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采用小尺寸模型对层状非均质堤基管涌发展过程进行了试验模拟,对非均质堤基管涌发展过程、管涌破坏临界水头进行了分析,并采用Mseep程序对试验结果进行验证.结合模型试验和Mseep程序计算,验证了Sellmejier管涌预测模型对非均质堤基的适用性,推导了非均质堤基管涌预测模型公式.通过两次施加水头的试验方法,初步分析了历史管涌对堤基整体抗渗能力的影响.

关键词：管涌非均质堤基预测模型历史管涌

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Prediction of delayed graft function using different scoring algorithms: A single-center experience

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World Journal of Transplantation 2017年第5期7卷 260-268页

作者： Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke dirk K Ysebaert vera Hartman Kathleen de Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds daniel Abramowicz Jean-Louis Bosmans department of Nephrology-Hypertension Antwerp University Hospital department of Medical Statistics Antwerp University Hospital StatUa Center for Statistics University of Antwerp department of Hepatobiliary Endocrine and Transplantation SurgeryAntwerp University Hospital Histocompatibility and immunogenetic Laboratory

AiM To compare the performance of 3 published delayed graftfunction(dGF) calculators that compute the theoretical risk of dGF for each *** This single-center,retrospective study included 247 consecutive kidney transplants from a deceased *** kidney transplantations were performed at our institution between January 2003 and december *** compared the occurrence of observed dGF in our cohort with the predicted dGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS dGF occurred in 15.3% of the transplants under *** c index of the irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the irish algorithm the predicted dGF risk and the observed dGF probabilities were close. The mean calculated dGF risk was significantly different between dGF-positive and dGF-negative subjects(P individual patient the calculated risk of dGF overlapped very widely with ranges from 10% to 51% for recipients with dGF and from 4% to 56% for those without *** sensitivity,specificity and positive predictive value of a calculated dGF risk ≥ 30% with the irish nomogram were 32%,91% and 38%. CONCLUSiON Predictive models for dGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations.

关键词： delayed graft function Kidney transplantation Nomogram Receiver operating characteristic curve Risk calculation

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Hybrid photonic-plasmonic cavities based on the nanoparticle-on-a-mirror configuration

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Photonics Research 2021年第12期9卷 2398-2419页

作者： ANGELA i.BARREdA MARiO ZAPATA-HERRERA iSABELLE M.PALSTRA LAURA MERCAdÉ JAViER AiZPURUA A.FEMiUS KOENdERiNK ALEJANdRO MARTÍNEZ institute of Solid State Physics Friedrich Schiller University Jena07743 JenaGermany institute of Applied Physics Abbe Center of PhotonicsFriedrich Schiller University Jena07745 JenaGermany Nanophotonics Technology Center Universitat Politècnica de ValènciaCamino de Vera s/n46022 ValenciaSpain Materials Physics Center CSiC-UPV/EHU 20018 Donostia-San SebastianSpain donostia international Physics Center diPC 20018 Donostia-San SebastianSpain Center for Nanophotonics AMOLF1098 XG AmsterdamThe Netherlands Van der Waals-Zeeman institute Institute of PhysicsUniversity of Amsterdam1090 GL AmsterdamThe Netherlands

Hybrid photonic-plasmonic cavities have emerged as a new platform to increase light-matter interaction capable to enhance the Purcell factor in a singular way not attainable with either photonic or plasmonic cavities *** the hybrid cavities proposed so far,the plasmonic element is usually a metallic bow-tie antenna,so the plasmonic gap—defined by lithography-is limited to minimum values of several ***-on-a-mirror(NPoM)cavities are far superior to achieve the smallest possible mode volumes,as plasmonic gaps smaller than 1 nm can be ***,we design a hybrid cavity that combines an NPoM plasmonic cavity and a dielectric-nanobeam photonic crystal cavity operating at transverse-magnetic *** metallic nanoparticle can be placed very close(dielectric cavity,which acts as a low-reflectivity *** demonstrate through numerical calculations of the local density of states that this hybrid plasmonic-photonic cavity exhibits quality factors𝑄above 10^(3) and normalized mode volumes𝑉down to 10^(−3),thus resulting in high Purcell factors(F_(P)≈10^(5)),while being experimentally feasible with current *** results suggest that hybrid cavities with sub-nanometer gaps should open new avenues for boosting light-matter interaction in nanophotonic systems.

关键词： mirror cavity nanoparticle

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The Adverse Event Profile in Patients Treated with Transferon<sup>TM</sup>(dialyzable Leukocyte Extracts): A Preliminary Report

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Pharmacology & Pharmacy 2015年第2期6卷 65-74页

作者： Toni Homberg Violeta Sáenz Jorge Galicia-Carreón iván Lara Edgar Cervantes-Trujano Maria C. Andaluz Erika vera Oscar Pineda Julio Ayala-Balboa Alejandro Estrada-García Sergio Estrada-Parra Mayra Pérez-Tapia Maria C. Jiménez-Martínez Clinical Trials Branch and Clinical immunology Service Unit of External Services and Clinical Research (USEIC) National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Unit of Pharmacovigilance Unit of External Services and Clinical Research (USEIC) National School of Biological Sciences National Polytechnic Institute Mexico City Mexico department of immunology National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Unit of R&d in Bioprocesses (UdiBi) National School of Biological Sciences National Poly-technic Institute Mexico City Mexico department of Biochemistry Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico

Background: dialyzable leukocyte extracts (dLE) are heterogeneous mixtures of peptides less than 10 kda in size that are used as immunomodulatory adjuvants in immune-mediated diseases. TransferonTM is dLE manufactured by National Polytechnic institute (iPN), and is registered by Mexican health-regulatory authorities as an immunomodulatory drug and commercialized nationally. The proposed mechanism of action of TransferonTM is induction of a Th1 immunoregulatory response. despite that it is widely used, to date there are no reports of adverse events related to the clinical safety of human dLE or TransferonTM. Objective: To assess the safety of TransferonTM in a large group of patients exposed to dLE as adjuvant treatment. Methods: We included in this study 3844 patients from our Clinical immunology Service at the Unit of External Services and Clinical Research (USEiC), iPN. Analysis was performed from January 2014 to November 2014, searching for clinical adverse events in patients with immune-mediated diseases and treated with TransferonTM as an adjuvant. Results: in this work we observed clinical nonserious adverse events (AE) in 1.9% of patients treated with TransferonTM (Md 1.9, iQR 1.7 - 2.0). AE were 2.8 times more frequently observed in female than in male patients. The most common AE were headache in 15.7%, followed by rash in 11.4%, increased disease-related symptomatology in 10%, rhinorrhea in 7.1%, cough in 5.7%, and fatigue in 5.7% of patients with AE. 63% of adverse event presentation occurred from day 1 to day 4 of treatment with TransferonTM, and mean time resolution of adverse events was 14 days. in 23 cases, the therapy was stopped because of adverse events and no serious adverse events were observed in this study. Conclusion: TransferonTM induced low frequency of nonserious adverse events during adjuvant treatment. Further monitoring is advisable for different age and disease groups of patients.

关键词： dialyzable Leukocyte Extracts Adverse Events Monitoring drug Safety Adjuvant Therapy immunoregulation Guidelines Transfer Factor Pharmacovigilance

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在孔子与罗素之间

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外国哲学 2000年第9期

作者： vera Schwarcz

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Phytosociology and Floristic Composition of the infesting Community in Rice Crop Waterlogged

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American Journal of Plant Sciences 2018年第3期9卷 353-367页

作者： Bruna Penha Costa Maria rosangela Malheiros Silva Carlos Augusto Rocha de Moraes Rego Juan López de Herrera Maria Soraia Fortado vera Cruz Ana Carolina Pinguelli Ristau Marinez Carpiski Sampaio Thatiane Nepomuceno Alves Shirlene Souza Oliveira Hannah Braz Nitalo Andre Farias Machado Center of Agrarian Sciences State University of Western Paraná Marechal Candido Rondon Brazil Center of Agrarian Sciences State University of Maranh&atilde o S&atilde o Luís Brazil University School of Agricultural Technical Engineering Polytechnic University of Madrid Madrid Spain

The objective of this study is to identify and quantify the floristic composition of the weed community in the rice crop waterlogged in the municipality of Arari-MA. The botanical material was obtained in three areas by randomly a hollow rectangle of 0.50 m × 0.30 m by forty five times in each plot. The aerial parts of weeds were harvested, identified, counted and oven dried with forced air ventilation at 333.15 K to 343.15 K. These data were used to determine the phytosociological parameters and the Shannon-Wiener diversity index was also calculated. A total of 6607 plants were collected, being 4115 (62.28%) in the vegetative phase and 2492 (37.72%) in the reproductive phase. The monocotyledonous group obtained the largest number of plants, 2882 in the vegetative phase and 1535 in the reproductive phase. The Cyperaceae family recorded nine species and four genera and the Poaceae, seven and four species in the vegetative and reproductive phases, respectively. The species of higher iVi in the vegetative phase was E. sellowiana in the area A1 with 82.86%, and in the reproductive F. dichotoma with iVi of 90.49% in the area A3. The individuals density and species richness were higher in the vegetative phase of the culture and the monocotyledonous group predominated with the Cyperaceae and Poaceae families, and the weed diversity among the areas was low.

关键词： diversity Oryza sativa L. Weeds

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