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国际眼科杂志 2009年第8期9卷 1451-1452页

作者： Bashkaran Karuppannan Bakiah Shaharuddin Ernbong Zunaina venkatesh ramaswamy naik 马来西亚吉兰丹马来西亚理科大学医学院眼科马来西亚吉兰丹马来西亚理科大学医学院眼理科

患者,女,42岁,马来人,无痛性进展性右上睑肿胀2a就诊,无外伤史,身体其他处无同样病损。进行肿块切除活组织检查,组织病理学检查结果显示与毛发囊肿表现相符。毛发囊肿,尽管罕见,在眼睑病变中需要考虑到。

关键词：毛发囊肿眼睑藏毛囊肿

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继发于巨细胞动脉炎的全眼肌麻痹、视神经鞘膜炎和视网膜中央动脉阻塞1例(英文)

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国际眼科杂志 2009年第12期9卷 2269-2272页

作者： Bashkaran Karuppannan Wan Hazabbah Wan Hitam Wahid Abdullah Salem Wajih Embong Zunaina venkatesh ramaswamy naik 马来西亚理科大学医学院眼科马来西亚理科大学医学院病理科

一位67岁男性患者出现右边颞侧头痛和右眼视力突发性无痛性丧失,出现这些症状时还伴有全部眼肌麻痹和视盘水肿。ESR和C-反应蛋白升高。核磁共振检查证实有视神经鞘膜炎的特征。右颞侧动脉的活组织切片检查正常。眼外肌运动随着全身激素... 详细信息

一位67岁男性患者出现右边颞侧头痛和右眼视力突发性无痛性丧失,出现这些症状时还伴有全部眼肌麻痹和视盘水肿。ESR和C-反应蛋白升高。核磁共振检查证实有视神经鞘膜炎的特征。右颞侧动脉的活组织切片检查正常。眼外肌运动随着全身激素的应用而好转。不幸的是此后患者右眼发展为中央视网膜动脉阻塞。全眼肌麻痹是巨细胞动脉炎的一种罕见表现,为了得到满意的治疗结果并且阻止对侧眼盲,疾病开始时使用皮质类固醇激素是必要的。

关键词：巨细胞动脉炎视神经鞘膜炎视网膜中央动脉阻塞

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Effect of Caralluma Fimbriata Extract on 3T3-L1 Pre-Adipocyte Cell Division

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Food and Nutrition Sciences 2011年第4期2卷 329-336页

作者： Soundararajan Kamalakkannan ramaswamy Rajendran Ramasamy V.venkatesh Paul Clayton Mohammad A.Akbarsha Department of Animal Science Bharathidasan UniversityTiruchirappalliIndia GreenChem BangaloreIndia Gencor Pacific Limited Discovery BayHong Kong(China Department of Life Sciences Oxford Brookes UniversityOxfordUK Mahatma Gandhi-Doerenk-amp Center for Alternatives Bharathidasan UniversityTiruchirappalliIndia College of Food Science and Agriculture King Saud Univer-sityRiyadhKingdom of Saudi Arabia

A standardized extract of the plant Caralluma fimbriata (Slimaluma?) is widely used in the management of obesity but its mode of action is not yet clarified. This study investigated the ability of Caralluma fimbriata extract (CFE) to modify pre-adipocyte cell division and thus the development of hyper-plastic obesity. Mouse 3T3-L1 pre-adipocyte cell line samples were treated with different concentrations of an extract of CFE standardized against its pregnane glycoside content. Plain medium formed the negative control and hydroxyurea was the positive control. The cells were counted at 12-hour intervals, and their viability tested using the MTT assay. The treated cells were subjected to direct and indirect immunofluorescent assays for cyclin D1. CFE inhibited 3T3-L1 cell growth in a dose and duration-dependent manner, with results comparable to those produced by hydroxyurea. The viability of CFE-treated cells was reduced. Direct and indirect immunofluorescent assays demonstrated that CFE inhibits import of cyclin D1into the nucleus. CFE appears to inhibit pre-adipocyte cell division by interfering with a mechanism preceding the import of cyclin D1-CDk4/6 complex into the nucleus during the early G1 phase of the cell cycle, suggesting that CFE has the potential to inhibit hyperplastic obesity.

关键词： Caralluma Fimbriata Cell Cycle Cyclin D1 Hyper-Plastic Obesity Slimaluma^(TM)

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Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients

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World Journal of Gastroenterology 2012年第8期18卷 814-820页

作者： Mohd Nizam Zahary Ravindran Ankathi Human Genome Centre Gurjeet Kaur Muhammad Radzi Abu Hassan Harjinder Singh venkatesh R naik School of Medical Sciences University Sains Malaysia Health Campus16150 Kubang KerianKelantanMalaysia Institute for Research in Molecular Medicine University Sains Malaysia11800 PenangMalaysia Internal Medicine Department Hospital Alor Star05460 Alor StarKedahMalaysia Department of Medicine Hospital Queen Elizabeth88586 Kota KinabaluSabahMalaysia Department of Pathology School of Medical SciencesUniversity Sains Malaysia Health Campus16150 Kubang KerianKelantanMalaysia

AIM: To investigate the protein expression profi le of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations. METHODS: Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein. Germline mutation screening was carried out on peripheral blood samples. The entire exon regions of MLH1 and MSH2 geneswere amplifi ed by polymerase chain reaction, screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations. RESULTS: Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry, indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells, respectively. dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene. However, no deleterious mutations were identifi ed in any of the 19 exons or coding regions of MLH1 gene, but we were able to identify MLH1 promoter polymorphism, -93G > A (rs1800734), in 21 out of 34 patients (61.8%). We identified one novel mutation, transversion mutation c.2005G > C, which resulted in a missense mutation (Gly669Arg), a transversion mutation in exon 1, c.142G > T, which resulted in a nonsense mutation (Glu48Stop) and splice-site mutation, c.2006-6T > C, which was adjacent to exon 13 of MSH2 gene. CONCLUSION: Germline mutations were identified in four Malaysian Lynch syndrome patients. Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes.

关键词： Denaturing high performance liquid chromatography DNA sequencing Germline mutation Mismatch repair genes Immunohistochemistry Lynchsyndrome

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Correlation of Programmed Death Ligand-1 (PD-L1) Expression with Clinicopathological Features in Non-Small Cell Lung Carcinoma: Experience from a Tertiary Cancer Care Center in India

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Journal of Cancer Therapy 2020年第3期11卷 172-187页

作者： Hafsa Saif K. S. Rajesh Kumar Suhail Sayeed Mufti Ritesh Giri V. Hrishi Vinu Sarathy Veena ramaswamy Diganta Hazarika Radheshyam naik Department of Pathology HealthCare Global (HCG) Hospital Bengaluru India Department of Translational Medicine & Therapeutics Health Care Global (HCG) Hospital Bengaluru India Department of Clinical Pharmacy Health Care Global (HCG) Hospital Bengaluru India Department of Medical Oncology Health Care Global (HCG) Hospital Bengaluru India Histopathology Department Health Care Global (HCG) Hospital Bengaluru India Department of Medical Oncology Hematology and BMT Bengaluru India

Background:?According to the GLOBOCAN 2018 report, the estimated incidence of lung cancer in India was 67,795 in both sexes. The treatment of advanced Non-small cell lung cancer (NSCLC) saw a major paradigm shift with recent advances in molecular-targeted therapy. Immune checkpoint blockade therapy is one such novel strategy with promising clinical benefits in advanced NSCLC. Programmed cell death receptor-1/Programmed cell death ligand-1 (PD-1/PD-L1) pathway is one such checkpoint and has thus become the current area of interest in the treatment of lung carcinoma. The PD-1/?PD-L1 pathway is under active investigation as it represents a promising therapeutic target in NSCLC. The expression of PD-L1 in tumor cells has been suggested as a predictive marker of the clinical response to PD-1/?PD-L1-targeted therapy. Methods: This study was carried out at the Department of Pathology, Health Care Global Specialty Hospital, Bangalore from May 2018 to May 2019. In this study, we analyzed pattern of PD-L1 expression by immunohistochemistry testing using our own Laboratory Developed Test (LDT) in NSCLC patients. Results:?Our study group comprised 50 patients of NSCLC. Among our study population, 40% of the patients exhibited PD-L1 immunopositivity (≥1%) with 28% of them having any expression (TPS 1% - 49%) and 12% of them having a high expression (TPS ≥ 50%) of PD-L1. Majority of them exhibited adenocarcinoma type of NSCLC under which the solid subtype showed a direct correlation with PD-L1 positivity (p-value: 0.004) with a poorly differentiated tumor histology being common in our population in relation to PD-L1 positivity (p-value: 0.043). PD-L1 expression did not correlate with age, gender, smoking status or clinical stage in our study. No association was found between tumor histology (SCC or AC) and driver mutation status with expression of PD-L1 in the present study. Conclusions: In our study, PD-L1 immunopositivity was found in 40% of patients and majority of them exhibi

关键词： Lung Cancer PD-L1 IHC Biomarker Immunotherapy

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第14章气候的辐射强迫:辐射强迫的概念、强迫机制及其量化和应用的历史演变

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气象科技进展 2019年第S1期9卷 217-236页

作者： V·拉马斯瓦米 W.COLLINS J.HAYWOOD J.LEAN N.MAHOWALD G.MYHRE V.naik K.P.SHINE B.SODEN G.STENCHIKOV T.STORELVMO 贾朋群(编译) 李婧华(编译) NOAA/GFDL 劳伦斯伯克利国家实验室/加州大学伯克利分校埃克塞特大学/英国气象局美国海军研究实验室康奈尔大学雷丁大学迈阿密大学沙特阿卜杜拉国王科技大学奥斯陆大学挪威国际气候和环境研究中心不详

我们描述地球气候"辐射强迫"(RF,见,例如,IPCC 1990)的概念化、公式化、量化、应用和使用的历史演变。短波和长波辐射的基本理论在19到20世纪发展起来,建立了确定和量化的自然和人为影响地球辐射能量平衡的扰动的分析框架。19世纪首次... 详细信息

我们描述地球气候"辐射强迫"(RF,见,例如,IPCC 1990)的概念化、公式化、量化、应用和使用的历史演变。短波和长波辐射的基本理论在19到20世纪发展起来,建立了确定和量化的自然和人为影响地球辐射能量平衡的扰动的分析框架。19世纪首次洞见到二氧化碳的变化会辐射强迫地球气候,并得到从1957年开始的大气气体浓度持续观测的经验支持。20世纪实验室和外场观测、仪器、计算技术、充分混合的温室气体和气候系统的数据和分析等的进步,使得RF的开发和形成体系成为可能,这使得RF在复杂程度增加的统计模式的帮助下,与全球平均海平面温度的变化联系到一起。这也反过来,在1990年前确立和牢固了RF是气候科学中的核心概念。与地表温度建立联系,被证明是RF概念最重要的应用,建立了评估不同机制的相对气候影响的简单指标。1970年代后期和1980年代,量化评估被加速开发,包括首次对二氧化碳加倍强迫的气候影响评估("查尼"报告),这一概念随后超越了充分混合的温室气体(WMGHG:二氧化碳、甲烷、一氧化二氮和卤化碳),拓展到宽泛的臭氧等短生命期要素的不同机制中。WMO和IPCC的国际评估开启了重要的系列周期性评估,量化自然(太阳辐射变化和火山喷发带来的平流层气溶胶)和不断增加的人为机制(WMGHG、臭氧、气溶胶、陆面改变、航迹云)强迫。从1990年代到现在,对作用于气候系统的辐射机制的知识和科学信度得到大幅提升。RF的概念基础也随着对辐射强迫气候变化方式的认识和强迫机制多样性的增加而演变,形成了当前以"有效辐射强迫"(ERF)作为实际辐射强迫的优先定义的情况,目的是更好地捕捉强迫与全球平均地表温度之间的联系。然而,ERF的使用,伴随其本身存在的问题,包括用气候模式对其诊断的挑战,应用于弱强迫和快速气候调节(快响应)与气候反馈之间的模糊不清;这必须在未来应用中进一步细化。全球气候模式模拟不同机制辐射扰动已经证实了强迫如何影响温度以外气候变量,例如降水。模式模拟的强迫-反馈联系,包括不同机制强迫空间分布的多样性,提供了在扰动能量平衡和引起气候变化方面机制有效性的实际展示。过去半个世纪的重要进步,在非常高的信度上确立了自工业化前时代以来的人类活动导致的全球平均ERF为正值(2013年IPCC评估给出最佳估计为2.3 W·m^-2,变化范围从1.1~3.3 W·m^-2;90%信度区间)。更进一步,排除了气候上有重要影响的火山喷发的直接后果后,净人类活动强迫超过自然辐射强迫机制而占主导。然而,人为净ERF存在的大量不确定性使得源自观测的气候敏感性估计和预测未来气候影响存在大的不确定性。ERF的不确定性,主要是由快速气候调节的表达、给出公认的工业化前大气状态的特征所面对的困难和气溶胶与云相互作用不完整认识等共同造成的。这种不确定性不利于气候适应量化未来减缓途径的评估。地球系统科学的一个巨大挑战,隐藏在持续维持辐射强迫概念最初设计时相对简单的构成的同时,改进强迫量化的过程中。这也反过来,需要准确、不断复杂化和全面的气候系统相关过程的解释。

关键词：地球气候平流层气溶胶气候敏感性一氧化二氮最佳估计大气状态计算技术加速开发

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