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患者和医院差异相关的冠状动脉旁路移植术后结局的种族差异

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世界核心医学期刊文摘（心脏病学分册） 2005年第9期1卷 40-41页

作者： Konety s.H. vaughan sarrazin m.s. Rosenthal G.E. 张迎捷 Dr.Div. of General Internal medicine Univ. of Iowa Hospitals and Clinics SE618 GH 200 Hawkins Dr Iowa City IA 52246 United States

Background -Few studies have examined the association of race and outcom.s.after coronary artery bypass graft(CABG)surgery while controlling for both patient and hospital effects. methods and Results -We retrospectively analyzed data on a cohort of 566 785 white and 24 354 black medicare beneficiaries 65 years old and older undergoing CABG in 1091 Us hospitals from 1997 to 2000. mortality and repeat revascularization rates were examined after sequential adjustment for patient and hospital differences by use of generalized estimating equations. Unadjusted mortality was higher(Ps at 30(6.4%versus 5.2%), 90(8.3%versus 6.6%), and 365 days(13.5%versus 9.8%) after surgery. Black patients were more likely(Pspitals with the highest mortality(56%versus 47%) and at hospitals in the lowest volume quintile(24%versus 20%). Adjusted only for patient characteristics, mortality was 8%, 11%, and 25%higher in black patients at 30, 90, and 365 days. After adjustment for hospital effects, 30 and 90 day mortality was similar but 17%higher in black patients at 365 days. Racial differences in mortality were greater in men than in women. On adjustment for patient and hospital effects, repeat revascularization rates were similar in black and white patients. Conclusions -Racial disparities in CABG outcom.s.are sensitive to the effects of sex and duration of postsurgical follow-up. The increasing disparity in outcom.s.as follow-up increased is consistent with the hypothesis that black patients have less access to secondary prevention and rehabilitation services after surgery.

关键词：种族差异血运重建广义估计方程校正死亡率二级预防康复治疗持续时间医疗保险

需求证书管理制度与急性心肌梗死后冠状动脉血运重建的实施

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 2-3页

作者： Popescu I. vaughan-sarrazin m.s. Rosenthal G. E. 罗亮 Department of Internal medicine University of Iowa Hospitals and Clinics 200 Hawkins Dr SE615-GH Iowa City IA 52240 United States Dr.

Context: Certificate of need regulations were enacted to control health care costs by limiting unnecessary expansion of services. While many states have repealed certificate of need regulations in recent years, few analyses have examined relationships between certificate of need regulations and outcom.s.of care. Objective: To compare rates of coronary revascularization and mortality after acute myocardial infarction in states with and without certificate of need regulations. Design, setting, and Participants: Retrospective cohort study of 1 139 792 medicare beneficiaries aged 68 years or older with AmI who were admitted to 4587 Us hospitals during 2000-2003. main Outcome measures: Thirty-day risk-adjusted rates of coronary revascularization with either coronary artery bypass graft surgery or percutaneous coronary intervention and 30-day all-cause mortality. Results: The 624 421 patients in states with certificate of need regulations were less likely to be admitted to hospitals with coronary revascularization services(321 573[51.5%] vs 323 695[62.8%]; Pscularization at the admitting hospital(163 120[26.1%] vs 163 877[31.8%]; Ps in states without certificates of need but were more likely to undergo revascularization at a transfer hospital(73 379[11.7%] vs 45 907[8.9%]; Psting for demographic and clinical risk factors, patients in states with highly and moderately stringent certificate of need regulations, respectively, were less likely to undergo revascularization within the first 2 days(adjusted hazard ratios, 0.68; 95%confidence interval[CI], 0.54-0.87; P=.002 and 0.80; 95%CI, 0.71-0.90; Ps in states without certificates of need, although no differences in the likelihood of revascularization were observed during days 3 through 30. Unadjusted 30-day mortality was similar in states with and without certificates of need(109 304[17.5%] vs 90 104[17.5%]; P=.76), as was adjusted mortalit

关键词：急性心肌梗死证书管理血运重建术血运重建治疗全因死亡率回顾性队列研究临床危险因素冠状动脉

接受主动脉瓣置换术的黑人和白人老年患者的治疗差异

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世界核心医学期刊文摘(心脏病学分册) 2006年第3期 44-45页

作者： schelbert E.B. Rosenthal G.E. Welke K.F. vaughan-sarrazin m.s. 马超 Department of Internal medicine University of Iowa Hospitals and Clinics 200 Hawkins Dr Iowa City IA 52242 United States Dr.

Background-m.s. prior studies of racial differences in the delivery of cardiac care have focused on potential differences in treatment by individual physicians and hospitals. However, differential use of hospitals with variable practice patterns might also contribute to variations in care. methods and Results -We compared the use of bioprosthetic valves(BPVs) in 78 154 black and white medicare beneficiaries ≥ 65 years of age undergoing aortic valve replacement in 904 Us hospitals during 1999 through 2001. Generalized linear mixed models were used to account first for differences in patient characteristics and then for differences in hospitals used by black and white patients. BPV use was lower in black patients relative to white patients after adjustment for patient characteristics(relative risk, 0.93; 95% CI, 0.91 to 0.95; Ps were more likely to undergo surgery in hospitals in the lowest quintile of BPV use overall(29% versus 20% of white patients; Pspital-level variability in BPV use was accounted for, the use of BPVs was actually somewhat higher in black patients(relative risk, 1.06; 95% CI, 1.04 to 1.09; Pmodel discrimination as measured by the c statistic was markedly higher after the addition of hospital effects(0.80 versus 0.59 for patient characteristics alone; Psions -Accounting for differences in hospitals preferentially used by black and white patients had a major impact on estimating racial differences in the use of BPVs in patients undergoing aortic valve replacement. Hospital-level effects explained a larger proportion of the variation in BPV use than race and other patient characteristics alone.

关键词：主动脉瓣置换术患者白人黑人差异

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Predicting maximum Lifespan Limits at mean menopausal Age

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Journal of mathematical Research with Applications 2025年第1期 133-142页

作者： m.s.mATHI s.ANTONY CARLA Department of mathematics N.M.S.S.Vellaichamy Nadar College Research scholar (Part-time) Madurai Kamaraj University

The age at which a woman enters natural menopause has also been associated to death from any cause. menopause is a natural component of aging that happens between the ages of 45 and 55, with the average menopausal age being 51. Previous research has revealed the age at which women reach menopause, but there is no evidence to support the link between menopause and longevity. We made a study in assessing the limits of maximum lifespan at menopausal age in our previous article. In this paper, we aim to predict the maximum lifespan of women at mean menopausal age.

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Brain-derived neurotrophic factor signaling in the neurom.s.ular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tom.s.Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-segura Aleksandra Polishchuk Laura Nadal marta Tom.s.Carolina silvera-simón manel m.s.ntafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neurom.s.ular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine m.s.arinic autoreceptors,coupled to downstream.s.rine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic m.s.arinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate m.s.arinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

solution‑Processed Thin Film Transparent Photovoltaics:Present Challenges and Future Development

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Nano-micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu munerah m.s.Almutairi Jie ma Aisling stewart Zhaohui Xing mengxia Liu Bo Hou Yuljae Cho Um.s.TU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China school of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for modern society to sustain economic *** soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban *** overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent semiconductors solution-processable transparent solar cell Emerging solar cell materials Buildingintegrated photovoltaics

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

simple operated multipurpose temperature control cryostat

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Journal of Zhejiang University-science A(Applied Physics & Engineering) 2007年第5期8卷 793-796页

作者： ABBAs T.A. OmAR m.s. Department of Physics College of Science University of SalahaddinArbilIraqi KurdistanIraq

A suitable simple optical cryostat for optical, magneto-optical, electrical and thermo-electrical measurements was designed. It is suitable for use in a magnetic pool gap as narrow as less than 1 cm. Throughout a long period of time, the heat diffusion process of the cryostat can be easily operated at slow increase in sample temperature in a range 1.25 K/min at 200 K that will be reduced gradually to 0.66 K at room temperature. Liquid nitrogen was used to cool down the temperature. During the operation, the change in the measured energy gap of a semiconductor sample and other physical parameters resulting from the change of temperature can be corrected through the temperature coefficient of that parameter at the corresponding temperature. The cryostat was successfully used for all experiments mentioned above to measure the properties of a single crystal of GaP (Gallium Phosphate) semiconductor.

关键词： Optical cryostat Electrical cryostat magneto-optical cryostat