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Immunogenetic factors driving formation of ultralong vH CDR3 in Bos taurus antibodies

Cellular & Molecular Immunology 2019年第1期16卷 53-64页

作者： Thaddeus C Deiss Melissa vadnais Feng Wang Patricia L Chen Ali Torkamani Waithaka Mwangi Marie-Paule Lefranc Michael F Criscitiello vaughn v smider Comparative Immunogenetics Laboratory Department of Veterinary PathobiologyCollege of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843USA Department of Molecular Medicine The Scripps Research InstituteLa JollaCA 92037USA California Institute for Biomedical Research La JollaCA 92037USA Department of Integrative Structural and Computational Biology The Scripps Research InstituteLa JollaCA 92037USA Department of Diagnostic Medicine and Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKS 66506USA IMGT the International ImMunoGeneTics information systemLaboratoire d’ImmunoGénétique MoléculaireInstitut de Génétique HumaineCNRSUniversity of MontpellierMontpellier 34396France Department of Microbial Pathogenesis and Immunology College of MedicineTexas A&M UniversityBryanTX 77807USA Fabrus Inc.La JollaCA 92037USA

The antibody repertoire of Bos taurus is characterized by a subset of variable heavy(vH)chain regions with ultralong third complementarity determining regions(CDR3)which,compared to other species,can provide a potent response to challenging antigens like HIv *** unusual CDR3 can range to over seventy highly diverse amino acids in length and form uniqueβ-ribbon‘stalk’and disulfide bonded‘knob’structures,far from the typical antigen binding *** genetic components and processes for forming these unusual cattle antibody vH CDR3 are not well *** we analyze sequences of Bos taurus antibody vH domains and find that the subset with ultralong CDR3 exclusively uses a single variable gene,IGHv1-7(vHBUL)rearranged to the longest diversity gene,*** eight nucleotide duplication at the 3′end of IGHv1-7 encodes a longer v-region producing an extended Fβ-strand that contributes to the stalk in a rearranged CDR3.A low amino acid variability was observed in CDR1 and CDR2,suggesting that antigen binding for this subset most likely only depends on the *** a novel,potentially AID mediated,deletional diversification mechanism of the *** vH ultralong CDR3 knob was discovered,in which interior codons of the IGHD8-2 region are removed while maintaining integral structural components of the knob and descending strand of the stalk in *** deletions serve to further diversify cysteine positions,and thus disulfide bonded ***,both germline and somatic genetic factors and processes appear to be involved in diversification of this structurally unusual cattle vH ultralong CDR3 repertoire.

关键词： bovine complementarity determining region 3 repertoire diversification deletions immunoglobulin heavy chain

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Physiological phenotypes differ among color morphs in introduced common wall lizards(Podarcis muralis)

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Integrative Zoology 2024年第3期19卷 505-523页

作者： Ali AMER Sierra SPEARS Princeton L.vaughn Cece COLWELL Ethan H.LIvINGSTON Wyatt MCQUEEN Anna SCHILL Dustin G.REICHARD Eric J.GANGLOFF Kinsey M.BROCK Department of Biological Sciences Ohio Wesleyan UniversityDelawareOhioUSA Department of Ecology and Evolutionary Biology Princeton UniversityPrincetonNew JerseyUSA Department of Biology Idaho State UniversityPocatelloIdahoUSA Department of Environmental Science Policyand ManagementCollege of Natural ResourcesUniversity of CaliforniaBerkeleyUSA Museum of vertebrate Zoology University of CaliforniaBerkeleyUSA

Many species exhibit color polymorphisms which have distinct physiological and behavioral ***,the consistency of morph trait covariation patterns across species,time,and ecological contexts remains *** trait covariation is especially relevant in the context of invasion biology and urban ***,physiological traits pertaining to energy maintenance are crucial to fitness,given their immediate ties to individual reproduction,growth,and population *** investigated the physiological traits of Podarcis muralis,a versatile color polymorphic species that thrives in urban environments(including invasive populations in Ohio,USA).We measured five physiological traits(plasma corticosterone and triglycerides,hematocrit,body condition,and field body temperature),which compose an integrated multivariate *** then tested variation among co-occurring color morphs in the context of establishment in an urban *** found that the traits describing physiological status and strategy shifted across the active season in a morph-dependent manner—the white and yellow morphs exhibited clearly different multivariate physiological phenotypes,characterized primarily by differences in plasma *** suggests that morphs have different strategies in physiological regulation,the flexibility of which is crucial to urban *** white-yellow morph exhibited an intermediate phenotype,suggesting an intermediary energy maintenance *** morphs also exhibited distinct phenotypes,but the low prevalence of this morph in our study populations precludes clear *** work provides insight into how differences among stable polymorphisms exist across axes of the phenotype and how this variation may aid in establishment within novel environments.

关键词： color polymorphism physiological status seasonal variation thermoregulation urban habitat

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Systematic review of dynamization vs exchange nailing for delayed/non-union femoral fractures

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World Journal of Orthopedics 2018年第7期9卷 92-99页

作者： Jacob E vaughn Ronit v Shah Tarek Samman Jacob Stirton Jiayong Liu Nabil A Ebraheim College of Medicine and Life Sciences University of Toledo Department of Orthopedic Surgery University of Toledo Medical Center

AIM To analyze the literature on efficacy of dynamamization vs exchange nailing in treatment of delayed and nonunion femur *** Ultimately, 31 peer-reviewed articles with 644 exchanged nailing patients and 131 dynamization patients were identified and analyzed. The following key words were inputted in different combinations in order to search the field of publications in its entirety: "nonunion", "delayed union", "ununited", "femur fracture", "femoral fracture", "exchange nailing", "dynaiz(s)ation", "secondary nailing", "dynamic", "static", and "nail revision". The initial search yielded over 150 results, and was refined based on the inclusion criteria: Only studies reporting on humans, non-unions and delayed unions, and the usage of exchange nailing and/or dynamization as a secondary treatment after failed IM nailing. The resulting 66 articles were obtained through online journal access. The results were filtered further based on the exclusion criteria: No articles that failed to report overall union rates, differentiate between success rates of their reported techniques, or articles that analyzed less than 5 patients. RESULTS Exchange nailing lead to fracture union in 84.785% of patients compared to the 66.412% of dynamization with statistically comparable durations until union(5.193 ± 2.310 mo and 4.769 ± 1.986 mo respectively). Dynamically locking exchange nails resulted in an average union time of 5.208 ± 2.475 mo compared to 5.149 ± 2.366 mo(P = 0.8682) in statically locked exchange nails. The overall union rate of the two procedures, statically and dynamically locked exchange nailing yielded union rates of 84.259% and 82.381% respectively. Therefore, there was no significant difference between the different locking methods of exchange nailing for union rate or time to union at a significance value of P < 0.05. The analysis showed exchange nailing to be the more successful choice in the treatment of femoral non-unions in respect to its higher succ

关键词： Non-union Delayed union Dynamization Femoral fracture Exchange nailing

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visual Basic和SQL Server编程指南第5版 G

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丛书名：解决方案开发人员系列

1999年

作者：（美）（W.R.沃恩）William R.vaughn 王书洪陈永基译

本书讲述的是目前较少论及的客户/服务器编程技术，而且本书的这一最新版本和以往版本相比有了很大的改进。书中通过对工作原理和操作方法的详细阐述，向读者介绍了如何使用visual Basic来设计、编码、调试和调谐SQL Server的前端应用... 详细信息

ISBN: (纸本)7302032912

本书讲述的是目前较少论及的客户/服务器编程技术，而且本书的这一最新版本和以往版本相比有了很大的改进。书中通过对工作原理和操作方法的详细阐述，向读者介绍了如何使用visual Basic来设计、编码、调试和调谐SQL Server的前端应用程序。此外，书中还全面讨论了Microsoft visual Basic中通过强大的RDO增强而提供的各项新功能，具体包括：对完全的事件驱动模式的支持；一个全新的游标库，提供了更快的客户方游标和其他新功能；对独立的rdoConnection对象和新的rdoQuery对象的实现。书中还全面探讨了ODBCDirect，这是一种可以使用户通过DAO来绕过JET的新的编程模式。最后，本书随附的CD-ROM中还包含了新的、经过更新的软件工具。

关键词：数据库管理系统关系型数据库 BASIC语言程序设计

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预靶向:放射免疫治疗的进阶之路

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中华核医学与分子影像杂志 2022年第12期42卷 759-768页

作者：葛雨秋(译) 付海田(译) 郁春景(审校) Sarah M.Cheal Sebastian K.Chung Brett A.vaughn Nai-Kong v.Cheung Steven M.Larson 江南大学无锡医学院无锡214122 江南大学附属医院核医学科无锡214122 Molecular Pharmacology Program Memorial Sloan Kettering Cancer CenterNew YorkNew York Department of Surgery Memorial Sloan Kettering Cancer CenterNew YorkNew York Department of Pediatrics Memorial Sloan Kettering Cancer CenterNew YorkNew York Department of Radiology Memorial Sloan Kettering Cancer CenterNew YorkNew York

预靶向放射免疫诊断(PRID)和预靶向放射免疫治疗(PRIT)旨在利用药用放射性核素有效标记抗肿瘤靶向抗体而分别应用于提高肿瘤显像的对比度和肿瘤治疗指数(TI)。与传统的放射性免疫偶联物不同,预靶向策略将肿瘤靶向步骤与有效载荷步骤分开... 详细信息

预靶向放射免疫诊断(PRID)和预靶向放射免疫治疗(PRIT)旨在利用药用放射性核素有效标记抗肿瘤靶向抗体而分别应用于提高肿瘤显像的对比度和肿瘤治疗指数(TI)。与传统的放射性免疫偶联物不同,预靶向策略将肿瘤靶向步骤与有效载荷步骤分开,在减少正常组织暴露的同时提高了肿瘤的摄取量。预靶向策略的关键参数除了对比度和TI外,还包括抗体的免疫原性和特异性、放射性核素的适用性以及在临床中使用的便利性。预靶向的每个步骤都可以单独优化,且作为模块化系统,预靶向策略可广泛地应用于不同的肿瘤靶点、肿瘤类型或放射性核素。然而,尽管预靶向的多功能性为肿瘤的诊疗提供了巨大的应用潜能,但其过程复杂,在临床转化及如何在患者体内达到最佳使用效果方面面临着较大的挑战。该文旨在简要回顾预靶向策略的起源和发展过程,重点阐述目前已被广泛研究的2种蛋白质递送系统(生物素-链霉亲和素及半抗原-双特异性单克隆抗体)、放射性半抗原和放射性核素。此外,该文还将重点阐述预靶向研究领域的创新成果,包括使用生物正交化学和新型蛋白质载体(如自组装-解组装蛋白质和亲和体分子)进行的预靶向。该文并不是对过去30年PRID和PRIT全面的回顾,而是突出阐述了预靶向发展过程中的里程碑成果,并从TI和毒性方面评价其在临床前模型和临床试验中的应用。相信预靶向策略能够帮助人们认识肿瘤临床诊疗一体化实施的障碍,重新激发人们对放射免疫疗法的兴趣,并指导预靶向研究的进一步发展。

关键词：普通外科肿瘤学放射性核素治疗放射性药物多重步骤预靶向放射免疫治疗放射免疫治疗

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Analysis Methods for the Determination of Anthropogenic Additions of P to Agricultural Soils

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Open Journal of Soil Science 2015年第2期5卷 59-68页

作者： Richard L. Haney virginia L. Jin Mari-vaughn v. Johnson Elizabeth B. Haney R. Daren Harmel Jeffrey G. Arnold Michael J. White United States Department of Agriculture-Agriculture Research Service Grassland Soil and Water Research Laboratory Temple TX USA United States Department of Agriculture-Agriculture Research Service Agroecosystem Management Research Laboratory University of Nebraska East Campus Lincoln NE USA United States Department of Agriculture-Natural Resource Conservation Service Temple TX USA Texas A&M University Texas AgriLife Research & Extension Center Temple TX USA

Phosphorus loading and measurement is of concern on lands where biosolids have been applied. Traditional soil testing for plant-available P may be inadequate for the accurate assessment of P loadings in a regulatory environment as the reported levels may not correlate well with environmental risk. In order to accurately assess potential P runoff and leaching, as well as plant uptake, we must be able to measure organic P mineralized by the biotic community in the soil. Soils with varying rates of biosolid application were evaluated for mineralized organic P during a 112-day incubation using the difference between P measured using a rapid-flow analyzer (RFA) and an axial flow varian ICP-OES. An increase in the P mineralized from the treated soils was observed from analysis with the varian ICP-OES, but not with the RFA. These results confirm that even though organic P concentrations have increased due to increasing biosolid application, traditional soil testing using an RFA for detection, would not accurately portray P concentration and potential P loading from treated soils.

关键词： Phosphorus Anthropogenic Additions Biosolids Rapid-Flow Analyzer (RFA) Inductively Coupled Plasma (ICP) Texas Commission of Environmental Quality (TCEQ) Soil Organic C (SOC) Total N (TN) Water-Soluble Organic C (WSOC) Water Soluble Organic N (WSON)

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TOPEX/POSEIDON卫星地球敏感器的在轨异常分析

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控制工程（北京） 1994年第6期 41-47,12页

作者： Gharles J.Gay Raymond v.Welch vaughn H.Selby 黄玢

TOPEX/POSEIDON卫星是于1992年8月10日发射的对地定向三轴稳定卫星。在姿态测量和控制分系统的全套敏感器中包含有2个相同的地球敏感器组件(ESA)。每一个ESA提供滚动和俯仰两轴姿态误差测量,这些信号一般用于星上计算机(OBC)故障检测和... 详细信息

TOPEX/POSEIDON卫星是于1992年8月10日发射的对地定向三轴稳定卫星。在姿态测量和控制分系统的全套敏感器中包含有2个相同的地球敏感器组件(ESA)。每一个ESA提供滚动和俯仰两轴姿态误差测量,这些信号一般用于星上计算机(OBC)故障检测和校正逻辑,在OBC初始捕获处理及地球指向安全保持模式运行期间也可作为主要的姿态测量。TOPEX/POSEIDON卫星发射后不久,即观测到地球敏感器信号的异常。本文叙述该地球敏感器的在轨性能及已实现的软件修正,这些软件修正保证卫星对异常数据的响应不会对卫星或飞行任务产生不利影响。本文还讨论了ESA异常机理与带电粒子作用的关系。这项工作是由国家航宇局委托加州理工大学的喷气发动机实验室进行的。

关键词：人造卫星地球敏感器在轨异常分析航天器

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ADO效率最好的练习——让您的ADO应用程序拥有最好的效率

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软件 2001年第12期22卷 135-139页

作者： Bill vaughn Mathias Pan Beta v公司

作者花了相当多的时间,研究出一些SQL Server数据存取的程序技巧、架构,以及要如何开发才能达到最好的效率。“效率”这个字有好几种不同以及隐含的含意。当某人提到某样东西的效率很好时,大部分可能是指在一段时间完成了许多的工作。例... 详细信息

作者花了相当多的时间,研究出一些SQL Server数据存取的程序技巧、架构,以及要如何开发才能达到最好的效率。“效率”这个字有好几种不同以及隐含的含意。当某人提到某样东西的效率很好时,大部分可能是指在一段时间完成了许多的工作。例如,效率良好的引擎代表的是运转安静并且可以产生很大的扭力。您可以将类似的衡量标准放到您的开发团队中:效率良好的开发团队。

关键词： ADO 应用程序效率数据库

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Genome-wide SNP Genotyping Resolves Signatures of Selection and Tetrasomic Recombination in Peanut

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Molecular Plant 2017年第2期10卷 309-322页

作者： Josh Clevenger Ye Chu Carolina Chavarro Gaurav Agarwal David J. Bertioli Soraya C.M. LeaI-Bertioli Manish K. Pandey Justin vaughn Brian Abernathy Noelle A. Barkley Ran Hovav Mark Burow Spurthi N. Nayak Annapurna Chitikineni Thomas G. Isleib C. Corley Holbrook Scott A. Jackson Rajeev K. varshney Peggy Ozias-Akins Department of Horticulture and Institute of Plant Breeding Genetics & Genomics The University of Georgia 2356 Rainwater Road Tifton GA 31793 USA Center for Applied Genetic Technologies and Institute of Plant Breeding Genetics & Genomics The University of Georgia Athens GA 30602 USA International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Hyderabad 502324 India University of Brasilia Institute of Biological Sciences Campus Darcy Ribeiro 70910-900 Brasilia DF Brazil Embrapa Genetic Resources and Biotechnology 70770-917 Brasflia DF Brazil eUSDA-ARS PGRCU Griffin GA 30223 USA Agricultural Research Organization Plant Sciences Institute 7528809 Rishon LeZion Israel Department of Plant and Soil Science Texas Tech University Lubbock TX 79409-2122 USA Department of Crop and Soil Sciences North Carolina State University Box 7629 Raleigh NC 28695-7629 USA USDA-ARS Tifton GA 31793. USA

Peanut （Arachis hypogaea; 2n = 4x = 40） is a nutritious food and a good source of vitamins, minerals, and healthy fats. Expansion of genetic and genomic resources for genetic enhancement of cultivated peanut has gained momentum from the sequenced genomes of the diploid ancestors of cultivated peanut. To facil- itate high-throughput genotyping of Arachis species, 20 genotypes were re-sequenced and genome-wide single nucleotide poiymorphisms （SNPs） were selected to develop a large-scale SNP genotyping array. For flexibility in genotyping applications, SNPs polymorphic between tetraploid and diploid species were included for use in cultivated and interspecific populations. A set of 384 accessions was used to test the array resulting in 54 564 markers that produced high-quality polymorphic clusters between diploid species, 47 116 polymorphic markers between cultivated and interspecific hybrids, and 15 897 polymorphic markers within A. hypogaea germplasm. An additional 1193 markers were identified that illuminated genomic re- gions exhibiting tetrasomic recombination. Furthermore, a set of elite cultivars that make up the pedigree of US runner germplasm were genotyped and used to identify genomic regions that have undergone pos- itive selection. These observations provide key insights on the inclusion of new genetic diversity in culti- vated peanut and will inform the development of high-resolution mapping populations. Due to its efficiency, scope, and flexibility, the newly developed SNP array will be very useful for further genetic and breeding applications in Arachis.

关键词： single nucleotide polymorphism groundnut Arachis hypogaea

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儿童多导睡眠图评分及科研新知

儿童多导睡眠图评分及科研新知

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国际注册多导睡眠技师（RPSGT）认证课程十周年大会

作者： Richard B.Berry Rita Brooks Chariene E.Gamaldo Susan M.Harding Robin M.Lloyd Stuart F.Quan Matthew M.Troester Bradley v.vaughn the American Academy of Sleep Medicine

＜正＞～～

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