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Near-Infrared Fluorescence Imaging Contrast Agents for Clinical Research: Limitations a.d.Alternatives

Open Journal of Biophysics 2024年第1期14卷 73-77页

作者： Serigne Moussa Badiane Elhadji A. L. Bathily Fawrou Seye Louis a.d. diouf department of Health Sciences Gaston BERGER University Saint-Louis Senegal department of Health Sciences Cheikh Anta DIOP University Dakar Senegal Cell Biology a.d.Histology Health Sciences Department Gaston BERGER University Saint-Louis Senegal

Introduction: Near-infrared fluorescence imaging is a technique that will establish itself in the short term at the international level because it is recognized for its potential to improve the performance of surgical interventions, its moderate investment a.d.operating costs a.d.its portability. Although the technology is now mature, there is currently the problem of the availability of contrast agents to be injected IV. The aim of this methodology article is to propose an alternative solution to the need for contrast agents for clinical research, particularly in oncology. Methodology: They consist of coupling a fluorescent marker in the form of an NHS derivative, such as IR dYE manufactured in compliance with GMP, with therapeutic monoclonal antibodies having marketing authorization for molecular imaging. For a given antibody, the marking procedure must be the subject of a validation file on the final preparation filtered on a sterilizing membrane at 0.22 μm. Once the procedure has been validated, it would be unnecessary to repeat the tests before each clinical research examination. A check of the marking by thin-layer chromatography (TLC) a.d.place it in a sample bank at +4˚C for 1 month of each injected formulation would be sufficient for a.d.tional tests if necessary. Conclusion: Molecular near-infrared fluorescence imaging is experiencing development, the process of which could be accelerated by greater availability of clinical contrast agents. Alternative solutions are therefore necessary to promote clinical research in this area. These methods must be shared to make it easier for researchers.

关键词： Fluorescence Imaging Contrast Agents Clinical Research

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Advancing Wound Filling Extraction on 3d Faces:An Auto-Segmentation a.d.Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： duong Q.Nguyen Thinh d.Le Phuong d.Nguyen Nga T.K.Le H.Nguyen-Xuan department of Mathematics a.d.Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science a.d.Technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning a.d.optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3d facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3d-FaIR dataset a.d.a.d.esses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments a.d.selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3d facial ***,based on the segmentation model,we propose an improved approach for extracting 3d facial wound fillers a.d.compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3d printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning a.d.intervention *** automating facial wound segmentation a.d.improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing a.d.optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning a.d.3d bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3d.

关键词： 3d printing technology face reconstruction 3d segmentation 3d printed model

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The influence of low voltage discharges on structure a.d.phase transformations of metallic foils

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广东有色金属学报 2005年第2期15卷 495-495页

作者： Pyachin S.A. verkhoturov a.d. Zavodinsky V.G. Pugachevsky M.A. Institute for Materials Science KSC FEB RAS Khabarovsk 680042 Russian

A low voltage electrospark processing of materials allows one to modify the chemical composition a.d.structure of metal layers due to thermo-mechanical influence of discharges a.d.transfer of materials from one electr... 详细信息

关键词：电压金属薄片化学成分相变化

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Snapshot imaging of ultrashort electron bunches

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Light(Science & Applications) 2024年第7期13卷 1226-1228页

作者： a.d.eas döpp Ludwig-Maximilian-Universität München Am Coulombwall 185748GarchingGermany Max Planck Institut für Quantenoptik Hans-Kopfermann-Strasse 1Garching85748Germany

New measurements combine spatial a.d.temporal information from optical transition radiation to estimate the three-dimensional structure of electron bunches from a laser wakefield accelerator.

关键词： ultrashort Snapshot electron

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Influence of variable viscosity a.d.double diffusion on the convective stability of a nanofluid flow in an inclined porous channel

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Applied Mathematics a.d.Mechanics(English Edition) 2024年第3期45卷 563-580页

作者： N.HUMNEKAR d.SRINIVASACHARYA department of Mathematics National Institute of TechnologyWarangal 506004TelanganaIndia

The influence of variable viscosity a.d.double diffusion on the convective stability of a nanofluid flow in an inclined porous channel is *** darcyBrinkman model is used to characterize the fluid flow dynamics in porous *** analytical solutions are obtained for the unidirectional a.d.completely developed *** on a normal mode analysis,the generalized eigenvalue problem under a perturbed state is *** eigenvalue problem is then solved by the spectral ***,the critical Rayleigh number with the corresponding wavenumber is evaluated at the assigned values of the other flow-governing *** results show that increasing the darcy number,the Lewis number,the dufour parameter,or the Soret parameter increases the stability of the system,whereas increasing the inclination angle of the channel destabilizes the ***,the flow is the most unstable when the channel is vertically oriented.

关键词： nanofluid inclined channel variable viscosity linear stability double dif-fusion porous medium

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decomposition mechanisms of nuclear-grade cationic exchange resin by advanced oxidation processes:Statistical molecular fragmentation model a.d.dFT calculations

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Journal of Environmental Sciences 2024年第1期135卷 433-448页

作者： Xiang Meng Pierre désesquelles Lejin Xu department of Nuclear Engineering a.d.Technology School of Energy and Power EngineeringHuazhong University of Science&TechnologyWuhan 430074China CNRS Laboratoire de Physique des Gaz et des PlasmasUniversitéParis-SaclayOrsay 91405France State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The treatment a.d.disposal of radioactive waste are presently facing great *** ion exchange resins have become a focus of attention due to their high production a.d.serious environmental *** this paper,a simplified model of cationic exchange resin is proposed,a.d.the degradation processes of cationic resin monomer initiated by hydroxyl radicals(·OH)are clarified by combining statistical molecular fragmentation(SMF)model a.d.density functional theory(dFT)*** prediction of active sites indicates that the S-O bonds a.d.the C-S bond of the sulfonic group are more likely to react during the *** meta-position of the sulfonic group on the benzene ring is the most active site,a.d.the benzene ring without the sulfonic group has a certain *** C11-C14 a.d.C17-C20 bonds,on the carbon skeleton,are the most easily *** is also found that dihydroxy a.d.tion a.d.elimination reactions play a major role in the process of desulfonation,carbon skeleton cleavage a.d.benzene ring *** decomposition mechanisms found through the combination of physical models a.d.chemical calculations,provide theoretical guidance for the treatment of complex polycyclic aromatic hydrocarbons.

关键词： Cationic exchange resin Statistical molecular fragmentation model density functional theory Hydroxyl radical decomposition mechanism

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Role of pituitary adenylate cyclase-activating polypeptide in peripheral nerve regeneration:a cellular a.d.molecular perspective

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Neural Regeneration Research 2024年第7期19卷 1429-1430页

作者： Grazia Maugeri Velia.d.Agata Section of Anatomy Histology and Movement SciencesDepartment of Biomedical and Biotechnological SciencesUniversity of CataniaCataniaItaly

Neuro regeneration is a very complex phenomenon characterized by the generation of new neurons a.d.synapses,involving connections between adjacent cells a.d.axonal *** supplies a.d.tional longterm resources to replace... 详细信息

关键词： replace functional regeneration

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Process engineering of demineralisation of moderate to high ash Indian coals through NaOH‑HCl leaching a.d.HF leaching

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International Journal of Coal Science & Technology 2024年第2期11卷 111-122页

作者： Heena.d.awan d.K.Sharma ANRF Ministry of ScienceNew DelhiIndia department of Energy Science a.d.Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Chemical leaching of coals would be required to produce cleaner coals for some special applications where physical benefi-ciation may not be effective *** would also help in recovering Li a.d.rare earth metals besides in the sequestration of CO_(2).About 20 Indian coals having complexly distributed moderate to high ash contents were sequentially treated with various alkali–acid such as NaOH-HCl,HF,HCl,HCl-HF,a.d.NaOH-HCl-HF *** aimed to establish a.d.design the best stepwise sequential process for the highest degree of demineralisation through a chemical leaching *** a.d.process intensification studies were carried *** than 80%demineralisation of Madhaipur a.d.Neemcha coals was observed using the best sequential treatment designed *** repeated stepwise treatment of the alkali a.d.the acid was also studied,which was found to significantly enhance the degree of demineralisation of *** integrated process of alkali–acid leaching followed by solvent extraction(Organo-refining)a.d.vice versa of the treated coal was also studied for producing cleaner coals.

关键词： Alkali–acid leaching demineralisation Integrated process Rare earth elements

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Improved Leap-frog Method for Time-domain Fault Location

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Journal of Modern Power Systems a.d.Clean Energy 2024年第2期12卷 670-674页

作者： Izudin džafić Rabih A.Jabr Faculty of Electrical Engineering University of SarajevoSarajevo 71000Bosnia and Herzegovina department of Electrical a.d.Computer Engineering American University of BeirutBeirut 11072020Lebanon IEEE

The partial differential equation(PdE)solution of the telegrapher is a promising fault location method among time-domain a.d.model-based *** research works have shown that the leap-frog process is superior to other explicit methods for the PdE ***,its implementation is challenged by determining the initial conditions in time a.d.the boundary conditions in *** letter proposes two implicit solution methods for determining the initial conditions a.d.an analytical way to obtain the boundary conditions founded on the signal *** results show that the proposal gives fault location accuracy superior to the existing leap-frog scheme,particularly in the presence of harmonics.

关键词： Fault location leap-frog partial differential equation time-domain analysis transmission line

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Therapeutic advances in neural regeneration for Huntington’s disease

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Neural Regeneration Research 2024年第9期19卷 1991-1997页

作者： Francesco d’Egidio Vanessa Castelli Giorgia Lomba.d.zzi Fabrizio Ammannito Annamaria Cimini Michele d’Angelo department of Life Health and Environmental SciencesUniversity of L’AquilaL’AquilaItaly

Huntington’s disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the HTT gene which is responsible for the production of the huntingtin (Htt) protein. In physiological conditions, Htt is involved in many cellular processes such as cell signaling, transcriptional regulation, energy metabolism regulation, dNA maintenance, axonal trafficking, a.d.antiapoptotic activity. When the genetic alteration is present, the production of a mutant version of Htt (mHtt) occurs, which is characterized by a plethora of pathogenic activities that, finally, lead to cell death. Among all the cells in which mHtt exerts its dangerous activity, the GABAergic Medium Spiny Neurons seem to be the most affected by the mHtt-induced excitotoxicity both in the cortex a.d.in the striatum. However, as the neurodegeneration proceeds ahead the neuronal loss grows also in other brain areas such as the cerebellum, hypothalamus, thalamus, subthalamic nucleus, globus pallidus, a.d.substantia nigra, determining the variety of symptoms that characterize Huntington’s disease. From a clinical point of view, Huntington’s disease is characterized by a wide spectrum of symptoms spanning from motor impairment to cognitive disorders a.d.dementia. Huntington’s disease shows a prevalence of around 3.92 cases every 100,000 worldwide a.d.an incidence of 0.48 new cases every 100,000/year. To date, there is no available cure for Huntington’s disease. Several treatments have been developed so far, aiming to reduce the severity of one or more symptoms to slow down the inexorable decline caused by the disease. In this context, the search for reliable strategies to target the different aspects of Huntington’s disease become of the utmost interest. In recent years, a variety of studies demonstrated the detrimental role of neuronal loss in Huntington’s disease condition highlighting how the replacement of lost cells would be a reasonable strategy to o

关键词： cell therapy exosomes extracellular vesicles Huntingtin Huntington’s disease medium spiny neurons neurodegenerative disease neurogenesis neuronal loss stem cells

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