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Lower limb balance,ankle dorsiflexion,orofacial tissue pressure,and occlusal force of rugby players

Sports Medicine and Health Science 2024年第2期6卷 173-178页

作者： Rafael R.Machado Marcelo Palinkas Paulo B.de Vasconcelos Sara Gollino veridiana w.arnoni Marcos Vinicios R.Prandi Isabela H.Regalo Selma Siessere Simone C.H.Regalo School of Dentistry of Ribeirao Preto University of Sao PauloBrazil National Institute for Translational Medicine(INCT-TM) Ribeirao PretoBrazil

This cross-sectional study examined the lower limb balance,ankle dorsiflexion,orofacial tissue pressure,and occlusal strength of rugby ***-six participants were divided into groups:rugby players(n=13)and healthy sedentary adults(n=13).Participants underwent an analysis of lower limb balance using a composite score(Y-Balance Test).Ankle dorsiflexion was measured using the Lunge *** Iowa Oral Performance Instrument was employed to measure orofacial tissue *** force was measured with a dynamometer,and T-Scan assessed occlusal contact *** were analyzed using the t-test(pwith age and weight as covariates,where it is possible to verify that these factors did not influence the results *** differences were observed in the balance of the right(p=0.07)and left(p=0.02)lower limbs,where rugby players had lower composite *** were significant differences in the right(p=0.005)and left(p=0.004)lunges,with rugby players showing lower values,as well as lower tongue pressure(p=0.01)and higher lip pressure(p=0.03),with significant differences to sedentary *** was no significant difference in molar bite force and distribution occlusal contacts between *** seems to reduce lower limb displacement,cause ankle hypomobility,lead to changes in orofacial tissues,particularly the tongue and *** study is significant for identifying significant differences between rugby players and sedentary individuals,providing new insights into the impact of rugby on health and performance,which can benefit sports training and injury prevention.

关键词： Rugby Y-balance test Lunge test Orofacial tissues Occlusal force

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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

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Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

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Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

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Understanding bark thickness variations for Araucaria angustifolia in southern Brazil

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Journal of Forestry Research 2021年第3期32卷 1077-1087页

作者： Emanuel arnoni Costa Veraldo Liesenberg César Augusto Guimaraes Finger AndréFelipe Hess Cristine Tagliapietra Schons Graduate Program in Forest Engineering Santa Catarina State University(UDESC)LagesSC 88520-000Brazil Department of Forest Engineering Federal University of Uberlandia(UFU)Monte CarmeloMG 38500-000Brazil Graduate Program in Forest Engineering Federal University of Santa Maria(UFSM)Santa MariaRS 97105-900Brazil Graduate Program in Agroecosystems Federal Technological University of Parana(UFTPR)Dois VizinhosPR 85660-000Brazil

This study aimed to understand bark thickness variations of Araucaria angustifolia(Bertol.)Kuntze trees growing in natural forest remnants in southern Brazil,and their relationship with quantitative and qualitative *** thickness must be accurately estimated in order to determine timber volume *** is an important variable for the sustainable management and conservation of araucaria *** spite of its importance and visibility,bark thickness variations have not been evaluated for this key species in southern Brazil.A total of 104 trees were selected,and their qualitative and quantitative attributes such as diameter at breast height(D_(BH)),height(H),crown base height(C_(BH)),crown length(C_(L)),social position(S_(P)),stoniness(S_(T)),position on the relief(P_(R)),vitality(V_T)and branch arrangement(B_(A))were *** trees were categorized into two groups:red bark or gray *** analysis and artificial neural networks(ANN)were used for modelling bark *** results indicate that:(1)bark thickness showed good correlation to D_(BH),with 0.76 as coefficient of determination(RS_P),0.540 as Mean Absolute Error(M_(AE))and 22.4 root-meansquare error in percentage(R_(MSE%));(2)the trend changed according to bark colour,with significant differences for the intersection(_0–Pr>F:p=0.0124)and slope(β_(1)–Pr>F:p=0.0126)of bark thickness curves between groups;(3)the highest correlation of bark thickness was found with:D_(BH)(ρ=0.88),H(ρ=0.58),C_(BH)(ρ=0.46),S_(P)(ρ=-0.52),and B_(A)(ρ=-0.32);(4)modelling with ANN confirmed high adjustment(R^(2)=0.99)and accuracy(R_(MSE%)=3.0)of the *** is an efficient and robust technique for the modelling of various qualitative and quantitative attributes commonly used in forest *** effective use of ANN to estimate araucaria bark in natural forests reinforces its potential,besides the possibility of application for other forest species.

关键词： Dendrometry attributes Crown characteristics Prediction models Bark factor Parana-pine

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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

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Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEwS pharmacokinetics study

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world Journal of Gastroenterology 2025年第2期31卷 102-112页

作者： Thanaboon Chaemsupaphan Aviv Pudipeddi Hui-Yu Lin Sudarshan Paramsothy Viraj C Kariyawasam Melissa Kermeen Rupert w Leong Department of Gastroenterology and Liver Services Concord Repatriation General HospitalSydney 2139New South WalesAustralia Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Faculty of Medicine and Health University of SydneySydney 2139New South WalesAustralia Department of Gastroenterology Tan Tock Seng HospitalSingapore 308433Singapore Faculty of Medicine and Health Sciences Macquarie UniversitySydney 2139New South WalesAustralia Department of Gastroenterology and Hepatology Blacktown HospitalSydney 2148New South WalesAustralia Blacktown Clinical School Western Sydney UniversitySydney 2148New South WalesAustralia

BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory condition requiring continuous treatment and *** is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thiopurines on vedolizumab trough concentrations is *** To investigate the exposure-response relationship of vedolizumab and the impact of thiopurine withdrawal in UC patients who have achieved sustained clinical and endoscopic remission during maintenance *** This is a post-hoc analysis of prospective randomized clinical trial(VIEwS)involving UC patients across 8 centers in Australia from 2018 to *** in clinical and endoscopic remission were randomized to continue or withdraw thiopurine while receiving *** evaluated vedolizumab serum trough concentrations,presence of anti-vedolizumab antibodies,and clinical outcomes over 48 weeks to assess exposure-response asso-ciation and impact of thiopurine *** There were 62 UC participants with mean age of 43.4 years and 42%were *** participants received vedolizumab as maintenance therapy with 67.7%withdrew *** serum trough concentrations remained stable over 48 weeks regardless of thiopurine use,with no anti-vedolizumab antibodies ***-tients with clinical remission had higher trough concentrations at week *** quartile analysis,a threshold of>11.3μg/mL was associated with sustained clinical remission,showing a sensitivity of 82.4%,specificity of 60.0%,and an area of receiver operating characteristic of 0.71(95%CI:0.49-0.93).Patients discontinuing thiopurine required higher vedolizumab concentrations for achieving *** A positive exposure-response relationship between vedolizumab trough concentrations and UC outcomes suggests that monitoring drug levels may be *** thiopurine did not influence vedolizumab levels,its with-drawal may necessitate higher vedolizumab trough concentrations to maintain remi

关键词： Pharmacokinetic Vedolizumab Thiopurine Ulcerative colitis Trough concentration Antibody Inflammatory bowel diseases

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Height-to-diameter ratios with temporal and dendro/morphometric variables for Brazilian pine in south Brazil

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Journal of Forestry Research 2021年第1期32卷 191-202页

作者： Andre Felipe Hess Myrcia Minatti Emanuel arnoni Costa Luis Paulo Baldissera Schorr Gabriel Teixeira da Rosa Isadora de Arruda Souza Geedre Adriano Borsoi Veraldo Liesenberg Thiago Floriani Stepka Roberta Abatti Department of Forest Engineering Santa Catarina State University2090 Luiz de Camoes AvenueLagesSanta Catarina State 88520-000Brazil Department of Forest Engineering Federal University of Parana(UFPR)Pref.Lothario Meissner Ave.900CuritibaParana 80060-000Brazil

Height-to-diameter ratios(HD)are an important measure of the stability,density and competition of forest *** refl ects the vertical growth of the trees,the vulnerability of the forest canopy structure and infl uences volumetric *** ratios vary according to tree size,availability of resources for growth,stand density and species *** were taken from 210 trees and a regression technique of generalized linear models for the HD ratio applicable for forest structure conservation was *** objective of this study was to model the HD ratios of dominant and co-dominant trees of Araucaria angustifolia according to morphometric,dendrometric,annual diameter increment,stand density,and age variables in three sites in southern *** results show that the HD ratio decreases with increasing age,crown area and basal area,and increases with stand density and annual diameter *** of the developed equations was demonstrated by the values of deviation,Bayesian and Akaike *** results are of interest to forest managers since they make decisions about silvicultural *** continuity and forest production indicate that any intervention should be directed at younger trees of smaller sizes,and that one of the main management factors for stand stability and growth is the formation of the stand and its capture of light.

关键词： Forest management Mixed forests Conservation Araucaria angustifolia

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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.w.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Improvement of Somatic Cervical Pain and Disability after the Application of a Portable TENS Device

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Journal of Biomedical Science and Engineering 2016年第10期9卷 451-459页

作者： Gabriela R. Lauretti Marcelo Antunes veridiana Marques Rebello Zuccolotto Rogério Costa Franco School of Medicine of Ribeirao Preto University of Sao Paulo Sao Paulo Brazil

Background: Cervical facet joints and neck muscles are common nociceptive pain generator, with neck and shoulder muscles pain, and limited retroflexion. Objective: To test the hypothesis that the portable TENS device would relieve cervical somatic pain. Methods: Forty-four patients with chronic cervical pain patients with somatic pain, but without radicular symptoms were evaluated in a double-blind, prospective, randomized fashion, divided into sham and active groups. The active TENS (TANYXò) or sham device was placed over C7-T1 spinous process, perpendicular to the spine, for 20 min at 12-hour interval during 3 days. The two groups were: placebo group (PG), with a sham device and the active TENS group (TG), which produced a mixed (85 Hz) frequency of stimulation, conventional, and burst. Diclofenac up to three times daily was available. Efficacy measures were pain relief, rescue analgesics and neck disability. Results: The active TENS device induced pain relief after its first application, which persisted during the 3-day treatment. By the end of the TENS application, the capability of rotation, lateral extension and retroflexion was improved (p were no adverse events. Conclusions: Somatic cervical pain and disability improved after active TENS application during the three consecutive days, which persisted upon the 1-month reevaluation.

关键词： Cervical Somatic Pain Neck Disability TENS

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