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Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit Residues of Brazilian Savanna Plants Aiming Its Use as Safe Fungicides

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Natural Products and Bioprospecting 2016年第4期6卷 195-204页

作者： Caroline Alves Breda Alessandra Marcon Gasperini vera lucia garcia Karin Maia Monteiro Giovana Anceski Bataglion Marcos Nogueira Eberlin Marta Cristina Teixeira Duarte School of Food Engineering State University of CampinasUNICAMPMonteiro Lobato Street80BaraōGeraldoCampinasSaōPaulo 13083-862Brazil Microbiology Division of Research Center for Chemistry Biology and Agriculture–CPQBAUniversity of CampinasUNICAMPAlexandre Cazelatto Street999BetelPaulı´niaSaöPaulo 13148-218Brazil Organic Chemistry and Pharmaceutical Division of Research Center for Chemistry Biology and Agriculture–CPQBAUniversity of CampinasUNICAMPAlexandre Cazelatto Street999BetelPaulíniaSaöPaulo 13148-218Brazil Pharmacology and Toxicology Division of Research Center for Chemistry Biology and Agriculture–CPQBAUniversity of CampinasUNICAMPAlexandre Cazelatto Street999BetelPaulíniaSaöPaulo 13148-218Brazil ThoMSon Mass Spectrometry Laboratory Institute of ChemistryState University of CampinasUNICAMPCampinasSaōPaulo 13084-971Brazil

The increasing demand for safe food without preservatives or pesticides residues has encouraged several studies on natural products with antifungal activity and low *** this study,ethanolic extracts from leaves and fruit residues(peel and seeds)of three Brazilian savanna species(Acrocomia aculeata,Campomanesia adamantium and Caryocar brasiliense)were evaluated against phytopathogenic ***,the most active extract was chemically characterized by ESI-MS and its oral acute toxicity was *** from ***(pequi)peel and leaves were active against Alternaria alternata,Alternaria solani and Venturia pirina with minimal inhibitory concentrations between 350 and 1000 lg/*** incorporated in solid media,these extracts extended the lag phase of *** and *** and reduced the growth rate of *** peel extract showed better antifungal activity and their ESI-MS analysis revealed the presence of substances widely reported as antifungal such as gallic acid,quinic acid,ellagic acid,glucogalin and *** oral acute toxicity was relatively low,being considered safe for use as a potential natural fungicide.

关键词： Brazilian savanna fruits Residues Natural fungicides Phytopathogens

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Effect of Mushroom Extract Hericium erinaceus on Spatial Memory and Morphology of Neurons in the CA1 and CA3 Regions of the Hippocampus in Ovariectomized Rats

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Open Journal of Veterinary Medicine 2024年第7期14卷 163-179页

作者： lucia garcia-Delgado Mariana Monserrath Verdía-Venegas Jacinto Bañuelos-Pineda Esther Albarrán-Rodríguez Guillermo Nolasco-Rodriguez José Ricardo Cuellar-Pérez Sergio Fausto-Guerra Manuel Rosales-Cortés Master in Behavioral Sciences Institute of Neurosciences University of Guadalajara Zapopan Mexico Department of Veterinary Medicine Division of Veterinary Sciences CUCBA University of Guadalajara Zapopan Mexico Botany and Zoology Laboratory CUCBA University of Guadalajara Zapopan Mexico

Various studies indicate that low levels of estradiol negatively impact cognitive abilities. Extracts from the fungus Hericium erinaceus (HE) contain bioactive components that promote the proper functioning of the nervous system and potential effects on protection against neurodegenerative diseases, including dementia and motor dysfunctions. The objective was to evaluate the effects of the administration of the HE mushroom extract on visuospatial memory and morphology of neurons in the CA1 and CA3 regions of the hippocampus in ovariectomized rats. 40 young Wistar rats weighing 90 ± 10 g BW were used, which were distributed into four groups of 10 animals;Control Group, non-ovariectomized and untreated rats;Group E2, ovariectomized rats treated with estradiol (2 μg/kg/body weight);Group HE, ovariectomized rats treated with the extract of the fungus Hericium erinaceus (0.5 mg/kg body weight) and Group Ovx/ST, ovariectomized rats, without treatment. The animals were tested in the Barnes and Open Field maze, then they were sacrificed, and their brains were obtained to perform a histological analysis of neuronal morphology in the CA1 and CA3 areas of the hippocampus. The most outstanding results showed that the Ovx/ST group recorded the longest time to arrive at the escape box and stay in the Barnes maze. A correlation was observed between neuronal damage and function;in the groups that did not present satisfactory performance in the maze tests, morphological alterations were identified such as the presence of some neuronal somata with degeneration characteristics such as pyknosis, nuclear basophilia and shrinkage of the cells. Its soma, as well as a decrease in the nuclear area of CA1 and CA3 neurons. It is concluded that the fungus Hericium erinaceus exerted a neuroprotective effect on the neuronal bodies of the hippocampus, associated with better performance in the visuospatial recognition memory test.

关键词： Ovariectomized Rats Ovarian Hypofunction Estradiol Hericium erinaceus Barnes Circular Labyrinth Open Field Labyrinth

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Study of corneal biomechanical properties in patients with childhood glaucoma

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1922-1927页

作者： Sara garcia Caride lucia Perucho González Federico Sáenz Francés Julián García Feijoo Ophthalmology Clinico San Carlos HospitalProfesor Martín Lagos StreetMadridES 28040Spain

AIM:To study of corneal biomechanical properties and intraocular pressure(IOP)measured with Corvis Scheimpflug Technology(ST)in patients with childhood glaucoma(CG).METHODS:Cross-sectional study in which 89 eyes were included 56 of them with *** one eye per patient was *** following variables were obtained from the clinical history and the ophthalmological examination:age,sex,IOP,number of surgeries,and the cup/disc ratio(CDR).The following parameters were recorded using Corvis ST:corrected by biomechanics IOP(b IOP),not corrected IOP(nct IOP),central corneal thickness(CCT),maximum concavity[radius,peak distance(PD)and deformation amplitude],applanation 1 and 2(length and velocity).The mean age was 23±14.55 and 33±19.5 years old for the control group and CG group,*** 36 were males and 53 were *** the CG group,7 patients were controlled only with medical *** had at least one previous goniotomy,19 had at least one trabeculectomy,and 11 had an Ahmed ***:A significant and positive intraclass correlation coefficient was found between Goldman IOP and the IOP measured by Corvis in both *** differences were found between the IOP measured with Corvis and Goldman using a student *** biomechanical parameters,there were differences in the applanation length 2(A-L2),in the applanation velocity 2(A-V2)and in the *** sex,only the applanation length 1(A-L1)was found to be different in control group.A positive and significant Pearson correlation was found between CDR and the ***:Corneal biomechanical properties have shown differences between CG and healthy subjects and also between men and women.

关键词： childhood glaucoma biomechanical properties Corvis Scheimpflug Technology

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Infections and inequalities: anemia in AIDS, the disadvantages of poverty

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 485-488页

作者： lucia Gonzalez Celeste Seley Julieta Martorano Isabella garcia-Moreno Alcides Troncoso Departments of Nutrition and Microbiology School of Nutrition Buenos Aires University Department of Foodborne Diseases University of Belgrano Department of NTD and Infectious Diseases School of Medicine Buenos Aires University

Objective:To study anemia in AIDS patients and its relation with socioeconomic, employment status and educational ***:A total number of 442 patients who visited the Infectious Diseases University Hospital in Buenos Aires, Argentina were included in the study. Patients were dividied into two groups,*** with anemia and the other without anemia. Anemia epidemiology and its relationship with educational level, housing, job situation, monthly income, total daily caloric intake and weekly intake of meat were ***:Anemia was found in 228 patients(54%). Comparing patients with or without anemia, a statistically significant difference was found(Pverage life expectancy, increases health care demand and tends to exacerbate poverty and iniquity.

关键词： HIV/AIDS Poverty Anemia Survival Infections Inequalities Socioeconomic status Educational level Employment status Prevalence

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Assessing Marine Protected Areas Effectiveness: A Case Study with the Tobago Cays Marine Park

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Open Journal of Marine Science 2017年第3期7卷 379-408页

作者： Alba garcia Rodriguez lucia M. Fanning Marine Affairs Program Dalhousie University Halifax Nova Scotia Canada

Given the socio-economic consequences associated with declaring areas of ocean protected in order to achieve conservation objectives, this paper contributes to the growing global need to assess Marine Protected Areas (MPAs) as an effective management tool. It adds to the current body of knowledge on MPA effectiveness by conducting an evaluation of the Tobago Cays Marine Park (TCMP), located in St. Vincent and the Grenadines (SVG) in the eastern Caribbean, using a modified MPA effectiveness framework. Due to the limited information existing about the current performance of this MPA, this assessment also provides needed insight on the effect that the TCMP is having on the marine ecosystem, as well as its overall management performance. By comparing the performance of the MPA over a 10-year span (2007 and 2016), the results indicate that overall, the TCMP could be described as having limited success when key management categories of context, planning, input, process, output and outcomes are evaluated. In particular, efforts dedicated to planning, process and outcomes are assessed as deficient. Furthermore, the analysis revealed that efforts to realize the stated goals relating to conservation, public awareness and public education were being neglected. However, considerable effort was being expended by TCMP staff on achieving the remaining goal focusing on deriving economic benefits from touristic activities in the Park. Preliminary field research examining the effects of the TCMP on the abundance and density of an economically important species, Lobatus gigas, (commonly referred to as the queen conch) showed the TCMP as having no effect towards conch protection. The results and recommendations of this study, combined with continued monitoring of a recommended targeted suite of indicators, could contribute to better-informed adaptive MPA management, leading to progress towards the achievement of the stated goals for the TCMP.

关键词： Marine Protected Areas MPA Effectiveness St. Vincent and the Grenadines Tobago Cays Marine Park Evaluation Framework Queen Conch

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Inverted Meckel’s diverticulum diagnosed using capsule endoscopy: A case report

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World Journal of Gastroenterology 2021年第36期27卷 6154-6160页

作者： Ismael El Hajra Martínez Marta Calvo JoséLuis Martínez-Porras lucia Gomez-Pimpollo garcia Jose L Rodriguez Carmen Leon JoséLuis Calleja Panero Department of Gastroenterology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Radiology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Diagnostic Pathology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Surgery Hospital Universitario Puerta de HierroMadrid 28222Spain

BACKGROUND Meckel’s diverticulum is a common asymptomatic congenital gastrointestinal ***,its presentation as an inverted Meckel's diverticulum is a rare complication,of which few cases have been reported in the *** SUMMARY Here,we report the case of a 33-year-old man with iron deficiency anemia without manifestation of gastrointestinal *** upper gastrointestinal endoscopy and total colonoscopy were performed,but no abnormalities were found within the observed ***,a capsule endoscopy was performed and offered us a clue to subsequently confirm the diagnosis of inverted Meckel's diverticulum via computed tomography *** intestinal resection surgery was *** final pathology report described a Meckel’s *** Since inverted Meckel's diverticulum is an uncommon disease and its clinical presentation is not specific,it may go undetected by capsule *** diagnosis and treatment of this disease requires a high index of clinical suspicion.

关键词： Inverted Meckel’s diverticulum Capsule endoscopy Anemia study Small bowel tumor Case report

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Association between physical activity and cardiovascular risk factors:Dose and sex matter

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Journal of Sport and Health Science 2021年第5期10卷 604-606页

作者： Alejandro Santos-Lozano Alberto Torres Barran Pablo Fernandez-Navarro Pedro L.Valenzuela Adrian Castillo-garcia Luis MRuilope David Rios Insua Jose M.Ordovas Victoria Ley Alejandro lucia i+HeALTH Department of Health SciencesEuropean University Miguel de CervantesValladolid 47012Spain Research Institute of the Hospital 12 de Octubre(imas12 PaHerg group)and(CIBER en Fragilidad y Envejecimiento Saludable-CIBEFES)Madrid 28041Spain Institute of Mathematical Sciences(ICMAT-CSIC) Madrid 28049Spain d Cancer and Environmental Epidemiology Unit National Center for EpidemiologyCarlos III Institute of HealthMadrid 28029Spain Consortium for Biomedical Research in Epidemiology&Public Health(CIBER en Epidemiologia y Salud Publica-CIBERESP) Madrid 28029Spain Department of Systems Biology University of AlcalaMadrid 28801Spain Fissac-Physiology Health and Physical ActivityMadrid 28801Spain Hypertension Unit and Cardiorenal Translational Laboratory Research Institute of the Hospital 12 de Octubre(imas12)Madrid 28041Spain Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University BostonMA 02111USA Spanish State Research Agency Ministry of ScienceInnovation and UniversitiesMadrid 28046Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain

Dear Editor,ETadegn TagedPFailure to meet World Health Organization(WHO)-determined minimum physical activity(PA)levels is an established risk factor for cardiovascular disease(CVD),^(1)but evidence is still scarce on its effects on other CVD risk ***,whether or not there are sex-specific effects on the association between PA and CVD risk is a matter of controversy,with some authors observing a protective effect of PA in men but not in women,^(2)and others finding the opposite trend.^(3)

关键词： cardiovascular protective finding

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Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2

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Journal of Molecular Cell Biology 2014年第4期8卷 299-311页

作者： lucia garcia-Guerra Rocio Vila-Bedmar Marta Carrasco-Rando Marta Cruces-Sande Mercedes Martin Ana Ruiz-Gomez Mar Ruiz-Gomez Margarita Lorenzo Sonia Fernandez-Veledo Federico Mayor Jr. Cristina Murga Iria Nieto-Vazquez Department of Biochemistry and Molecular Biology II School of Pharmacy Complutense University 28040 Madrid Spain CIBER de Diabetes y Enfermedades Metab61icas Asociadas (CIBERDEM) 08017 Barcelona Spain Instituto de Investigaciones Biomedicas Alberto Sols (CSIC-UAM) 28029 Madrid Spain CIBER de enfermedades neurodegenerativas (CIBERNED) 28049 Madrid Spain Departament of Molecular Biology and Centro de Biologia Molecular Severo Ochoa (CSIC-UAM) 28049 Madrid Spain Instituto de Investigacion Sanitaria la Princesa 28006 Madrid Spain Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) 28049 Madrid Spain Hospital Universitari de Tarragona Joan XXIII. IISPV. Universitat Rovira i Virgili 43007 Tarragona Spain

G 联合蛋白质的受体 kinase (GRK2 ) 2 是调整不同的膜 receptorsand 的重要 serine/threonine-kinase 细胞内部的蛋白质。在胚胎或成年苍蝇的果蝇 Gprk2 的变细导致了体的肌肉，纤维的损失，和不能飞行的 *** 的有缺点的区别脊椎动物，... 详细信息

G 联合蛋白质的受体 kinase (GRK2 ) 2 是调整不同的膜 receptorsand 的重要 serine/threonine-kinase 细胞内部的蛋白质。在胚胎或成年苍蝇的果蝇 Gprk2 的变细导致了体的肌肉，纤维的损失，和不能飞行的 *** 的有缺点的区别脊椎动物， GRK2 hemizygous 老鼠少些，但是更包含了 hypertrophied 骨胳的肌肉纤维比野类型的 *** C2C12 myoblasts ， GRK2 kinase缺乏的异种( K220R )的 overexpression 引起了房间 intoimmature myotubes 的早熟的区别，它在尺寸是更宽的并且包含了更多的熔化原子核，当时 GRK2 overexpression b 熔化事件由提高的 GRK2 层次支持了的损害 differentiationand 少数被 p38MAPK 异种概括，它能由 GRK2 模仿 p38MAPK 的 theinhibitory phosphorylation，而在表示 GRK2 观察的弄钝的区别面对 p38MAPK 小径的一个组成地活跃的在上游的激发器克隆 wasrescued。这些结果建议 thatbalanced GRK2 功能为一个及时、完全的 myogenic 过程是必要的。

关键词： G蛋白偶联受体激酶骨骼肌纤维 p38MAPK 丝氨酸/苏氨酸激酶缺失突变体偶合过度表达体细胞

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The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis

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Cellular & Molecular Immunology 2015年第6期12卷 777-779页

作者： Jose AG Agundez Elena garcia-Martin Carmen Martinez Julian Benito-Leon Julian Benito-Leon Jorge Millan-PascualMaria Diaz-Sanchez Patricia Calleja Diana Pisa Laura Turpin-Fenoll Hortensia Alonso-Navarro lucia Ayuso-Peralta Dolores Torrecillas Esteban Garcla-Albea Jose Francisco Plaza-Nieto Felix Javier Jimenez-Jimenez Department of Pharmacology University of Extremadura CAceres Spain Department of Biochemistry and Molecular Biology University of Extremadura Caceres Spain CiBERNED Centro de InvestigaciOn BiomEdica en Red de Enfermedades Neurodegenerativas Instituto de Salud Carlos III Spain Service of Neurology Hospital Universitario Doce de Octubre Madrid Spain Department of Medicine University Complutense Madrid Spain Section of Neurology Hospital La Mancha-Centro Alcazar de San Juan (Ciudad Real) Spain Centro de Biologfa Molecular Severo Ochoa (CSIC-UAM) Facultad de Ciencias Universidad Autonoma Cantoblanco 28049 Madrid Spain Department of Medicine-Neurology Hospital 'Principe de Asturias' Universidad de Alcala Alcala de Henares (Madrid) Spain Section of Neurology Hospital Universitario del Sureste Arganda del Rey (Madrid) Spain Correspondence: Dr FJ Jimenez-Jimenez C/Marroquina 14 3° B E-28030 Madrid Spain.

We analyzed the allelic and genotypic frequencies of the glutathione-S-transferase P1 （GSTPI） rs1695 single nucleotide polymorphism （SNP） in 290 patients with multiple sclerosis （MS） and in 310 healthy controls. We found no significant association between the rs1695 variant and MS. Among MS patients, there was no relationship between the rs1695 variant and either gender, clinical type of MS or the age of onset of MS.

关键词： associated increased sclerosis

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无问东西全球一家——对话印尼和西班牙青年文化使者

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孔子学院（中法文对照版） 2023年第2期 76-80页

作者：张珺竹光洁王文新(翻译) 不详

Tuti Walandari Bin Ahma,汉语名张珺竹,就读于印尼哈山努丁大学文学院。2022年获“中央广播电视总台联合国汉语日青年文化使者”称号。擅长手工制作,热爱汉语诗歌和国画。她说:“学习汉语,其乐无穷。”

关键词：手工制作文化使者汉语诗歌广播电视总台学习汉语其乐无穷西班牙印尼

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