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Journal of Pharmaceutical Analysis 2019年第1期9卷 62-69页

作者： verónica arancibia Johisner Penagos-Llanos Edgar Nagles Olimpo García-Beltrán John J.Hurtado Pontificia Universidad Católica de Chile Facultad de Química Facultad de Ciencias Naturales y Matemáticas Universidad de Ibagué Departamento de Química Universidad de los Andes

This study presents for the first time a new composite of carbon paste(CP), single-walled carbon nanotubes(SWCNTs) and Nd2 O3(NdOX). This versatile composite(NdOX-SWCNT/CPE) was applied to the oxidation of paracetamol(PCM). The newly formed surface was characterized by scanning electron microscopy(SEM), electrochemical impedance spectroscopy(EIS) and cyclic voltammetry(CV). The results showed greater conductivity and a higher surface area for the composite than those of the carbon paste alone. Moreover, the anodic peak currents for PCM increased from 1.6 to 3.6 m A with CPE and NdOXSWCNT/CPE, indicating an increase of nearly 51.0% for the anodic peak current. On the other hand, the anodic peak potentials shifted from 0.67 to 0.57 V. The detection limits were 0.05 mmol/L with NdOXSWCNT/CPE and 0.50 mmol/L with SWCNT/CPE. The relative standard deviations(RSDs) were 1.5%(n=7). The accuracy and interference of the methods were evaluated with a urine chemistry control spiked with known quantities of PCM, uric acid, dopamine, ascorbic acid, caffeine, acetylsalicylic acid,tartrazine, sunset yellow, allure red, rutin, morin and metal ions. Finally, the novelty and usefulness of the composite were evaluated to quantify PCM in pharmaceutical dosage forms such as tablets, powders and syrups for children.

关键词： Paracetamol Neodymium(Ⅲ) Oxide Single-walled carbon nanotubes Pharmaceutical dosage

Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

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Food Science and Human Wellness 2024年

作者： Emily P.Laveriano-Santos Sara Castro-Barquero Camila arancibia-Riveros Ana María Ruiz-León Rosa Casas Ramón Estruch Patricia Bodega Mercedes de Miguel Amaya de Cos-Gandoy Jesús Martínez-Gómez Gloria Santos-Beneit Juan M.Fernández-Alvira Rodrigo Fernández-Jiménez Rosa M.Lamuela-Raventós Anna Tresserra-Rimbau The Zena and Michael A.Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai Department de Nutrició Ciències de l'Alimentació I Gastronomia XIA Facultat de Farmàcia i Ciències de l'alimentació Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB) Universitat de Barcelona Department of Internal Medicine Hospital Clínic Institutd'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) University of Barcelona Consorcio CIBER M.P.Fisiopatología de la Obesidad y Nutrición (CIBERObn) Instituto de Salud Carlos III (ISCIII) Mediterranean Diet Foundation 5. Foundation for Science Health and Education (SHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBER de Enfermedades Cardiovasculares (CIBERCV) 9. Hospital Universitario Clínico San Carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in adolescents.Objective: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. Methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the SI! Program for Secondary Schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex z-score， blood pressure (BP) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health parameters.Results: Compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， P-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， P-for trend=0.206)， and HDL-c (β=-1.52， 95%CI=-2.90;-0.14， P-for trend=0.108)， after multivariable adjustment. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， P-for trend=0.013) and HDL-c (β=-2.16， 95%CI=-3.78;-0.53， P-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， P-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， P-for trend <0.001)， and the highest quintile of stilbene intake with lower BG (β=-1.83， 95%CI= -3.103;-0.64， P-for trend <0.001) and TG (β=-3.22， 95%CI= -4.95;-1.49， P-for trend=0.034)， and with higher HDL-c (β=2.328， 95%CI= 1.40;3.17， P-for trend=0.466) compared to the lowest quintile. Conclusion: A higher intake of (poly)phenols， especially flavonoids， phenolic acids， and stilbenes

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Growth Hormone Prevents the Memory Deficit Caused by Oxidative Stress in Early Neurodegenerative Stage in Rats

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Neuroscience & Medicine 2012年第3期3卷 287-293页

作者： Diana verónica Castillo-Padilla Gabino Borgornio-Pérez Alejandro Zentella-Dehesa Adrian Sandoval-Montiel José Luis Ventura Gallegos Selva Rivas-arancibia Facultad de Medicina Departamento de Fisiología Universidad Nacional Autónoma de México Ciudad Universitaria México Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México Ciudad Universitaria México Unidad de Bioquímica Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Tlalpan México

Oxidative stress has been involved in neurodegenerative diseases. The growth hormone (GH) counteracts the levels of reactive oxygen species. Previously, we showed that the prolonged exposure to ozone causes oxidative stress in the hippocampus and memory deficits. In this work, we analyzed the effects of the growth hormone on the memory deficit generated by ozone exposure, growth hormone effects on the Insulin-like growth factor I (IGF-I), and the serinethreonine protein kinase (Akt) activation in the dentate gyrus. Our results show that GH prevents memory deficits in early stages of the neurodegenerative process.

关键词： Oxidative Stress Growth Hormone Insulin Growth Factor Ozone Serine-Threonine Protein Kinase Water Maze Passive Avoidance

Domain Decomposition for Quasi-Periodic Scattering by Layered Media via Robust Boundary-Integral Equations at All Frequencies

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Communications in Computational Physics 2019年第6期26卷 265-310页

作者： Carlos Perez-arancibia Stephen P.Shipman Catalin Turc Stephanos Venakides Institute for Mathematical and Computational Engineering School of Engineering and Faculty of MathematicsPontificia Universidad Catlica de ChileSantiagoChile Department of Mathematics Louisiana State UniversityBaton RougeLA 70803USA Department of Mathematical Sciences New Jersey Institute of TechnologyNewarkNJ 07102USA Department of Mathematics Duke UniversityDurhamNC 27708USA

We develop a non-overlapping domain decomposition method(DDM)for scalar wave scattering by periodic layered media.Our approach relies on robust boun-dary-integral equation formulations of Robin-to-Robin(RtR)maps throughout the frequency spectrum,including cutoff(or Wood)frequencies.We overcome the obsta-cle of non-convergent quasi-periodic Green functions at these frequencies by incor-porating newly introduced shifted Green functions.Using the latter in the defini-tion of quasi-periodic boundary-integral operators leads to rigorously stable computations of RtR operators.We develop Nystr̈om discretizations of the RtR maps that rely on trigonometric interpolation,singularity resolution,and fast convergent windowed quasi-periodic Green functions.We solve the tridiagonal DDM system via recursive Schur complements and establish rigorously that this procedure is always completed successfully.We present a variety of numerical results concerning Wood frequencies in two and three dimensions as well as large numbers of layers.

关键词： Helmholtz transmission problem domain decomposition periodic layered media lattice sum

Review of Statistical Water Temperature Models for a Peruvian Andean River

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Journal of Environmental Science and Engineering(B) 2022年第5期11卷 155-164页

作者： Efrain Noa-Yarasca Diana Chaca Ayuque Hugo A.Galvan Ccora Ivan A.Ayala Bizarro Ada arancibia School of Civil&Construction Engineering Oregon State UniversityCorvallisOR 97331USA Faculty of Civil Engineering National University of HuancavelicaHuancavelica 09001Peru Faculty of Civil Engineering National University of EngineeringLima 15333Peru

The rapid increase in Water Temperature Rivers (WTR) observed globally in recent decades and projections for the coming decades under climate change scenarios make water temperature prediction essential to assess changes in aquatic biota. Statistical models for stream temperature prediction have been widely used because they are computationally simple, involve few parameters, and because of their relatively good accuracy. However, these models have not been evaluated in Peruvian Andean rivers. This work evaluates the main water temperature statistical models from the literature and fits them with data recorded in the Ichu River experimental watershed, Huancavelica-Peru. Three well-known models were reviewed: the Stefan & Preud’homme linear regression model and the Mohseni & Stefan 3- and 4-parameter logistic regression models. Ichu river water temperatures were simulated using the SWAT (Soil and Water Assessment Tool) hydrometeorological model, which defaults to the Stefan & Preud’homme model. Modifications and adjustment of coefficients of the evaluated models were configured in the SWAT code using the “Latin Hypercube Sampling” technique. The evaluated models showed poor performance in predicting the water temperature in the Ichu River with NSE (Nash-Sutcliffe Efficiency) values ranging from -2.6 to 0.49, while the modified models showed NSE values of 0.72 in all three cases. Findings suggest that the statistical models shown in the literature should be validated for Andean rivers.

关键词： Water temperature modeling Ichu River Peruvian Andes River statistical modeling

Potential impacts of UV exposure on lichen communities:a pilot study of Nothofagus dombeyi trunks in southernmost Chile

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Ecosystem Health and Sustainability 2015年第4期1卷 40-52页

作者： Marie T.Trest Susan Will-Wolf Rachel Keuler Nathaniel Shay Karen Hill Alyssa Studer Andy Muench Zachary Alexander Axel Adams Leah Dittberner Martin Feehan Hannah Lee Nicholas Galleguillos-Katz Joy B.Zedler Linda Graham Patricia arancibia-Avila Department of Botany University of WisconsinMadisonWisconsin 53706 USA Department of Basic Sciences University of Bio-BioChillan 3800708 Chile

High-latitude terrestrial ecosystems face the triple threats of climate warming,increased exposure to UV arising from polar ozone depletion,and deforestation.Lichen communities of southernmost Chile are recognized for their high diversity,which includes nitrogen-fixing cyanolichens.Such lichens are common on forest trees,contribute nitrogen to forests,and are sensitive to exposure following deforestation(widespread in this region).In a pilot study of exposure effects on tree lichens,using nondestructive imaging methods,we compared lichen communities on trunks of isolated vs.forest tree trunks of southern Chilean beech(Nothofagus dombeyi,Nothofagaceae).We chose trees of similar diameter and trunk lean angle in conserved forest and nearby logged meadow on Navarino Island,XII Region Magallanes and Chilean Antarctica,Chile,within the annual southern ozone hole.Ninety-five percent of cyanolichen records,including Nephroma antarcticum,and 66%of records for other foliose lichens were from the forest,whereas pendulous usneoid lichens dominated N.dombeyi bark at the meadow site.Limitation of cyanolichen growth on isolated trees could affect ecosystem function in this poorly studied habitat.Possible factors contributing to strong community differences were increased light intensity,UV radiation,and wind stress,plus limited ability of lichens to colonize isolated trees in the logged meadow.UV radiation was likely an important stressor for some lichen species but not others.We recommend more extensive monitoring to pinpoint causes of differing lichen communities,and we encourage better protection of bark-dwelling lichens in southern hemisphere regions facing multiple threats.

关键词： bark lichens Chile cyanolichens deforestation forest fragmentation lichen diversity Nothofagus dombeyi southern ozone hole UV radiation

Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus

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World Journal of Hepatology 2016年第25期8卷 1075-1086页

作者： Juan P Arab Juan C Claro Juan P arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez Departamento de Gastroenterología Escuela de Medicina Pontificia Universidad Católica de Chile Departamento de Medicina Interna and Programa de Salud Basada en la Evidencia Escuela de Medicina Pontificia Universidad Católica de Chile Sección de Gastroenterología Departamento de Medicina Hospital Clínico Universidad de Chile and Clínica Santa María Unidad de Gastroenterología Universidad del Desarrollo Clínica Alemana Servicio de Gastroentero-logía Unidad de Trasplante Hepático Hospital del Salvador Facultad de Medicina Universidad de Chile and Unidad de Gastroenterología Clínica Alemana de Santiago Clínica Indisa Clínica Las Condes y Servicio de Gastroenterología Hospital Fuerza Aérea de Chile Departamento de Nefrología Facultad de Medicina Pontificia Universidad Católica de Chile

AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1.

关键词： Hepatorenal syndrome Delphi Consensus Evidence-based medicine Treatment

Chronic exposure to low doses of ozone produces a state of oxidative stress and blood-brain barrier damage in the hippocampus of rat

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Advances in Bioscience and Biotechnology 2013年第11期4卷 24-29页

作者： Selva Rivas-arancibia Luis Fernando Hernández-Zimbrón Erika Rodríguez-Martínez Gabino Borgonio-Pérez Varsha Velumani Josefina Durán-Bedolla Centro de Investigación Sobre Enfermedades Infecciosas Instituto Nacional de Salud Pública Cuernavaca México Departamento de Fisiología Facultad de Medicina Universidad Nacional Autónoma de México México D. F. México

Chronic exposure to low doses of ozone similar to a day of high pollution in Mexico City causes a state of oxidative stress. This produces a progressive neurodegeneration in hippocampus of rats exposed to the gas. The aim of this study was to analyze the effect of chronic exposure on the changes in the blood-brain barrier in rats exposed to low doses of ozone. Method: each group received one of the following treatments, control group received air without ozone, and groups 2, 3, 4, 5, and 6 received ozone doses of 0.25 ppm for 4 h daily during 7, 15, 30, 60 and 90 days respectively. Each group was processed to inmunohistochemical technique against of the following antibody: blood-brain barrier, guanylyl cyclase, Iba-1, GFAP, NFκ-B, TNF-α. The results show that there is a correlation between the time exposure of ozone and the progressive damage, on the blood-brain barrier rupture, finally causing edema of endothelial cell, increase in guanylyl cyclase type 1, thickening of the processes and astrocytes foot, and an increase in the expression of factors NFκ-B and TNF-α at 30 and 60 days of exposure to this gas. All the above indicates that the chronic state of oxidative stress causes a neurodegeneration process, accompanied by disruption of the blood-brain barrier likely to occur in the Alzheimer’s disease.

关键词： Ozone Oxidative Stress Blood-Brain Barrier Neurodegenerative Diseases

Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review

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World Journal of Gastroenterology 2014年第34期20卷 12182-12201页

作者： Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme Departamento de Gastroenterología Escuela de MedicinaPontificia Universidad Católica de Chile8330024 SantiagoChile Sección de Gastroenterología Hospital del SalvadorEscuela de MedicinaUniversidad de Chile7500922 SantiagoChile Unidad de Gastroenterología Universidad del DesarrolloClínica Alemana7650568 SantiagoChile Unidad de Trasplante Hepático Hospital del SalvadorUnidad de GastroenterologíaClínica Las Lilas7510524 SantiagoChile Sección de Gastroenterología Departamento de MedicinaHospital Clínico Universidad de ChileChile8380456 SantiagoChile Sección de Gastroenterología Hospital Clínico Universidad de ChileEscuela de MedicinaUniversidad de Chile8380456 SantiagoChile Digestive Diseases Unit Clínica Re?aca2540364 Vi?a del MarChile Gastroenterology Department Clínica Las Condes6770128 SantiagoChile Centre for Medical Education Escuela de MedicinaPontificia Universidad Católica de Chile8330024 SantiagoChile

AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events.

关键词： Nonalcoholic fatty liver disease Steatosis Consens

嘌呤受体P2Y13调节小胶质细胞形态、功能及白细胞介素-1β的释放水平

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神经损伤与功能重建 2019年第10期14卷 F0003-F0003页

作者： Kyrargyri V Madry C Rifat A arancibia-Carcamo IL Jones SP Chan VTT Xu Y Robaye B Attwell D 杜一星 Department of Neuroscience Physiology & Pharmacology University College London Department of Immunology Laboratory of Molecular Genetics Hellenic Pasteur Institute Institute of Neurophysiology Charité-Universitatsmedizin Berlin Faculté de Médecine Université Libre de Bruxelles 不详

小胶质细胞利用一系列膜受体来感知周围环境。虽然已知P2Y12受体在小胶质细胞的突起向释放ATP/ADP的损伤部位的靶向运动定中起关键作用,但对P2Y13的作用知之甚少。转录组数据表明P2Y13是小胶质细胞中第2高表达的神经递质受体。本研究显... 详细信息

小胶质细胞利用一系列膜受体来感知周围环境。虽然已知P2Y12受体在小胶质细胞的突起向释放ATP/ADP的损伤部位的靶向运动定中起关键作用,但对P2Y13的作用知之甚少。转录组数据表明P2Y13是小胶质细胞中第2高表达的神经递质受体。本研究显示,在缺乏P2Y13受体小鼠的急性脑切片,膜片钳记录由ADP激活P2Y12受体引起的THIK-1 K+电流密度增加了约50%。这种增加表明P2Y12依赖的趋化性反应增强。但是在P2Y13敲除小鼠,P2Y12介导的小胶质细胞突起向充灌ADP的电极或激光融蚀点聚集所需的时间更长。解剖分析表明,在P2Y13敲除小鼠中,小胶质细胞的密度没有变化,但分枝较少,突起长度较短。因此在基因敲除的小鼠,小胶质细胞趋化的突起必须进一步生长然后才能到达靶标,且脑部监视降低了约30%。在P2Y13敲除小鼠脑片中,阻断P2Y12受体并不会影响监视,表明监视过程不需要这些高亲和力受体的补充激活。令人惊讶的是,在P2Y13敲除小鼠白细胞介素-1β释放的基础值增加了5倍,而LPS和ATP引起的释放不受影响;P2Y13敲除小鼠完整脑中的小胶质细胞未被检测到激活。因此,尽管P2Y13受体与P2Y12非常接近,但它们在调节小胶质细胞形态和功能方面起着不同的作用。

关键词：二磷酸腺苷三磷酸腺苷嘌呤受体P2Y12 嘌呤受体P2Y13 嘌呤能信号传递