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Activation of RAS/MAPK pathway confers MCl-1 mediated acquired resistance to BCl-2 inhibitor venetoclax in acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2022年第3期7卷 856-868页

作者： Qi Zhang Bridget Riley-Gillis lina Han Yanan Jia Alessia lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie CWeng Cassandra lRamage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis venkata l.battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel leverson Relja Popovic Marina Konopleva Department of leukemia The University of Texas MD Anderson Cancer CenterHoustonTXUSA AbbVie Inc. North ChicagoILUSA Institute of Hematology Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjinChina Department of Nutritional Sciences Department of PediatricsDepartment of OncologyDell Medical SchoolThe University of Texas at AustinAustinTX 78712USA Department of Cell Developmental&Cancer BiologyDivision of Hematology&Medical OncologyKnight Cancer InstituteOregon Health&Science UniversityPortlandORUSA Universite de Paris Institut de la Recherche Saint-Louis(IRSL)Inserm Unit 1131ParisFrance Dana-Farber Cancer Institute BostonMAUSA Department of Hematopathology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Princess Margaret Cancer Center TorontoONCanada High Resolution Electron Microscopy Facility The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Bioinformatics&Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Hematology The First Hospital Affiliated Harbin Medical UniversityHarbinChina Department of lymphoma&Myeloma Research The University of Texas MD Anderson Cancer CenterHoustonTXUSA

Despite high initial response rates,acute myeloid leukemia(AMl)treated with the BCl-2-selective inhibitor venetoclax(VEN)alone or in combinations commonly acquires *** performed gene/protein expression,metabolomic and methylation analyses of isogenic AMl cell lines sensitive or resistant to VEN,and identified the activation of RAS/MAPK pathway,leading to increased stability and higher levels of MCl-1 protein,as a major acquired mechanism of VEN resistance.

关键词： acute myeloid acquired

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Correction: Activation of RAS/MAPK pathway confers MCl-1 mediated acquired resistance to BCl-2 inhibitor venetoclax in acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1860-1860页

作者： Qi Zhang Bridget Riley-Gillis lina Han Yannan Jia Alessia lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie C.Weng Cassandra l.Ramage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis venkata l.battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel leverson Relja Popovic Marina Konopleva The University of Texas MD Anderson Cancer Center Department of Leukemia Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) AbbVie Inc. North Chicago USA (GRID:grid.431072.3) (ISNI:0000 0004 0572 4227) The University of Texas MD Anderson Cancer Center Department of Leukemia Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Hematology Tianjin China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839) The University of Texas at Austin Department of Nutritional Sciences Department of Pediatrics Department of Oncology Dell Medical School Austin USA (GRID:grid.89336.37) (ISNI:0000 0004 1936 9924) Oregon Health & Science University Department of Cell Developmental & Cancer Biology Division of Hematology & Medical Oncology Knight Cancer Institute Portland USA (GRID:grid.5288.7) (ISNI:0000 0000 9758 5690) Université de Paris Institut de la Recherche Saint-Louis (IRSL) Inserm Unit 1131 Paris France (GRID:grid.508487.6) (ISNI:0000 0004 7885 7602) Dana-Farber Cancer Institute Boston USA (GRID:grid.65499.37) (ISNI:0000 0001 2106 9910) The University of Texas MD Anderson Cancer Center Department of Hematopathology Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) Princess Margaret Cancer Center Toronto Canada (GRID:grid.415224.4) (ISNI:0000 0001 2150 066X) The University of Texas MD Anderson Cancer Center High Resolution Electron Microscopy Facility Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) The University of Texas MD Anderson Cancer Center Department of Bioinformatics & Computational Biology Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) The University of Texas MD Anderson Cancer Center Department of Leukemia Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) The First Hospital Affiliated Harbin Medical University Department of Hematology Harbin China (GRID:grid.410736.7) (ISNI:0000 0001 2204 9268) The University of Texas MD Anderson Cance

Correction to:Signal Transduction and Targeted Therapy(2022)7:1–13,https://***/10.1038/s41392-021-00870-3 In the original version of this article,given name of 4th author Yannan Jia was incorrectly published as Yanan *** original article has been *** Access This article is licensed under a Creative Commons Attribution 4.0 International license,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source.

关键词： myeloid Therapy resistance

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Knotting ligands to control metal coordination geometry

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Science China Chemistry 2025年第2期68卷 403-404页

作者： Fabien B.l.Cougnon Department of Chemistry and Nanoscience Centre University of JyväskyläJyväskyläFinland

Zinc is a metal of particular importance for life[1].It is the most abundant transition metal in biological systems after iron and contributes both structural and catalytic roles to many cellular *** properties of Zn^(Ⅱ),unlike those of any other first-row transition metal ions,explain its biological *** to its filled d-shell orbitals,Zn^(Ⅱ) is redox-stable,has a ligand-field energy stabilization of zero and,consequently,no typical coordination number and *** metalloproteins exploit these features to carry a broad range of chemical reactions in mild *** metalloenzymes,unsaturated ZnII centres often act as redox-stable lewis *** protein backbone provides a highly preorganized environment around the metal centre and accompanies the changes in coordination geometry occurring as substrate transformation proceeds,thereby modulating the metal reactivity.

关键词： coordination geometry centre

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Morphology and phylogeny of two species of Bathypathes from the tropical western Pacific,with description of a new species

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Journal of Oceanology and limnology 2025年第1期43卷 248-260页

作者： Ting lÜ Zifeng ZHAN Kuidong XU laboratory of Marine Organism Taxonomy and Phylogeny Qingdao Key Laboratory of Marine Biodiversity and ConservationInstitute of OceanologyChinese Academy of SciencesQingdao 266071China laboratory for Marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

The black coral genus Bathypathes Brook,1889 represents a relatively diverse and ecologically important assemblage comprising the deep-sea hard substrate *** phylogenetic investigations have revealed the polyphyletic nature of Bathypathes,urging further morphological analysis to understand its *** combing morphological and molecular data,we describe Bathypathes multifurcata *** report *** Molodtsova,Opresko&Wagner,2022based on the specimens collected from the tropical western *** phylogenetic topology reconstructed using nuclear ITS1-5.8S-ITS2 and three mitochondrial fragments suggests the separation of Bathypathes into four *** analysis of morphological characters,particularly the colony branch and pinnule patterns also roughly classify Bathypathes into four morphological groups A–*** A is characterized by the unbranched colony and the subopposite arrangement of *** contrast to Group A,Groups B–D have the alternately arranged *** these,Group C exhibits a distinctly long unpinnulated stem compared to Groups B and *** B has unbranched colony,relatively short unpinnulated stem,and spines on pinnules have blunt *** Group D,large colonies(higher than 40 cm)have one or a few branches,small colonies(less than 40 cm)are unbranched,and spines on pinnules have acute *** data particularly those species without sequences are necessary to verify the classification of these groups.

关键词： Antipatharia black coral taxonomy phylogeny seamount western Pacific

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Magnetosymbiosis discovery:new perspectives in magnetotaxis research

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Journal of Oceanology and limnology 2025年第1期43卷 177-186页

作者： Caroline l.MONTEIl Christopher T.lEFEVRE Aix-Marseille Université CEACNRSInstitute of Biosciences and Biotechnologies of Aix-MarseilleSaint-Paul-lez-Durance 13115France

Magnetotactic bacteria have been the only known magnetoreceptive microorganisms for *** if the existence of magnetotactic protists was suggested in 1986,this is only 30 years later that magnetotaxis was extended to the domain of Eukaryota,thanks to the characterization of magnetotactic symbiotic assemblies composed of a flagellated protist and bacteria biomineralizing magnetic *** mutualistic ectosymbiosis relies on a collective magnetotaxis coupled to a hydrogen-based *** new form of cooperation challenges our view of magnetic biomineralization in prokaryotes and magnetoreception in *** this review,we present how magnetosymbiosis was discovered and how cooperation ***,we discuss the future research and the new perspectives such discovery brought to the field of magnetotaxis.

关键词： magnetotaxis biomineralization symbiosis magnetotactic

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Seismites of the late Triassic lockatong Formation,Pennsylvania,USA:implications for Newark Basin border fault movement

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Journal of Palaeogeography 2025年第1期14卷 1-14页

作者： Edward l.Simpson Michael C.Wizevich David l.Fillmore Department of Physical Sciences Kutztown University of Pennsylvania Department of Earth and Space Sciences Central Connecticut State University

Numerous soft-sediment deformation structures(SSDS) within thin-bedded, heterolithic lacustrine shoreline deposits of the Upper Triassic Tumble Falls Member, lockatong Formation of eastern Pennsylvania, demonstrate liquefaction, fluidization and shearing features processes affecting sediment. This study employs thin-section analysis of SSDS to interpret them as probable seismites from the Triassic-Jurassic Newark Basin. Sedimentary structures include right-lateral offset of desiccation cracks and ichnofossils, thrust,reverse, and normal faults with mm-scale offsets, horsts and grabens, lateral spreads, and single and complex multiple networks of dikes and sills and associated sedimentary volcanoes, thin mudflows on a paleosurface linked to sediment dikes, load and flame structures, ball and pillow structures, recumbent folds, and incipient breccias. Dike fill consists of mudstone, angular sedimentary clasts, sandstone margins with mudstone cores,and plastically deformed sediment fill. The SSDS indicate that late Triassic lacustrine shoreline sediments were subjected to forces, probably compressive with a minimal shear component reflected in the offset of the dikes and ichnofossils, that induced liquefaction followed by fluidization and vertical movement of *** forces that altered sediment vertical stability, leading to deformation of the sediment included gravitationally unstable density gradients, vertical shear stress, and gravitational body forces. SSDS can be induced by seismic and aseismic processes. However, this unique combination of forces and resulting sedimentary structures indicate an origin by earthquake activity, likely produced by the nearby, active Newark Basin border fault system. The lockatong Formation SSDS seismites improve our understanding via thin section analysis of the rheology and preservation potential of SSDS in lacustrine shoreline deposits, critical for the geologic history of Newark Basin, as well as the refinement for paleos

关键词： Seismites Triassic lockatong Formation lacustrine Soft-sediment deformation structures

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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Plant Cell Wall-like Soft Materials:Micro-and Nanoengineering,Properties,and Applications

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Nano-Micro letters 2025年第5期17卷 37-77页

作者： Roya Koshani Mica l.Pitcher Jingyi Yu Christine l.Mahajan Seong H.Kim Amir Sheikhi Department of Chemical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Chemistry The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Huck Institutes of the life Sciences The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Neurosurgery College of MedicineThe Pennsylvania State UniversityHersheyPA 17033USA

Plant cell wall(CW)-like soft materials,referred to as artificial CWs,are composites of assembled polymers containing micro-/nanoparticles or fibers/fibrils that are designed to mimic the composition,structure,and mechanics of plant ***-like materials have recently emerged to test hypotheses pertaining to the intricate structure–property relationships of native plant CWs or to fabricate functional ***,research on plant CWs and CW-like materials is reviewed by distilling key studies on biomimetic composites primarily composed of plant polysaccharides,including cellulose,pectin,and hemicellulose,as well as organic polymers like ***-and nanofabrication of plant CW-like composites,characterization techniques,and in silico studies are reviewed,with a brief overview of current and potential ***-/nanofabrication approaches include bacterial growth and impregnation,layer-by-layer assembly,film casting,3-dimensional templating microcapsules,and particle *** characterization techniques are necessary for the comprehensive mechanical,chemical,morphological,and structural analyses of plant CWs and CW-like ***-like materials demonstrate versatility in real-life applications,including biomass conversion,pulp and paper,food science,construction,catalysis,and reaction *** review seeks to facilitate the rational design and thorough characterization of plant CW-mimetic materials,with the goal of advancing the development of innovative soft materials and elucidating the complex structure–property relationships inherent in native CWs.

关键词： Synthetic plants Biomimicry Acellular wall Composites living materials Soft matter

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