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Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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Nano Research 2025年第1期18卷 260-269页

作者： Nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,Ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(NMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TONs of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

An update on the molecular biology of glioblastoma,with clinical implications and progress in its treatment

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Cancer Communications 2022年第11期42卷 1083-1111页

作者： Elena verdugo Iker Puerto MiguelÁngel Medina Department of Molecular Biology and Biochemistry University of MálagaMálagaMálaga E-29071Spain Biomedical Research Institute of Málaga(IBIMA-Plataforma Bionand) MálagaMálaga E-29071Spain Spanish Biomedical Research Network Center for Rare Diseases(CIBERER) Spanish Health Institute Carlos III(ISCIII)MálagaMálaga E-29071Spain

Glioblastoma multiforme(GBM)is the most aggressive and common malig-nant primary brain *** with GBM often have poor prognoses,with a median survival of∼15 *** understanding of the molecular biology of central nervous system tumors has led to modifications in their classifications,the most recent of which classified these tumors into new categories and made some changes in their nomenclature and grading *** review aims to give a panoramic view of the last 3 years’findings in glioblastoma characterization,its heterogeneity,and current advances in its *** molecular parameters have been used to achieve an accurate and personalized characterization of glioblastoma in patients,including epigenetic,genetic,transcriptomic and metabolic features,as well as age-and sex-related patterns and the involvement of several noncoding RNAs in glioblastoma ***-like neural stem cells and outer radial glial-like cells from the subven-tricular zone have been proposed as agents involved in GBM of IDH-wildtype origin,but this remains *** metabolism is characterized by upregulation of the PI3K/Akt/mTOR signaling pathway,promotion of the gly-colytic flux,maintenance of lipid storage,and other *** metabolism also contributes to glioblastoma’s resistance to conventional *** heterogeneity,a hallmark of GBM,has been shown to affect the genetic expresion,modulation of metabolic pathways,and immune system ***’s aggressive invasion potential is modulated by cell-to-cell crosstalk within the tumor microenvironment and altered expressions of specific genes,such as ANXA2,GBP2,FN1,PHIP,and ***,the rising number of active clinical trials illustrates the efforts to identify new targets and drugs to treat this *** is still relevant for research purposes,given the amount of ongoing clinical trials based on this strategy to treat GBM,and neoantigen and nuclei

关键词： cancer molecular biology diagnosis glioblastoma multiforme ongoing clinical trials targeted therapy tumor heterogeneity tumor metabolism

Decoupling the adsorption mechanisms of arsenate at molecular level on modified cube-shaped sponge loaded superparamagnetic iron oxide nanoparticles

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Journal of Environmental Sciences 2022年第11期34卷 1-12页

作者： Xiang-Yang Lou Roberto Boada Veronica verdugo Laura Simonelli Gustavo Pérez Manuel Valiente GTS-UAB Research Group Department of ChemistryFacultat de CiènciesUniversitat Autonoma de Barcelona08193 BellaterraSpain ALBA Synchrotron Carrer de la llum 2-26Cerdanyola del Valles08290 BarcelonaSpain Centro de Excelencia en Nanotecnologia Leitat ChileSantiago 7500724Chile

In this study, a commercial cube-shaped open-celled cellulose sponge adsorbent was modified by in-situ co-precipitation of superparamagnetic iron oxide nanoparticles(SPION) and used to remove As(V) from aqueous solutions. Fe K-edge X-ray absorption spectroscopy(XAS) and TEM identified maghemite as the main iron phase of the SPION nanoparticles with an average size 13 nm. Batch adsorption experiments at 800 mg/L showed a 63% increase of adsorption capacity when loading 2.6 wt.% mass fraction of SPION in the *** determination of the adsorption thermodynamic parameters indicated that the As(V) adsorption on the composite material is a spontaneous and exothermic *** K-edge XAS results confirmed that the adsorption enhancement on the composite can be attributed to the nanoparticles loaded. In addition, adsorbed As(V) did not get reduced to more toxic As(Ⅲ) and formed a binuclear corner-sharing complex with SPION. The advantageous cube-shape of the sponge-loaded SPION composite together with its high affinity and good adsorption capacity for As(V), good regeneration capability and the enhanceddiffusion attributed to its open-celled structure make this adsorbent a good candidate for industrial applications.

关键词： Adsorption Cube composite adsorbent Arsenate removal Regeneration X-ray absorption spectroscopy

Bifurcation Analysis of a Nonlinear Genetic Network Model with Time Delay

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Journal of Applied Mathematics and Physics 2023年第8期11卷 2252-2266页

作者： Anael verdugo Department of Mathematics California State University Fullerton USA

This paper presents a bifurcation study of a mRNA-protein network with negative feedback and time delay. The network is modeled as a coupled system of N ordinary differential equations (ODEs) and N delay differential equations (DDEs). Linear analysis of the stable equilibria shows the existence of a critical time delay beyond which limit cycle oscillations are born in a Hopf bifurcation. The Poincaré-Lindstedt perturbation method is applied to the nonlinear system, resulting in closed form approximate expressions for the amplitude and frequency of oscillation. We confirm our perturbation analysis results by numerically simulating the full 2N-dimensional nonlinear system for N = 2, 7, 15, and 30. Our results show that for small perturbations the equilibrium undergoes a supercritical Hopf and the system exhibits stable periodic solutions. Furthermore, our closed form numerical expressions exhibit the importance of the network’s negative feedback and nonlinear effects.

关键词： Bifurcation Analysis Hopf Delay Differential Equations

Empirically supported psychological treatments:The challenges of comorbid psychiatric and behavioral disorders in people with intellectual disability

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World Journal of Psychiatry 2021年第11期11卷 1039-1052页

作者： Laura E Gómez Patricia Navas MiguelÁngel verdugo Marc J Tassé Department of Psychology University of OviedoOviedo 33011AsturiasSpain Department of Personality Evaluation and Psychological TreatmentsInstitute on Community IntegrationUniversity of SalamancaSalamanca 37005SalamancaSpain Department of Psychology and Psychiatry The Ohio State University Nisonger Center-UCEDDColumbusOH 43210-1257United States

This paper reviews the current state of knowledge on psychological interventions with empirical evidence of efficacy in treating common psychiatric and behavioral disorders in people with intellectual disability(ID)at all stages of their *** begin with a brief presentation of what is meant by psychiatric and behavioral disorders in this population,along with an explanation of some of the factors that contribute to the increased psychosocial vulnerability of this group to present with these *** then conduct a review of empirically supported psychological therapies used to treat psychiatric and behavioral disorders in people with *** review is structured around the three generations of therapies:Applied behavior analysis(e.g.,positive behavior support),cognitive behavioral therapies(e.g.,mindfulness-based cognitive therapy),and contextual therapies(e.g.,dialectical behavior therapy).We conclude with some recommendations for professional practice in the fields of ID and psychiatry.

关键词： Behavior disorder Intellectual disability Psychiatry Applied behavior analysis Cognitive behavioral therapies Contextual therapies

Hopf Bifurcation Analysis of the Repressilator Model

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American Journal of Computational Mathematics 2018年第2期8卷 137-152页

作者： Anael verdugo Department of Mathematics California State University Fullerton CA USA Center for Computational and Applied Mathematics California State University Fullerton CA USA

The repressilator is a genetic network that exhibits oscillations. The net-work is formed of three genes, each of which represses each other cyclically, creating a negative feedback loop with nonlinear interactions. In this work we present a computational bifurcation analysis of the mathematical model of the repressilator. We show that the steady state undergoes a transition from stable to unstable giving rise to a stable limit-cycle in a Hopf bifurcation. The nonlinear analysis involves a center manifold reduction on the six-dimensional system, which yields closed form expressions for the frequency and amplitude of the oscillation born at the Hopf. A parameter study then shows how the dynamics of the system are influenced for different parameter values and their associated biological significance.

关键词： Hopf Bifurcation Repressilator Center Manifold Analysis

Trichoderma *** Bacillus *** growth promoters in maize(Zea mays L.)

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Phyton-International Journal of Experimental Botany 2019年第1期88卷 37-46页

作者： López-Valenzuela BE Armenta-Bojórquez AD Hernández-verdugo S Apodaca-Sánchez MA Samaniego-Gaxiola JA Valdez-Ortiz A Universidad Autónoma de Sinaloa.Facultad de Agricultura del Valle del Fuerte.Avenida Japaraqui y Calle 16 s/n Juan JoséRíosSinaloaC.P 81110México Universidad Autónoma de Baja California.Instituto de Ciencias Agrícolas.Carretera a Delta s/n Ejido Nuevo leónBaja CaliforniaC.P.21705México Instituto Politécnico Nacional.Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Sinaloa.Blvd.Juan de Dios Bátiz Paredes#250 Colonia San JoachinGuasaveSinaloaC.P.81101México Universidad Autónoma de Sinaloa Facultad de Agronomía.Km.17.5Carretera Culiacán-El DoradoCuliacán RosalesSinaloaC.P.80000México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Campo Experimental La LagunaBlvd.JoséSantos Valdez 1200 Pte.MatamorosCoahuilaC.P.27440México Universidad Autónoma de Sinaloa Facultad de Ciencias Químico Biológicas.Calzada de las Américas y Calle Universitarioss/n.Ciudad UniversitariaCuliacánSinaloaC.P.80013México

Microbes that are beneficial to plants are used to enhance the crop growth,yield and are alternatives to chemical *** and Bacillus are the predominant plant growth-promoting fungi and *** objective of this study was select,characterize,and evaluate isolates of Trichoderma *** Bacillus *** from the northern region of Sinaloa,Mexico,and assess their effect on growth promotion in maize(Zea mays L.).In greenhouse conditions,four Trichoderma isolates and twenty Bacillus isolates,as well as two controls,were tested in a completely randomized design with three *** selected the two best strains of Trichoderma and Bacillus:TB=Trichoderma asperellum,TF=Trichoderma virens,B14=Bacillus cereus sensu lato and B17=Bacillus cereus,which were evaluated in the field in a completely randomized blocks in factorial arrangement design with three replicates applying different rates of nitrogen fertilizer(0,150 kg N/ha,and 300 kg N/ha).Treatments 5(B17=***)and 11(TF=***)both fertilized with 150 kg N/ha showed similar yields and they did not reveal significant differences from the treatments fertilized with 300 kg N/*** indicated that treatment 5(B17=*** with 150 kg N/ha)and treatment 11(TF=*** with 150 kg N/ha)were efficient as growth promoters,by not showing significant differences in root volume and dry weight of *** results indicated a reduction of 50% in the rate of nitrogen to fertilizer required for maize(Zea mays L.)*** microorganisms Trichoderma and Bacillus could be an alternative to reduce the use of chemical fertilizers in maize.

关键词： Trichoderma Bacillus Native strains Biofertilizers

A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3221-3224页

作者： JoséManuel García-Heredia Marco Pérez Eva M.verdugo-Sivianes María M.Martínez-Ballesteros Sara M.Ortega-Campos Amancio Carnero Instituto de Biomedicina de Sevilla(IBIS)/HUVR/Universidad de Sevilla/CSIC SevillaSpain Departamento de Bioquímica Vegetal y Biología Molecular Universidad de SevillaSevillaSpain CIBERONC IS Carlos IIIMadridSpain Departamento de Anatomía Patológica HUVRSevillaSpain Departamento de Lenguajes y Sistemas Informáticos Escuela Superior de Ingeniería InformáticaUniversidad de SevillaSevillaSpain

Dear Editor Sarcomas are a group of heterogeneous mesodermic rare tumors with high incidence in children,reaching up to 20%of *** treatment for sarcomas is surgical resection,and only some patients are treated with ch... 详细信息

关键词： neoplasms chemotherapy treatment

Characteristics of Thyroid Hormones in Hypertensive Hispanic Population

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Journal of Life Sciences 2012年第2期6卷 155-163页

作者： Rodrigo verdugo Graciela Wendel Liliana Trujillo Guillermo Orellano Lucia Fuentes Department of Pharmacology National University of San Luis San Luis 5700 Argentina D.O.S.P.U. Cardiologic Center San Luis 5700 Argentina Orellano-Elorza Biochemical Laboratory San Luis 5700 Argentina

The aim was to characterize thyroid function in Hispanic hypertensive population. Retrospective study of 1,023 individuals was performed, in which 68.23% had hypertension （74.21% women） and 37.25% had thyroid pathology. Age, weight, blood pressure, biochemical measurements were recorded, mean age： 53.02 ± 14.80 yr, mean weight： 83.05 ±16.95 kg, thyrotropin-stimulating hormone （TSH） hypertensive patients： 5.55±1.63 μUI/mL and without hypertension： 3,72 ± 1.60 μUI/mL. TSH range concentration distributed by sex indicates： 1.50-2.49 μUI/mL men, 2.50-5.01 μUI/mL women. TSH categories vs. age were positively associated （r = ＋ 0.114, P = 0.044） and hypertension by age was also correlated （r = ＋ 0.178, P = 0.0001）. Significant positive association we found between TSH and diastolic blood pressure （r = ＋ 0.197, P = 0.008）. Systolic and diastolic blood pressure vs. age were positively increasing （r = ＋ 0.410,p = 0.0001; r = ＋0.285, P = 0.0001, respectively）. Prevalence of thyroid pathology in hypertensive subjects are hyperthyroidism 5.87%; hypothyroidism 20.34% （5.73% subclinic） and autoimmune disease 6.25%. High percentage of hypertensive population has concomitant thyroid diseases, more common in women （50-70 years）. Systematic surveillance for occult thyroid dysfunction in patients with hypertension could prevent future cardiovascular disease.

关键词： Thyroid hormones blood pressure thyroid pathologies patients Hispanic.