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Role of phase separation in nanocomposite indium-tin-oxide films for transparent thermoelectric applications

Journal of Materiomics 2021年第3期7卷 612-620页

作者： Peter P.Murmu Akhil Shettigar Shen V.Chong Zihang Liu Dana Goodacre vedran jovic Takao Mori Kevin E.Smith John Kennedy National Isotope Centre GNS SciencePO Box 30368Lower Hutt5010New Zealand The MacDiarmid Institute for Advanced Materials and Nanotechnology New Zealand Robinson Research Institute Victoria University of WellingtonPO Box 33436Lower Hutt5046New Zealand International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukubaIbaraki305-0044Japan School of Chemical Sciences University of AucklandAuckland1142New Zealand Department of Physics Boston University BostonMA02215USA

We report that oxygen vacancies have a profound impact on phase separation and thermoelectric properties of ITO films grown at room *** vacancies in non-stoichiometric In1.8Sn0.2O2.5 films aided the formation of In-rich metallic *** yields a high electrical conductivity s=1540 Scm1 and Seebeck coefficient|a|=27.2 mVK1,which resulted in the highest power factor(a2 s=113.8 mW m1 K2)but low optical transmission(Top-25%).An increase in oxygen partial pressure resulted in stochiometric In1.8Sn0.2O3 films which improved the optical transparency by 300%(Top-75.4%),but power factor was reduced by-85%due to a decrease in a and s.A decrease in a was due to the lack of energy filtering of charge carriers in the stoichiometric ITO film which did not have In-rich metallic *** results showed that the valence band energy shifts with a change in oxygen partial pressure due to a decrease in carrier density,which implied a change in Fermi energy due to the reverse Moss-Burstein *** results showed that phase separation can be obtained in nanocomposite ITO films by tuning their stoichiometry simply by varying the oxygen partial pressure during deposition of thermoelectric materials at low temperatures.

关键词： Thermoelectric Indium-tin-oxide(ITO) Seebeck coefficient Power factor X-ray photoelectron spectroscopy(XPS)

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Pathogenesis and management issues for non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2007年第34期13卷 4539-4550页

作者： Marko Duvnjak Ivan Leroti Neven Bari vedran Tomai Lucija Virovi Juki vedran Velagi Division of Gastroenterology and Hepatology Department of Medicine 'Sestre milosrdnice' University Hospital Vinogradska 29 Zagreb 10000 Croatia

Nonalcoholic fatty liver disease (NAFLD) has, although it is a very common disorder, only relatively recently gained broader interest among physicians and scientists. Fatty liver has been documented in up to 10 to 15 percent of normal individuals and 70 to 80 percent of obese individuals. Although the pathophysiology of NAFLD is still subject to intensive research, several players and mechanisms have been suggested based on the substantial evidence. Excessive hepatocyte triglyceride accumulation resulting from insulin resistance is the first step in the proposed 'two hit' model of the pathogenesis of NAFLD. Oxidative stress resulting from mitochondrial fatty acids oxidation, NF-κB-dependent inflammatory cytokine expression and adipocytokines are all considered to be the potential factors causing second hits which lead to hepatocyte injury, inflammation and fibrosis. Although it was initially believed that NAFLD is a completely benign disorder, histologic follow-up studies have showed that fibrosis progression occurs in about a third of patients. A small number of patients with NAFLD eventually ends up with end-stage liver disease and even hepatocellular carcinoma. Although liver biopsy is currently the only way to confirm the NAFLD diagnosis and distinguish between fatty liver alone and NASH, no guidelines or firm recommendations can still be made as for when and in whom it is necessary. Increased physical activity, gradual weight reduction and in selected cases bariatric surgery remain the mainstay of NAFLD therapy. Studies with pharmacologic agents are showing promising results, but available data are still insufficient to make specific recommendations; their use therefore remains highly individual.

关键词： Non-alcoholic fatty liver disease Metabolic

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Managing end-stage carcinoid heart disease:A case report and literature review

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1076-1083页

作者： Nikola Bulj vedran Tomasic Maja Cigrovski Berkovic Department of Cardiology University Hospital Centre“Sestre Milosrdnice“Zagreb 10000Croatia Division of Gastroenterology Department of Internal MedicineUniversity Hospital Centre“Sestre Milosrdnice”Zagreb 10000Croatia Department for Sport and Exercise Medicine University of Zagreb Faculty of KinesiologyZagreb 10000Croatia

BACKGROUND Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)are rare tumors,often diagnosed in an advanced stage when curative treatment is impossible and grueling symptoms related to vasoactive substance release by tumor cells affect patients’quality of *** complications of GEP-NENs,primarily tricuspid and pulmonary valve disease,and right-sided heart failure,are the leading cause of death,even compared to metastatic *** SUMMARY We present a case of a 35-year-old patient with progressive dyspnea,back pain,polyneuropathic leg pain,and nocturnal diarrhea lasting for a decade before the diagnosis of neuroendocrine carcinoma of unknown primary with extensive liver *** the initial presentation,serum biomarkers were not evaluated,and the patient received five cycles of doxorubicin,which he did not tolerate well,so he refused further therapy and was lost to *** 10 years,he presented to the emergency room with signs and symptoms of right-sided heart *** markers,serum chromogranin A,and urinary 5-hydroxyindoleacetic acid were extremely elevated(900 ng/mL and 2178µmol/L),and transabdominal ultrasound confirmed hepatic *** tomo-graphy(CT)showed liver metastases up to 6 cm in diameter and metastases in mesenteric lymph nodes and ***,an Octreoscan showed lesions in the heart,thoracic spine,duodenum,and ascendent colon.A standard trans-thoracic echocardiogram confirmed findings of carcinoid heart *** patient was not a candidate for valve *** started octreotide acetate treatment,and the dose escalated to 80 mg IM *** biochemical CONCLUSION Carcinoid heart disease occurs with carcinoid syndrome related to advanced neuroendocrine tumors,usually with liver metastases,which manifests as right-sided heart valve dysfunction leading to right-sided heart *** heart disease and tumor burden are major prognostic factors of poor surviva

关键词： Gastroenteropancreatic neuroendocrine neoplasms Carcinoid syndrome Carcinoid heart disease Diagnosis Treatment Case report

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Genetic polymorphisms in non-alcoholic fatty liver disease:Clues to pathogenesis and disease progression

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World Journal of Gastroenterology 2009年第48期15卷 6023-6027页

作者： Marko Duvnjak Neven Bari vedran Tomai Ivan Leroti Division of Gastroenterology and Hepatology Department of Medicine"Sestre milosrdnice" University Hospital

The spectrum of non-alcoholic fatty liver disease(NAFLD) ranges from simple steatosis through steatohepatitis to advanced f ibrosis and *** the reason why only a minority of patients develop progressive forms of disease still remains largely unclear,recent research has identified genetic factors as a possible basis for this variation in disease *** of the studies have been focused on f inding associations between advanced disease forms and selected single nucleotide polymorphisms in genes encoding various proteins involved in disease *** there are many limitations regarding the study design and interpretation of published data,further carefully planned studies together with implementation of new genetic technologies will likely bring new insights into disease pathogenesis and potential benefits to the management of patients with NAFLD.

关键词： Genetics Liver fibrosis Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Single nucleotide polymorphisms

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Can infrared thermography be used to monitor fatigue during exercise? A case study

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Journal of Sport and Health Science 2019年第1期8卷 89-92页

作者： vedran Had?i Brane irok Ale? Malner?i? Milan oh Faculty of Sport University in Ljubljana Faculty of Mechanical Engineering University in Ljubljana

Background: Infrared thermographic imaging(IRTG) is a safe and reliable technology used to monitor skin temperature. The main aim of our study was to evaluate the relationship between skin temperature changes and muscle fatigue in order to answer the main research question if IRTG can be used to monitor muscle ***: This was a case study performed on a 23-year-old trained middle distance runner. After warm-up the subject was exercising on the dynamometer for 7.5 min at 120?/s performing only concentric contractions of quadriceps. At the same time IRTG recording of both(exercising and non-exercising) quadriceps was ***: A correlational analysis that was performed in order to quantify the relationship between power and temperature change over time has shown that there is a significant negative correlation between skin temperature increase and power decrease(r = -0.543, p = 0.036) of exercising quadriceps. In linear regression model the exercising quadriceps power could be predicted from skin temperature. No such relationships were noted for the non-exercising limb that served as a ***: We believe that correlation between skin temperature change and muscle power output as described in this case study deserves further analysis on the larger sample including subjects of the different ages, health status, and physical abilities in order to create a new tool for monitoring the muscle fatigue.

关键词： Correlation Fatigue Isokinetic Quadriceps Strength Thermographic imaging

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Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2012年第30期18卷 3945-3954页

作者： Neven Bari Ivan Leroti Lea Smiri-Duvnjak vedran Tomai Marko Duvnjak Division of Gastroenterology and Hepatology Department of Medicine"Sestre milosrdnice" University Hospital Center10000 ZagrebCroatia Vuk Vrhovac University Clinic for Diabetes Endocrinology and Metabolic Diseases10000 ZagrebCroatia

High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology *** methods have been investigated in the recent years,including imaging methods like ultrasound and magnetic resonance imaging,different forms of liver stiffness measurement,various biomarkers of necroinflammatory processes (acute phase reactants,cytokines,markers of apoptosis),hyaluronic acid and other biomarkers of liver *** tests,scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis *** all of the cases,performance of noninvasive methods was compared with liver biopsy,which is still considered to be a gold standard in diagnosis,but is by itself far from a perfect comparative *** present here the overview of the published data on various noninvasive diagnostic tools,some of which appear to be very promising,and we address as well some of still unresolved issues in this interesting field.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Liver biopsy Biomarkers Transient elastography Cytokeratin-18 Oxidative stress Insulin resistance Hyaluronic acid

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Risk factors for musculoskeletal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model

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Military Medical Research 2022年第4期9卷 444-483页

作者： Stefan Sammito vedran Hadzic Thomas Karakolis Karen R.Kelly Susan P.Proctor Ainars Stepens Graham White Wes O.Zimmermann Section Experimental Aerospace Medicine Research German Air Force Centre of Aerospace MedicineFlughafenstraBe 151147 CologneGermany Occupational Medicine Faculty of MedicineOtto-Von-Guericke-University of Magdeburg39120 MagdeburgGermany Faculty of Sport University of Ljubljana1000 LjubljanaSlovenia Defence Research and Development Canada TorontoON M3K 2C9Canada Warfighter Performance Naval Health Research CenterSan DiegoCA 921063599USA Military Performance Division US Army Research Institute of Environmental MedicineNatickMA 01760USA Research Service VA Boston Healthcare SystemBostonMA 02130USA Centre for Military Medicine Research Riga Stradins UniversityRiga 1007Latvia Human and Social Sciences Group Defense Science and Technology LaboratoryPortsdown Hill RoadFareham PO176ADUK Department of Military Sports Medicine Royal Netherlands Army3584 AB UtrechtThe Netherlands Department of Military/Emergency Medicine Uniformed Services University of the Health SciencesBethesdaMD 20814USA.

Background: Musculoskeletal injuries(MSkIs) are a leading cause of health care utilization, as well as limited duty and disability in the US military and other armed forces. MSkIs affect members of the military during initial training,operational training, and deployment and have a direct negative impact on overall troop readiness. Currently, a systematic overview of all risk factors for MSkIs in the military is not ***: A systematic literature search was carried out using the PubMed, Ovid/Medline, and Web of Science databases from January 1, 2000 to September 10, 2019. Additionally, a reference list scan was performed(using the “snowball method”). Thereafter, an international, multidisciplinary expert panel scored the level of evidence per risk factor, and a classification of modifiable/non-modifiable was ***: In total, 176 original papers and 3 meta-analyses were included in the review. A list of 57 reported potential risk factors was formed. For 21 risk factors, the level of evidence was considered moderate or strong. Based on this literature review and an in-depth analysis, the expert panel developed a model to display the most relevant risk factors identified, introducing the idea of the “order of importance” and including concepts that are modifiable/nonmodifiable, as well as extrinsic/intrinsic risk ***: This is the qualitative systematic review of studies on risk factors for MSkIs in the military that has attempted to be all-inclusive. A total of 57 different potential risk factors were identified, and a new, prioritizing injury model was developed. This model may help us to understand risk factors that can be addressed, and in which order they should be prioritized when planning intervention strategies within military groups.

关键词： Military Musculoskeletal injuries Risk factors Prevention Intervention Injury

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Wireless organic electronic ion pumps driven by photovoltaics

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npj Flexible Electronics 2019年第1期3卷 126-131页

作者： Marie Jakešová Theresia Arbring Sjöström vedranĐerek David Poxson Magnus Berggren Eric Daniel Głowacki Daniel T.Simon Laboratory of Organic Electronics ITN Campus NorrköpingLinköping UniversitySE-60174 NorrköpingSweden Wallenberg Centre for Molecular Medicine Linköping UniversitySE-58185 LinköpingSweden

The organic electronic ion pump(OEIP)is an emerging bioelectronic technology for on-demand and local delivery of pharmacologically active species,especially targeting alkali ions,and *** electrical control is advantageous for providing precise spatial,temporal,and quantitative delivery,traditionally,it necessitates *** complicates ***,we demonstrate integration of an OEIP with a photovoltaic driver on a flexible carrier,which can be addressed by red light within the tissue transparency *** thin-film bilayer photovoltaic pixels are arranged in series and/or vertical tandem to provide the 2.5–4.5 V necessary for operating the high-resistance electrophoretic ion *** demonstrate light-stimulated transport of cations,ranging in size from protons to *** device,laminated on top of the skin,can easily be driven with a red LED emitting through a 1.5-cm-thick *** end result of our work is a thin and flexible integrated wireless device platform.

关键词： precise transparency alkali

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Physical activity recommendations during the coronavirus disease-2019 virus outbreak

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Journal of Sport and Health Science 2020年第4期9卷 325-327页

作者： Gregor Jurak Shawnda A.Morrison Bojan Leskosek Marjeta Kovac vedran Hadzic Janez Vodicar Polonca Truden Gregor Starc Faculty of Sport University of Ljubljan1Ljubljan1SI 1000Slovenia National Institute of Public Health Ljubljan1SI 1000Slovenia

Physical activity(PA)significantly reduces the risk of viral infections1,2 and levels of anxiety.3,4 In addition to its shortterm benefits,regular PA lowers one’s risk of suffering from chronic health conditions(e.g.,diabetes,coronary heart disease,and hypertension),which are cited as the most frequent comorbidities in recent studies of coronavirus disease-2019(COVID-19).5 Because of the COVID-19 pandemic that has become a global problem,many will face the necessity of requiring hundreds of millions of people to volitionally selfconfine themselves in their own homes,or even be“locked down”in a quarantined *** affects most aspects of human physiology considerably.

关键词： coronary hundreds considerably

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Thermodynamic Analysis of a Condensate Heating System from a Marine Steam Propulsion Plant with Steam Reheating

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Journal of Marine Science and Application 2021年第1期20卷 117-127页

作者： vedran Mrzljak Ivan Lorencin Nikola Anđelić Zlatan Car Faculty of Engineering University of RijekaVukovarska 5851000 RijekaCroatia

The thermodynamic(energy and exergy)analysis of a condensate heating system,its segments,and components from a marine steam propulsion plant with steam reheating is performed in this *** is found that energy analysis of any condensate heating system should be avoided because it is highly influenced by the measuring equipment accuracy and *** the components from the observed marine condensate heating system have energy destructions lower than 3 kW,while the energy efficiencies of this system are higher than 99%.The exergy efficiency of closed condensate heaters continuously increases from the lowest to the highest steam pressures(from 70.10%to 92.29%).The ambient temperature variation between 5℃and 45℃notably influences the exergy efficiency change of both low pressure heaters and the low pressure segment equal to 31.61%,12.37%,and 18.35%,respectively.

关键词： Condensate heating system Marine steam propulsion plant Steam reheating Thermodynamic analysis Energy and exergy analyses Segmental analysis Ambient temperature change

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