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A proctolin-like peptide is regulated after baculovirus infection and mediates in caterpillar locomotion and digestion

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insect Science 2022年第1期29卷 230-244页

作者： Angel Llopis-Giménez Stefano Parenti Yue Han vera i.d.ros Salvador Herrero department of Genetics and institut Universitari en Biotecnologia i Biomedicina(BiOTECMEd) Universitat de ValenciaValenciaSpain Laboratory of Virology Wageningen University and ResearchWageningenthe Netherlands Current address.department of Pathology University of CambridgeCambridgeUK

Baculoviruses constitute a large group of invertebrate dNA viruses, predominantly infecting larvae of the insect order Lepidoptera. during a baculovirus infection, the virus spreads throughout the insect body producing a systemic infection in multiple larval tissues, included the central nervous system (CNS). As a main component of the CNS, neuropeptides are small protein-like molecules functioning as neurohormones, neurotransmitters, or neuromodulators. These peptides are involved in regulating animal physiology and behavior and could be altered after baculovirus infection. in this study, we have investigated the effect of Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) infection on expression of Spodoptera exigua neuropeptides and neuropeptide-like genes. Expression of the gene encoding a polypeptide that resembles the well-known insect neuropeptide proctolin and named as proctolin-like peptide (PLP), was downregulated in the larval brain following infection and was chosen for further analysis. A recombinant Autographa californica multiple nucleopolyhedrovirus (AcMNPV) overexpressing the C-terminal part of the PLP was generated and used in bioassays using S. exigua larvae to study its influence on the viral infection and insect behavior. AcMNPV-PLP-infected larvae showed less locomotion activity and a reduction in growth compared to larvae infected with wild type AcMNPV or mock-infected larvae. These results are indicative of this new peptide as a neuromodulator that regulates visceral and skeletal muscle contractions and offers a novel effector involved in the behavioral changes during baculovirus infection.

关键词： beet armyworm behavior neuromodulator neuropeptide physiology SeM-NPV

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Kinetics and mechanism of the low-energy b-a phase transition of the second kind in 2,4-dinitroanisole

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defence Technology（防务技术） 2024年第10期40卷 210-224页

作者： Aleksandr V.Stankevich Nikolay A.Rasputin Anisa KhRudina Gennady L.Rusinov vera i.Filyakova Valery N.Charushin y1.postovsky institute of organic synthesis ural branch of the russian academy of sciencesekaterinburg 620108russia russian federal nuclear center e zababakhin all-russia research institute of technical physics snezhinsk 456770russia kazan national research technological university kazan 420015russia

in this work,comprehensive studies of 2,4-dinitroanisole(2,4dNAN)were carried out using powder thermorentgenography of the internal *** time of the complete polymorphic transition in the solid phase b/a in 2,4dNAN under various combinations of conditions has been *** has been established that,regardless of the season of manufacture of the substance,when it is stored for 8e9 months,with a change in ambient temperature from minus 30℃ to plus 30℃,a complete polymorphic transition b/a *** stored in conditions below minus 5℃,polymorphic transition does not *** stored in conditions above plus 30℃ in a closed container,polymorphic transition occurs within 3 *** polymorphic transition is accompanied by a decrease in density by 1.3%e1.5%and an increase in melting temperature by 10-12℃,depending on the degree of purity of the starting *** activation energy of the molecular rearrangement was 68e70 kJ/mol(16.5±3 kcal/mol).The mechanism of polymorphic transition has been evaluated,which is presumably based on internal homodiffusion and energy transfer to the surface of the mass of powder particles and the *** average activation energy of the polymorphic transition process was 110±6.2 kJ/mol(26.2 kcal/mol).in an open container,reactions proceed by a homogeneous mechanism,and in a closed container by a heterogeneous mechanism involving the gas phase.

关键词： Energetic materials Melt-castable 2,4-dinitroanisole Polymorphic transition Kinetics Mechanism Homodiffusion Sublimation

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Litter production and leaf nutrient concentration and remobilization in response to climate seasonality in the central Amazon

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Journal of Forestry Research 2024年第3期35卷 131-141页

作者： Ricardo Antonio Marenco Saul Alfredo Antezana-vera daniela Pereira dias Luiz Antonio Candido instituto Nacional de Pesquisas da Amazonia Coordenagao de Uso da Terra e Mudanca ClimaticaAv.Andre Araujo 2936ManausAM69067-375Brazil Programa de pos-Graduagao em Agricultura no Tropico Umido Instituto Nacional de Pesquisas da Amazonia-INPAManausAMBrazil Unidade Academica de Ciencias Agrarias Universidade Federal de JataiBR 364km 195JataiGO 75801-615Brazil

Litterfall is the largest source of nutrients to for-est soils of tropical ***,variability in lit-terfall production,nutrient remobilization,and changes in leaf nutrient concentration with climate seasonality remain largely unknown for the central *** study meas-ured litterfall production,leaf nutrient remobilization,and leaf area index on a forest plateau in the central *** was measured at monthly intervals during 2014,while nitrogen,phosphorus,potassium,calcium and mag-nesium concentrations of leaf litter and canopy leaves were measured in the dry and rainy seasons,and remobilization rates *** area index was also recorded in the dry and rainy *** litterfall varied from 33.2(in the rainy season)to 87.6 g m^(-2) in the dry season,while leaf area index increased slightly in the rainy *** seasonality had no effect on concentrations of nitrogen,calcium,and magnesium,whereas phosphorous and potassium responded to rainfall seasonality *** phosphorous increased,potassium decreased during the dry *** seasons,nitrogen,potassium,and phosphorous decreased in leaf litter;calcium increased in leaf litter,while magnesium remained unaffected with leaf ***,the five nutrients had similar remobilization rates over the *** absence of climate seasonality on nutrient remobilization suggests that the current length of the dry season does not alter nutrient remobilization rates but this may change as dry periods become more prolonged in the future due to climate change.

关键词： Throughfall Nutrient cycling Climatic seasonality Leaf mass per area

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MicroRNA-630:A promising avenue for alleviating inflammation in diabetic kidney disease

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World Journal of diabetes 2024年第7期15卷 1398-1403页

作者： Javier donate-Correa Ainhoa González-Luis Jésica díaz-vera Juan Ramón Hernandez-Fernaud Research Unit University Hospital Nuestra Señora de Candelaria(UHNSC)Santa Cruz de Tenerife 38010Spain department of Biochemistry MicrobiologyCell Biology and GeneticsInstituto de Tecnologías BiomédicasUniversidad de La LagunaSanta Cruz de Tenerife 38000Spain

diabetic kidney disease(dKd)is one of the complications of diabetes,affecting millions of people *** relentless progression of this condition can lead to kidney failure,requiring life-altering interventions such as dialysis or *** evidence suggests that immunologic and inflammatory elements play an important role in initiating and perpetuating the damage inflicted on renal tissues,exacerbating the decline in organ ***-like receptors(TLRs)are a family of receptors that play a role in the activation of the innate immune system by the recognition of pathogen-associated molecular *** data from in vitro and in vivo studies have highlighted the critical role of TLRs,mainly TLR2 and TLR4,in the pathogenesis of *** the diabetic milieu,these TLRs recognize diabetic-associated molecular signals,triggering a proinflammatory cascade that initiates and perpetuates inflammation and fibrogenesis in the diabetic *** non-traditional strategies targeting TLR signaling with potential therapeutic implications in dKd have been *** of these approaches is the use of microRNAs,small non-coding RNAs that can regulate gene *** editorial comments on the results of this approach carried out in a rat model of diabetes by Wu et al,published in this issue of the World Journal of *** results of the experimental study by Wu et al shows that microRNA-630 decreased levels compared to non-diabetic ***,microRNA-630 exerted anti-inflammatory effects in the kidneys of diabetic rats through the modulation of *** findings indicate that the microRNA-630/TLR4 axis might represent a pathological mechanism of dKd and a potential therapeutic target capable of curbing the destructive inflammation characteristic of dKd.

关键词： diabetes diabetic kidney disease inflammation Toll-like receptor 4 microRNA-630

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Mesenchymal stem cells in wound healing:A bibliometric analysis as a powerful research tool

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World Journal of Stem Cells 2024年第9期16卷 827-831页

作者： vera V Voinova daria V Vasina Anton P Bonartsev Faculty of Biology MV Lomonosov Moscow State UniversityMoscow 119234Russia NF Gamaleya National Research Centre for Epidemiology and Microbiology Ministry of Health of the Russian FederationMoscow 123098Russia

Bibliographic analysis is still very rarely used in experimental basic study *** comprehensive bibliometric analysis of scientific literature on research progress and challenges in stem cell therapy for diabetic chronic wounds,which was conducted in the work of Shi et al can be a case study and a source of valuable information for writing reviews and experimental papers in this *** experimental studies on a role of mesenchymal stem cells(MSCs)in wound healing that are published in 2023-2024,such as Zhang et al in 2023,Hu et al in 2023,Wang et al in 2023 are certainly also subjects for applying this powerful tool to analyze current research,challenges and perspectives in this *** is due to the fact that these studies have addressed a great variety of aspects of the application of MSCs for the treatment of chronic wounds,such as using both the cells themselves and their various products:Sponges,hydrogels,exosomes,and genetic *** a wide variety of directions in the field of study and biomedical application of MSCs requires a deep understanding of the current state of research in this area,which can be provided by bibliometric ***,the use of such elements of bibliographic analysis as publication count by year and analysis of top-10 keywords calculated independently or cited from bibliometric analysis studies can be safely recommended for every basic study manuscripts,primarily for the“introduction”section,and review.

关键词： Bibliometric analysis Mesenchymal stem cells Wound healing Tissue engineering dressing Hydrogels Matrix Exosomes

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A Local differential Privacy Trajectory Protection Method Based on Temporal and Spatial Restrictions for Staying detection

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Tsinghua Science and Technology 2024年第2期29卷 617-633页

作者： Weiqi Zhang Zhenzhen Xie Akshita Maradapu vera Venkata Sai Qasim Zia Zaobo He Guisheng Yin College of Computer Science and Technology Harbin Engineering UniversityHarbin 150001China School of Computer Science and Technology Shandong UniversityQingdao 266237China department of Computer Science Georgia State UniversityAtlantaGA 30303USA College of information Science and Technology Jinan UniversityGuangzhou 510632China

The widespread availability of GPS has opened up a whole new market that provides a plethora of location-based ***-based social networks have become very popular as they provide end users like us with several such services utilizing GPS through our ***,when users utilize these services,they inevitably expose personal information such as their id and sensitive location to the *** to untrustworthy servers and malicious attackers with colossal background knowledge,users'personal information is at risk on these ***,many privacy-preserving solutions for protecting trajectories have significantly decreased utility after *** have come up with a new trajectory privacy protection solution that contraposes the area of interest for ***,Staying Points detection Method based on Temporal-Spatial Restrictions(SPdM-TSR)is an interest area mining method based on temporal-spatial restrictions,which can clearly distinguish between staying and moving ***,our privacy protection mechanism focuses on the user's areas of interest rather than the entire ***,our proposed mechanism does not rely on third-party service providers and the attackers'background knowledge *** test our models on real datasets,and the results indicate that our proposed algorithm can provide a high standard privacy guarantee as well as data availability.

关键词： local-differential privacy stay points detection trajectory data areas of interest temporal-spatial clustering

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The iLux^(®) compared to the mechanical meibomian gland expression for the treatment of moderate and severe meibomian gland dysfunction

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international Journal of Ophthalmology(English edition) 2024年第6期17卷 1042-1048页

作者： María Ximena Núñez Andrea Acosta-Ortega Guillermo Raul vera-duarte Catalina Gómez-duarte Unit of Cornea Cataract and Refractive SurgeryVision Sana Research GroupClínica de Oftalmología de CaliFaculty of Medicine Pontificia Universidad Javeriana CaliCali 760031Colombia department of Ophthalmology Faculty of Medicine Pontificia Universidad Javeriana CaliCali 760031Colombia department of Ophthalmology Hospital de ClínicasNational University of AsunciónAsunción 111421Paraguay

AiM:To compare the safety and effectiveness of eyelid treatment with the iLux®-MGd Treatment System in one session versus five sessions of mechanical meibomian gland expression(MMGE)in patients with moderate to severe meibomian gland dysfunction(MGd).METHOdS:A prospective,randomized,open-label,and controlled clinical trial that compared one session of the iLux®MGd Treatment System versus five sessions of MMGE in both eyes of 130 patients aged≥18y with Ocular Surface disease index(OSdi)scores≥13,total meibomian gland scores(MGS)ofin the lower eyelid of each eye,and non-invasive tear break-up time(Ni-TBUT)domized 1:1 to iLux®or ***:The mean age was 58±*** total MGS scores in both treatment groups were *** follow-up,there were significant differences in total MGS and per sector with Pis was performed using generalized estimating equations corresponding to the generalized linear model for repeated means to determine the treatment relationship with total MGS,NiBUT,and *** was a significant difference between iLux®and MMGE(Pirst to the twelfth month in MGS,Ni-BUT,and OSdi *** adverse events were ***:iLux®treatment compared to MMGE significantly improves symptoms and signs in patients with moderate to severe MGd for one year without adverse events.

关键词： meibomian gland dysfunction iLux® ocular surface dry eye

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A review of recent advances of kesterite thin films based on magnesium,iron and nickel for photovoltaic application:insights into synthesis,characterization and optoelectronic properties

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Clean Energy 2024年第2期8卷 217-238页

作者： Nelson Mauricio Espinel Pérez Enrique vera López Jairo Alberto Gómez Cuaspud Juan Bautista Carda Castelló Grupo de investigación en integridad y Evaluación de Materiales(GiEM).instituto para la investigación e innovación en Ciencia y Tecnología de Materiales(iNCiTEMA).Universidad Pedagógica y Tecnológica de Colombia Av.Central del Norte 39-115.Tunja-BoyacáColombia Servicio Nacional de Aprendizaje(Sena).Centro Minero.Vereda MorcáSector Batá.Sogamoso-Boyacá Colombia Universidad Jaume i.Grupo de Química inorgánica y Orgánica.Castellón de la Plana Campus del Riu Sec.Castellón de la PlanaEspaña

This review emphasizes the recent advancements and prospects of thin-film kesterite-based photovoltaic(PV)applications using magnesium,iron and *** quest for novel materials employed in solar cells has resulted in incorporating these elements into the composition of kesterite as substitutes or modifiers(dopants)for *** integration has induced notable repercussions on the structural,optoelectronics and morphological properties,which are *** first section of this paper offers a comprehensive review of the general characteristics of kesterite *** crucial materials exhibit a high absorption coefficient(104 cm-1)and an optical band gap of 1.0-1.8 ***,they are free of critical raw materials,non-toxic and *** second section depicts the substitution or modification of zinc by magnesium in ***,this paper provides a comprehensive review of the quaternary and pentanary systems Cu_(2)MgSn(S,Se)_(4) and Cu_(2)Zn_(1-x)Mg_(x)SnS_(4),highlighting their advantages and *** the last section,a review of the quaternary or pentanary systems is conducted,namely Cu_(2)ZnxFe_(1-x)SnS_(4) and Cu_(2)ZnxNi_(1-x)SnS_(4),along with their effects on optoelectronic *** conclusion,various methods for obtaining modified or substituted kesterite materials using magnesium,iron and nickel have demonstrated sustainability,scalability for industrial production and potential candidacy as substitutes for conventional PV *** prospects for pentanary materials(Cu_(2)Zn_(1-x)Mg_(x)SnS_(4),Cu_(2)Zn_(1-x)FexSnS_(4) and Cu_(2)Zn_(1-x)NixSnS_(4))are to overcome the efficiency record of kesterite reported in 2014,which was 12.6%for Cu_(2)ZnSn(S,Se)_(4),and to enhance its optoelectronic properties through synthesis conditions that comply with the principles of green chemistry.

关键词： kesterite thin film magnesium iron nickel substitutes or modifiers novel materials sustainability

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Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea

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Molecular Plant 2024年第7期17卷 1073-1089页

作者： Francisco J.Escaray Amelia Felipo-Benavent Cristian J.Antonelli Begona Balaguer Maria Pilar Lopez-Gresa Pablo vera instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The gray mold fungus Botrytis cinerea is a necrotrophic pathogen that causes diseases in hundreds of plant species,including high-value *** polyxenous nature and pathogenic success are due to its ability to perceive host signals in its *** this study,we found that laticifer cells of Euphorbia lathyris are a source of susceptibility factors required by *** to cause ***,poor-in-latex(pil)mutants,which lack laticifer cells,show full resistance to this pathogen,whereas lot-of-latex mutants,which produce more laticifer cells,are *** S factors are triterpenoid saponins,which are widely distributed natural products of vast structural *** downregulation of laticifer-specific oxydosqualene cyclase genes,which encode the first committed step enzymes for triterpene and,therefore,saponin biosynthesis,conferred disease resistance to ***,the Medicago truncatula iha-1 mutant,compromised in triterpenoid saponin biosynthesis,showed enhanced ***,the application of different purified triterpenoid saponins pharmacologically complemented the diseaseresistant phenotype ofpil and hla-1 mutants and enhanced disease susceptibility in different plant *** found that triterpenoid saponins function as plant cues that signal transcriptional reprogramming in ***,leading to a change in its growth habit and infection strategy,culminating in the abundant formation of infection cushions,the multicellular appressoria apparatus dedicated to plant penetration and biomass destruction in *** together,these results provide an explanation for how plant triterpenoid saponins function as disease susceptibility factors to promote *** pathogenicity.

关键词： Euphorbia lathyris laticifer cell latex appressorium infection cushion necrotrophic fungi

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Bresse Beam with damping and Logarithmic Source

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Chinese Annals of Mathematics,Series B 2024年第5期45卷 685-702页

作者： Sebasti?o CORdEiRO Carlos BALdEZ Carlos RAPOSO ducival PEREiRA Octavio vera department of Mathematics Federal University of Pará department of Mathematics State University of Pará department of Mathematics University of Tarapacá

This paper investigates the stabilization of a Bresse system with internal damping and logarithmic source. The authors use the potential well theory. For initial data in the stability set created by the Nehari surface, the existence of a global solution is proved by using Faedo-Galerkin's approximation. The Nakao theorem gives the exponential decay.A numerical approach is presented to illustrate the results obtained.

关键词： 35A01 35B40 35L70 74H40 93d15 Bresse beam Exponential decay Global solution Logarithmic source Numerical approach

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