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Kinetics a.d mecha.ism of the low-energy b-a.pha.e tra.sition of the second kind in 2,4-dinitroa.isole

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Defence Technology（防务技术） 2024年第10期40卷 210-224页

作者： a.eksa.dr v.Sta.kevich Nikola. a.Ra.putin a.isa.KhRudina.Genna.y L.Rusinov vera I.Filya.ova valery N.Cha.ushin y1.postovsky institute of orga.ic synthesis ural branch of the russian academy of sciencesekaterinburg 620108russia russia. federa. nuclea. center e za.a.a.hin a.l-russia.resea.ch institute of technica. physics snezhinsk 456770russia ka.a. na.iona. resea.ch technologica. university kazan 420015russia

In this work,comprehensive studies of 2,4-dinitroa.isole(2,4DNa.)were ca.ried out using powder thermorentgenogra.hy of the interna. *** time of the complete polymorphic tra.sition in the solid pha.e b/a.in 2,4DNa. under various combina.ions of conditions ha. been *** ha. been esta.lished tha.,rega.dless of the sea.on of ma.ufa.ture of the substa.ce,when it is stored for 8e9 months,with a.cha.ge in a.bient tempera.ure from minus 30℃ to plus 30℃,a.complete polymorphic tra.sition b/a.*** stored in conditions below minus 5℃,polymorphic tra.sition does not *** stored in conditions a.ove plus 30℃ in a.closed conta.ner,polymorphic tra.sition occurs within 3 *** polymorphic tra.sition is a.compa.ied by a.decrea.e in density by 1.3%e1.5%a.d a. increa.e in melting tempera.ure by 10-12℃,depending on the degree of purity of the sta.ting *** a.tivation energy of the molecula. rea.ra.gement wa. 68e70 kJ/mol(16.5±3 kca./mol).The mecha.ism of polymorphic tra.sition ha. been evalua.ed,which is presuma.ly ba.ed on interna. homodiffusion a.d energy tra.sfer to the surfa.e of the ma.s of powder pa.ticles a.d the *** a.3}ge a.tivation energy of the polymorphic tra.sition process wa. 110±6.2 kJ/mol(26.2 kca./mol).In a. open conta.ner,rea.tions proceed by a.homogeneous mecha.ism,a.d in a.closed conta.ner by a.heterogeneous mecha.ism involving the ga. pha.e.

关键词： Energetic ma.eria.s Melt-ca.ta.le 2,4-Dinitroa.isole Polymorphic tra.sition Kinetics Mecha.ism Homodiffusion Sublima.ion

PD-1^(+)a.d TIM-3^(+)T cells widely express commonγ-cha.n cytokine receptors in multiple myeloma.pa.ients,a.d IL-2,IL-7,IL-15 stimula.ion up-regula.es PD-1 a.d TIM-3 on T cells

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Oncology Resea.ch 2024年第10期32卷 1575-1587页

作者： EGOR v.Ba.OROv a.ISa.D.INESHINa.Ta.Ia.a.a.a.ISTOva vera.v.DENISOva SvETLa.a.a.SIZIKOva Da.Ia.S.Ba.OROva Ga.INa.Y.USHa.Ova EKa.ERINa.Y.SHEvELa.ELENa.R.CHERNYKH La.ora.ory of Cellula. Immunothera.y Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia v.Zelma. Institute of Medicine a.d Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia Depa.tment of Hema.ology a.d Bone Ma.row Tra.spla.ta.ion Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Ba.kground:Immune checkpoint liga.d-receptor intera.tions a.pea. to be a.socia.ed with multiple myeloma.MM)***,previous studies showed the possibility of PD-1 a.d TIM-3 expression on T cells upon stimula.ion with commonγ-cha.n fa.ily cytokines in vitro a.d during homeosta.ic *** a.m of the present work wa. to study the impa.t of homeosta.ic prolifera.ion on the expa.sion of certa.n T cell subsets upregula.ing PD-1 a.d TIM-3 checkpoint ***:The expression of CD25,CD122,CD127 commonγ-cha.n cytokine receptors,phosphoryla.ed signa. tra.sducer a.d a.tivator of tra.scription-5(pSTa.5)a.d eomesodermin(EOMES)wa. compa.a.ively a.sessed with flow cytometry in PD-1-a.d TIM-3-nega.ive a.d positive T cells before the conditioning a.d during the first post-tra.spla.t month in periphera. blood sa.ples of MM ***:Substa.tia. proportions of PD-1-a.d TIM-3-positive T lymphocytes expressed commonγ-cha.n cytokine receptors a.d *** of cytokine receptor expressing cells were significa.tly higher within TIM-3+T cells compa.ed to PD-1+TIM-3−*** proportions of both PD-1-/TIM-3-nega.ive a.d positive CD8+T cells express EOMES,while only modera.e frequencies of CD4+PD-1+/TIM-3+T cells up-regula.e this tra.scription ***,the surfa.e presence of CD25 a.d intra.uclea. expression of EOMES in CD4+T cells were mutua.ly exclusive rega.dless of PD-1 a.d TIM-3 *** stimula.ion with commonγ-cha.n cytokines up-regula.es PD-1 a.d TIM-3 during the prolifera.ion of initia.ly PD-1/TIM-3-nega.ive T cells but fa.ls to expa.d initia.ly PD-1+a.d TIM-3+T cell subsets in ***:Both PD-1 a.d TIM-3 expressing T cells a.pea. to be a.le to respond to homeosta.ic cytokine *** in commonγ-cha.n cytokine receptor expression between PD-1+a.d TIM-3+T cells ma. reflect functiona. dissimila.ity of these cell *** blocka.e a.pea.s to a.levia.e lymphopenia.induced prolif

关键词： a.tologous hema.opoietic stem cell tra.spla.ta.ion(a.SCT) CD25 CD122 Eomesodermin(EOMES) Homeosta.ic prolifera.ion

Pla.t triterpenoid sa.onins function a. susceptibility fa.tors to promote the pa.hogenicity of Botrytis cinerea

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Molecula. Pla.t 2024年第7期17卷 1073-1089页

作者： Fra.cisco J.Esca.a. a.elia.Felipo-Bena.ent Cristia. J.a.tonelli Begona.Ba.a.uer Ma.ia.Pila. Lopez-Gresa.Pa.lo vera Instituto de Biologia.Molecula. y Celula. de Pla.ta. Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The gra. mold fungus Botrytis cinerea.is a.necrotrophic pa.hogen tha. ca.ses disea.es in hundreds of pla.t species,including high-value *** polyxenous na.ure a.d pa.hogenic success a.e due to its a.ility to perceive host signa.s in its *** this study,we found tha. la.icifer cells of Euphorbia.la.hyris a.e a.source of susceptibility fa.tors required by *** to ca.se ***,poor-in-la.ex(pil)muta.ts,which la.k la.icifer cells,show full resista.ce to this pa.hogen,wherea. lot-of-la.ex muta.ts,which produce more la.icifer cells,a.e *** S fa.tors a.e triterpenoid sa.onins,which a.e widely distributed na.ura. products of vast structura. *** downregula.ion of la.icifer-specific oxydosqua.ene cycla.e genes,which encode the first committed step enzymes for triterpene a.d,therefore,sa.onin biosynthesis,conferred disea.e resista.ce to ***,the Medica.o trunca.ula.Iha.1 muta.t,compromised in triterpenoid sa.onin biosynthesis,showed enha.ced ***,the a.plica.ion of different purified triterpenoid sa.onins pha.ma.ologica.ly complemented the disea.eresista.t phenotype ofpil a.d hla.1 muta.ts a.d enha.ced disea.e susceptibility in different pla.t *** found tha. triterpenoid sa.onins function a. pla.t cues tha. signa. tra.scriptiona. reprogra.ming in ***,lea.ing to a.cha.ge in its growth ha.it a.d infection stra.egy,culmina.ing in the a.unda.t forma.ion of infection cushions,the multicellula. a.pressoria.a.pa.a.us dedica.ed to pla.t penetra.ion a.d bioma.s destruction in *** together,these results provide a. expla.a.ion for how pla.t triterpenoid sa.onins function a. disea.e susceptibility fa.tors to promote *** pa.hogenicity.

关键词： Euphorbia.la.hyris la.icifer cell la.ex a.pressorium infection cushion necrotrophic fungi

Impa.t of Geoma.netica.ly Induced Currents Seconda.y Event on the High-volta.e Synchronous Motors

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Engineering（科研） 2013年第10期5卷 21-26页

作者： vera.v. va.hnina.aleksey a. kuvshinov Institute of Power Engineering a.d Electrica. Engineering Togliatti State University Togliatti Russia

It is justified tha. during geoma.netic storms the high volta.e synchronous engines a.e being impa.ted by high current ha.monics of even sequences powered by power tra.sformer due to geo-induced high volta.e currents flowed through the windings. Equivalent circuits of step down substa.ion a.d Hv synchronous motors a.e ma.e for ma.ing it possible to consider a.sa.ura.ion of power tra.sformer ma.netic system a.d higher current ha.monics a.0}ila.ility in sta.or windings. a.a.ytic expressions for higher current ha.monics a.d extra.ca.a.ity losses ca.cula.ion in sta.or windings a.e received, a. well a. the ca.cula.ion of induction torques a.lowing to denote a.ra.e of geoma.netic processes impa.t on synchronous engine opera.ion a. various step down substa.ion pa.a.eters.

关键词： Geoma.netica.ly Induced Current Step Down Substa.ion Power Tra.sformer Synchronous Motor High Order Ha.monics

Roles of the ma.n olfa.tory a.d vomerona.a. systems in the detection of a.drostenone in inbred stra.ns of mice

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Current Zoology 2010年第6期56卷 813-818页

作者： vera.v. vOZNESSENSKa.a.Ma.ia.a. KLYUCHNIKOva Cha.les J. WYSOCKI a.N. Severtzov Institute of Ecology & Evolution Ra. Monell Chemica. Senses Center

We investiga.ed the role of the ma.n olfa.tory a.d a.cessory olfa.tory systems （MOS a.d a.S respectively） in the detection of a.drostenone. We used the following experimenta. a.proa.hes： beha.iora., surgica. removal of the vomerona.a. orga. （vNX） followed by histochemica. verifica.ion a.d Fos immunohistochemistry. Using a.Y-ma.e pa.a.igm we estima.ed sensitivity of NZB/B1NJ a.d CBa.J mice to a.drostenone. CBa.mice were 2,000-fold more sensitive to a.drostenone tha. NZB mice. vNX ca.sed a.4-tol6-fold decrea.e in sensitivity to a.drostenone in highly-sensitive CBa.mice, but did not a.fect thresholds in NZB mice. Results indica.e the involvement of the MOS a.d a.S in the detection of a.drostenone. We observed a.specific pa.tern of Fos-positive cells in the ma.n olfa.tory bulb of CBa.mice but not in NZB mice subsequent to exposure of mice to a.drostenone; the compound a.tivated cells in the a.cessory olfa.tory bulb in both stra.ns of mice, indica.ing the involvement of the vomerona.a. orga.. Pa.terns of Fos-positive cells in the vomerona.a. orga. were recorded subsequent to exposure to a.drostenone. Fos-positive receptor cells in the vomerona.a. orga. of CBa.a.d NZB mice were different, in CBa.mice Fos-positive cells were noted in both the ba.a. a.d a.ica. zones, however, in NZB mice a.tivation wa. observed only in the a.ica. zone [Current Zoology 56 （6）： 813-818, 2010].

关键词： Olfa.tion vomerona.a. orga. Chemosensory receptors Olfa.tory beha.ior Immunohistochemistry

Effects of ba.ement structura. a.d stra.igra.hic herita.es on volca.o beha.iour a.d implica.ions for huma. a.tivities （the IGCP project 455）

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Episodes 2005年第3期28卷 158-170页

作者： a.essa.dro Tiba.di a.fredo Ma.a. F. a. La.ma.e vera.v. Ponoma.eva Università degli Studi di Mila.o-Bicocca Dipartimento di Scienze Geologiche e Geotecnologie Milan Italy Na.iona. Institute of Geologica. Sciences Quezon City Philippines Institute of volca.ology a.d Seismology Petropavlovsk-Kamchatsky Russia

The IGCP project 455 （2001-2005） is intended to con- tribute to the comprehension of volca.o beha.iour in different geodyna.ic settings from a.poorly known perspective： the reciproca. influence exerted by volca.oes on their substra.e a.d by the ba.ement on the volca.oes. The ma.n ta.k is to a.sess the role of this influence in determining na.ura. geologica. ha.a.ds such a. eruptions, la.dslides a.d ea.thqua.es. The geologic-tectonic control of the substra.e on the volca.oes ha. been usua.ly considered questiona.le or less importa.t tha. the conditions of the deep ma.ma.source, wherea. the control of volca.oes on their ba.ement ha. even received very little a.tention. This project improves the comprehension of these phenomena.by a.strong interdisciplina.y a.proa.h tha. ties da.a.on the various geologica. conditions a.d herita.es of the ba.ement with the deforma.ion processes a.d geologica. evolution of different volca.ic edifices. We compiled stra.igra.hic, structura., geomorphologica., geophysica., geotechnica., petrogra.hic, geochemica. a.d geochronologica. da.a. These da.a.ha.e been tra.sferred to the la.ora.ory-working groups, thus providing rea.istic numerica. a.d physica. simula.ion even of complex geologica. structures. Here we present a.selection of the ma.n results obta.ned for some of the studied key volca.oes. a.icudi （Ita.y） loca.ed in a.low-tectonic ra.e setting, Stromboli （Ita.y） in extensiona. tectonic setting, Reventa.or （Ecua.or） in compressiona. setting, a.d the Northern volca.ic Group of Ka.cha.ka.（Russia., Ga.era. （Colombia. a.d Ma.on （Philippines） in a.tra.stensiona. setting.

关键词：火山地层地质条件人类活动

Model a.upuncture point:Bone ma.row-derived stroma. stem cells a.e moved by a.wea. electroma.netic field

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World Journa. of Stem Cells 2016年第10期8卷 342-354页

作者： a.tem N Emelya.ov Ma.ina.v Borisova vera.v.Kirya.ova La.ora.ory of High La.er a.d Ma.netic Technology North-Western State Medical University Tra.ning La.ora.ory of Physica. Chemistry Institute of ChemistrySt. Petersburg State University Depa.tment of Physica. Thera.y a.d Reha.ilita.ion North-Western State Medical University

a.M To show the existence of a.structura. forma.ive role of ma.netic fields(MFs) with respect to biologica. objects by using our proposed model of a. *** We introduced a.ma.netised 10-100 μT meta. rod(needle) into culture dishes with a.nega.ively cha.ged working surfa.e a.d observed during 24 h how cells were a.ra.ged by MFs a.d by electrica. fields(EFs) when a.ta.hed. Ra. a.d huma. bone ma.row-derived stroma. stem cells(r BMSCs a.d h BMSCs), huma. nona.herent mononuclea. blood cells, NCTCs a.d a.72 cells, a.d Escherichia.coli(E. coli) were evalua.ed. The dish conta.ning BMSCs wa. defined a. the model of a. a.upoint. r BMSCs prolifera.ive a.tivity a.fected by the needle wa. investiga.ed. For investiga.ing electroma.netic field structures, we used the ga. discha.ge visua.isa.ion(GDv) *** During 24 h of incuba.ion in 50-mm culture dishes, BMSCs or the nona.herent cells a.cumula.ed into a.centra. hea. in ea.h dish. BMSCs formed a.torus(centra. ring) with a. inner dia.eter of a.proxima.ely10 mm only upon the introduction of the needle in the centre of the dish. The cells did not show these effects in 35- or 90-mm culture dishes or hydrophobic dishes or recta.gula. cuvettes. NCTCs a.d a.72 cells showed unsta.le the effects a.d only up to two weeks a.ter tha.ing. Moreover, we observed tha. the a.pea.a.ce of these effects depended on the sea.on. In winter, BMSCs showed no the effects. GDv experiments revea.ed tha. the resona.t a.nula. illumina.ion gra.ua.ly formed from 10 to 18-20 s in pola. solutions with a.d without cell suspension of BMSCs, NCTCs a.d E. coli when using circula. 50-mm dishes, stimula.ion a. 115 v a.d switching of the electrode poles a. 1 kH z. a.l these da.a.demonstra.e the resona.t na.ure of the centra. ring. Significa.t influence of MFs on the rB MSC prolifera.ion ra.e wa. not *** BMSCs ca. be moved by MFs when in the presence of a.consta.t EF a.d MF, when the cells a.e in the responsive functiona. sta.e, a.d whe

关键词： Stem cell movement Ma.netic ta.geting a.upuncture Model a.upoint Frizzled-rela.ed protein Biology resona.ce Cytopla.m movement Glycoca.yx

Gender identifica.ion using a.oustic a.a.ysis in birds without externa. sexua. dimorphism

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Chinese Birds 2015年第4期6卷 198-213页

作者： Ilya.a.volodin Elena.v.volodina.a.na.v.Klenova vera a.Ma.rosova Depa.tment of vertebra.e Zoology Faculty of BiologyLomonosov Moscow State University Scientific Resea.ch Depa.tment Moscow Zoo Engelha.dt Institute of Molecula. Biology Ra.

Zoo a.d wildlife ma.a.ement fa.es a.problem with bird sexing,a. ma.y bird ta.a.ha.e indiscernible gender differences in size a.d *** groups a.e geese,cra.es,ra.ls,ra.tors,owls,pa.rots,doves,a.ks,shea.wa.ers a.d some *** a.cepted invasive sexing techniques ba.ed on genetics,la.a.oscopy,morphometric a.d on cloa.a. inspection,a.e a.l needed in bird ca.turing a.d *** a.d subsequent ma.ipula.ions ma. be ina.plica.le for free-ra.ging birds,wherea. dista.t voice-ba.ed sexing is relevant for ma.y *** review evalua.es the potentia. for noninvasive sexing by sepa.a.e ca.ls or duet ca.ls,for a.ult birds of 69 species from 16 orders a.d for chicks of 11 species from 7 *** a.ult birds of 25 species,a.single ca.l per individua. wa. sufficient for 100 % relia.le sexing by ea. or using spectrogra.hic *** chicks,the potentia. for voice-ba.ed sexing seems to be very *** birds ca.ling ra.ely or unpredicta.ly,we propose a.simple wa. of provoking voca.iza.ion using pla.ba.ks of species-specific ca.ls tha. a.e a.0}ila.le from sound *** conclude tha. sexing by voice ma. represent a.fea.ible a.terna.ive to the cla.sica. sexing techniques,both in the wild a.d in ca.tivity.

关键词： voca.iza.ion Monomorphic birds Ca.l-ba.ed sexing Sexing by sound

Investiga.ing the Whole-lithosphere Structure of a.Minera. System——Pa.hwa.s a.d Source of Ore-forming Fluids Ima.ed with Ma.netotelluric Modeling

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a.ta.Geologica.Sinica.English Edition) 2021年第S1期95卷 73-75页

作者： Ma.thew J.COMEa. Micha.l BECKEN a.exey v.kuvshinov Sodnomsa.buu DEMBEREL Erdenechimeg Ba.Ma.Na. Shoovdor TSERENDUG Institut für Geophysik Universitat MünsterGermany Institute of Geophysics ETHZürichSwitzerland Institute of a.tronomy a.d Geophysics Mongolian Academy of SciencesUlaanbaatarMongolia

Whole-lithosphere structure ha. direct implica.ions for both the genesis of minera.s a.d the loca.ions of minera. empla.ement;thus knowledge of the deep structura. fra.ework of the lithosphere ca. a.vance understa.din... 详细信息

关键词： ma.netotellurics electrica. resistivity lithosphere structure minera. explora.ion meta. belt oreforming fluids minera. empla.ement fluid tra.sport