检索结果-南通市图书馆

Re-Contextualizing Lu Xun＇s Early Thought and Poetics in the Journal Henan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2018年第3期12卷 388-423页

作者： Jon Eugene von KowaUis Chinese Studies Program School of Humanities and Languages The University of New South Wales Sydney NSW 2052 Australia

In this paper I will re-contextualize Lu Xun＇s early thought, as evidenced in his lengthy classical-style essays, which are concerned with issues in literature, philosophy, politics and aesthetics during an era when China was facing profound cultural changes. Part of their significance lies in the way they provide us with an unabashed glimpse at what Lu Xun set out to accomplish, early on, in his new-found literary career. Although they are mainly the product of his final Lehrjahre （years of study） in Japan, the fact that he chose to include the two longest of them in the very first pages of his important 1926 anthology Fen （The grave） indicates that he considered the views expressed therein neither too immature nor too pass- to reprint at the height of his career as a creative writer. In fact, he wrote that one of his reasons for doing so was that a number of the literary figures and issues treated in these essays had, ironically, taken on an increased relevance for China ＂since the founding of the Republic.＂ The central concern of all the essays turns on questions of cultural crisis and transition. What I propose to do in this paper is to re-examine the essays within the context in which they first appeared, i.e., the expatriate Chinese journal Henan, then published in Tokyo as an unofficial organ of the anti-Manchu Tongmenghui （Revolutionary Alliance）.

关键词： Lu Xun Zhou Zuoren Mara Poetry Henan (Journal) Tongmenghui Lu Xun's early essays Lu Xun's poetics "Wenhua pianzhi lun " "Moluo shi li shuo " "Po e'sheng lun"

A review on exosome-based cancer therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 521-530页

作者： Alex von Schulze Fengyan Deng Department of Molecular and Integrative Physiology University of Kansas Medical CenterKansas CityKS 66160USA

Cancer is one of the leading causes of mortality and morbidity *** types of cancer treatments have been developed,such as chemotherapy,surgery,radiotherapy,and ***,these therapies can also kill healthy cells and lead to severe side ***,scientists are looking for new strategies to eliminate cancerous cells ***,nanometer-sized lipid bilayer-enclosed vesicles secreted from various cell types,exist in nearly all body fluids,including blood,breast milk,saliva,urine,bile,pancreatic juice,cerebrospinal,and peritoneal *** carry myriad donor cell-derived bioactive molecules such as proteins,lipids,and RNAs(including microRNA and lncRNA)and can deliver them to both nearby and distant recipient *** to these characteristics,exosomes have attracted great interest in cancer treatment(especially serving as a biological carrier for some drugs,microRNA,lncRNA,inhibitors,and antibodies).In this paper,we will review the current knowledge of exosome therapeutic applications in cancer.

关键词： Exosomes cancer cancer therapy gene carrier drug carrier

Oxidative Degradation of 2,4,6-Trichlorophenolin the Presence of Air Ions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2001年第3期12卷 211-214页

作者： Hui Min MA Jens WOHLERS Uwe MEIERHENRICH Axel BERNECKER vera SULING Wolfram THIEMANN Center for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100080 Department of Chemistry University of BremenD-28334 BremenGermany

2,4,6-trichlorophenol (TCP) was firstly treated with air ions generated by electric discharge, and high dechlorination (53%) was observed after 60 min treatment, indicating that air ions are an efficient dechlorination means and might have a future in the oxidative removal of chlorinated phenols. In addition, a stepwise degradation of TCP, beginning with the formation of a major product 2,6-dichloro-1,4-benzenediol via substitution, is proposed through a detailed analysis of gas chromatography/mass spectrometry.

关键词： 2,4,6-trichlorophenol air ions electric discharge oxidative degradation pollutant treatment

Dual-Targeting of Arabidopsis 6-Phosphogluconolactonase 3 （PGL3）to Chloroplasts and Peroxisomes Involves Interaction with Trx m2 in the Cytosol

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2014年第1期7卷 252-255页

作者： Christian Holscher Tanja Meyer Antje von Schaewen Institut for Biologie und Biotechnologie der Pflanzen Westfalische Wilhelms-Universitat Munster Schlossgarten 3 48149 Munster Germany

The oxidative pentose-phosphate pathway （OPPP） represents a central branch of cellular metabolism emanating from glucose-6-phosphate （G6P） to provide reductive power （NADPH） and sugar phosphates for anabolic biosyntheses. In plant cells, the oxidative OPPP branch is found in the cytosol and in plastids, consisting of glucose-6-phosphate dehydrogenase （G6PD）, 6-phosphogluconolactonase （PGL）, and 6-phosphogluconate dehydrogenase （6PGD）. These enzymes are encoded by small gene families in the nuclear genome, which, in Arabidopsis, comprise six G6PD, five 6-PGL, and three 6-PGD isoforms （Kruger and von Schaewen, 2003）. Specific targeting motifs at the C-terminus of 6-PGL and 6-PGD isoforms suggested that the OPPP may also occur in peroxisomes （Reumann et al., 2004）.

关键词： Cytosol C-Terminus nuclear genome Plastid Peroxisomes 6-phosphogluconolactonase Gene families Plant cells chloroplasts Glucosephosphate Dehydrogenase Dual Glucose-6-Phosphate Arabidopsis sugar phosphates

Mitochondrial apoptosis:facilitator of NK cell-mediated immunotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第9期7卷 3170-3171页

作者： Evelyn Ullrich Meike Vogler Ivana von Metzler University Hospital Frankfurt Department for Children and Adolescents MedicineGoethe UniversityFrankfurt am MainGermany Experimental Immunology Goethe UniversityFrankfurt am MainGermany Frankfurt Cancer Institute Goethe UniversityFrankfurt am MainGermany University Cancer Center Frankfurt(UCT) University Hospital FrankfurtGoethe UniversityFrankfurt am MainGermany Institute for Experimental Cancer Research in Pediatrics Goethe UniversityFrankfurtGermany Department of Medicine Hematology and OncologyUniversity Hospital FrankfurtGoethe UniversityFrankfurt am MainGermany

In a recent study published in Cell,Pan et *** how NK cell-based immunotherapy can be combined with BCL2 Homology Domain(BH)3 mimetics to increase tumor cell killing,thus highlighting a novel strategy for cancer immunotherapy.1Induc-tion of mitochondrial apoptosis is a multi-step procedure,and knowledge about the regulation of apoptosis may pave the way for new treatment approaches in immune-oncology.

关键词： BCL2 apoptosis NK cell

Systems approaches to urban underground space planning and management-A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Underground Space 2020年第2期5卷 144-166页

作者： Loretta von der Tann Raymond Sterling Yingxin Zhou Nicole Metje Department of Civil Environmental and Geomatic EngineeringUniversity College LondonUK Civil Engineering Louisiana Tech University(Emeritus)United States Defence Science and Technology Agency 1 Depot RoadSingapore 109679Singapore Department of Civil Engineering School of EngineeringUniversity of BirminghamUK

The necessity to recognize the subsurface or underground and all its current and potential uses as part of our urban environment,to integrate this into urban planning and governance,and to foster conscious allocation of subsurface space has been increasingly recognized over the last *** the same time,systems thinking as a‘buzz-word’has gained relevance for approaching complex problem areas in all kinds of disciplines including those preoccupied with the *** paper reviews the literature about urban underground planning through a *** set this in context,it is outlined how organizational principles for the urban subsurface have evolved,and the main aspects of systems thinking are introduced followed by a discussion of how this thinking could be applied to the urban *** and tools presented in the recent literature in the field are then reviewed based on this perspective,asking how systemic the proposed strategies and tools are when the local geology,as well as legal and institutional settings are accepted as a baseline for analysis or *** approaches built on this premise have the potential to capture existing and evolving complexities,foster a better understanding of the value of subsurface space for a city and ultimately enable an efficient and fair allocation of underground ***,propositions for holistic solutions remain dispersed,interventions often remain based in an engineering mindset,and a shift in mind-set remains a *** research in collaboration with local and regional administrations or authorities based on systems thinking frameworks could help to facilitate this shift.

关键词： Systems thinking Urban underground space Underground space governance Subsurface planning and management

Microbiome and pancreatic cancer: A comprehensive topic review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第10期23卷 1899-1908页

作者： Natalie Ertz-Archambault Paul Keim Daniel von Hoff Department of Internal Medicine Mayo School of Graduate Medical EducationMayo Clinic Arizona Genomics Division Translational Genomics Institute and Regents Northern Arizona University Translational Genomics Institute(TGen) Mayo Clinic Arizona

To review microbiome alterations associated with pancreatic cancer, its potential utility in diagnostics, risk assessment, and influence on disease *** comprehensive literature review was conducted by all-inclusive topic review from PubMed, MEDLINE, and Web of Science. The last search was performed in October *** microbiome alterations exist among several body sites including oral, gut, and pancreatic tissue, in patients with pancreatic cancer compared to healthy *** study successes in non-invasive screening strategies warrant further investigation for future translational application in early diagnostics and to learn modifiable risk factors relevant to disease prevention. Pre-clinical investigations exist in other tumor types that suggest microbiome manipulation provides opportunity to favorably transform cancer response to existing treatment protocols and improve survival.

关键词： Pancreatic Cancer Human microbiome Biomarkers cancer Cancer screening tests Treatment effectiveness

Canonical Workflows in Simulation-based Climate Sciences

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Data Intelligence 2022年第2期4卷 212-225页

作者： Ivonne Anders Karsten Peters-von Gehlen Hannes Thiemann German Climate Computing Center(DKRZ) BundesstraBe 45aD-20146 HamburgGermany

In this paper we present the derivation of Canonical Workflow Modules from current workflows in simulation-based climate science in support of the elaboration of a corresponding framework for simulationbased *** first identified the different users and user groups in simulation-based climate science based on their reasons for using the resources provided at the German Climate Computing Center(DKRZ).What is special about this is that the DKRZ provides the climate science community with resources like high performance computing(HPC),data storage and specialised services,and hosts the World Data Center for Climate(WDCC).Therefore,users can perform their entire research workflows up to the publication of the data on the same *** analysis shows,that the resources are used by two primary user types:those who require the HPC-system to perform resource intensive simulations to subsequently analyse them and those who reuse,build-on and analyse existing *** then further subdivided these top-level user categories based on their specific goals and analysed their typical,idealised workflows applied to achieve the respective project *** find that due to the subdivision and further granulation of the user groups,the workflows show apparent ***,similar"Canonical Workflow Modules"can be clearly made *** modules are"Data and Software(Re)use","Compute","Data and Software Storing","Data and Software Publication","Generating Knowledge"and in their entirety form the basis for a Canonical Workflow Framework for Research(CWFR).It is desirable that parts of the workflows in a CWFR act as FDOs,but we view this aspect ***,we reflect on the question whether the derivation of Canonical Workflow modules from the analysis of current user behaviour still holds for future systems and work processes.

关键词： Canonical Workflow Fair Digital Objects HPC infrastructures Data services Climate science

Digital holography and its application for microsystems inspection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2008年第1期4卷 72-77页

作者： Werner Jüptner Christoph von Kopylow Claas Falldorf BIAS D-28359 BremenKlagenfurter Str.2Germany

A large number of applications in the before mentioned sense is reported in the literature. In this paper a special remark will be given to the application of 3D deformation measurements using only one illumination direction for the recording of the two holograms in the reference and the loaded state, and only one observation direction for the

关键词：微型系统检查数字全息技术全息光学三维变形测量