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Uptake of citrate-coated iron oxide nanoparticles into atherosclerotic lesions in mice occurs via accelerated transcytosis through plaque endothelial cells

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Nano Research 2016年第11期9卷 3437-3452页

作者： Wolfram C. Poller Evelyn Ramberger Philipp Boehm-Sturm Susanne Mueller Konstantin Moller Norbert Lowa Frank Wiekhorst Susanne Wagner Matthias Taupitz Eyk Schellenberger Gert Baumann Karl stangl verena stangl Antje Ludwig Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charite-Universitatsmedizin Berlin Campus Mitte Chariteplatz 1 10117 Berlin Germany Abteilung fur Experimentelle Neurologie Center for Stroke Research Charite-Universitatsmedizin Berlin Chariteplatz 1 10117 Berlin Germany Charite Core Facility '7 T experimental MRIs' Charite-Universitatsmedizin Berlin Chariteplatz 1 10117 Berlin Germany Physikalisch-Technische Bundesanstalt Abbestr. 2-12 10587Berlin Germany Institut fur Radiologie Charite-Universitatsmedizin Berlin Campus Mitte Charit@platz 1 10117 Berlin Germany DZHK (German Centre for Cardiovascular Research) partner site Berlin 10115 Berlin Germany Berlin Institute of Health (BIH) 10117 Berlin Germany

Very small superparamagnetic iron oxide nanoparticles （VSOPs） rapidly accumulate in atherosclerotic lesions, thereby enabling plaque visualization by magnetic resonance imaging （MRI）. This study was performed to identify the uptake mechanisms of VSOPs into atherosclerotic plaques. Low-density lipoprotein receptor-deficient （LDLR^-/-） mice with advanced atherosclerosis were analyzed using MRI and transmission electron microscopy （TEM） at various time points after intravenous administration of VSOPs. Post-mortem MRI detected VSOP labeling of atherosclerotic plaques 10 min after injection, and the signal increased over the first 3 h. TEM revealed that the intensive plaque labeling was mediated by accelerated transcytosis of VSOPs through endothelial cells overlaying atherosclerotic lesions. Experiments with endocytosis inhibitors and small interfering RNA （siRNA） revealed a dynamin-dependent mechanism involving both clathrin- and caveolin-mediated processes. In cell culture experiments, endothelial VSOP uptake was enhanced under proatherogenic flow and TNFα stimulation, conditions that are both present in plaque areas. Our study demonstrates that VSOPs enable non-invasive MRI assessment of accelerated endothelial transcytosis, an important pathomechanism in atherosclerotic plaque formation.

关键词： atherosclerosis,unstable plaques,magnetic resonanceimaging decreased endothelial barrier function,superparamagnetic ironoxide nanoparticles

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车辆轮端问题的预防详析

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现代制造 2012年第46期 30-32页

作者： Mark stangl 铁姆肯公司

无论是在车间．还是在道路上．维修人员应与驾驶员共同努力．避免车辆轮端问题．以减少停车时间。

关键词：车辆预防停车时间维修人员驾驶员道路

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车辆轮端问题的预防

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汽车与配件 2012年第48期 58-60页

作者： Mark stangl 铁姆肯公司

北美的卡车驾驶员每年在公路上穿行无数小时，将货物安全、准时地运往目的地。然而，涉及车辆轮端的维修问题有时却会导致代价昂贵的运输延误和潜在的安全风险。

关键词：车辆预防货物安全安全风险驾驶员目的地公路卡车

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Numerical Analysis of the Thermal Behavior of a Hermetic Reciprocating Compressor

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地球科学与工程：英文版 2017年第1期7卷 1-9页

作者： Stefan Posch Johann Hopfgartner Erwin Berger Bemhard Zuber Lukas Dtir Stefan stangl Raimund Almbauer Institute of Internal Combustion Engines and Thermodynamics Graz University of Technology Inffeldgasse 19 8010 Graz Austria Secop Austria GmbH Jahnstraβe 30 8280 Furstenfeld Austria

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Detailed Micro Raman Spectroscopy Analysis of Doped Silicon Thin Film Layers and Its Feasibility for Heterojunction Silicon Wafer Solar Cells

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Journal of Materials Science and Chemical Engineering 2013年第5期1卷 1-14页

作者： Z. P. Ling J. Ge R. stangl A. G. Aberle T. Mueller Solar Energy Research Institute of Singapore National University of Singapore Singapore Solar Energy Research Institute of Singapore National University of Singapore Singapore Department of Electrical and Computer Engineering National University of Singapore Singapore Solar Energy Research Institute of Singapore National University of Singapore Singapore National University of Singapore Graduate School for Integrative Sciences and Engineering Singapore

Hydrogenated doped silicon thin films deposited using RF (13.56 MHz) PECVD were studied in detail using micro Raman spectroscopy to investigate the impact of doping gas flow, film thickness, and substrate type on the film characteristics. In particular, by deconvoluting the micro Raman spectra into amorphous and crystalline components, qualitative and quantitative information such as bond angle disorder, bond length, film stress, and film crystallinity can be determined. By selecting the optimum doped silicon thin film deposition conditions, and combining our p-doped and n-doped silicon thin films in different heterojunction structures, we demonstrate both (i) an efficient field effect passivation and (ii) further improvement to c-Si/a-Si:H(i) interface defect density with observed improvement in implied open-circuit voltage VOC and minority carrier lifetimes across all injections levels of interest. In particular, the heterojunction structure (a-Si:H(p)/a-Si:H(i)/c-Si(n)/a-Si:H(i)/a-Si:H(p)) demonstrates a minority carrier lifetime of 2.4 ms at an injection level of 1015 cm-3, and a high implied open-circuit voltage of 725 mV. Simulation studies reveal a strong dependence of the interface defect density Dit on the heterojunction silicon wafer solar cell performance, affected by the deposition conditions of the overlying doped silicon thin film layers. Using our films, and a fitted Dit of 5 × 1010 cm-2·eV-1, we demonstrate that a solar cell efficiency of ~22.5% can be potentially achievable.

关键词： Raman Spectroscopy Heterojunction Silicon Wafer Solar Cells Doped Silicon Simulation Passivation

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Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics

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npj Computational Materials 2020年第1期6卷 1592-1600页

作者： Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue Wang Hansong Xue Jose Dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph J.Brabec Rolf stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius Peters Tonio Buonassisi Singapore-MIT Alliance for Research and Technology SMART Singapore 138602Singapore Solar Energy Research Institute of Singapore(SERIS) National University of SingaporeSingapore 117574Singapore Massachusetts Institute of Technology CambridgeMA 02139USA Institute of Materials for Electronics and Energy Technology(i-MEET) Friedrich-Alexander University Erlangen-Nürnberg91058 ErlangenGermany Helmholtz Institute HI-ErN Forschungszentrum JülichImmerwahrstrasse 291058 ErlangenGermany National University of Singapore Singapore 119077Singapore

Process optimization of photovoltaic devices is a time-intensive,trial-and-error endeavor,which lacks full transparency of the underlying physics and relies on user-imposed constraints that may or may not lead to a global ***,we demonstrate that embedding physics domain knowledge into a Bayesian network enables an optimization approach for gallium arsenide(GaAs)solar cells that identifies the root cause(s)of underperformance with layer-by-layer resolution and reveals alternative optimal process windows beyond traditional black-box *** Bayesian network approach links a key GaAs process variable(growth temperature)to material descriptors(bulk and interface properties,e.g.,bulk lifetime,doping,and surface recombination)and device performance parameters(e.g.,cell efficiency).For this purpose,we combine a Bayesian inference framework with a neural network surrogate device-physics model that is 100×faster than numerical *** the trained surrogate model and only a small number of experimental samples,our approach reduces significantly the time-consuming intervention and characterization required by the *** a demonstration of our method,in only five metal organic chemical vapor depositions,we identify a superior growth temperature profile for the window,bulk,and back surface field layer of a GaAs solar cell,without any secondary measurements,and demonstrate a 6.5%relative AM1.5G efficiency improvement above traditional grid search methods.

关键词： knowledge network enable

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PTe热敏电阻——具有广泛应用的陶瓷部件

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传感器与微系统 1982年第Z1期 77-80页

作者： Franz stangl ,温惠琴

铁电陶瓷领域的深入发展,为陶瓷PTC热敏电阻开辟了种种新的应用可能。在不同场合的应用中,有些已是众所周知的了。而有些却是新近才发现的。这些首先包括PTC热敏电阻作为电阻依赖温度变化的电平敏感元件和开关延迟元件。这为稳流、自动... 详细信息

铁电陶瓷领域的深入发展,为陶瓷PTC热敏电阻开辟了种种新的应用可能。在不同场合的应用中,有些已是众所周知的了。而有些却是新近才发现的。这些首先包括PTC热敏电阻作为电阻依赖温度变化的电平敏感元件和开关延迟元件。这为稳流、自动振荡保护和加热系统的广泛领域提供了新的应用可能性。

关键词：热敏电阻电流 PTC 敏感元件热敏元件电子元件敏感电阻器 PTe 部件

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Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma

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World Journal of Gastroenterology 2007年第9期13卷 1422-1426页

作者： Andreas Weber Sonja Landrock Jochen Schneider Manfred stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz Department of Internal Medicine Ⅱ Technical University of Munich Germany Department of Surgery Technical University of Munich Germany Department of Internal Medicine Rudolf Virchow Klinikum Charite Berlin Germany

AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated.

关键词：肝门胆管癌患者长期预后预兆因素

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纳米光束的X射线散射探测纳米物质

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国外科技新书评介 2014年第4期 18-18页

作者： Julian stangl 聂树真不详中国科学院光电研究院

X射线散射技术是一种较常用的非破坏性分析技术，可用于揭示物质的晶体结构、化学组成以及物理性质。利用纳米聚焦光束的X射线散射技术来研究纳米尺度的物质特性是本书的主旨，

关键词： X射线散射纳米物质聚焦光束探测非破坏性分析晶体结构物理性质化学组成

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High-density lipoprotein endocytosis in endothelial cells

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World Journal of Biological Chemistry 2013年第4期4卷 131-140页

作者： Stefanie Fruhwürth Margit Pavelka Robert Bittman Werner J Kovacs Katharina M Walter Clemens Rhrl Herbert stangl Clemens R hrl Herbert StanglCenter for Pathobiochemistry and GeneticsInstitute of Medical ChemistryMedical University of Vienna Department of Cell Biology and Ultrastructure Research Center for Anatomy and Cell BiologyMedical University of Vienna Department of Chemistry and Biochemistry Queens College of The City University of New York Institute of Molecular Health Sciences Swiss Federal Institute of Technology Zürich Center for Pathobiochemistry and Genetics Institute of Medical ChemistryMedical University of Vienna

AIM: To describe the way stations of high-density lipoprotein(HDL) uptake and its lipid exchange in endothelial cells in vitro and in vivo. METHODS: A combination of fluorescence microscopy using novel fluorescent cholesterol surrogates and electron microscopy was used to analyze HDL endocytosis in great detail in primary human endothelial cells. Further, HDL uptake was quantified using radio-labeled HDL particles. To validate the in vitro findings mice were injected with fluorescently labeled HDL and particle uptake in the liver was analyzed using fluorescencemicroscopy. RESULTS: HDL uptake occurred via clathrin-coated pits, tubular endosomes and multivesicular bodies in human umbilical vein endothelial cells. During uptake and resecretion, HDL-derived cholesterol was exchanged at a faster rate than cholesteryl oleate, resembling the HDL particle pathway seen in hepatic cells. In addition, lysosomes were not involved in this process and thus HDL degradation was not detectable. In vivo, we found HDL mainly localized in mouse hepatic endothelial cells. HDL was not detected in parenchymal liver cells, indicating that lipid transfer from HDL to hepatocytes occurs primarily via scavenger receptor, class B, type Ⅰ mediated selective uptake without concomitant HDL endocytosis. CONCLUSION: HDL endocytosis occurs via clathrincoated pits, tubular endosomes and multivesicular bodies in human endothelial cells. Mouse endothelial cells showed a similar HDL uptake pattern in vivo indicating that the endothelium is one major site of HDL endocytosis and transcytosis.

关键词： High-density lipoprotein Endocytosis Endothelium Human umbilical vein endothelial cells Human coronary artery endothelial cells Cholesterol

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