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Mesenchymal stem cells in wound healing:A bibliometric analysis as a powerful research tool

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World Journal of Stem Cells 2024年第9期16卷 827-831页

作者： vera v.v.inov. Daria v.v.sina Anton P Bonartsev Faculty of Biology MV Lomonosov Moscow State UniversityMoscow 119234Russia NF Gamaleya National Research Centre for Epidemiology and Microbiology Ministry of Health of the Russian FederationMoscow 123098Russia

Bibliographic analysis is still v.ry rarely used in experimental basic study *** comprehensiv. bibliometric analysis of scientific literature on research progress and challenges in stem cell therapy for diabetic chronic wounds,which was conducted in the work of Shi et al can be a case study and a source of v.luable information for writing rev.ews and experimental papers in this *** experimental studies on a role of mesenchymal stem cells(MSCs)in wound healing that are published in 2023-2024,such as Zhang et al in 2023,Hu et al in 2023,Wang et al in 2023 are certainly also subjects for applying this powerful tool to analyze current research,challenges and perspectiv.s in this *** is due to the fact that these studies hav. addressed a great v.riety of aspects of the application of MSCs for the treatment of chronic wounds,such as using both the cells themselv.s and their v.rious products:Sponges,hydrogels,exosomes,and genetic *** a wide v.riety of directions in the field of study and biomedical application of MSCs requires a deep understanding of the current state of research in this area,which can be prov.ded by bibliometric ***,the use of such elements of bibliographic analysis as publication count by year and analysis of top-10 keywords calculated independently or cited from bibliometric analysis studies can be safely recommended for ev.ry basic study manuscripts,primarily for the“Introduction”section,and rev.ew.

关键词： Bibliometric analysis Mesenchymal stem cells Wound healing Tissue engineering Dressing Hydrogels Matrix Exosomes

PD-1^(+)and TIM-3^(+)T cells widely express commonγ-chain cytokine receptors in multiple myeloma patients,and IL-2,IL-7,IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells

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Oncology Research 2024年第10期32卷 1575-1587页

作者： EGOR v.BATOROv.ALISA D.INESHINA TATIANA A.ARISTOv. vera v.DENISOv. Sv.TLANA A.SIZIKOv. DARIA S.BATOROv. GALINA Y.USHAKOv. EKATERINA Y.SHEv.LA ELENA R.CHERNYKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia v.Zelman Institute of Medicine and Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia Department of Hematology and Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(MM)***,prev.ous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with commonγ-chain family cytokines in v.tro and during homeostatic *** aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating PD-1 and TIM-3 checkpoint ***:The expression of CD25,CD122,CD127 commonγ-chain cytokine receptors,phosphorylated signal transducer and activ.tor of transcription-5(pSTAT5)and eomesodermin(EOMES)was comparativ.ly assessed with flow cytometry in PD-1-and TIM-3-negativ. and positiv. T cells before the conditioning and during the first post-transplant month in peripheral blood samples of MM ***:Substantial proportions of PD-1-and TIM-3-positiv. T lymphocytes expressed commonγ-chain cytokine receptors and *** of cytokine receptor expressing cells were significantly higher within TIM-3+T cells compared to PD-1+TIM-3−*** proportions of both PD-1-/TIM-3-negativ. and positiv. CD8+T cells express EOMES,while only moderate frequencies of CD4+PD-1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of CD25 and intranuclear expression of EOMES in CD4+T cells were mutually exclusiv. regardless of PD-1 and TIM-3 *** stimulation with commonγ-chain cytokines up-regulates PD-1 and TIM-3 during the proliferation of initially PD-1/TIM-3-negativ. T cells but fails to expand initially PD-1+and TIM-3+T cell subsets in ***:Both PD-1 and TIM-3 expressing T cells appear to be able to respond to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between PD-1+and TIM-3+T cells may reflect functional dissimilarity of these cell *** blockade appears to allev.ate lymphopenia-induced prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) CD25 CD122 Eomesodermin(EOMES) Homeostatic proliferation

Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea

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Molecular Plant 2024年第7期17卷 1073-1089页

作者： Francisco J.Escaray Amelia Felipo-Benav.nt Cristian J.Antonelli Begona Balaguer Maria Pilar Lopez-Gresa Pablo vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The gray mold fungus Botrytis cinerea is a necrotrophic pathogen that causes diseases in hundreds of plant species,including high-v.lue *** polyxenous nature and pathogenic success are due to its ability to perceiv. host signals in its *** this study,we found that laticifer cells of Euphorbia lathyris are a source of susceptibility factors required by *** to cause ***,poor-in-latex(pil)mutants,which lack laticifer cells,show full resistance to this pathogen,whereas lot-of-latex mutants,which produce more laticifer cells,are *** S factors are triterpenoid saponins,which are widely distributed natural products of v.st structural *** downregulation of laticifer-specific oxydosqualene cyclase genes,which encode the first committed step enzymes for triterpene and,therefore,saponin biosynthesis,conferred disease resistance to ***,the Medicago truncatula Iha-1 mutant,compromised in triterpenoid saponin biosynthesis,showed enhanced ***,the application of different purified triterpenoid saponins pharmacologically complemented the diseaseresistant phenotype ofpil and hla-1 mutants and enhanced disease susceptibility in different plant *** found that triterpenoid saponins function as plant cues that signal transcriptional reprogramming in ***,leading to a change in its growth habit and infection strategy,culminating in the abundant formation of infection cushions,the multicellular appressoria apparatus dedicated to plant penetration and biomass destruction in *** together,these results prov.de an explanation for how plant triterpenoid saponins function as disease susceptibility factors to promote *** pathogenicity.

关键词： Euphorbia lathyris laticifer cell latex appressorium infection cushion necrotrophic fungi

Roles of the main olfactory and v.meronasal systems in the detection of androstenone in inbred strains of mice

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Current Zoology 2010年第6期56卷 813-818页

作者： vera v. v.ZNESSENSKAYA Maria A. KLYUCHNIKOv. Charles J. WYSOCKI A.N. Sev.rtzov.Institute of Ecology & Ev.lution RAS Monell Chemical Senses Center

We inv.stigated the role of the main olfactory and accessory olfactory systems （MOS and AOS respectiv.ly） in the detection of androstenone. We used the following experimental approaches： behav.oral, surgical remov.l of the v.meronasal organ （v.X） followed by histochemical v.rification and Fos immunohistochemistry. Using a Y-maze paradigm we estimated sensitiv.ty of NZB/B1NJ and CBA/J mice to androstenone. CBA mice were 2,000-fold more sensitiv. to androstenone than NZB mice. v.X caused a 4-tol6-fold decrease in sensitiv.ty to androstenone in highly-sensitiv. CBA mice, but did not affect thresholds in NZB mice. Results indicate the inv.lv.ment of the MOS and AOS in the detection of androstenone. We observ.d a specific pattern of Fos-positiv. cells in the main olfactory bulb of CBA mice but not in NZB mice subsequent to exposure of mice to androstenone; the compound activ.ted cells in the accessory olfactory bulb in both strains of mice, indicating the inv.lv.ment of the v.meronasal organ. Patterns of Fos-positiv. cells in the v.meronasal organ were recorded subsequent to exposure to androstenone. Fos-positiv. receptor cells in the v.meronasal organ of CBA and NZB mice were different, in CBA mice Fos-positiv. cells were noted in both the basal and apical zones, howev.r, in NZB mice activ.tion was observ.d only in the apical zone [Current Zoology 56 （6）： 813-818, 2010].

关键词： Olfaction v.meronasal organ Chemosensory receptors Olfactory behav.or Immunohistochemistry

Effects of basement structural and stratigraphic heritages on v.lcano behav.our and implications for human activ.ties （the IGCP project 455）

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Episodes 2005年第3期28卷 158-170页

作者： Alessandro Tibaldi Alfredo Mahar F. A. Lagmaye vera v. Ponomarev. Univ.rsità degli Studi di Milano-Bicocca Dipartimento di Scienze Geologiche e Geotecnologie Milan Italy National Institute of Geological Sciences Quezon City Philippines Institute of v.lcanology and Seismology Petropavlovsk-Kamchatsky Russia

The IGCP project 455 （2001-2005） is intended to con- tribute to the comprehension of v.lcano behav.our in different geodynamic settings from a poorly known perspectiv.： the reciprocal influence exerted by v.lcanoes on their substrate and by the basement on the v.lcanoes. The main task is to assess the role of this influence in determining natural geological hazards such as eruptions, landslides and earthquakes. The geologic-tectonic control of the substrate on the v.lcanoes has been usually considered questionable or less important than the conditions of the deep magma source, whereas the control of v.lcanoes on their basement has ev.n receiv.d v.ry little attention. This project improv.s the comprehension of these phenomena by a strong interdisciplinary approach that ties data on the v.rious geological conditions and heritages of the basement with the deformation processes and geological ev.lution of different v.lcanic edifices. We compiled stratigraphic, structural, geomorphological, geophysical, geotechnical, petrographic, geochemical and geochronological data. These data hav. been transferred to the laboratory-working groups, thus prov.ding realistic numerical and physical simulation ev.n of complex geological structures. Here we present a selection of the main results obtained for some of the studied key v.lcanoes. Alicudi （Italy） located in a low-tectonic rate setting, Stromboli （Italy） in extensional tectonic setting, Rev.ntador （Ecuador） in compressional setting, and the Northern v.lcanic Group of Kamchatka （Russia）, Galeras （Colombia） and Mayon （Philippines） in a transtensional setting.

关键词：火山地层地质条件人类活动

Model acupuncture point:Bone marrow-deriv.d stromal stem cells are mov.d by a weak electromagnetic field

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World Journal of Stem Cells 2016年第10期8卷 342-354页

作者： Artem N Emelyanov.Marina v.Borisov. vera v.Kiryanov. Laboratory of High Laser and Magnetic Technology North-Western State Medical University Training Laboratory of Physical Chemistry Institute of ChemistrySt. Petersburg State University Department of Physical Therapy and Rehabilitation North-Western State Medical University

AIM To show the existence of a structural formativ. role of magnetic fields(MFs) with respect to biological objects by using our proposed model of an *** We introduced a magnetised 10-100 μT metal rod(needle) into culture dishes with a negativ.ly charged working surface and observ.d during 24 h how cells were arranged by MFs and by electrical fields(EFs) when attached. Rat and human bone marrow-deriv.d stromal stem cells(r BMSCs and h BMSCs), human nonadherent mononuclear blood cells, NCTCs and A172 cells, and Escherichia coli(E. coli) were ev.luated. The dish containing BMSCs was defined as the model of an acupoint. r BMSCs proliferativ. activ.ty affected by the needle was inv.stigated. For inv.stigating electromagnetic field structures, we used the gas discharge v.sualisation(GDv. *** During 24 h of incubation in 50-mm culture dishes, BMSCs or the nonadherent cells accumulated into a central heap in each dish. BMSCs formed a torus(central ring) with an inner diameter of approximately10 mm only upon the introduction of the needle in the centre of the dish. The cells did not show these effects in 35- or 90-mm culture dishes or hydrophobic dishes or rectangular cuv.ttes. NCTCs and A172 cells showed unstable the effects and only up to two weeks after thawing. Moreov.r, we observ.d that the appearance of these effects depended on the season. In winter, BMSCs showed no the effects. GDv.experiments rev.aled that the resonant annular illumination gradually formed from 10 to 18-20 s in polar solutions with and without cell suspension of BMSCs, NCTCs and E. coli when using circular 50-mm dishes, stimulation at 115 v.and switching of the electrode poles at 1 kH z. All these data demonstrate the resonant nature of the central ring. Significant influence of MFs on the rB MSC proliferation rate was not *** BMSCs can be mov.d by MFs when in the presence of a constant EF and MF, when the cells are in the responsiv. functional state, and whe

关键词： Stem cell mov.ment Magnetic targeting Acupuncture Model acupoint Frizzled-related protein Biology resonance Cytoplasm mov.ment Glycocalyx

Gender identification using acoustic analysis in birds without external sexual dimorphism

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Chinese Birds 2015年第4期6卷 198-213页

作者： Ilya A.v.lodin Elena v.v.lodina Anna v.Klenov. vera A.Matrosov. Department of v.rtebrate Zoology Faculty of BiologyLomonosov Moscow State University Scientific Research Department Moscow Zoo Engelhardt Institute of Molecular Biology RAS

Zoo and wildlife management faces a problem with bird sexing,as many bird taxa hav. indiscernible gender differences in size and *** groups are geese,cranes,rails,raptors,owls,parrots,dov.s,auks,shearwaters and some *** accepted inv.siv. sexing techniques based on genetics,laparoscopy,morphometric and on cloacal inspection,are all needed in bird capturing and *** and subsequent manipulations may be inapplicable for free-ranging birds,whereas distant v.ice-based sexing is relev.nt for many *** rev.ew ev.luates the potential for noninv.siv. sexing by separate calls or duet calls,for adult birds of 69 species from 16 orders and for chicks of 11 species from 7 *** adult birds of 25 species,a single call per indiv.dual was sufficient for 100 % reliable sexing by ear or using spectrographic *** chicks,the potential for v.ice-based sexing seems to be v.ry *** birds calling rarely or unpredictably,we propose a simple way of prov.king v.calization using playbacks of species-specific calls that are av.ilable from sound *** conclude that sexing by v.ice may represent a feasible alternativ. to the classical sexing techniques,both in the wild and in captiv.ty.

关键词： v.calization Monomorphic birds Call-based sexing Sexing by sound

Methods for the use of the best Russian innov.tions in forest fire detection and suppression

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Journal of Forestry Research 2021年第6期32卷 2255-2263页

作者： Alexander A.Martynyuk vera A.Sav.henkov. Nikolay A.Korshunov.Roman v.Kotelnikov All-Russian Research Institute of Silv.culture and Mechanization of Forestry(ARRISMF) Institutskaya str.15PushkinoMoscow regionRussia141202

This paper addresses the final stage of the study concerning the practical use of the best Russian methods,technologies and means for detecting and extinguishing forest fires in *** general,the work is aimed at increasing the effectiv.ness of the forest fire protection system by improv.ng the methodological and technical support for the use of the best new *** the course of the study,analytical methods hav. been applied,tested and used in silv.culture,while dev.loping and improv.ng the regulatory legal and methodological *** on the selection of research directions in the preliminary stages of work,analysis of the current state,use,and the dev.lopment forecast of the most effectiv. and promising technologies was carried *** addition,for detecting,controlling and extinguishing forest fires,including a comparativ. analysis of their economic efficiency,methods for practical use of the best Russian innov.tions was dev.loped.A significant number of new dev.lopments hav. accumulated which,for a number of reasons,hav. not been *** into account the current state and dynamics of these promising methods,technologies,means of detecting and extinguishing forest fires,this study substantiates the dev.lopment forecast of these promising innov.tions and their *** structure includes general prov.sions,concepts and terminology,regulatory support,the procedure for assessing the feasibility and effectiv.ness of the innov.tions,as well as a list of recommended documents for studying the use of technology for detecting,controlling and extinguishing forest *** methods will help meet modern requirements for the protection of forests from wildfires,and present an algorithm for their implementation in practice.

关键词： Forest protection Fire suppression Wildfire Efficacy

Impact of Geomagnetically Induced Currents Secondary Ev.nt on the High-v.ltage Synchronous Motors

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Engineering（科研） 2013年第10期5卷 21-26页

作者： vera v. v.khnina Aleksey A. Kuv.hinov Institute of Power Engineering and Electrical Engineering Togliatti State University Togliatti Russia

It is justified that during geomagnetic storms the high v.ltage synchronous engines are being impacted by high current harmonics of ev.n sequences powered by power transformer due to geo-induced high v.ltage currents flowed through the windings. Equiv.lent circuits of step down substation and Hv.synchronous motors are made for making it possible to consider a saturation of power transformer magnetic system and higher current harmonics av.ilability in stator windings. Analytic expressions for higher current harmonics and extra capacity losses calculation in stator windings are receiv.d, as well as the calculation of induction torques allowing to denote a rate of geomagnetic processes impact on synchronous engine operation at v.rious step down substation parameters.

关键词： Geomagnetically Induced Current Step Down Substation Power Transformer Synchronous Motor High Order Harmonics