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MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer

World Journal of Gastroenterology 2014年第33期20卷 11727-11735页

作者： verena stiegelbauer Samantha Perakis Alexander Deutsch Hui Ling Armin Gerger Martin Pichler Division of Clinical Oncology Department of Internal Medicine Medical University of Graz 8036 Graz Austria Division of Hematology Department of Internal Medicine Medical University of Graz 8036 Graz Austria Department of Experimental Therapeutics University of Texas MD Anderson Cancer Center Houston TX 77030 United States

Colorectal cancer(CRC) is the third most common cancer in western countries. Despite significant improvement in available treatment options, CRC still remains the second leading cause of cancer-related death. Traditionally, 5-fluorouracil has been used as the main chemotherapy drug for treatment of metastatic CRC(mCRC). However, during the last two decades more effective chemotherapeutic agents such as oxaliplatin, irinotecan and the monoclonal antibodies cetuximab, panitumumab and bevacizumab have been used in clinical practice. More recently, the therapeutic armamentarium has been supplemented by the monoclonal antibodies bevacizumab, cetuximab and panitumumab as well as the protein-trap aflibercept and the smallmolecule multi-kinase inhibitor regorafenib. One of the major problems for the management of CRC is the inherent or acquired resistance to therapeutic approaches. The discovery of microRNAs(miRNAs), a class of small, endogenous, non-coding, single-stranded RNAs that play a role as post-transcriptional regulators, has added new dimensions to the diagnosis and treatment of cancer. Because miRNAs are important regulators of carcinogenesis, progression, invasion, angiogenesis and metastases in CRC, they might serve as potential predictive and prognostic factors and even as therapeutic targets themselves. Several miRNAs are already known to be dysregulated in CRCs and have been linked to biological processes involved in tumor progression and response to anti-cancer therapies. This review summarizes current therapeutic approaches for treating CRC and highlights the role of miRNAs as novel predictive biomarkers and potential drug targets in CRC patients.

关键词： Colorectal cancer MicroRNAs 5-fluorouracil Epidermal growth factor receptor Targeted therapy

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The Legendary King Arthur and its Possible Oral History Flourishing Transmitters from the Dark Ages until the Middle Ages

The Legendary King Arthur and its Possible Oral History Flou...

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2012 International Conference on Humanity, History and Society （ICHHS 2012）

作者： Laura Rebeca Precup stiegelbauer Speranta Sofia Milancovici Narcisa Tirban Vasile Goldi Western University of Arad

This Article starts by analysing the first mentioning of the legendary King Arthur in the world history and it goes on by describing its possible Oral History *** analysing the way people dressed and behaved during the Dark Ages and further on during the Middle Ages this Article intends to emphasise the importance of the Arthurian Oral History Transmitters along the *** article proposes to analyse the society which moulded the Legend from generation to generation always,existing means of transmitting it regardless the Age or the social status.

关键词： King Arthur,Oral History,Transmitters,Dark Age,Middle Age

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Challenges and Barriers for International Students in Romania

Challenges and Barriers for International Students in Romani...

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2012 International Conference on Knowledge, Culture and Society (ICKCS 2012)

作者： Narcisa Tirban Laura Rebeca Precup stiegelbauer Paula-Andreea Onofrei Teodor Ptrut "Vasile Goldis" Western University of Arad Romania "Alexandru Ioan Cuza" University of Iasi Romania"George Enescu" University of FineOrnamental Arts and Design of IasiRomania

The phenomenon of medical migration refers to medical doctor travelling far and wide in search of new knowledge and skills,has been practiced for several ***,Great Britain,France,Germany have all attracted international students at different times by their dominance of medical education and *** the 19th century,American physicians travelled to Europe,especially France and Germany,to pursue medical *** they returned,the knowledge and skills these physicians brought back to the United States profoundly changed medicine in *** the end of World War II,the United States has been the preferred destination for medical doctor from all over the world for training in graduate ***,these recent international physician visitors differed from previous generations in that they frequently did not return to their native *** a framework created by the literature,the primary purpose of this study was to examine the needs of international students within their academic and social *** implications of these findings are *** are made for how higher education institutions can help facilitate these students' integration into their new communities.

关键词： International Students,Medicine,Education,Challenges,Language Barriers,Culture

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