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In vitro Antibacterial Activity of Moringa oleifera Ethanolic Extract against Tomato Phytopathogenic Bacteria

Phyton-International Journal of Experimental Botany 2021年第3期90卷 895-906页

作者： Roberto Arredondo-Valdés Francisco D.Hernández-Castillo Mario Rocandio-Rodríguez Julia C.Anguiano-Cabello Madai Rosas-Mejía venancio vanoye-eligio Salvador Ordaz-Silva Imelda V.López-Sánchez Laura D.Carrazco-Peña Julio C.Chacón-Hernández Institute of Applied Ecology Universidad Autónoma de TamaulipasCiudad VictoriaTamaulipas87019México Parasitology Department Universidad Autónoma Agraria Antonio NarroSaltillo25315México Health Area Universidad La Salle SaltilloSaltillo25298México Faculty of Engineering and Business San Quintin Universidad Autónoma de Baja CaliforniaSan Quintín22930México

The tomato(Solanum lycopersicum L.)is one of the world’s most important vegetable ***,phytopathogenic bacteria affect the yield and quality of tomato cultivation,like Agrobacterium tumefeciens(At),Clavibacter michiganensis ***(Cmm),Pseudomonas syringae ***(Pst),Ralstonia solanacearum(Rs),and Xanthomonas axonopodis(Xa).Synthetic chemical products are used mostly on disease plant control,but overuse generates resistance to bacterial *** study aimed to evaluate the in vitro antibacterial activity of the ethanolic extract of Moringa oleifera *** against At,Cmm,Pst,Rs,and Xa,as well as information about this plant species’chemical *** activity against pathogens observed by microplate technique,phytochemical screening,and FTIR analysis revealed different bio-active compounds on ethanolic extracts with antibacterial *** growth inhibition rate ranged between 0.08%and 99.94%.The inhibitory concentration,IC50,required to inhibit 50%of At,Cmm,Pst,Rs,and Xa bacterial growth,was 276.67,350.48,277.85,351.49,and 283.22 mg/L,*** of phytopathogen bacteria’s growth increased as the concentrations of the extract also *** oleifera extract can be recommended as a potent bio-bactericide.

关键词： Biological control secondary metabolites tomato crop inhibitory concentration botanical extract

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Immunohistochemistry panel segregates molecular types of hepatocellular carcinoma in Brazilian autopsy cases

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World Journal of Gastroenterology 2016年第27期22卷 6246-6256页

作者： Aloísio Felipe-Silva Alda Wakamatsu Cinthya dos Santos Cirqueira venancio Avancini Ferreira Alves LIM 14-Patologia Hepatica Faculdade de Medicina da USP01246-903 Sao Paulo SPBrazil Department of Pathology Medical Research Laboratory LIM14University of Sao Paulo School Of Medicine01246-903 Sao Paulo SPBrazil

AIM: To assess the distribution of proteins coded by genes reported as relevant for the molecular classification of hepatocellular carcinoma (HCC).METHODS: In this retrospective cross-sectional study, the following clinicopathological data were analyzed in 80 autopsied HCC patients: sex, age, ethnicity, alcohol intake, infection with hepatitis B and/or C virus, infection with human immunodeficiency virus, prior treatment, basic and immediate causes of death, liver weight, presence of cirrhosis, number and size of nodules, gross pattern, histological grade and variants, architectural pattern, invasion of large veins, and presence and location of extrahepatic metastases. The protein products of genes known to be involved in molecular pathogenesis of HCC, including epidermal growth factor receptor (EGFR), MET, keratin 19 (K19), vimentin, beta-catenin, mechanistic target of rapamycin (mTOR), extracellular signaling-related kinase (ERK)1, ERK2, Ki67, cyclin D1, caspase 3 and p53, were detected by immunohistochemistry on tissue microarrays. The expression levels were scored and statistically assessed for correlation with HCC ***: Infection with hepatitis C virus was identified in 49% of the 80 autopsy patients, cirrhosis in 90%, advanced tumors in 95%, and extrahepatic metastases in 38%. Expression of K19, p53 and ERK1 correlated to high-grade lesions. Expression of ERK1, nuclear beta-catenin, cyclin D1 and ERK2 correlated to higher rates of cell proliferation as determined by Ki67. Expression of MET, EGFR (> 0) and caspase 3 correlated with lower histological grades. Expression of EGFR correlated to that of caspase 3, and overexpression of EGFR (≥ 200/300) was observed in low-grade tumors more frequently (grades 1 and 2: 67% vs grade 3: 27% and grade 4: 30%). Expression of ERK1 was associated with that of K19 and vimentin, whereas expression of ERK2 was associated with that of cyclin D1, MET and membrane beta-catenin. Expression of vimentin

关键词： Hepatocellular carcinoma Epidermal growth factor receptor Autopsy Immunohistochemistry Liver Classification

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Efficacy of Magnesium and Alpha Lipoic Acid Supplementation in Reducing Premature Uterine Contractions

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Open Journal of Obstetrics and Gynecology 2014年第9期4卷 578-583页

作者： eligio Parente Giulia Colannino Pasquale Ferrara Clinic Center “Trusso” Naples Italy Obstetric and Gynecological Center “Villa delle Querce” Naples Italy

Objective: Premature uterine contractions represent one of the major symptoms related to preterm labor. So far, primary prevention of preterm labor is based on the early identification of symptoms and on pharmacological treatments which are prone of several secondary effects. In this double-blinded, randomized, placebo-controlled trial, the efficacy of a supplementation of magnesium and alpha-lipoic acid has been evaluated. Methods: Three hundred pregnant women at 14 - 34 weeks of gestation were enrolled and randomly divided to receive a daily single tablet containing a supplement of magnesium and alpha-lipoic acid (DAV®LoLiPharmasrl, Rome-Italy) or placebo until delivery. The incidence of episodes of preterm uterine contraction, associated or not with pain, as well as maternal need of hospitalization was evaluated. Results: Magnesium and lipoic acid supplementation was effective to significantly reduce the incidence of preterm uterine contractions compared to placebo. In particular, 52% of women who received the supplementation reported no symptoms of preterm uterine contractions throughout pregnancy, and persistent episodes of uterine contractions were significantly reduced compared to placebo (20% vs 60%, respectively). Furthermore, only 20% of subjects who received the supplementation required hospitalization, while it has been necessary for 40% of women who received placebo. Conclusions: Our findings suggest that supplementation with magnesium and lipoic acid is effective in reducing the incidence of premature uterine contraction and related episodes of hospitalization, compared to placebo. Nevertheless, further studies based on larger cohorts of patients are necessary to confirm the efficacy of these preliminary results.

关键词： Magnesium Alpha-Lipoic Acid Preterm Labor Tocolysis Pregnancy

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Prognostic factors for progression of liver structural lesions in chronic hepatitis C patients

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World Journal of Gastroenterology 2008年第16期14卷 2522-2528页

作者： Liliana SC Mendes Marcelo E Nita Suzane K Ono-Nita Evandro S Mello Luiz Caetano da Silva venancio AF Alves Flair J Carrilho Department of Gastroenterology-Hepatology Branch University of So Paulo School of Medicine So Paulo 04537-040 So Paulo-SP Brazil Department of Pathology University of So Paulo School of Medicine So Paulo 04537-040 So Paulo-SP Brazil

AIM: To evaluate the epidemiological, clinical, laboratory and histological variables capable of predicting the progression of hepatic structural disturbances in chronic hepatitis C patients during the time interval between two liver biopsies. METHODS: Clinical charts of 112 chronic hepatitis C patients were retrospectively analyzed, whereas liver biopsies were revised. Immunohistochemical detection of interferon receptor was based on the Envision-Peroxidase System. RESULTS: In the multivariate analysis, the variables in the age at first biopsy, ALT levels, presence of lymphoid aggregates and siderosis were the determinants of the best model for predicting the severity of the disease. The direct progression rate of hepatic structural lesions was significantly higher in untreated patients, intermediate in treated non-responders and lower in treated responders to antiviral therapy (non-treated vs responders, 0.22 ± 0.50 vs -0.15 ± 0.46, P = 0.0053). Immuno-expression of interferon receptor is not a relevant factor. CONCLUSION: The best predictors of the progression of fibrosis are age at the first liver biopsy, extent of ALT elevation, inflammation at liver histology and hepatic siderosis. Antiviral treatment is effective in preventing the progression of liver structural lesions in chronic hepatitis C patients.

关键词： Hepatitis C Histology Fibrosis Interfemns Disease progression

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Intestinal parasitic infections in Aetas and domesticated swine in Pampanga,Philippines

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Asian Pacific Journal of Tropical Medicine 2022年第11期15卷 522-524页

作者： Jessica Joyce R De Guia Mary Jane C Flores Derick Erl P Sumalapao eligio Santiago V Maghirang Vicente Y Belizario Jr. Department of Biology College of ScienceDe La Salle UniversityManilaPhilippines Biological Control Research Unit(BCRU) Center for Natural Sciences and Environmental Research(CENSER)College of ScienceManila Ehime University-De La Salle University International Collaborative Research Laboratory De La Salle UniversityLaguna CampusLaguna ProvincePhilippines Department of Epidemiology and Biostatistics College of Public HealthUniversity of the PhilippinesManilaPhilippines Department of Internal Medicine-Section of General Medicine Department of Medical Education and Research the Makati Medical Center Department of Emergency Medicine Asian Hospital and Medical CenterMetro ManilaPhilippines Department of Parasitology College of Public HealthUniversity of the PhilippinesManilaPhilippines

Indigenous peoples account for about 6%of the world’s population and are highly vulnerable to parasitic infections[1,2].Aetas,one of the indigenous people groups in the Philippines,rely on backyard swine production as their primary means of livelihood[3].Literature indicated that zoonoses arise from close physical contact and the cohabitation of humans with domesticated animals[4].Ascaris spp.

关键词： swine domestica habitat

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First Update to Herpetofaunal Records from Timor-Leste

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Asian Herpetological Research 2012年第2期3卷 114-126页

作者： Mark O'SHEA Caitlin SANCHEZ Scott HEACOX Andrew KATHRINER venancio LOPES CARVALHO Agivedo VARELA RIBEIRO Zito AFRANIO SOARES Luis LEMOS DE ARAUJO Hinrich KAISER West Midland Safari Park Bewdley Worcestershire DY12 1LF United Kingdom and Australian Venom Research Unit Department of Pharmacology University of MelbourneVictoria 3010 Australia Department of Biology Victor Valley College 18422 Bear Valley Road VictorvilleCalifornia 92395 USA Department of Ecology and Evolution Stony Brook University Stony Brook New York 11794 USA Present Address: Department of Biology Villanova University 800 Lancaster Avenue VillanovaPennsylvania 19085 USA Universidade National Timor-Lorosa’e Faculdade de Ciencias da Educa ao Departamentu da Biologia Avenida Cidade de Lisboa Liceu Dr. Francisco MachadoDili Timor-Leste

Herpetological surveys of locations in six districts of Timor-Leste(Dili, Baucau, Ermera, Liqui a, Manatuto, Viqueque) during 2010 led to the discovery of a new, high-altitude species of Cryptoblepharus from Ermera District, a new country record(Hemidactylus cf. tenkatei), and the recording of two previously unvouchered species(Python r. reticulatus and Liasis m. mackloti). In this article, we summarize these new records and present numerous new district records for Timor-Leste and four records for road-killed snakes seen in West Timor(Indonesia). With the addition of the results from our 2009 survey, the update presented herein increases the confirmed number of amphibian and reptile species for Timor-Leste to 47.

关键词： herpetofauna biodiversity Timor-Leste West Timor Wallacea Cryptoblepharus Hemidactylus cf.tenkatei

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Application of formal languages in polynomial transformations of instances between NP-complete problems

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第8期14卷 623-633页

作者： Jorge A. RUIZ-vanoye Joaquín PREZ-ORTEGA Rodolfo A. PAZOS RANGEL Ocotlán DíAZ-PARRA Héctor J. FRAIRE-HUACUJA Juan FRAUSTO-SOLíS Gerardo REYES-SALGADO Laura CRUZ-REYES DACI Universidad Autónoma del Carmen Computer Science Centro Nacional de Investigación y Desarrollo Tecnológico Systems and Computer Science Instituto Tecnológico de Ciudad Madero Informatics Universidad Politécnica del Estado de Morelos Computer Science Instituto Tecnológico de Cuautla

We propose the usage of formal languages for expressing instances of NP-complete problems for their application in polynomial transformations. The proposed approach, which consists of using formal language theory for polynomial transformations, is more robust, more practical, and faster to apply to real problems than the theory of polynomial transformations. In this paper we propose a methodology for transforming instances between NP-complete problems, which differs from Garey and Johnson's. Unlike most transformations which are used for proving that a problem is NP-complete based on the NP-completeness of another problem, the proposed approach is intended for extrapolating some known characteristics, phenomena, or behaviors from a problem A to another problem B. This extrapolation could be useful for predicting the performance of an algorithm for solving B based on its known performance for problem A, or for taking an algorithm that solves A and adapting it to solve B.

关键词： Formal languages Polynomial transformations NP-completeness

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Herpetological Diversity of Timor-Leste: Updates and a Review of Species Distributions

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Asian Herpetological Research 2015年第2期6卷 73-131页

作者： Mark O'SHEA Caitlin SANCHEZ Andrew KATHRINER Sven MECKE venancio LOPES CARVALHO Agivedo VARELA RIBEIRO Zito AFRANIO SOARES Luis LEMOS DE ARAUJO Hinrich KAISER Faculty of Science and Engineering University of Wolverhampton Wulfruna Street Wolverhampton WV1 1LY United Kingdom and West Midland Safari Park Bewdley Worcestershire DY12 LF United Kingdom Department of Biology Victor Valley College Department of Biology Villanova University 800 East Lancaster Avenue Villanova Pennsylvania 19085 USA Department of Herpetology Bronx Zoo 2300 Southern Boulevard Bronx New York 10460 USA Department of Animal Evolution and Systematics Faculty of Biology Philipps Universit?t Marburg Universidade National Timor-Lorosa’e Faculdade de Ciencias da Educa?ao Departamentu da Biologia Avenida Cidade de Lisboa Liceu Dr. Francisco Machado Dili Timor-Leste Department of Vertebrate Zoology National Museum of Natural History Smithsonian Institution

We report the results of five herpetological surveys during 2011-2013 that included visits to all districts of Timor-Leste （Aileu, Ainaro, Baucau, Bobonaro, Dili, Covalima, Ermera, Laut6m, Liquiga, Manatuto, Manufahi, Viqueque） except the Oecusse exclave. Our fieldwork culminated in the discovery of one putative new frog species （genus Kaloula）, at least five putative new lizard species （genera Cyrtodactylus, Cryptoblepharus, and Sphenomorphus）, and two putative new snake species （genera Stegonotus and Indotyphlops）. In addition, we present new distribution records of amphibians and reptiles for 11 of the country＇s 12 contiguous districts, along with additional natural history data. Results from our surveys increase the number of amphibian and reptiles known to occur in Timor-Leste from 22 species before our surveys began to over 60, including over 20 as yet undescribed species.

关键词： Timor-Leste Kaloula Cyrtodactylus Eremiascincus Stegonotus

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Surgical treatment of fibrolamellar hepatocellular carcinoma:an underestimated malignant tumor?

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 618-621页

作者： Paulo Herman Aline Lopes Chagas Marcos Vinicius Perini Fabricio Ferreira Coelho Gilton Marques Fonseca venancio Avancini Ferreira Alves Flair José Carrilho Ivan Cecconello Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil Department of Pathology University of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil

BACKGROUND： Fibrolamellar hepatocellular carcinoma （FLHCC） is a rare disease with an indolent behavior. Its prognosis is better than that of patients with hepatocellular carcinoma. The authors present their experience with resection of FLHCC. METHODS： Twenty-one patients with FLHCC were treated at our institution between 1990 and 2012. Of these patients, 14 were subjected to resection of the tumor. Patient demographics, medical history, results of imaging studies and laboratory tests, surgical data, and pathologic findings were evaluated. RESULTS： The median age of the patients at the diagnosis of the tumor was 20 years and 14 patients were female. None of the patients had tumor-associated chronic liver disease or cirrhosis. The mean tumor size was 12.8 cm （range 6-19） and 18 patients had a single liver nodule. Fourteen patients were subjected to hepatectomy and six of them had lymph node metastases resected. Pathologic evaluation revealed that 5 （35.7%） patients had major vascular invasion. Tumor recurrence was seen in 8 patients （66.7%）, during a follow-up. The median survival time for patients who were subjected to resection was 36 months. The 5-year overall survival rate and disease free survival rate were 28.0% and 8.5%, respectively. Univariate analysis showed that vascular invasion was the only variable associated with the disease free survival ***： Despite an aggressive treatment, patients with FLHCC presented unexpected low survival rates. It seems that an underestimated malignant behavior is attributed to this disease, and that the forms of adjuvant treatment should be urgently evaluated.

关键词： fibrolamellar hepatocellular carcinoma hepatectomy hepatocellular carcinoma lymph node excision survival

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Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra Marina Alessandra Pereira Leonardo Cardili venancio Avancini Ferreira Alves Evandro Sobroza de Mello Ulysses Ribeiro Jr Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-L1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the PD-L1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive *** PD-L1+PT staged as pN+were also tested for PD-L1 expression in their ***-L1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had PD-L1+PT and 24 of them had pN+.For comparison,44 PD-L1(-)cases with pN+were included(sample loss of 4 cases).Of the PD-L1+PT,54.2%(13/24 cases)were also PD-L1+in the *** PD-L1(-)PT,9.1%(4/44)had PD-L1+in the *** agreement between PT and LNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with PD-L1 positivity in both *** was no statistical difference in overall survival for PT and LNM according to the PD-L1 status(P=0.166 and P=0.837,respectively).CONCLUSION Intra-patient heterogeneity in PD-L1 expression was observed between the PT and matched *** disagreement in PD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer Lymph node Programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

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