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Modular Filter Convergence Theorems for Urysohn Integral Operators and Applications

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Acta Mathematica Sinica,English Series 2013年第6期29卷 1055-1066页

作者： Antonio BOCCUTO Xenofon dimitriou Dipartimento di Matematica e Informatica via Vanvitelli Department of Mathematics University of Athens Panepistimiopolis

We prove some versions of modular convergence theorems for nonlinear Urysohn-type integral operators with respect to filter convergence. We consider pointwise filter convergence of functions giving also some applicati... 详细信息

关键词： Egorov filter Lebesgue filter filter convergence filter exhaustiveness filter singularity integral operator Mellin operator modular convergence modular space

Biomechanical Analysis of Personalised 3D-Printed Clavicle Plates of Different Materials to Treat Midshaft Clavicle Fractures

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Journal of Shanghai Jiaotong university(Science) 2021年第3期26卷 259-266页

作者： CHENG Rongshan JIANG Ziang dimitriou dimitriou GONG Weihua TSAI Tsung-Yuan School of Biomedical Engineering&Med-X Research Institute Shanghai Jiao Tong UniversityShanghai200030China Department of Orthopaedic Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Department of Orthopedics Bürgerspital SolothurnSchöngrünstrasse 42CH-4500SolothurnSwitzerland

This study was aimed at comparing the biomechanical performance of personalised 3D-printed clavicle plates of different materials to treat midshaft clavicle fractures with the finite element(FE)*** FE model of a fractured clavicle with a personalised 3D-printed clavicle plate and screws was *** types of materials were simulated,including stainless steel,titanium alloy,and magnesium *** loading conditions(axial compression and inferior bending)were applied at the distal end of the clavicle to simulate arm *** stiffness,peak stress,and bone strain at the clavicle fracture site were measured and *** stiffness of the stainless steel clavicle plate was significantly greater than that of the titanium alloy clavicle *** stiffness of the magnesium alloy clavicle plate was similar to that of the intact clavicle;peak stress of the magnesium alloy clavicle plate was the lowest;thus,it had less stress-shielding effects on bone *** magnesium alloy clavicle plate was more likely to form bone by distributing proper strain at the clavicle fracture *** to the influence of different materials on the tensile strength,magnesium alloy clavicle plates might be preferred owing to their bionic stiffness in the treatment of patients with a low risk of *** patients who engage in contact sports,a titanium alloy clavicle plate might be more suitable.

关键词： personalised treatment 3D printing clavicle plate biomechanical analysis

Determinants of inspiratory muscle function in healthy children

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Journal of Sport and Health Science 2019年第2期8卷 183-188页

作者： Theodore Dassios Gabriel dimitriou Department of Child Health King's College Hospital Department of Paediatrics University of Patras Medical School

Background: Children are affected by disorders that have an impact on the respiratory muscles. Inspiratory muscle function can be assessed by means of the noninvasive tension–time index of the inspiratory muscles(TTImus). Our objectives were to identify the determinants of TTImus in healthy children and to report normal values of TTImus in this ***: We measured weight, height, upper arm muscle area(UAMA), and TTImusin 96 children aged 6–18 years. The level and frequency of aerobic activity was assessed by ***: TTImuswas significantly lower in male subjects(0.095 ± 0.038, mean ± SD) compared with female subjects(0.126 ± 0.056)(p = 0.002).TTImus was significantly lower in regularly exercising(0.093 ± 0.040) compared with nonexercising subjects(0.130 ± 0.053)(p < 0.001). TTImus was significantly negatively related to age(r =-0.239, p = 0.019), weight(r =-0.214, p = 0.037), height(r =-0.355, p < 0.001), and UAMA(r =-0.222, p = 0.030). Multivariate logistic regression analysis revealed that height and aerobic exercise were significantly related to TTImus independently of age, weight, and UAMA. The predictive regression equation for TTImus in male subjects was TTImus = 0.228-0.001 × height(cm), and in female subjects it was TTImus = 0.320-0.001 × height(cm).Conclusion: Gender, age, anthropometry, skeletal muscularity, and aerobic exercise are significantly associated with indices of inspiratory muscle function in children. Normal values of TTImus in healthy children are reported.

关键词： Aerobic exercise Children Inspiratory muscle function Maximal inspiratory pressure Skeletal muscle function Tension-time index of the inspiratory muscles

Low rectal cancer:Sphincter preserving techniques-selection of patients,techniques and outcomes

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World Journal of Gastrointestinal Oncology 2015年第7期7卷 55-70页

作者： Nikoletta dimitriou Othon Michail Dimitrios Moris John Griniatsos 1st Department of Surgery University of AthensMedical SchoolLaiko Hospital

Low rectal cancer is traditionally treated by abdominoperineal resection. In recent years, several new techniques for the treatment of very low rectal cancer patients aiming to preserve the gastrointestinal continuity and to improve both the oncological as well as the functional outcomes, have been emerged. Literature suggest that when the intersphincteric resection is applied in T1-3 tumors located within 30-35 mm from the anal verge, is technically feasible, safe, with equal oncological outcomes compared to conventional surgery and acceptable quality of life. The Anterior Perineal Plan E for Ultra-low Anterior Resection technique, is not disrupting the sphincters, but carries a high complication rate, while the reports on the oncological and functional outcomes are limited. Transanal Endoscopic Micro Surgery(TEM) and Trans Anal Minimally Invasive Surgery(TAMIS) should represent the treatment of choice for T1 rectal tumors, with specific criteria according to the NCCN guidelines and favorable pathologic features. Alternatively to the standard conventional surgery, neoadjuvant chemo-radiotherapy followed by TEM or TAMIS seems promising for tumors of a local stage T1sm2-3 or T2. Transanal Total Mesorectal Excision should be performed only when a board approved protocol is available by colorectal surgeons with extensive experience in minimally invasive and transanal endoscopic surgery.

关键词： Low rectal cancer Sphincter preservingsurgery Intersphincteric resection Anterior PerinealPlanE for Ultra-low Anterior Resection of the Rectum Total mesorectal excision TransAnal Minimally InvasiveSurgery Transanal Total Mesorectal Excision Quality oflife Oncological outcome Functional outcome

Complete mesocolic excision: Techniques and outcomes

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 383-388页

作者： Nikoletta dimitriou Othon Michail Dimitrios Moris John Griniatsos 1st Department of Surgery University of AthensMedical SchoolLaiko Hospital

Complete mesocolic excision(CME) for the treatment of colon cancer was first introduced in the West in 2008. The first aim of this procedure is to remove the afflicted colon and its accessory lymphovascular supply by resecting the colon and mesocolon in an intact envelope of visceral peritoneum, which holds potentiallyinvolved lymph nodes. The second component of CME is a central vascular tie to remove completely all lymph nodes in the central(vertical) direction. In its original iteration, CME was performed via laparotomy, although many centers preferentially perform laparoscopic surgery, with its associated benefits and similar oncolo-gical outcomes, as the standard treatment for colonic cancer. Here, we present the surgical techniques for CME in open and laparoscopic surgery, as well as the surgical, pathological and oncological outcomes of the procedure that are available to date. Because there are no randomized control trials comparing CME to "standard" colon surgery, the principles underlying CME seem anatomical and logical, and the results published from the Far East, reporting an 80% 5-year survival rate for Stage III cancer, should guide us.

关键词： Colon cancer Complete mesocolic excision Laparotom

Lymph node,peritoneal and bone marrow micrometastases in gastric cancer:Their clinical significance

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World Journal of Gastrointestinal Oncology 2012年第2期4卷 16-21页

作者： John Griniatsos Othon Michail Nikoletta dimitriou Ioannis Karavokyros 1st Department of Surgery University of AthensMedical SchoolGR 115-27AthensGreece

The 7th TNM classification clearly states that micro-metastases detected by morphological techniques(HE stain and immunohistochemistry) should always be reported and calculated in the staging of the disease(pN1mi or M1),while patients in whom micrometas-tases are detected by non-morphological techniques(e.g.,ow cytometry,reverse-transcriptase polymerase chain reaction) should still be classif ied as N0 or *** gastric cancer patients,micrometastases have been de-tected in lymph nodes,the peritoneal cavity and bone ***,the clinical implications and/or their prognostic signif icance are still a matter of ***-rent literature suggests that lymph node micrometasta-ses should be encountered for the loco-regional staging of the disease,while skip lymph node micrometastases should also be encountered in the total number of infiltrated lymph *** fluid cytology ex-amination should be obligatorily performed in pT3 or pT4 tumors.A positive cytology classif ies gastric cancer patients as stage Ⅳ.Although a curative resection is not precluded,these patients face an overall dismal *** patients with a positive cytology should be treated similarly to patients with macroscopic peritoneal recurrence should be evaluated ***-tric cancer cells are detected with high incidence in the bone ***,the published results make comparison of data between groups almost impossible due to severe methodological *** these meth-odological problems are overcome in the future,specif ic target therapies may be designed for specif ic groups of patients.

关键词： Gastric cancer D2 lymphadenectomy Lymph node micrometastases Peritoneal micrometastases Bone marrow micrometastases

Testing optically stimulated luminescence dating on sand-sized quartz of deltaic deposits from the Sperchios delta plain, central Greece

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Journal of Palaeogeography 2018年第2期7卷 130-145页

作者： Evangelos Tsakalos Elias dimitriou Maria Kazantzaki Christos Anagnostou John Christodoulakis Eleni Filippaki Hellenic Centre for Marine Research Institute of Inland Waters Laboratory of Archaeometry Institute of Nanoscience and Nanotechnology National Centre for Scientific Research N.C.S.R. "Demokritos" Department of Geophysics Division of Earth and Planetary Sciences Graduate School of Science Kyoto University Hellenic Centre of Marine Research Institute of Oceanography Climate Research Group Division of Environmental Physics and Meteorology Faculty of Physics National and Kapodistrian University of Athens

This study reports on the first investigation into the potential of luminescence dating to establish a chronological framework for the depositional sequences of the Sperchios delta plain, central Greece. A series of three borehole cores(20 m deep) and two shallow cores(4 m deep), from across the delta plain, were extracted, and samples were collected for luminescence dating. The luminescence ages of sand-sized quartz grains were obtained from small aliquots of quartz, using the Single-Aliquot Regenerative-dose(SAR) *** equivalent dose determination included a series of tests and the selection of the Minimum Age Model(MAM) as the most appropriate statistical model. This made it possible to confirm the applicability of quartz Optically Stimulated Luminescence(OSL) dating to establish absolute chronology for deltaic sediments from the Sperchios delta *** age results of the five cores showed that the deltaic sediments were deposited during the Holocene.A relatively rapid deposition is implied for the top14 m possibly as a result of the deceleration in the rate of the sea-level rise and the transition to terrestrial conditions, while on the deeper parts, the reduced sedimentation rate may indicate a lagoonal or coastal environment.

关键词： Luminescence dating Holocene Sedimentation rates Deltaic deposits Sperchios delta plain Central Greece

Acute poisoning:an old-time classic issue in pediatrics

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World Journal of Pediatrics 2019年第6期15卷 622-623页

作者： Despoina Gkentzi Xenophon Sinopidis Diamanto Gourdoupi Manolis Mentis Ageliki Karatza Gabriel dimitriou Department of Paediatrics University of Patras Medical SchoolRioPatrasGreece Department of Social Services University General Hospital of PatrasPatrasGreece

Acute poisoning remains a major public health problem in childhood worldwide[1,2].The profile of these incidents differs between countries[1-3].In general,unintentional poisonings occur in children younger than 5 year... 详细信息

关键词： Epidemiology Poisoning Children

Retroperitoneal perivascular epithelioid cell tumours: A case report and review of literature

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World Journal of Clinical Cases 2019年第21期7卷 3524-3534页

作者： Zisis Touloumis Niki Giannakou Christos Sioros Argiro Trigka Maria Cheilakea Nikoletta dimitriou John Griniatsos Department of Surgery Athens Medical GroupAthens 11525Greece Department of Pathology Athens Medical GroupAthens 11525Greece Emergency Department Konstantopouleio General HospitalN.Ionia 14233Greece Department of Surgery National and Kapodistrian University of AthensAthens 11527Greece

BACKGROUND The perivascular epithelioid cell tumour(PEComa)family of tumours mainly includes renal and hepatic angiomyolipomas,pulmonary lymphangioleiomyomatosis and clear cell“sugar”tumour of the *** uncommon tumours with similar morphological and immunophenotypical characteristics arising at a variety of sites(abdominal cavity,digestive tract,retroperitoneum,skin,soft tissue and bones)are also included in the PEComa family and are referred to as PEComas not otherwise *** SUMMARY We present a 37-year-old female patient who underwent resection of an 8.5 cm×8 cm×4 cm retroperitoneal tumour,which eventually was diagnosed as PEComa of uncertain biological *** years after the operation,the patient remains without any evidence of recurrence.A search was performed in the Medline and EMBASE databases for articles published between 1996 and 2018,and we identified 31 articles related to retroperitoneal and perinephric *** focused on sex,age,maximum dimension,histological and immunohistochemical characteristics of the tumour,follow-up and long-term ***-four retroperitoneal(including the present one)and ten perinephric PEComas were identified,carrying a malignant potential rate of 44%and 60%,*** half of the potentially malignant PEComas presented with or developed metastases during the course of the *** Retroperitoneal PEComas are not as indolent as they are supposed to *** surgical resection constitutes the treatment of choice for localized disease,while mammalian target of the rapamycin(mTOR)inhibitors constitute the most promising therapy for disseminated *** role of mTOR inhibitors as adjuvant or neoadjuvant therapies needs to be evaluated in the future.

关键词： Perivascular epithelioid cell tumour Retroperitoneum Mammalian target of the rapamycin inhibitors Tuberous sclerosis complex Case report Treatment