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Finding the seed of recurrence:Hepatocellular carcinoma circulating tumor cells and their potential to drive the surgical treatment

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 967-978页

作者： Francesca Carissimi Matteo Nazzareno Barbaglia Livia Salmi Cristina Ciulli Linda Roccamatisi Giuseppe Cordaro venkata ramana mallela Rosalba Minisini Biagio Eugenio Leone Matteo Donadon Guido Torzilli Mario Pirisi Fabrizio Romano Simone Famularo School of Medicine and Surgery University of Milano-BicoccaMonza 20900Italy Department of Translational Medicine Universitàdel Piemonte OrientaleNovara 28100Italy Unit of Pathology San Gerardo HospitalMonza 20900Italy Department of Hepatobiliary and General Surgery IRCCS Humanitas Clinical and Research Hospital-Department of Biomedical ScienceHumanitas UniversityPieve Emanuele 20090Italy Department of Medicine and Surgery University of Milan-BicoccaMonza 20900Italy

The treatment for hepatocellular carcinoma(HCC)relies on liver resection,which is,however,burdened by a high rate of recurrence after surgery,up to 60%at 5 *** pre-operative tools are currently available to assess the recurrence risk tailored to every single *** liquid biopsy has shown interesting results in diagnosis,prognosis and treatment allocation strategies in other types of cancers,since its ability to identify circulating tumor cells(CTCs)derived from the primary *** cells were advocated to be responsible for the majority of cases of recurrence and cancer-related deaths for *** fact,after being modified by the epithelial-mesenchymal transition,CTCs circulate as“seeds”in peripheral blood,then reach the target organ as dormant cells which could be subsequently“awakened”and activated,and then initiate *** presence may justify the disagreement registered in terms of efficacy of anatomic vs non-anatomic resections,particularly in the case of microvascular invasion,which has been recently pointed as a histological sign of the spread of those ***,their presence,also in the early stages,may justify the recurrence event also in the contest of liver *** the mechanism behind the tumor progression may allow improving the treatment selection according to the biological patient-based ***,it may drive the development of novel biological tailored tests which could address a specific patient to neoadjuvant or adjuvant strategies,and in perspective,it could also become a new method to allocate organs for transplantation,according to the risk of relapse after liver *** present paper will describe the most recent evidence on the role of CTCs in determining the relapse of HCC,highlighting their potential clinical implication as novel tumor behavior biomarkers able to influence the surgical choice.

关键词： Hepatocellular carcinoma Liquid biopsy Circulating tumor cells Liver surgery Microvascular invasion Hepatocellular carcinoma recurrence

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