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Characterization of monocarboxylate transporter activity in hepatocellular carcinoma

World Journal of Gastroenterology 2014年第33期20卷 11780-11787页

作者： venncio af alves Céline Pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar Laboratory of Medical Investigation (LIM) 14 Department of Pathology University of S?o Paulo School of Medicine S?oPaulo SP 1246-903 Brazil Life and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho 4704-553 Braga Portugal ICVS/3B’s-PT Government Associate Laboratory 4710-057 Braga/ Guimar?es Portugal Barretos School of Health Sciences Dr. Paulo Prata-FACISB Barretos S?o Paulo SP 13083-970 Brazil Molecular Oncology Research Center Barretos Cancer Hospital Barretos Sao Paulo 14780-000 Brazil Molecular Oncology Research Center Barretos Cancer Hospital Pio XII Foundation Barretos 14780-000 Brazil

AIM: To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma(HCC).METHODS: From a total of 5836 autopsies performed at the Pathology Department- University of Sao Paulo School of Medicine Hospital- from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters(MCTs)-1, 2 and 4, CD147 and glucose transporter-1(GLUT1)was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software(version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's χ2 test and Fisher's exact test(when n < 5). The threshold for significant P values was established as P < ***: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1(overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis.

关键词： Hepatocellular carcinoma Monocarboxylate transport

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Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival

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World Journal of Gastroenterology 2014年第6期20卷 1585-1593页

作者： Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz venncio af alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho So Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de So Paulo Hospital das Clínicas Department of Gastroenterology University of So Paulo School of Medicine So Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de So Paulo Hospital das Clínicas Department of Radiology University of So Paulo School of Medicine So Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de So Paulo Hospital das Clínicas Department of Pathology University of So Paulo School of Medicine

AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-y

关键词： Hepatocellular carcinoma Radiofrequency ablation O

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Friction ridge analysis in disaster victim identification(DVI):Brazilian case studies

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Forensic Sciences Research 2022年第2期7卷 323-329页

作者： Marco Antonio de Souza Gabriel de Oliveira Urtiaga Renata Cristina Grangeiro Ferreira Luciene Marques da Silva Jade Kende Gonçalves Umbelino Flávio Roberto de Melo Simone de Jesus Instituto Nacional de Identificação Polícia FederalBrasíliaBrazil Grupo de Identificação Superintendência Regional da Polícia FederalPorto AlegreBrazil Departamento de Polícia Técnica Polícia Civil do Distrito FederalBrasíliaBrazil Núcleo de Identificação Superintendência Regional de Polícia FederalBelo HorizonteBrazil Instituto de Identificação Polícia CivilGoiâniaBrazil

Depending on the magnitude and nature of a disaster,identifying the victims can be a complex task that requires coordinated work by disaster victim identification(DVI)teams based on pre-established ***,the analysis of fingerprints has been presented as a method to establish,when possible,the identity of the victims during the DVI *** study discusses the importance of this primary method of identification and the results obtained in four different disasters in which Brazilian DVI teams were involved:the Air France Flight af447 plane crash in the Atlantic Ocean,floods and mudslides in the State of Rio de Janeiro,Brazil,the LaMia Flight 2933 plane crash in Colombia,and the tailings dam collapse in Brumadinho,***,we also report the use of the automatic fingerprint capture and identification system,called Alethia,developed by the Federal Police of Brazil and used in the victim identification process in the two latter events mentioned above.

关键词： Forensic sciences disaster victim identification DVI fingerprint ridgeology Alethia System

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Spontaneous rupture of hepatic hemangiomas:A review of the literature

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World Journal of Hepatology 2010年第12期2卷 428-433页

作者： Marcelo af Ribeiro Francine Papaiordanou Juliana M Gonalves Eleazar Chaib Department of Surgery Medical SchoolUniversity of Santo Amaro Professor of Surgery at University Cidade de So Paulo Universidade Cidade de So Paulo Medical Student at Universidade Cidade de So Paulo Liver and Portal Hypertension Surgery Clinicas HospitalUniversity of So Paulo Medical School Nuffield Department of Surgery Churchill HospitalUniversity of Oxford

Hepatic hemangiomas are congenital vascular malformations,considered the most common benign mesenchymal hepatic tumors,composed of masses of blood vessels that are atypical or irregular in arrangement and size. Hepatic hemangiomas can be divided into two major groups:capillary hemangiomas and cavernous hemangiomas These tumors most frequently affect females (80%) and adults in their fourth and fifth decades of life. Most cases are asymptomatic although a few patients may present with a wide variety of clinical symptoms,with spontaneous or traumatic rupture being the most severe complication. In cases of spontaneous rupture,clinical manifestations consist of sudden abdominal pain,and anemia secondary to ahaemoperitoneum. Disseminated intravascular coagulopathy can also occur. Haemodynamic instability and signs of hypovolemic shock appear in about one third of cases. As the size of the hemangioma increases,so does the chance of rupture. Imaging studies used in the diagnosis of hepatic hemangiomas include ultrasonography,dynamic contrast-enchanced computed tomography scanning,magnetic resonance imaging,hepatic arteriography,digital subtraction angiography,and nuclear medicine studies. In most cases hepatic hemangiomas are asymptomatic and should be followed up by means of periodic radiological examination. Sur gery should be restricted to specific situations. Absolute indications for surgery are spontaneous or trau m atic rupture with hemoperitoneum,intratumoral blee ding and consumptive coagulopathy (Kassabach-Merrit syndrome). In a patient presenting with acute abdo minal pain due to unknown abdominal disease,sponta neous rupture of a hepatic tumor such as a hemangio ma should be considered as a rare differential diagnosis.

关键词： Hepatic hemangioma Giant hepatic hemangioma Liver tumor Spontaneous rupture Surgery

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Prognostic factors for progression of liver structural lesions in chronic hepatitis C patients

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World Journal of Gastroenterology 2008年第16期14卷 2522-2528页

作者： Liliana SC Mendes Marcelo E Nita Suzane K Ono-Nita Evandro S Mello Luiz Caetano da Silva venancio af alves Flair J Carrilho Department of Gastroenterology-Hepatology Branch University of So Paulo School of Medicine So Paulo 04537-040 So Paulo-SP Brazil Department of Pathology University of So Paulo School of Medicine So Paulo 04537-040 So Paulo-SP Brazil

AIM: To evaluate the epidemiological, clinical, laboratory and histological variables capable of predicting the progression of hepatic structural disturbances in chronic hepatitis C patients during the time interval between two liver biopsies. METHODS: Clinical charts of 112 chronic hepatitis C patients were retrospectively analyzed, whereas liver biopsies were revised. Immunohistochemical detection of interferon receptor was based on the Envision-Peroxidase System. RESULTS: In the multivariate analysis, the variables in the age at first biopsy, ALT levels, presence of lymphoid aggregates and siderosis were the determinants of the best model for predicting the severity of the disease. The direct progression rate of hepatic structural lesions was significantly higher in untreated patients, intermediate in treated non-responders and lower in treated responders to antiviral therapy (non-treated vs responders, 0.22 ± 0.50 vs -0.15 ± 0.46, P = 0.0053). Immuno-expression of interferon receptor is not a relevant factor. CONCLUSION: The best predictors of the progression of fibrosis are age at the first liver biopsy, extent of ALT elevation, inflammation at liver histology and hepatic siderosis. Antiviral treatment is effective in preventing the progression of liver structural lesions in chronic hepatitis C patients.

关键词：丙肝组织学纤维化症状

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Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats

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World Journal of Gastroenterology 2006年第12期12卷 1905-1911页

作者： Claudia PMS de Oliveira Fernanda I Simplicio Vicencia MR de Lima Katia Yuahasi Fabio P Lopasso venancio af alves Dulcinéia SP Abdalla Flair J Carrilho Francisco RM Laurindo Marcelo G de Oliveira University of Sāo Paulo School of Medicine Department of Gastroenterology Saoo Paulo SP Brazil School of Medicine Department of Pathology Sāo Paulo SP Brazil University of So Paulo Medical School Heart Institute InCor Sāo Paulo SP Brazil University of Sāo Paulo School of Pharmaceutical Sciences Department of Clinical and Toxicological Analysis Sao Paulo SP Brazil State University of CamDinas. Chemistry Department. Campinas. SE Brazil

瞄准：在一个动物模型在不含酒精的脂肝疾病(NafLD ) 的预防每氧化和口头的 SNAC 管理的效果在类脂化合物的抑制评估 S-nitroso-N-acetylcysteine (SNAC ) 的潜力。方法：NafLD 被胆碱缺乏的饮食为 4 wk 在 Wistar 雄的老鼠导致。对待 S... 详细信息

瞄准：在一个动物模型在不含酒精的脂肝疾病(NafLD ) 的预防每氧化和口头的 SNAC 管理的效果在类脂化合物的抑制评估 S-nitroso-N-acetylcysteine (SNAC ) 的潜力。方法：NafLD 被胆碱缺乏的饮食为 4 wk 在 Wistar 雄的老鼠导致。对待 SNAC 的动物(n=6 )(1.4 mg/kg 每 SNAC 的天，口头上地) 与 2 个控制组相比：(n=6 ) 收到了 PBS 答案，其它(n=6 ) 收到了 NAC 答案(7 mg/kg 每天) 。组织学的变量半关于宏和 microvacuolar 脂肪被测定变化，它的带的分发，坏死的 foci，门和 perivenular 纤维变性，并且煽动性与带的分发渗入。从肝 homogenates 的样品的 LOOH 被 HPLC 确定。在门静脉的血浆的硝酸盐层次被化合光估计。水的低密度的脂蛋白(LDL ) 暂停(200 microg protein/mL ) 在 37 度摄氏为 15 h 在 SNAC (300 micromol/L ) 的缺席和存在与 CuCl (2 )(300 micromol/L ) 被孵化。LDL 氧化的程度被 fluorimetry 估计。亚油酸(LA )(18.8 micromol/L ) 氧化被大豆 lipoxygenase (SLO )(0.056 micromol/L ) 当面在 37 度摄氏导致并且 N-acetylcysteine (NAC ) 和 SNAC (56 和 560 micromol/L ) 的缺席并且在 234 点监视了 nm。结果：在控制组的动物在仙子门区域开发了中等的宏和微小囊的丰满的变化。对待 SNAC 的动物与丰满的变化的缺席显示了仅仅分离的组织学的改变并且没得肝脂肪变性。在对待 SNAC 的组的 NafLD 的缺席断然在肝匀浆在 LOOH 的集中与减少被相关，与控制组相比(0.7+/-0.2 nmol/mg 对 3.2+/-0.4 nmol/mg 蛋白质，分别地 PafLD 的发作。这效果与 SNAC 的能力被相关每氧化在试管内和在试管内堵住类脂化合物的繁殖。

关键词： S-亚硝基-N-乙酰半胱氨酸脂肪肝酒精病理机制

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Phase angle and non-alcoholic fatty liver disease before and after bariatric surgery

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World Journal of Hepatology 2020年第11期12卷 1004-1019页

作者： Joise Teixeira Claudio Augusto Marroni Paula Rosales Zubiaurre Ana Henz Lais Faina Lilian KethelynPinheiro Claudio Cora Mottin Sabrina alves Fernandes Department of Postgraduate Program in Medicine:Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050170RSBrazil Department of Gastroenterology and Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 91760470RSBrazil Department of Center of Morbid Obesity Pontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto Alegre 90610000RSBrazil Department of Nutrition Centro Universitario Metodista(IPA)Porto Alegre 90420060RSBrazil Department of Vascular Surgery Hospital Federal dos Servidores do Estado do Rio de JaneiroRio de Janeiro 20221161RJBrazil Department of Obesity and Metabolic Syndrome Center Pontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto Alegre 90619-900RSBrazil

BACKGROUND Obesity is a global health problem that is continuing to increase in the young *** Brazil,the frequency of obesity in 2018 was 19.8%.Several comorbidities are directly associated with obesity,such as non-alcoholic fatty liver disease(NafLD),which is considered the most common liver disorder in Western countries and affects up to 46%of *** surgery is effective in treating obesity and can improve NafLD;however,the effect of bariatric surgery on body composition,phase angle(PA),and improving NafLD needs to be further *** To analyze the PA in the postoperative period of bariatric surgery and to correlate it with changes in body composition and liver *** This study is a retrospective cohort study of the analysis of the medical records of patients undergoing bariatric surgery in a reference center of a teaching hospital in Porto Alegre over a 2-year *** older than 18 years whose record contained all information relevant to the study were *** data analyzed were body composition and PA through electrical bioimpedance and NafLD through liver biopsy in the pre-and postoperative *** level of significance adopted for the statistical analyses was 5%.RESULTS We evaluated 379 patients with preoperative *** PA,169 patients were analyzed,and 33 patients had liver biopsy pre-and postoperatively with NafLD *** total,79.4%were female,with a mean age of 39.1±10.6 *** average body mass index(BMI)was 45.9±7.5 kg/m².The PA showed a mean of 5.8±0.62°in the preoperative period and a significant reduction in the postoperative period.A postoperative reduction in body composition data(skeletal muscle mass,fat percentage,fat mass,body cell mass,BMI and visceral fat area)was shown as *** liver disease,all patients presented a reduction in the degrees and stages of liver disease in the postoperative period,and some had no degree of liver disease at *** PA decreased af

关键词： Obesity Body composition Bariatric surgery Phase angle Non-alcoholic fatty liver disease Liver disease

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Antagonistic　efects　of　trifluoperazine,imipramine,and　chlorpromazine　against　acetylcholine-induced　contractions　in　isolated　rat　uterus

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Acta Pharmacologica Sinica 1997年第2期 2-5页

作者： Samira Youssef Hussein BALAIS, Wiliam alves PRADO 2, Wilson alves do PRADO 3 ( Department of Pharmacology, University of Maringi, 87020 900, Parana, PR, Brazil 2 Department of Pharmacology, Faculty of Medicine of Ribeiro Preto, 14049 900

Ａｎｔａｇｏｎｉｓｔｉｃｅｆｅｃｔｓｏｆｔｒｉｆｌｕｏｐｅｒａｚｉｎｅ，ｉｍｉｐｒａｍｉｎｅ，ａｎｄｃｈｌｏｒｐｒｏｍａｚｉｎｅａｇａｉｎｓｔａｃｅｔｙｌｃｈｏｌｉｎｅｉｎｄｕｃｅｄｃｏｎｔｒａｃｔｉｏｎｓｉｎｉｓ... 详细信息

Ａｎｔａｇｏｎｉｓｔｉｃｅｆｅｃｔｓｏｆｔｒｉｆｌｕｏｐｅｒａｚｉｎｅ，ｉｍｉｐｒａｍｉｎｅ，ａｎｄｃｈｌｏｒｐｒｏｍａｚｉｎｅａｇａｉｎｓｔａｃｅｔｙｌｃｈｏｌｉｎｅｉｎｄｕｃｅｄｃｏｎｔｒａｃｔｉｏｎｓｉｎｉｓｏｌａｔｅｄｒａｔｕｔｅｒｕｓＳａ...

关键词：子宫收缩乙酰胆碱米帕明哌仑西平 af-DX116 4-DAMP 阿托品氯丙嗪三氟拉嗪

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Combinate effect of antimelanosic agents(acerola fruit extract and sodium metabisulphite)with the modified atmosphere packaging on the quality of white shrimp(Litopenaeus vannamei)stored under refrigeration

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Food Innovation and Advances 2023年第3期2卷 233-246页

作者： Alex Augusto Gonçalves Adriene Rosceli Menezes de Oliveira Laboratório de Tecnologia e Controle de Qualidade do Pescado Departamento de Ciência AnimalPrograma de Pós-Graduação em Ciências AnimaisCentro de Ciências AgráriasUniversidade Federal Rural do SemiÁridoMossoróRNBrazil59625-900

The current study set out to find out how shrimp quality in cold storage(4°C)for 21 d was impacted by antimelanosic treatments(10%acerola fruit extract(af)and 1.25%sodium metabisulphite(SMS)solutions for 10 min)in combination with modified atmosphere packaging(MAP,including vacuum):Atmospheric air(AIR),MAP1[70%N_(2):25%CO_(2):5%O_(2)],MAP2[25%N_(2):70%CO_(2):5%O_(2)],and vacuum(VAC).Untreated samples were considered as Control(C).Every three days,microbiological,physicochemical,and sensory investigations were ***,the findings show that MAP improve the shelf-life of shrimp stored under 4°*** the battle to control melanosis,SMS's effectiveness–either alone or in combination with MAP–was ***,the af was also efficient and can be an effective and a natural substitute in the control of *** considering the results of the physico-chemical and microbiological results,the SMS often did not differ from the treatment with af,demonstrating the excellent viability of the af on the quality of the shrimp stored under ***,given that acerola's high levels of vitamin C and phenolic compounds are known to have antioxidant activity,it is advised that additional studies be ***,these studies should aim to isolate specific fruit parts(peel,pulp,seeds)to determine where the highest concentration of phenolic compounds is found,or even to purify acerola extracts to comprehend the fruit's true antimelanosic potential.

关键词： shelf modified vacuum

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Fibrosis assessment using Fibro Meter combined to first generation tests in hepatitis C

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World Journal of Hepatology 2017年第6期9卷 310-317页

作者： Maria Chiara Chindamo Jerome Boursier Ronir Raggio Luiz Isabelle Fouchard-Hubert Vera Lúcia Nunes Pannain Joao Marcello de Araújo Neto Henrique Sérgio Moraes Coelho Renata de Mello Perez Paul Calès Cristiane alves Villela-Nogueira Departament of Internal Medicine Federal University of Rio de Janeiro Department of Hepatology University Hospital HIFIH Laboratory UPRES 3859SFR 4208Bretagne Loire University Institute of Public Health Studies Federal University of Rio de Janeiro Departament of Pathology Federal University of Rio de Janeiro Gastroenterology Department University of the State of Rio de Janeiro D’Or Institute for Research and Education

AIM To evaluate the performance of FibroMeter^(Virus3G) combined to the first generation tests aspartate aminotransferase-to-platelet ratio index(APRI) or Forns index to assess significant fibrosis in chronic hepatitis C(CHC).METHODS First generation tests APRI or Forns were initially applied in a derivation population from Rio de Janeiro in Brazil considering cut-offs previously reported in the literature to evaluate significant ***^(Virus3G) was sequentially applied to unclassified cases from APRI or *** of non-invasive combination of tests,APRI plus FibroMeter^(Virus3G) and Forns plus FibroMeter^(Virus3G) was evaluated in the Brazilian derivation *** plus FibroMeter^(Virus3G) combination was validated in a population of CHC patients from Angers in *** patients were submitted to liver biopsy staged according to METAVIR score by experienced *** fibrosis was considered as METAVIR F≥*** fibrosis stage classification was used as the reference for accuracy evaluation of non-invasive combination of *** samples for the calculation of serum tests were collected on the same day of biopsy procedure or within a maximum 3 mo interval and stored at-70 ℃.RESULTS Seven hundred and sixty CHC patients were included(222 in the derivation population and 538 in the validation group).In the derivation population,the FibroMeter^(Virus3G) AUROC was similar to APRI AUROC(0.855 vs 0.815,P=0.06) but higher than Forns AUROC(0.769,Pafter applying APRI and Forns corresponded to 49% and 54%,respectively,of the

关键词：长期的丙肝纤维变性肝活体检视非侵略的方法 FibroMeter Virus3G 联合算法

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