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Endothelial progenitor cells as factors in neovascularization and endothelial repair

World Journal of Cardiology 2010年第12期2卷 411-420页

作者： Stefano Capobianco venu chennamaneni Mayank Mittal Department of Cardiology Gaetano Rummo Hospital Department of Internal Medicine University of Missouri-Columbia

Endothelial progenitor cells(EPCs)are a heterogeneous population of cells that are provided by the bone marrow and other adult tissue in both animals and *** express both hematopoietic and endothelial surface markers,which challenge the classic dogma that the presumed differentiation of cells into angioblasts and subsequent endothelial and vascular differentiation occurred exclusively in embryonic *** breakthrough stimulated research to understand the mechanism(s)underlying their physiologic function to allow development of new therapeutic *** focus has been on their ability to form new vessels in injured tissues,and another has been on their ability to repair endothelial damage and restore both monolayer integrity and endothelial function in denuded ***,measures of their density have been shown to be a better predictor of cardiovascular events,both in healthy and coronary artery disease populations than the classical tools used in the clinic to evaluate the risk *** the present paper we review the effects of EPCs on revascularization and endothelial repair in animal models and human studies,in an attempt to better understand their function,which may lead to potential advancement in clinical management.

关键词： Atherosclerosis Bone marrow Endothelial dysfunction Endothelial progenitor cells Neovascularization Stem cells

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