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Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study

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World Journal of Gastroenterology 2022年第21期28卷 2334-2349页

作者： Sabrina Berens Yuanjun Dong Nikola Fritz jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler Department of General Internal Medicine and Psychosomatics University Hospital HeidelbergHeidelberg 69120Germany Department of Human Molecular Genetics Institute of Human GeneticsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal Medicine and Psychosomatics Internal Medicine IIUniversity Hospital HeidelbergHeidelberg 69120Germany Department of Human Molecular Genetics University of HeidelbergHeidelberg 69120Germany Gastrointestinal Genetics Lab CIC bioGUNE-BRTADerio 48160Spain IKERBASQUE Basque Foundation for ScienceBilbao 48001Spain Unit of Clinical Epidemiology Department of Medicine SolnaKarolinska InstitutetStockholm 17177Sweden Institute of Medical Biometry and Informatics Heidelberg UniversityHeidelberg 69120Germany Lleida Institute for Biomedical Research Dr.PifarréFoundation(IRBLleida) Av.Alcalde Rovira RoureLleida 25198Spain Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersKU LeuvenLeuven 3000Belgium Department of Gastroenterology Infectious Diseases and IntoxicationsUniversity of HeidelbergHeidelberg 69120Germany Department of General Internal Medicine and Psychosomatics Heidelberg UniversityHeidelberg 69120Germany Nottingham Digestive Diseases Centre University of NottinghamNottingham NG72QLUnited Kingdom Helios Klinikum Rottweil Rottweil 78628Germany Department of Medicine Institute of Neurogastroenterology(H.M.)Martin-Luther-HospitalBelin 14193Germany Israelitisches Krankenhaus in Hamburg Hamburg 22297Germany Internal Medicine II Helios Klinikum KrefeldKrefeld 47805Germany Israelitisches Krankenhaus Hamburg Hamburg 22297Ghana Krankenhaus Vilsbiburg Vilsbiburg 84137Germany Division of Microbiome and Cancer German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Psychiatry and Neurobehavioral Science University College CorkCork T23Ireland Medicine in Digestive Disorders Department of MedicineLynda K.and David M.Underwood Center for Digestive DisordersHou

BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with *** In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and ***,anxiety,and somatization symptoms and sociodemographic characteristics were *** functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive *** also performed separate analyses for sex and IBS *** scores were calculated as the number of minor alleles of the SNPs *** impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx *** Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in *** potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant *** We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with *** SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.

关键词： Irritable bowel syndrome 5-HT3 receptor subunit gene polymorphisms Single-nucleotide polymorphism score Depression Anxiety Somatization

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Contamination of Environment with Polycyclic Aromatic Hydrocarbons in India

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Journal of Environmental Protection 2015年第11期6卷 1268-1278页

作者： Khageshwar Singh Patel Shobhana Ramteke Yogita Naik Bharat Lal Sahu Saroj Sharma jutta Lintelmann Matuschek Georg School of Studies in Chemistry/Environmental Science Pt. Ravishankar Shukla University Raipur India Department of Chemistry Devi Rathi Mahila Mahavidhaya Rajnandagaon India GSF-Forschungszentrum für Umwelt und Gesundheit Institut für &#214 kologische Chemie Neuherberg Germany

Environment in India is contaminated with polycyclic aromatic hydrocarbons (PAHs) due to occurring of large anthropogenic activities i.e. fuel combustion, mineral roasting and biomass burning. Hence, contamination of 13 toxic PAHs: phenanthrene, anthracene, fluoranthene, pyrene, benz (a) anthracene, ben-zo (b) fluoranthene, benzo (k) fluoranthene, benzo (a) pyrene, benzo (ghi) perylene, dibenz (ah) anthracene, indeno1,2,3-(cd) pyrene, coronene and coronene in the environment (i.e. ambient particulate matter, road dust, sludge and sewage) of the most industrialized area: Raipur city, India is described. The ΣPAH13 concentration in the 16 environment materials was ranged from 7980 - 1,051,300 μg/kg with mean value of 172,613 ± 154,726 μg/kg. The concentration variations, toxicities and sources of the PAHs in various environmental compartments are discussed.

关键词： Polycyclic Aromatic Hydrocarbons Dust Sewage Sludge

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Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model

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World Journal of Hepatology 2016年第8期8卷 401-410页

作者： Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann jutta M Nagel Manuel O Carranza Doris Mayr Christian Rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald U Denk Department of Medicine Ⅱ Liver Center Munich University of Munich Institute of Pathology University of Munich Department of Medicine Ⅰ Krankenhaus Barmherzige Brüder Research Unit for Experimental and Molecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine Hans Popper Laboratory of Molecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine Ⅲ Medical University of Vienna Transplant Center Munich of the University of Munich

AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse ***: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P < 0.001; MannWhitney U-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P < 0.05; Mann-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P < 0.05; Mann-Whitney U-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P < 0.001; Mann-Whitney U-te

关键词： Cholestasis Primary sclerosing cholangitis The ATP-binding cassette transporter b4 Liver fibrosis Interleukin-1

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血红素氧化酶1基因多态和冠状动脉旁路移植后的炎症反应

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中国组织工程研究与临床康复 2009年第22期13卷 4261-4265页

作者：李萍 Jules Sanders Emma Hawe David Brull jutta Palmen Jayshree Achary Hugh Montgomery Steve E.Humphries 南昌大学第二附属医院心血管内科江西省南昌市330006 英国伦敦大学学院心血管遗传病学中心

背景:血红素氧化酶1是降解血红素生成胆红素、亚铁及一氧化碳过程的限速酶,具有重要的抗炎功能,其启动子部位GT重复序列的多态性可使该基因表达的水平不同,重复序列较短者基因转录活性较高。目的:观察冠状动脉旁路移植术后炎性标记物白... 详细信息

背景:血红素氧化酶1是降解血红素生成胆红素、亚铁及一氧化碳过程的限速酶,具有重要的抗炎功能,其启动子部位GT重复序列的多态性可使该基因表达的水平不同,重复序列较短者基因转录活性较高。目的:观察冠状动脉旁路移植术后炎性标记物白细胞介素6,C-反应蛋白及纤维蛋白原的水平及其相关性,探讨血红素氧化酶1基因变量对它们的影响。设计、时间及地点:观察性试验,于2003年在英国伦敦大学学院心血管遗传病学中心完成。对象:220例符合入选条件的行冠状动脉旁路移植术的患者,男179例,女41例,年龄(63.34±9.64)岁。方法:PCR方法和DNA测序仪分析其血红素氧化酶1基因启动子部位GT重复序列的长短;于手术前及术后6,24,48,72,96,120h分别测白细胞介素6、C-反应蛋白和纤维蛋白原水平。主要观察指标:血红素氧化酶1基因启动子部位GT重复序列的长短;手术前及术后不同时间白细胞介素6、C-反应蛋白和纤维蛋白原水平。结果:术前白细胞介素6水平与C-反应蛋白及纤维蛋白原值显著相关(r=0.48,P<0.0001;r=0.41,P<0.0001),术后3者均显著升高,白细胞介素6峰质量浓度与C-反应蛋白峰质量浓度显著相关(r=0.34,P=0.0009),但与纤维蛋白原峰值无明显相关性(r=0.15,P=0.13)。术前C-反应蛋白值在血红素氧化酶1各基因组间存在明显差异,长GT重复序列者比短GT重复序列携带者高[(3.76±0.79),(2.07±0.17)mg/L,P=0.013];术后则各基因型组间水平相似。结论:炎症标志物的水平间存在相关性,血红素氧化酶1基因多态只与术前的基础C-反应蛋白和纤维蛋白原值有关,提示其可能只影响疾病的慢性炎症状态,从而影响炎性疾病的发生,而非急性炎症反应。

关键词：血红素氧化酶1 基因多态炎症反应冠状动脉旁路移植术

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提高平板显示屏镀膜应用中的靶材利用率

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液晶与显示 1998年第2期13卷 128-131页

作者： jutta Trube HeikoStrunk ChristophDaube HelmutFrankenberger

平板显示屏的经济生产，不仅要求可靠的工艺技术，而且绝对要求较高的靶利用率。本文介绍了在保持ＩＴＯ工艺的标准阴极法所获得的膜特性基础上，用移动磁场的方法可以获得＞５０％的靶利用率。

关键词：靶材利用率大尺寸基片平板显示屏薄膜溅射镀膜移动磁场 ITO靶

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公众对纳米技术在食品领域应用的理解:科学、技术、自然之观念的潜在影响

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世界农业 2011年第12期 76-78页

作者： Frederic Vandermoere Sandrine Blanchemanche Andrea Bieberstein Stephan Marette jutta Roosen 吴洪钟孙铮

尽管纳米技术的潜在应用值得广泛期待,但本研究表明,公众对于纳米技术应用于食品领域既没有表现得含糊、盲目,也没有表现得悲观、失落。本研究结论来自一项公众对于纳米食品和纳米技术应用于食品包装的观念的调查。多元回归分析表明,公... 详细信息

尽管纳米技术的潜在应用值得广泛期待,但本研究表明,公众对于纳米技术应用于食品领域既没有表现得含糊、盲目,也没有表现得悲观、失落。本研究结论来自一项公众对于纳米食品和纳米技术应用于食品包装的观念的调查。多元回归分析表明,公众关于食品风险和纳米技术的知识显著影响着公众对于纳米技术应用于食品包装的观念。但是,公众具备知识的区别并不与公众对纳米食品的支持相关,这表明公众知识的增加并不必然会调和一些食品工业的行业巨头对于纳米技术的极端乐观与公众对纳米技术应用的克制。另外,对纳米食品的反对与公众的直观经验无关,但是与公众对政府机构的信任与否有关。另外,公众对于科学、技术、自然的观念显著影响着公众对于食品领域纳米科学的观念。

关键词：食品科学纳米技术风险态度

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Exposure of Common Bean Seeds to Liquid Nitrogen Modifies Mineral Composition of Young Plantlet Leaves

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American Journal of Plant Sciences 2016年第12期7卷 1612-1617页

作者： Inaudis Cejas Annekathrin Rumlow Ariel Turcios Florent Engelmann Marcos Edel Martínez Lourdes Yabor jutta Papenbrock José Carlos Lorenzo Laboratory for Plant Breeding Centro de Bioplantas Universidad de Ciego de ávila Ciego de ávila Cuba Leibniz University Hannover Institute of Botany Hannover Germany IRD UMR DIADE Montpellier France

Many publications describe cryopreservation techniques but only a few studies have focused on the biochemical and physiological changes occurring in plants regenerated from seeds exposed to liquid nitrogen. This paper aims at describing the effect of common bean seed cryostorage on mineral nutrition of young plantlets. The following elements were measured on leaves of 10-day-old plantlets from non-cryopreserved and cryopreserved seeds: Al, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, P, S, Se, Sr and Zn. At 10 days after sowing, both treatments (control and cryopreserved seeds) showed 100% seed germination without any visual phenotypic difference. However, contents of several elements in the leaves were different. Exposure of seeds to liquid nitrogen decreased Cu, Cd and Na uptake and increased absorption of B and Al. Further studies are required to understand the mechanisms underlying the relationship between seed exposure to liquid nitrogen and mineral nutrition during the early stages of plantlet growth.

关键词： Common Bean Cryopreservation Cryostorage

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Incidental congenital coronary artery vascular fistulas in adults:Evaluation with adenosine-13N-ammonia PET-CT

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World Journal of Cardiology 2018年第10期10卷 153-164页

作者： Salah AM Said Aly Agool Arno HM Moons Mounir WZ Basalus Nils RL Wagenaar Rogier LG Nijhuis jutta M Schroeder-Tanka Riemer HJA Slart Department of Cardiology Hospital Group TwenteAlmelo-Hengelo 7555 DLOverijsselThe Netherlands Department of Nuclear Medicine Hospital Group TwenteAlmelo-Hengelo 7555 DLOverijsselThe Netherlands Department of Cardiology Slotervaart HospitalAmsterdam 1066 ECNorth HollandThe Netherlands Department of Cardiology Hospital Onze Lieve Vrouwe GasthuisLocation WestAmsterdam 1061 AENorth HollandThe Netherlands Department of Nuclear Medicine and Molecular Imaging University Medical Center GroningenGroningen 9713 GZThe Netherlands Faculty of Science and Technology Biomedical Photonic ImagingUniversity of TwenteEnschede 7522 NBThe Netherlands

AIM To assess the functionality of congenital coronary artery fistulas(CAFs) using adenosine stress ^(13)N-ammonia positron emission tomography computed tomography(PET-CT).METHODS Congenital CAFs were incidentally detected during coronary angiography(CAG) procedures in 11 adult patients(six males and five females) with a mean age of 64.3 years(range 41-81). Patients were collected from three institutes in the Netherlands. The characteristics of the fistulas(origin, pathway and termination), multiplicity of the origins and pathways of the fistulous vessels were assessed by CAG. Five patients underwent adenosine pharmacologic stress ^(13)N-ammonia PET-CT to assess myocardial perfusion and the functional behavior of the fistula. RESULTS Eleven patients with 12 CAFs, 10 unilateral and one bilateral, originating from the left anterior descending coronary artery(n = 8), right coronary artery(n = 2) and circumflex(n = 2). All fistulas were of the vascular type, terminating into either the pulmonary artery(n = 11) or coronary sinus(n = 1). The CAG delineated the characteristics of the fistula(origin, pathway and termination). Multiplicity of the origins and pathways of the fistulous vessels were common in most fistulas(8/12, 67% and 9/12, 75%, respectively). Multiplicity was common among the different fistula components(23/36, 64%). Adenosine pharmacologic stress ^(13)N-ammonia PET-CT revealed normal myocardial perfusion and ejection fraction in all but one patient, who showed a reduced ejection *** PET-CT may be helpful for assessing the functional status of congenital CAFs in selected patients regarding clinical decision-making. Studies with a larger patient series are warranted.

关键词： Coronary angiography Coronary-pulmonary artery fistulas Adenosine ammonia positron emission tomography computed tomography Coronary vascular fistulas Congenital coronary artery fistulas

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接头连接PCR步行法鉴定转基因烟草

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烟草科技 2007年第4期40卷 49-53页

作者：万秀清 jutta TUERCK MARTIN WARD 郭兆奎李丽杰颜培强徐香玲哈尔滨师范大学哈尔滨市南岗区和兴路50号150080 剑桥高新技术有限责任公司黑龙江省烟草科学研究所

应用接头连接PCR步行法,建立了分子水平鉴定不同转基因事件的方法和体系;并利用不同转基因事件外源基因与植物基因组DNA整合位点处核酸序列的差异,设计了不同转基因烟草事件的标签引物,成功地对几个转TMV-CP材料进行了鉴定。

关键词：转基因烟草 PCR步行个案鉴定

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全球化时代的历史教育——访[德]苏珊·波普教授与尤塔·舒曼博士

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历史教学问题 2011年第2期 26-31页

作者：苏珊·波普尤塔·舒曼孟钟捷国际历史教育协会德国奥格斯堡大学华东师范大学历史学系

尊敬的苏珊·波普教授，尊敬的尤塔·舒曼博士，热烈欢迎二位访问华东师范大学历史系。十分感谢二位接受本刊访谈。苏珊·波普教授，您既是国际历史教育协会（Internationale Gesellschaft fur Geschichtsdidaktik，IGG）主席团成员，... 详细信息

尊敬的苏珊·波普教授，尊敬的尤塔·舒曼博士，热烈欢迎二位访问华东师范大学历史系。十分感谢二位接受本刊访谈。苏珊·波普教授，您既是国际历史教育协会（Internationale Gesellschaft fur Geschichtsdidaktik，IGG）主席团成员，又是德国历史教育学会（Konferenz fur Geschichtsdidaktik Deutschlands，KGD）主席。您可以为中国历史学家们简单介绍一下上述两个学术团体吗？

关键词：历史教育全球化时代教授波普苏珊博士舒曼华东师范大学

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