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Can chronic gastritis cause an increase in fecal calprotectin concentrations?

World Journal of Gastroenterology 2010年第27期16卷 3406-3410页

作者： Massimo Montalto Antonella Gallo Gianluca Ianiro Luca Santoro Ferruccio D Onofrio Riccardo Ricci Giovanni Cammarota Marcello Covino Monica vastola antonio Gasbarrini Giovanni Gasbarrini Ricca rdo Ricci Institute of Internal Medicine Catholic University Institute of Pathology Institute of Pa thology Catholic University00168RomeItaly

AIM:To evaluate fecal calprotectin concentrations(FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity ***:FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy *** grading of gastritis was performed according to the updated Sydney gastritis *** were subdivided into 2 groups according to the presence/absence of an active *** with chronic active gastritis were divided into 3 subgroups on the basis of the activity score(mild,moderate,marked).FFCs in relation to Helicobacter pylori(***) infection and proton pump inhibitor(PPI) use were also ***:FCCs in patients with chronic active gastritis were not significantly different to FCCs either in subjects with non active gastritis or in healthy *** patients with chronic active gastritis(even marked),FCCs did not significantly differ according to activity *** significant differences in FCCs were found when considering ***,as well as when considering PPI chronic ***:FCCs were not significantly increased in subjects with chronic gastritis,even in those patients with a marked neutrophil infiltration.

关键词： Chronic gastritis Fecal calprotectin Intestinal inflammation Neutrophils

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Management and treatment of lactose malabsorption

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World Journal of Gastroenterology 2006年第2期12卷 187-191页

作者： Massimo Montalto Valentina Curigliano Luca Santoro Monica vastola Giovanni Cammarota Raffaele Manna antonio Gasbarrini Giovanni Gasbarrini Department of Internal Medicine Catholic UniversityRomeItaly

Lactose malabsorption is a very common condition characterized by intestinal lactase deficiency. Primary lactose malabsorption is an inherited deficit present in the majority of the world＇s population, while secondary hypolactasia can be the consequence of an intestinal disease. The presence of malabsorbed lactose in the colonic lumen causes gastrointestinal symptoms. The condition is known as lactose intolerance. In patients with lactase nonpersistence, treatment should be considered exclusively if intolerance symptoms are present. In the absence of guidelines, the common therapeutic approach tends to exclude milk and dairy products from the diet. However, this strategy may have serious nutritional disadvantages. Several studies have been carried out to find alternative approaches, such as exogenous β-galactosidase, yogurt and probiotics for their bacterial lactase activity, pharmacological and non pharmacological strategies that can prolong contact time between enzyme and substrate delaying gastrointestinal transit time, and chronic lactose ingestion to enhance colonic adaptation. In this review the usefulness of these approaches is discussed and a therapeutic management with a flow chart is proposed.

关键词： Lactose Malabsorption Intolerance Therapy

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