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Protocol for lower back pain management: Insights from the French healthcare system

World Journal of Clinical Cases 2024年第11期12卷 1875-1880页

作者： Lea Evangeline boyer Mathieu Boudier-Revéret Min Cheol Chang Department of Physical Medicine and Rehabilitation CHU de la RéunionReunion Island CIC 1410France Department of Rehabilitation Medicine University of Montreal Health CenterMontrealQC H2X 3E4Canada Department of Physical Medicine and Rehabilitation Yeungnam University HospitalDaegu 705-717South Korea

In this editorial we comment on the article published in a recent issue of the World Journal of Clinical *** article described a novel ultrasound-guided lateral recess block approach in treating a patient with lateral recess *** impact of spinal pain-related disability extends significantly,causing substantial human suffering and medical *** county has its preferred treatment strategies for spinal ***,we explore the lower back pain(LBP)treatment algorithm recommended in *** treatment algorithm for LBP recommended by the French National Authority for Health emphasizes early patient activity and minimal medication *** encourages the continuation of daily activities,limits excessive medication and spinal injections,and incorporates psychological assessments and non-pharmacological therapies for chronic ***,the algorithm may not aggressively address acute pain in the early stages,potentially delaying relief and increasing the risk of ***,the recommended infiltrations primarily involve caudal epidural steroid injections,with limited consideration for other injection procedures,such as transforaminal or interlaminar epidural steroid *** fixed follow-up timeline may not accommodate patients who do not respond to initial treatment or experience intense pain,potentially delaying the exploration of alternative *** these limitations,understanding the strengths and weaknesses of the French approach could inform adaptations in LBP treatment strategies globally,potentially enhancing patient outcomes and satisfaction across diverse healthcare systems.

关键词： Lower back pain Protocol France Treatment Chronic pain

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Differences between the healthcare systems of Quebec and France for the treatment of pain due to spinal disorders

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World Journal of Clinical Cases 2024年第15期12卷 2682-2685页

作者： Lea Evangeline boyer Mathieu Boudier-Revéret Min Cheol Chang Department of Physical Medicine and Rehabilitation CHU de la RéunionReunion Island CIC 1410France Department of Rehabilitation Medicine University of Montreal Health CenterMontrealQC H2X 3E4Canada Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaegu 705-717South Korea

In Quebec,Canada,the public healthcare system offers free medical ***,patients with spinal pain often encounter long waiting times for specialist appointments and limited physiotherapy *** contrast,private clinics provide expedited care but are relatively scarce and entail out-of-pocket *** a patient with pain caused by a spinal disorder meets a pain medicine specialist,spinal intervention is quickly performed when indicated,and patients are provided lifestyle *** epidural steroid injections are frequently administered to patients with radicular pain,and steroid injections are administered on a facet joint to control low back or neck ***,medial branch blocks are performed prior to ***’s universal healthcare system ensures accessibility at controlled *** emphasizes physical activity and provides free physical therapy ***,certain interventions,such as transforaminal and interlaminar epidural injections,are not routinely used in France owing to limited therapeutic efficacy and safety *** underutilization may be a potential cause of chronic pain for many *** examining the differences,strengths,and weaknesses of these two systems,valuable insights can be gained for the enhancement of global spinal pain management strategies,ultimately leading to improved patient outcomes and satisfaction.

关键词： Spinal pain Healthcare system France Quebec Pain treatment

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Astrocyte chloride,excitatory-inhibitory balance and epilepsy

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Neural Regeneration Research 2024年第9期19卷 1887-1887页

作者： verena Untiet Maiken Nedergaard Alexei Verkhratsky Division of Glial Disease and Therapeutics Center for Translational NeuromedicineUniversity of CopenhagenCopenhagenDenmark Division of Glial Disease and Therapeutics Center for Translational NeuromedicineDepartment of NeurosurgeryUniversity of Rochester Medical CenterRochesterNYUSA Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Centre for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain

Excitation and inhibition are at the core of brain function and *** sustain the activity of neuronal networks over time and space,glutamatergic excitation is balanced by GABAergic *** equipoise of excitation and inhibition,known as the excitation/inhibition(E/I)balance,is crucial for proper brain *** E/I balance is highly dynamic and shifts across different brain states:wakefulness primarily augments excitatory activity,while sleep promotes a decrease in excitation and an increase in inhibition(Bridi et al.,2020).Neuronal activity during various brain states is primarily regulated by neurotransmitters(Schiemann et al.,2015),alongside non-synaptic mechanisms that operate on a slower *** non-synaptic mechanisms are many,with the ionic composition of the extracellular space playing a significant role;altering extracellular ion concentrations affects sleep,arousal,electroencephalogram patterns,and behavioral states(Ding et al.,2016).

关键词： epilepsy excitatory excitation

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Prenatal and postnatal factors associated with sudden infant death syndrome:an umbrella review of meta-analyses

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World Journal of Pediatrics 2024年第5期20卷 451-460页

作者： Tae Hyeon Kim Hyeri Lee Selin Woo Hayeon Lee Jaeyu Park Guillaume Fond Laurent boyer Jong Woo Hahn Jiseung Kang Dong Keon Yon Department of Medicine Kyung Hee University College of MedicineSeoulSouth Korea Center for Digital Health Medical Science Research InstituteKyung Hee University College of MedicineSeoulSouth Korea Department of Regulatory Science Kyung Hee UniversitySeoulSouth Korea Department of Biomedical Engineering Kyung Hee UniversityYonginSouth Korea CEReSS-Health Service Research and Quality of Life Center Assistance Publique des Hôpitaux de MarseilleAix-Marseille UniversityMarseilleFrance Department of Pediatrics Seoul National University College of MedicineSeoulSouth Korea Department of Pediatrics Seoul National University Bundang HospitalSeongnamSouth Korea Department of Anesthesia Critical Care and Pain MedicineMassachusetts General Hospital14913th StreetRoom 4140CharlestownBostonMAUSA Division of Sleep Medicine Harvard Medical SchoolBostonMAUSA Department of Pediatrics Kyung Hee University Medical CenterKyung Hee University College of Medicine23 Kyungheedae-roDongdaemun-guSeoul02447South Korea Department of Precision Medicine Kyung Hee University College of MedicineSeoulSouth Korea

Background Comprehensive quantitative evidence on the risk and protective factors for sudden infant death syndrome(SIDS)effects is *** investigated the risk and protective factors related to *** We conducted an umbrella review of meta-analyses of observational and interventional studies assessing SIDS-related ***/MEDLINE,Embase,EBSCO,and Google Scholar were searched from inception until January 18,*** extraction,quality assessment,and certainty of evidence were assessed by using A Measurement Tool Assessment Systematic Reviews 2 following PRISMA *** to observational evidence,credibility was graded and classified by class and quality of evidence(CE;convincing,highly suggestive,suggestive,weak,or not significant).Our study protocol was registered with PROSPERO(CRD42023458696).The risk and protective factors related to SIDS are presented as equivalent odds ratios(eORs).Results We identified eight original meta-analyses,including 152 original articles,covering 12 unique risk and protective factors for SIDS across 21 countries/regions and five *** risk factors,including prenatal drug exposure[eOR=7.84(95%CI=4.81–12.79),CE=highly suggestive],prenatal opioid exposure[9.55(95%CI=4.87–18.72),CE=suggestive],prenatal methadone exposure[9.52(95%CI=3.34–27.10),CE=weak],prenatal cocaine exposure[4.38(95%CI=1.95–9.86),CE=weak],prenatal maternal smoking[2.25(95%CI=1.95–2.60),CE=highly suggestive],postnatal maternal smoking[1.97(95%CI=1.75–2.22),CE=weak],bed sharing[2.89(95%CI=1.81–4.60),CE=weak],and infants found with heads covered by bedclothes after last sleep[11.01(95%CI=5.40–22.45),CE=suggestive],were *** the other hand,three protective factors,namely,breastfeeding[0.57(95%CI=0.39–0.83),CE=non-significant],supine sleeping position[0.48(95%CI=0.37–0.63),CE=suggestive],and pacifier use[0.44(95%CI=0.30–0.65),CE=weak],were also *** Based on the evidence,we propose several risk and protecti

关键词： Infant Protective factor Risk factor Sudden infant death syndrome Umbrella review

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Global public concern of childhood and adolescence suicide:a new perspective and new strategies for suicide prevention in the post-pandemic era

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World Journal of Pediatrics 2024年第9期20卷 872-900页

作者： Soeun Kim Jaeyu Park Hyeri Lee Hayeon Lee Selin Woo Rosie Kwon Sunyoung Kim Ai Koyanagi Lee Smith Masoud Rahmati Guillaume Fond Laurent boyer Jiseung Kang Jun Hyuk Lee Jiyeon Oh Dong Keon Yon Center for Digital Health Medical Science Research InstituteKyung Hee University College of MedicineSeoulSouth Korea Department of Precision Medicine Kyung Hee University College of MedicineSeoulSouth Korea Department of Regulatory Science Kyung Hee UniversitySeoulSouth Korea Department of Family Medicine Kyung Hee University Medical CenterKyung Hee University College of MedicineSeoulSouth Korea Research and Development Unit Parc Sanitari Sant Joan de DeuBarcelonaSpain Centre for Health Performance and WellbeingAnglia Ruskin UniversityCambridgeUK Department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan UniversityKhoramabadIran Department of Physical Education and Sport Sciences Faculty of Literature and HumanitiesVali-e-Asr University of RafsanjanRafsanjanIran CEReSS-Health Service Research and Quality of Life Center Assistance Publique-Hôpitaux de MarseilleAix Marseille UniversityMarseilleFrance Department of Anesthesia Critical Care and Pain MedicineMassachusetts General HospitalBostonMAUSA Division of Sleep Medicine Harvard Medical SchoolBostonMAUSA Health and Human Science University of Southern CaliforniaLos AngelesCAUSA Department of Medicine Kyung Hee University College of MedicineSeoulSouth Korea Department of Pediatrics Kyung Hee University Medical CenterKyung Hee University College of Medicine23 Kyungheedae-roDongdaemun-guSeoul02447South Korea

Background Suicide is the second leading cause of death in young people worldwide and is responsible for about 52,000 deaths annually in children and adolescents aged 5-19 ***,social,psychological,and behavioral factors play important roles in suicide *** traumatic events such as the COVID-19 pandemic may contribute to suicidal behaviors in young people,there is a need to understand the current status of suicide in adolescents,including its epidemiology,associated factors,the influence of the pandemic,and management *** sources We investigated global and regional suicide mortality rates among children and adolescents aged 5-19 years using data from the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)*** suicide mortality rates from 1990 to 2019 were examined in 204 countries and territories across six World Health Organization(WHO)***,we utilized electronic databases,including PubMed/MEDLINE and Scopus,and employed various combinations of terms such as“suicide”,“adolescents”,“youth”,“children”,“risk factors”,“COVID-19 pandemic”,“prevention”,and“intervention”to provide a narrative review on suicide within the pediatric population in the post-pandemic *** Despite the decreasing trend in the global suicide mortality rate from 1990 to 2019,it remains *** mortality rates from suicide by firearms or any other specified means were both greater in ***,Southeast Asia had the highest suicide rate among the six WHO *** COVID-19 pandemic seems to contribute to suicide risk in young people;thus,there is still a strong need to revisit appropriate management for suicidal children and adolescents during the *** The current narrative review integrates up-to-date knowledge on suicide epidemiology and the effects of the COVID-19 pandemic,risk factors,and intervention *** numerous studies have characterized trends in suicide among young people during the

关键词： COVID-19 Global Pandemic Suicide Children Adolescents

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ITPK1 is an InsP_(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2024年第7期17卷 1151-1157页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert K.Harmel Philipp Gaugler verena Gaugler Michael Frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider Adolfo Saiardi Dorothea Fiedler Henning J.Jessen Gabriel Schaaf Ricardo F.H.Giehi 不详

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects Figures 2D,3C,4C,and 7D and Figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute

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ESCRTing in cereals: still a long way to go

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Science China(Life Sciences) 2019年第9期62卷 1144-1152页

作者： verena Ibl Department of Ecogenomics and Systems Biology University of Vienna

The multivesicular body(MVB) sorting pathway provides a mechanism for the delivery of cargo destined for degradation to the vacuole or *** endosomal sorting complex required for transport(ESCRT) is essential for the MVB sorting pathway by driving the cargo sorting to its *** efforts in plant research have identified the ESCRT machinery and functionally characterised the first plant ESCRT ***,most studies have been performed in the model plant Arabidopsis thaliana that is genetically and physiologically different to *** crops are important for animal feed and human nutrition and have further been utilized as promising candidates for recombinant protein *** this review,I summarize the role of plant ESCRT components in cereals that are involved in efficient adaptation to environmental stress and grain development.A special focus is on barley(Hordeum vulgare L.) ESCRT proteins,where recent studies show their quantitative mapping during grain development,*** HvSNF7.1 with protein trafficking to protein bodies(PBs) in starchy ***,it is indispensable to identify the molecular key-players within the endomembrane system including ESCRT proteins to optimize and possibly enhance tolerance to environmental stress,grain yield and recombinant protein production in cereal grains.

关键词： ESCRT cereal barley grain endosperm SNF7 abiotic stress biotic stress

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Impact of pre-existing cardiometabolic diseases on metastatic cancer stage at diagnosis:a prospective multinational cohort study

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Cancer Communications 2024年第5期44卷 593-597页

作者： Anna Jansana Aviane Auguste Marina Kvaskoff Agnès Fournier Emma Fontvieille Laia Peruchet-Noray Carine Biessy Reynalda Cordova Kristina Elin Nielsen Petersen Anne Tjoneland verena Katzke Rudolf Kaaks Fulvio Ricceri Salvatore Panico Paolo Contiero Maria-Jose Sánchez Jesus Castilla Marta Crous-Bou Alicia Heath Elom Kouassivi Aglago Elisabete Weiderpass Marc James Gunter Pietro Ferrari Elio Riboli Vivian Viallon Heinz Freisling International Agency for Research on Cancer(IARC-WHO) LyonFrance Paris-Saclay University University of Versailles-Saint-Quentin-en-YvelineUniversity Paris-SudFrench National Institute for Health and Medical Research(Inserm)Gustave Roussy“Exposome and Heredity”TeamCESPVillejuifFrance Department of Nutritional Sciences University of ViennaViennaAustria Danish Cancer Society Research Center CopenhagenDenmark Department of Public Health University of CopenhagenCopenhagenDenmark Division of Cancer Epidemiology German Cancer Research CentreHeidelbergGermany Department of Clinical and Biological Sciences University of TurinTurinItaly Unit of Epidemiology Regional Health Service ASL TO3GrugliascoTurinItaly Department of Clinical Medicine and Surgery Federico II UniversityNaplesItaly Environmental Epidemiology Unit Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)-Istituto Nazionale dei TumoriMilanItaly Cancer Registry of Granada Institute for Biosanitary Research of Granada(ibs.GRANADA)GranadaSpain Epidemiology and Control of Chronic Diseases Group Epidemiology and Public Health Networking Biomedical Research CentreMadridSpain Navarra Public Health Institute PamplonaSpain Unit of Nutrition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of Oncology(ICO)-Bellvitge Biomedical Research Institute(IDIBELL)L’Hospitalet de LlobregatBarcelonaSpain Department of Epidemiology Harvard Tseng-Hsi Chan School of Public HealthBostonMassachusettsUSA Department of Epidemiology and Biostatistics School of Public HealthImperial College LondonSt Mary’s CampusNorfolk PlaceLondonUK

Owing to shared risk factors between cardiometabolic diseases(CMDs)and cancer,coupled with population aging,the lifetime risk of an individual developing cancer after a CMD is ***,biological mechanisms such as insulin resistance or inflammation may not only predispose individuals withCMDto an elevated risk of certain types of cancer but also to a diagnosis of cancer at an advanced stage[1,2].

关键词： diagnosis diseases cancer

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Progesterone:a universal stimulus for neuronal cells?

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Neural Regeneration Research 2015年第4期10卷 547-549页

作者： verena Theis Carsten Theiss Department of Cytology Institute of AnatomyMedical FacultyRuhr-University Bochum

Progesterone： The sexual hormone progesterone is a mem- ber of the steroid hormone family, and is the most import- ant representative of the gestagenes sub-group. It plays an elementary role in the female menstruation cycle and is essential for the establishment and the maintenance of a pregnancy, however gestagenes like progesterone are also abundant in males. In 1990, the existence of steroids was described in different cells of the central nervous system （CNS）（Baulieu and Robel, 1990）. Up until this point, the effect of sexual hormones on neural cells was rather unknown,

关键词： RNA cell Progesterone Figure PNS

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Improving contrast and sectioning power in confocal imaging by third harmonic generation in SiOx nanocrystallites

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Chinese Optics Letters 2007年第8期5卷 477-479页

作者： Gilbert boyer Karsten Plamann Laboratoire d'Optique Appliqude Ecole Polytechnique-Ecole Nationale Supérieure de Techniques A vancdes-CNRS UMR 7639 Centre de l'Yvette chemin de la Hunière 91761 Palaiseau cedex France

We present a new optical microscope in which the light transmitted by a sample-scanned transmission confocal microscope is frequency-tripled by SiOx nanocrystallites in lieu of being transmitted by a confocal pinhole. This imaging technique offers an increased contrast and a high scattered light rejection. It is demonstrated that the contrast close to the Sparrow resolution limit is enhanced and the sectioning power are increased with respect to the linear confocal detection mode. An experimental implementation is presented and compared with the conventional linear confocal mode.

关键词： mode Improving contrast and sectioning power in confocal imaging by third harmonic generation in SiO_x nanocrystallites THG

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