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Evidence of endometrial amino acid metabolism and transport modulation by peri-ovulatory endocrine profiles driving uterine receptivity

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Journal of Animal Science and Biotechnology 2017年第4期8卷 852-865页

作者： Moana Rodrigues Franca Maressa Izabel Santos da Silva Guilherme Pugliesi veerle van hoeck Mario Binelli Department of Animal Reproduction School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo225Duque de Caxias Norte Ave.Jd.Elite13635-900 PirassunungaSPBrazil Gamete Research Centre University of AntwerpAntwerpBelgium

Background: In beef cattle, changes in the periovulatory endocrine milieu are associated with fertility and conceptus growth. A large preovulatory follicle(POF) and the resulting elevated concentrations of progesterone(P4) during diestrus positively affect pregnancy rates. Amino acids(AA) are important components of maternally derived secretions that are crucial for embryonic survival before implantation. The hypothesis is that the size of the POF and the concentration of P4 in early diestrus modulate the endometrial abundance of SLC transcripts related to AA transport and metabolism and subsequently impact luminal concentrations of AA. The follicle growth of Nelore cows was manipulated to produce two experimental groups: large POF and CL(LF-LCL group) and small POF and CL(SF-SCL group). On Day 4(D4; Experiment 1) and Day 7(D7; Experiment 2) after Gn RH-induced ovulation(Gn RH treatment = D0), the animals were slaughtered and uterine tissues and uterine washings were collected. q RT-PCR was used to evaluate the expression levels of AA transporters in D4 and D7 endometrial *** concentrations of AA were quantified in D4 and D7 uterine washings by ***: Transcript results show that, on D4, SLC6 A6, SLC7 A4, SLC17 A5, SLC38 A1, SLC38 A7 and SCLY and on D7 SLC1 A4, SLC6 A1, SLC6 A14, SLC7 A4, SLC7 A7, SLC7 A8, SLC17 A5, SLC38 A1, SLC38 A7, SLC43 A2 and DDO were more abundant in the endometria of cows from the LF-LCL group(P < 0.05). In addition, concentrations of AA in the uterine lumen were influenced by the endocrine profiles of the mother. In this context, D4 uterine washings revealed that greater concentrations of taurine, alanine and α-aminobutyric acid were present in SF-SCL(P < 0.05).In contrast, lower concentrations of valine and cystathionine were quantified on D7 uterine washings from SF-SCL cows(P < 0.05).Conclusion: The present study revealed an association between the abundance of transcripts related to AA transport and metabolism in the endo

关键词： Amino acids Beef cattle Sex steroids Uterus

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Chromium propionate improves performance and carcass traits in broilers

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Animal Nutrition 2020年第4期6卷 480-487页

作者： veerle van hoeck Mahendra Sonawane Antonio L.Gonzalez Sanchez Iris van Dosselaer Chris Buyens Dany Morisset Kemin Europa N.V. Animal Nutrition and Health EMENAToekomstlaan 422200HerentalsBelgium

There is evidence to suggest that poultry may have a dietary requirement for metabolically available chromium(Cr)that exceeds the amount provided through wheat soybean meal *** objective of the present study was to investigate the effects of dietary supplemental organic Cr from Cr propionate at different dose levels(control=0μg/kg,T1=200μg/kg,T2=400μg/kg)on the growth performance,carcass traits,and meat quality of *** gain and feed intake of each treatment were recorded at the start and after 14,28 and 35 d,and feed conversion ratios(FCR)were calculated ***35 d of age,birds were randomly selected and euthanized for carcass *** of the first trial indicate that both Cr propionate treatments increased final body weight(P<0.05),feed efficiency(P<0.05)and body weight gain(P<0.0001).Furthermore,Cr propionate supplementation improved(P<0.0001)all carcass ***,with increased Cr dosage,carcass yield,dressing percentage and breast meat yield increased linearly(P<0.0001).The second study reveals that the feed intake in the control group was significantly higher compared to both Cr propionate supplemented groups(T1&T2).Furthermore,the Cr propionate supplemented T2 group displayed a significantly lower FCR than the control and T1 group(P=0.027).Finally,Cr propionate supplementation increased the dressing percentage compared to control birds(P<0.0001).In the third experiment,Cr propionate supplementation(T1&T2)increased final body weight and decreased FCR compared with the control *** effects were highly significant(P<0.0001)throughout all feeding phases of the *** propionate supplementation also increased(P<0.0001)carcass yield,dressing percentage,breast meat yield,leg and thigh weights compared with the control *** conclusion,growth performance,feed conversion,carcass yield,breast and leg meats of broiler birds can be significantly improved by dietary inclusion of Cr *** pro

关键词： Chromium propionate Broiler Performance Carcass trait

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Infliximab induces remission in cryptogenic multifocal ulcerous stenosing enteritis:First case

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World Journal of Gastroenterology 2013年第10期19卷 1661-1664页

作者： De Schepper Heiko Macken Elisabeth van Marck veerle Spinhoven Maarten Pelckmans Paul Moreels Tom Department of Gastroenterology and Hepatology Antwerp University HospitalB-2650 Edegem-AntwerpBelgium Department of Pathology Antwerp University HospitalB-2650 Edegem-AntwerpBelgium Department of Radiology Antwerp University HospitalB-2650 Edegem-AntwerpBelgium

We present the case of a 29-year-old patient with a history of abdominal pain and *** on wireless video capsule findings he was previously diagnosed with ileal Crohn's disease at a different institution,although the clinical and radiological picture was not typical and the response to corticosteroids was *** performed a single-balloon enteroscopy showing a short,ulcerous stenosis 50 cm proximal from Bauhin's *** endoscopic and clinical histopathological findings were compatible with cryptogenic multifocal ulcerous stenosing enteritis(CMUSE).High dose corticosteroids were again started,without *** monoclonal tumor necrosis factor-α(TNF-α) antibody infliximab was added to the medical *** induction therapy,both clinical and endoscopic amelioration was *** case studies are needed to confirm the efficacy of TNF-α inhibition in steroid refractory CMUSE.

关键词： Cryptogenic multifocal ulcerous stenosing enteritis Infliximab Stenosis Intestinal ulceration Inflammatory bowel disease

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Intracellular Delivery of mRNA in Adherent and Suspension Cells by Vapor Nanobubble Photoporation

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Nano-Micro Letters 2020年第12期12卷 404-420页

作者： Laurens Raes Stephan Stremersch Juan CFraire Toon Brans Glenn Goetgeluk Stijn De Munter Lien van hoecke Rein Verbeke Jelter van hoeck Ranhua Xiong Xavier Saelens Bart vandekerckhove Stefaan De Smedt Koen Raemdonck Kevin Braeckmans Laboratory of General Biochemistry&Physical Pharmacy Ghent University9000 GhentBelgium Cancer Research Institute Ghent(CRIG) 9000 GhentBelgium Department of Diagnostic Sciences Ghent University9000 GhentBelgium VIB-UGent Center for Medical Biotechnology 9052 GhentBelgium Department of Biomedical Molecular Biology Ghent University9000 GhentBelgium Department of Biochemistry and Microbiology Ghent University9000 GhentBelgium

Efficient and safe cell engineering by transfection of nucleic acids remains one of the long-standing hurdles for fundamental biomedical research and many new therapeutic applications,such as CAR T cell-based *** has recently gained increasing attention as a more safe and versatile alternative tool over viral-or DNA transposon-based approaches for the generation of adoptive T ***,limitations associated with existing nonviral mRNA delivery approaches hamper progress on genetic engineering of these hard-to-transfect immune *** this study,we demonstrate that gold nanoparticle-mediated vapor nanobubble(VNB)photoporation is a promising upcoming physical transfection method capable of delivering mRNA in both adherent and suspension *** transfection experiments on HeLa cells showed the importance of transfection buffer and cargo concentration,while the technology was furthermore shown to be effective for mRNA delivery in Jurkat T cells with transfection efficiencies up to 45%.Importantly,compared to electroporation,which is the reference technology for nonviral transfection of T cells,a fivefold increase in the number of transfected viable Jurkat T cells was ***,our results point toward the use of VNB photoporation as a more gentle and efficient technology for intracellular mRNA delivery in adherent and suspension cells,with promising potential for the future engineering of cells in therapeutic and fundamental research applications.

关键词： Transfection mRNA Photoporation Optoporation Gold nanoparticles Vapor nanobubbles

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Generic and disease-specific health-related quality of life in patients with Hirschsprung disease:A systematic review and meta-analysis

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World Journal of Gastroenterology 2022年第13期28卷 1362-1376页

作者： veerle Huizer Naveen Wijekoon Daniëlle Roorda Jaap Oosterlaan Marc A Benninga LW Ernest van Heurn Shaman Rajindrajith Joep PM Derikx Department of Pediatric Surgery Emma Children's HospitalAmsterdam UMCUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdam Reproduction and DevelopmentAmsterdam 1105 AZNetherlands Department of Surgery University of Colombo and Department of Paediatric SurgeryLady Ridgeway Hospital for ChildrenColombo 00800Sri Lanka Department of Pediatrics Emma Children's HospitalAmsterdam UMCUniversity of AmsterdamEmma Neuroscience GroupAmsterdam Reproduction and DevelopmentAmsterdam 1105 AZNetherlands Department of Pediatrics Lady Ridgeway Hospital for ChildrenColombo 00800Sri Lanka

BACKGROUND Patients with Hirschsprung disease(HD)are at risk of persistent constipation,fecal incontinence or recurrent enterocolitis after surgical treatment,which in turn may impact physical and psychosocial *** health-related quality of life(HRQoL)and disease-specific health-related quality of life are relevant outcome measures to assess the impact of HD on the QoL of these *** To summarize all available evidence on HRQoL of patients with HD after surgery and the impact of possible moderating *** Pubmed,Web of Sciences,Psyc Info and Embase were searched with search terms related to’Hirschsprung disease’,’Pediatrics’and’Quality of life’.Mean and standard deviation of generic HRQoL overall and domain scores were extracted from each study,as well as data describing potential factors associated with *** effect models were used for meta-analytic aggregation of generic HRQoL ***-regression was used to assess the relationship between patient and clinical characteristics and generic ***-specific HRQoL outcomes of patients with HD were systematically *** Seventeen articles were included in the systematic review(n=1137 patients)and 15 in the quantitative meta-analysis(n=1024 patients).Four studies reported disease-specific ***’s age ranged between 0 and 21 ***-analytic aggregation showed a nonsignificantly impaired generic HRQoL(d=-0.168[95%CI:-0.481;0.145],P=0.293,I^(2)=94.9)in patients with HD compared to healthy ***(d=-0.042[95%CI:-0.419;0.335],P=0.829,I^(2)=95.1),psychosocial(d=-0.159[95%CI:-0.458;0.141],P=0.299,I^(2)=93.6)and social HRQoL(d=-0.092[95%CI:-0.642;0.457],P=0.742,I^(2)=92.3)were also not significantly lower compared to healthy *** was no relation between health-related outcomes and the sex of the patients and whether generic HRQoL was measured by parental proxy or ***-specific complaints of patients with HD impaired physical

关键词： Hirschsprung disease Health-related quality of life Meta-analysis Systematic review Pediatrics

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北京大气PM_(2.5)中铅的同位素测定和来源研究

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环境科学 2006年第3期27卷 401-407页

作者：李显芳刘咸德李冰董树屏刘锋 veerle vanLierde Frank vanhaecke 中国环境科学研究院国家地质实验测试中心北京100037 国家环境分析测试中心北京100029 根特大学核科学研究所

用石英滤膜连续采集北京2003—02～2003—03的12个PM2．5样品，进行无机多元素、OC、EC和铅同位素丰度比的分析测定．对样品进行聚类分析，结合气象信息讨论了分组结果，描述了2003年春北京市的2个大气铅污染过程．2个污染过程均表现出... 详细信息

用石英滤膜连续采集北京2003—02～2003—03的12个PM2．5样品，进行无机多元素、OC、EC和铅同位素丰度比的分析测定．对样品进行聚类分析，结合气象信息讨论了分组结果，描述了2003年春北京市的2个大气铅污染过程．2个污染过程均表现出铅含量高，^206Pb／^207Pb丰度比低的特点．Al、Ca、K等地壳元素的含量与Pb的含量负相关，表明土壤尘对铅的贡献不大．比较Pb、A5、Zn、Se和Al、Ca等地壳元素含量的相关性，2个铅污染过程是由有色冶金排放和燃煤排放共同主导的．而02—28～03-02的铅污染过程中，燃煤排放贡献增大，有色冶金排放贡献下降．结果表明，汽油无铅化以后，北京市春季大气颗粒物中的铅主要来源于有色冶金排放与燃煤排放。

关键词：铅大气颗粒物同位素丰度比

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渤海湾西岸第二道贝壳堤的细分及其年龄序列

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地球学报（中国地质科学院院报） 2000年第3期21卷 320-327页

作者：王宏张玉发张金起李建芬李凤林 Mark van Strydonck veerle Hendrix 中国地质调查局天津地调中心 Royal Institute for Culture Heritage

渤海湾西岸贝壳堤平原的第二道贝壳堤 (II堤 )在上古林可进一步划分为被泻湖盐沼沉积物所分隔的两道大致平行、互不相连的堤 (II 1、II 2堤 )。以系统的1 4 C年代学研究为基础 ,在II贝壳堤的下部或底部、下伏地层顶部及相邻的泥质沉... 详细信息

渤海湾西岸贝壳堤平原的第二道贝壳堤 (II堤 )在上古林可进一步划分为被泻湖盐沼沉积物所分隔的两道大致平行、互不相连的堤 (II 1、II 2堤 )。以系统的1 4 C年代学研究为基础 ,在II贝壳堤的下部或底部、下伏地层顶部及相邻的泥质沉积物的合适层位获得一批经过校正的1 4 C年龄。II 1堤和II 2堤的起止时间分别约为公元前 10～ 5世纪、公元前 3世纪— 3世纪。

关键词： Ⅱ贝壳堤放射性碳年代学渤海湾西岸古海岸线

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渤海湾西岸的第一道贝壳堤的年代学研究及1千年来的岸线变化

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海洋地质与第四纪地质 2000年第2期20卷 7-14页

作者：王宏张金起张玉发李建芬李凤林 Mark van Strydonck veerle Hendrix 中国地质调查局天津地调中心天津300170 Royal Institute for Culture Heritage

取自堤下部的 1 4 C平均校正年龄表明 ,渤海湾西岸沿现代海岸线展布的第一道贝壳堤 ( 堤 )的初始年龄约在 90 0～ 70 0 cal BP/AD10 5 0～ 12 5 0 ,堤的发育延续至 18、19世纪。以往 1 4 C数据因取样位置不当 (一般取自堤的中部 ) ,不... 详细信息

取自堤下部的 1 4 C平均校正年龄表明 ,渤海湾西岸沿现代海岸线展布的第一道贝壳堤 ( 堤 )的初始年龄约在 90 0～ 70 0 cal BP/AD10 5 0～ 12 5 0 ,堤的发育延续至 18、19世纪。以往 1 4 C数据因取样位置不当 (一般取自堤的中部 ) ,不能用于支持文献中关于该堤起始时间的判断 ;但是这批数据连同文献中获自岸外残存贝壳碎屑堆积层的数据 ,暗示隋、唐贝壳堤存在的可能性。近 1千年来该地区贝壳堤的发育反映了海岸线的重大变化。

关键词：渤海湾贝壳堤年代学海岸线变化碳同位素

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中国北京和长岛大气颗粒物中铅的同位素丰度比测定(英文)

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岩矿测试 2005年第1期24卷 7-12页

作者：李冰刘咸德董树屏 veerle van Lierde Frank vanhaecke Freddy C Adams 国家地质实验测试中心北京100037 中国环境科学研究院北京100012 国家环境分析测试中心北京100029 Laboratory of Analytical Chemistry Ghent University University of Antwerp UIAB 2610Wilrijk AntwerpenBelgium

采用高分辨电感耦合等离子体质谱技术(HRICPMS)分析了48个不同季节大气气溶胶颗粒样品中铅同位素丰度(A)比值,为中国城市铅污染源研究提供数据。样品采自中国北京和山东长岛地区(2002～2003年期间不同季节)。A(206Pb/207Pb)和A(208Pb/20... 详细信息

采用高分辨电感耦合等离子体质谱技术(HRICPMS)分析了48个不同季节大气气溶胶颗粒样品中铅同位素丰度(A)比值,为中国城市铅污染源研究提供数据。样品采自中国北京和山东长岛地区(2002～2003年期间不同季节)。A(206Pb/207Pb)和A(208Pb/207Pb)的10次测定精密度为0.05%～0.19%RSD。

关键词：电感耦合等离子体质谱大气颗粒物铅同位素丰度比

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Specificity of serological screening tests and reference laboratory tests to diagnose gambiense human African trypanosomiasis: a prospective clinical performance study

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Infectious Diseases of Poverty 2024年第4期13卷 48-63页

作者： Martial Kassi N'Djetchil Oumou Camara Mathurin Koffi Mamadou Camara Dramane Kaba Jacques Kabore Alkali Tall Brice Rotureau Lucy Glover Melika Barkissa Traorel Minayegninrin Kone Bamoro Coulibaly Guy Pacome Adingra Aissata Soumah Mohamed Gassama Abdoulaye Dansy Camara Charlie Franck Alfred Compaore Aissata Camara Salimatou Boiro Elena Perez Anton Paul Bessell Nick van Reet Bruno Bucheton Vincent Jamonneau Jean-Mathieu Bart Philippe Solano Sylvain Bieler veerle Lejon Laboratory of Biodiversity and Ecosystem Management Jean Lorougnon Guede UniversityDaloaCote d'ivoire National Program for Neglected Tropical Disease Control Patient ManagementMinistry of HealthConakryGuinea Trypanosomosis Research Unit Pierre Richet InstituteBouakeCote d'ivoire International Research and Development Centre on Livestock in Subhumid Zones Bobo-DioulassoBurkina Faso National Program for Malaria Control ConakryGuinea Parasitology Unit Institut Pasteur de GuineeConakryGuinea Trypanosome Molecular Biology Unit Department of Parasites and Insect VectorsPasteur InstituteParis Cite UniversityParisFrance Intertryp IRD-CIRAD-University of MontpellierMontpellierFrance Independent Consultant EdinburghUk Department of Biomedical Sciences Institute of Tropical MedicineAntwerpBelgium Foundation for Innovative New Diagnostics GenevaSwitzerland

Background Serological screening tests play a crucial role to diagnose gambiense human African trypanosomiasis(gHAT).Presently,they preselect individuals for microscopic confrmation,but in future"screen and treat"strategies they willidentify individuals for *** in reported specificities,the development of new rapid diagnos-tic tests(RDT)and the hypothesis that malaria infection may decrease RDT specificity led us to evaluate the specificity of 5 gHAT screening *** During active screening,venous blood samples from 1095 individuals from Cote d'ivoire and Guinea were tested consecutively with commercial(CATT,HAT Sero-K-SeT,Abbott Bioline HAT 2.0)and prototype(DCN HAT RDT,HAT Sero-K-SeT 2.0)gHAT screening tests and with a malaria *** with≥1 positive gHAT screening test underwent microscopy and further immunological(trypanolysis with *** LiTat 1.3,1.5 and 1.6;indirect ELISA/***;*** inhibition ELISA with *** LiTat 1.3 and 1.5 VSG)and molecular reference laboratory tests(PCR TBRN3,18S and TgsGP;SHERLOCK 18S Tids,7SL Zoon,and TgsGP;Trypanozoon S2-RT-qPCR 18S2,177T,GPl-PLC and TgsGP in multiplex;RT-qPCR DT8,DT9 and TgsGP in multiplex).Microscopic trypanosome detection confrmed gHAT,while other individuals were considered gHAT *** in fractions between groups were assessed by Chi square and differences in specificity between 2 tests on the same individuals by *** One gHAT case was *** test specificities(n=1094)were:CATT 98.9%(95%CI:98.1-99.4%);HAT Sero-K-SeT 86.7%(95%CI:84.5-88.5%);Bioline HAT 2.082.1%(95%CI:79.7-84.2%);DCN HAT RDT 78.2%(95%CI:75.7-80.6%);and HAT Sero-K-SeT 2.078.4%(95%CI:75.9-80.8%).In malaria positives,gHAT screening tests appeared less specific,but the difference Was significant only in Guinea for Abbott Bioline HAT 2.0(P=0.03)and HAT Sero-K-Set 2.0(P=0.0006).The specificities of immunological and molecular laboratory tests in gHAT seroposit

关键词： Human African trypanosomiasis Trypanosoma brucei gambiense Diagnosis Specificity Rapid diagnostic test Immunoloaical test Molecular test

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