduces a significant tension into science fiction’s efforts to imagine a way out of the crisis and toward some kind of utopian future that is not simply a repetition of the present. In the context of today’s climate crisis, what are the possibilities for utopian thought that succumbs neither to the anxieties that arise in the face of inevitable and radical change nor to an optimistic “techno-utopianism” that threatens to repeat all the errors of the past? What are the possibilities for utopian thought that takes account of human beings as an inter-relational species deeply imbricated with all life on Earth? I look at a variety of twenty-first-century Anglo-American sf stories through the lens of eco-philosopher Timothy Morton’s theory of climate change as a “hyperobject” and in the framework of sf writer Geoff Ryman’s “Mundane Manifesto” (2004)—his call for a kind of science fiction that recognizes the Earth as the only home that can sustain us.

关键词： utopia science fiction (sf) Anthropocene hyperobjects non- humanism terraforming space opera

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Light spectral filtering based on spatial adiabatic passage

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Light(Science & Applications) 2013年第1期2卷 90-97页

作者： Ricard Menchon-Enrich Andreu Llobera Jordi Vila-Planas Victor J Cadarso Jordi Mompart veronica Ahufinger Department of Physics Universitat Auto`noma de BarcelonaE-08193 BellaterraBarcelonaSpain Chemical Transducers Group Institut de Microelectro`nica de Barcelona(IMBCNMCSIC)E-08193 BellaterraBarcelonaSpain Microsystems Laboratory(LMIS1) Ecole Polytechnique Federale de Lausanne(EPFL)CH-1015 LausanneSwitzerland

We present the first experimental realization of a light spectral filter based on the spatial adiabatic passage *** demonstrate that a fully integrable CMOS-compatible system of three coupled identical total internal reflection silicon oxide waveguides with variable separation along their propagation direction can be used simultaneously as a low-and high-pass spectral filter within the visible range of *** is injected into the right waveguide,and after propagating along the system,long wavelengths are transferred into the left output,whereas short wavelengths propagate to the right and central *** stopband reaches values up to 211 dB for the left output and approximately 220 dB for the right plus central *** passband values are close to 0 dB for both *** also demonstrate that the filtering characteristics of the device can be controlled by modifying the parameter values,which define the geometry of the triple-waveguide ***,the general filtering behavior of the system does not critically depend on technological ***,the spatial adiabatic passage filtering approach constitutes an alternative to other integrated filtering devices,such as interference or absorbance-based filters.

关键词： CMOS-compatible technology integrated optics devices spatial adiabatic passage wavelength filtering devices

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APEC Promoting to Develop FTAAP

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China's Foreign Trade 2014年第Z2期 10-11页

作者： veronica Cui

On November 10 and 11,the22nd Economic Leaders’Meeting of APEC will be held in *** October 16,ShenDanyang,the spokesman of the Ministry of Commerce(MOC),introduced the theme of this year’s APEC Economic Leaders’Mee... 详细信息

关键词： Regular Director cooperation innovative trading ad

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Artificial gauge field switching using orbital angular momentum modes in optical waveguides

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Light(Science & Applications) 2020年第1期9卷 577-583页

作者： Christina Jorg Gerard Queralto Mark Kremer Gerard Pelegri Julian Schulz Alexander Szameit Georg von Freymann Jordi Mompartand veronica Ahufinger Physics Department and Research Center OPTIMAS Technische Universitat Kaiserslautern67663 KaiserslauternGermany Departament de Fisica Universitat Auto’noma de BarcelonaE-08193 BellaterraSpain Institut fur Physik Universitat RostockAlbert-Einstein-StraBe 2318059 RostockGermany Department of Physics and SUPA University of StrathclydeGlasgow G40NGUK Fraunhofer Institute for Industrial Mathematics ITWM 67663 KaiserslauternGermany

The discovery of artificial gauge fields controlling the dynamics of uncharged particles that otherwise elude the influence of standard electromagnetic fields has revolutionised the field of quantum ***,developing new techniques to induce these fields is essential to boost quantum simulation of photonic ***,we experimentally demonstrate the generation of an artificial gauge field in a photonic lattice by modifying the topological charge of a light beam,overcoming the need to modify the geometry along the evolution or impose external *** particular,we show that an effective magnetic flux naturally appears when a light beam carrying orbital angular momentum is injected into a waveguide lattice with a diamond chain *** demonstrate the existence of this flux,we measure an effect that derives solely from the presence of a magnetic flux,the Aharonov-Bohm caging effect,which is a localisation phenomenon of wavepackets due to destructive ***,we prove the possibility of switching on and off artificial gauge fields just by changing the topological charge of the input state,paving the way to accessing different topological regimes in a single structure,which represents an important step forward for optical quantum simulation.

关键词： gauge momentum orbital

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Systems Biology Approach Pinpoints Minimum Requirements for Auxin Distribution during Fruit Opening

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Molecular Plant 2019年第6期12卷 863-878页

作者： Xin-Ran Li Renske M.A.Vroomans Samantha Fox veronica A.Grieneisen Lars Φstergaard Athanasius F.M.Maree Crop Genetics John Innes Centre Norwich NR4 7UH UK Computational and Systems Biology John Innes Centre Norwich NR4 7UH UK Centre of Excellence in Computational and Experimental Developmental Biology Institute of Biotechnology University of Helsinki 00014 Helsinki Finland Cell and Developmental Biology John Innes Centre Norwich NR4 7UH UK School of Biosciences Cardiff University Cardiff CF10 3AX Wales UK

The phytohormone auxin is implied in steering various developmental decisions during plant morphogenesis in a concentration-dependent *** maxima have been shown to maintain meristematic activity,for example,of the root apical meristem,and position new sites of outgrowth,such as during lateral root initiation and *** recently,it has been demonstrated that sites of auxin minima also provide positional *** the developingArabidopsis fruit,auxin minima are required for correct differentiation of the valve *** remains unclear,however,how this auxin minimum is generated and ***,we employ a systems biology approach to model auxin transport based on experimental *** allows us to determine the minimal requirements for its *** simulations reveal that two alternative processes-which we coin "flux-barrier" and "flux-passage"-are both able to generate an auxin minimum,but under different parameter *** models are in principle able to yield similar auxin profiles but present qualitatively distinct patterns of auxin *** models were tested by tissue-specific inducible ablation,revealing that the auxin minimum in the fruit is most likely generated by a flux-passage *** predictions were further supported through 3D PIN localization imaging and implementing experimentally observed transporter *** such an experimental-modeling cycle,we predict how the auxin minimum gradually matures during fruit development to ensure timely fruit opening and seed dispersal.

关键词： auxin mathematical modeling polar auxin transport fruit development systems biology of patterning

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